What does deas analysis mean? Bioavailability when applied topically

Dehydrepiandrosterone sulfate is an androgenic hormone classified as a ketosteroid, which is synthesized in the adrenal glands. The level of dehydrepiandrosterone sulfate in the body can be used to judge the state of the adrenal glands and how actively they produce androgenic hormones. As a result of metabolic reactions, male sex hormones - testosterone and dihydrotestosterone - are formed from dehydrepiandrosterone sulfate. being more active forms androgenic hormones. Normally, the production of dehydrepiandrosterone sulfate (DHEA sulfate, DHEA-S) is a fairly stable process; the adrenal glands produce a certain amount of it every day, which is then excreted from the body by the kidneys along with urine, without allowing sharp fluctuations.

In pregnant women, dehydrepiandrosterone sulfate is synthesized not only in the adrenal cortex of the woman herself, but also in the adrenal cortex of the fetus; subsequently, the placenta produces estrogen from it. With excess production of dehydrepiandrosterone sulfate, women experience masculinization and disappearance of menstruation - amenorrhea.

Dehydrepiandrosterone sulfate is normal. Explanation of the result (table)

Increased production of dehydrepiandrosterone sulfate is used as a marker in the diagnosis of certain diseases of the adrenal glands, such as tumors of the adrenal glands, both benign and malignant, or hyperplasia.

A test for the level of dehydrepiandrosterone sulfate is carried out simultaneously with identifying the level of other hormones, especially if there is a suspicion that the patient has problems with the synthesis of androgens.

Blood is drawn from a vein in the morning on an empty stomach.

If dehydrepiandrosterone sulfate is elevated - what does this mean?

Excess normal level dehydrepiandrosterone sulfate is observed in the following cases:

  • tumor diseases of the adrenal cortex,
  • adrenal hyperplasia,
  • Cushing's disease
  • tumor diseases producing adrenocorticotropic hormone,
  • hirsutism in women.

It should be understood that an increase in the patient’s blood level of dehydrepiandrosterone sulfate in itself is not a sign of a specific disease. However, this phenomenon certainly indicates hormonal imbalance, and, therefore, further examination is necessary to identify its causes. Taking certain dietary supplements containing dehydroepiandrosterone sulfate supplements can also lead to an increase in the concentration of this hormone.

If dehydrepiandrosterone sulfate is low - what does this mean?

Insufficient production of dehydrepiandrosterone sulfate in the patient's body is usually observed with insufficient adrenal function. As a rule, it is not of diagnostic interest, although delays in puberty may occur in adolescents. Taking certain medications, in particular hormonal ones, can also lead to a decrease in the level of dehydrepiandrosterone sulfate oral contraceptives and glucocorticoids.

Other articles on this topic:

http://www.medmoon.ru/med/degidrojepiandrosteron_sulfat_norma_tablica.html

The level of DHEA sulfate is increased - in women, during pregnancy, causes and treatment

The hormone dehydroepiandrosterone sulfate (DHEA S, DHEA S, DEA S04) belongs to the class of androgens, steroid substances. This is a sex hormone. It is generated mostly by the adrenal glands, a small part of it is produced by the testicles in men, and by the ovaries in women. That is, the substance is present in people of both sexes.

Dehydroepiandrosterone sulfate is elevated in women with adrenal dysfunction. If the analysis shows high DHEA C, it is necessary to diagnose the functioning of these organs. Dehydroepiandrosterone increases with problems with reproductive function. What kind of hormone is this and what does it affect?

Functions of DHEA S

DEA S04 in women affects her well-being and youthful appearance. In both sexes, the hormone affects sexual desire. A woman’s menstrual cycle depends on DHEA sulfate. It affects the condition of hair and skin. If the level of the substance increases, skin rashes and symptoms of hair loss may appear.

In the body of men, DHEA C hormone is converted into testosterone, and in the body of a woman, estrogens are obtained from it. Analysis for DHEA S04 shows where intensive formation of the steroid occurs - if it is elevated, then the generator is the adrenal glands, if it is reduced, then the ovaries (in men, the testes).

The substance is formed from cholesterol with the assistance of enzymes. Therefore biologically active additives(dietary supplements) containing DHEA sulfate can reduce body weight. But you can’t get carried away with them. What happens when the hormone increases above normal, we will consider below.

In women during pregnancy, dehydroepia is absorbed by the placenta for subsequent production of estrogen. If a pregnant woman has elevated DHEA C levels. This means the placenta is not saturated with this hormone, and this situation can lead to miscarriage.

In male children, DHEA S affects the development of secondary sexual characteristics.

The amount of steroid in the body does not depend on puberty. It also does not depend, unlike many other substances, on the time of day.

Steroid norm in women

The volume of DHEA sulfate is affected by a person’s gender and age. Scientists have determined that the most high level substances are present in embryos in the mother's uterus. After birth, the amount of the hormone in a child drops sharply, then it increases during puberty.

In a woman under 30 years of age who is capable of conceiving a child, the androgen content should be from 2700 nmol/l to 11000 nmol/l. A man who has strong sperm capable of fertilizing eggs has at least 5500 nmol/l dehydroepiandrosterone sulfate.

During pregnancy, the content of the described substance in the expectant mother decreases every 3 months. If from 1 to 3 months it ranges from 3 to 12 µmol/l, then from 7 to 9 months the DHEA hormone decreases to levels from 0.8 to 3.5 µmol/l. The figures are approximate. The interpretation of the analysis should be carried out by a gynecologist-endocrinologist.

After 30 years, androgen levels in women are reduced. The table of the dependence of the amount of androgen on age looks like this:

Lower limit (mg/l)

Causes of elevated DHEA C in women

DHEA S is a male hormone. Its increase in women indicates pathology. It could be:

  • Congenital disease of the adrenal cortex;
  • Tumor disease (benign or malignant) of the adrenal glands;
  • Pituitary tumors;
  • Excessive generation of adrenocorticotropin by tumor cells;
  • Multiple ovarian cysts;
  • Puberty too late;
  • Osteoporosis disease;
  • Ovarian pathology.

It is clear that increasing the volume of the hormone in itself is not a problem. It only indicates pathologies of the listed types. To treat elevated DHEA C, it is necessary to treat the disease that caused it.

Consequences increased amount androgen, excluding the consequences of a tumor, may be:

  • Diagnosing a woman with infertility;
  • Miscarriages and premature births;
  • Aging too early;
  • Excessive fat deposition;
  • Irritability and nervousness;
  • Insomnia or sleep with nightmares;
  • Hair growth of parts of a woman's body.

Low androgen may indicate endocrine disease, in which the adrenal glands cannot cope with their functions, due to a lack of sex hormones and other pathologies. It also occurs during late puberty.

Indications for laboratory testing

Your doctor may order a blood test for the hormone DHEA C in the following cases:

  • Early or late puberty.
  • Suspicion of a tumor in the adrenal glands.
  • Determination of normal growth and maturation of follicles.
  • Frequent miscarriages.
  • Suspicion of a pituitary tumor.

The pituitary gland produces adrenocorticotropic hormone, which affects the production of DEAS. Some preparation is required before taking the test.

Preparation for analysis on DEA S04

Blood is taken for analysis from a woman in the morning on days 5–7 of the cycle. A few days before the study, the woman needs to reduce physical exercise. Should be excluded from drinking alcoholic drinks and coffee. 2 days before the test you must abstain from sexual intercourse.

The day before you should not eat fatty or too much food. salty food. Semi-finished products containing artificial additives for color and smell should also be excluded from the menu. You can have dinner, but it is not recommended to overeat at night; you are allowed to snack on kefir or something light. After this, you can neither eat nor drink until blood is drawn.

Smoking in the morning is not advisable. If it is not possible not to smoke, you can smoke for the last time an hour before the test.

On the day of the study, before the analysis, you cannot undergo other tests. diagnostic procedures- Ultrasound, radiography, CT or MRI. It is also prohibited to take physiotherapeutic procedures.

Treatment for elevated DHEA C

To treat an elevated level of a substance, it is necessary, first of all, to cure the disease that caused this increase. Tumor disease requires surgical treatment. Chemotherapy may then be prescribed. If a tumor is found on early stage, a specialist can replace the operation drug treatment. These measures will be a factor reducing the indicator.

In case of infertility, a consultation with a doctor from a family planning center is required, who will prescribe a detailed examination to determine the cause. On the center’s website there are many reviews from families, women who were successfully treated to make it possible to conceive a baby.

Treatment depends on the woman's plans. If she does not intend to have a baby, she may be prescribed contraceptives in the form of hormonal pills, which will reduce the production of androgens. That is, there are hormonal drugs that can reduce DHEA C, but they will only eliminate the consequences of the disease, while its cause will remain. Hormonal medications prescribed only when other treatments are unacceptable. Such periods include pregnancy. But a pregnant woman should take unsafe drugs under the constant supervision of a gynecologist or endocrinologist.

After a course of treatment with hormones, signs of increased DAE S04 may disappear. But after some time a relapse is possible. If a woman is close to menopause in age, her DHEA C levels decrease naturally and the consequences of its increase disappear - body hair, the onset of baldness, and so on. Despite this, you need to keep your health under control - undergo periodic examinations, visit a doctor and do hormone tests.

DHEA C should also be increased in the manner recommended by the doctor. First you need to conduct an examination and understand why the hormone is low. Then you need to eliminate the disease that led to its decrease. You should not immediately take medications containing DHEA S.

http://gormonytela.ru/endokrinologiya/dgea-sulfat-povyshen.html

Elevated DHEA sulfate: how to treat it?

If DHEA sulfate is elevated, in the vast majority of cases, a targeted study of the functionality of the adrenal glands is required. An increase in the level of this substance occurs when congenital dysfunction adrenal glands

Dehydrepiandrosterone sulfate in its structure is an androgen not associated with puberty and is produced by the adrenal glands. When DHEA sulfate is elevated, disruptions in many body systems can occur, but this anomaly is especially noticeable in women.

If DHEA-C is elevated in a woman, there may be serious disorders at work reproductive system. In addition, in some cases, other significant symptomatic manifestations may occur, including skin and hair problems. Many women with elevated DHEA sulfate levels long time suffer from hair loss and the appearance of rashes on the skin of the face and body.

Dehydrepiandrosterone sulfate is a catosteroid and is produced in women in the amount of 13-35 mg per day, but at the same time most of This substance is catabolized, while only a small amount, up to about 10% of the substance, can be excreted by the body in the urine. It is noteworthy that dehydrepiandrosterone sulfate is not associated with specific proteins, and therefore does not affect their concentration in the blood. At the same time, it must be taken into account that dehydrepiandrosterone sulfate can bind to albumin contained in the blood serum.

Dehydrepiandrosterone sulfate in women is produced exclusively in the adrenal cortex, while in men it is produced in small quantities in the gonads. Despite the fact that dehydrepiandrosterone sulfate itself has a low androgynous effect, during metabolism in peripheral tissues it can be converted into the male hormone - testosterone and its derivative dehydrotestosterone. Excess male hormones leads to the emergence of a wide variety of deviations.

The reason for the appearance of elevated levels of dehydrepiandrosterone sulfate in women may be associated not only with congenital disorder in the adrenal cortex, but also by the appearance malignant tumors in this area, osteoporosis, delayed puberty and even a number of ovarian diseases. That is why increased level DHEA sulfate is not a problem in itself, but only a marker of existing problems in the body.

In order to effectively treat increased levels of DHEA sulfate, it is very important to find out the root cause of this pathology. Some hormonal medications can eliminate elevated levels of DHEA sulfate, but do not eliminate the root cause of the pathology. Usage hormonal drugs justified only in cases where other methods of therapy can cause significant harm, for example, during pregnancy.

If DHEA sulfate was detected during the diagnosis of infertility, a targeted course of treatment for the underlying disease is required, and not only conservative but also surgical methods, depending on the root cause of deviations in hormonal background. In women who do not plan to have a child in the near future, the diagnosis of DHEA sulfate may be associated with problems that appear due to an excess of male hormones, including hair loss and deterioration of skin condition.

The choice of treatment strategy largely depends on the woman’s plans to have children in the future, as well as on how severe the existing symptoms are. If a woman does not plan to become pregnant in the near future, then hormonal contraceptives that have an antiandrogenic effect are used to eliminate the increased level of DHEA sulfate. There are several types of these drugs that allow short terms eliminate excess male hormones from a woman’s body.

At the same time, it must be borne in mind that this method of treatment only eliminates symptoms, including problems with skin and hair, but cannot provide positive effect to the root cause of the disease and restore normal work adrenal cortex. IN in rare cases can be used to eliminate elevated levels of DHEA sulfate non-hormonal drugs, which have an antiandrogenic effect, but their use is not always justified.

After completing the course drug therapy there may be attenuation of all symptomatic manifestations, indicating an increase in the level of male hormones in the blood, but this does not happen in all cases. Often when women stop taking hormonal medications, there is a relapse of hair loss and deterioration of the skin.

As you age, all symptoms indicating an excess of male hormones may completely disappear, which is associated with the processes of fading hormone production and the rapid approach of menopause. During menopause, most women experience a decrease in the production of DHEA sulfate.

Although doctors may take a wait-and-see approach if there are no obvious problems that may be caused by elevated levels of DHEA sulfate, regular screening and blood tests should be done as a preventive measure to monitor levels of this substance.

http://www.webkarapuz.ru/article/dgea-sulfat-povyishen-chem-lechit

Sometimes you have to deal with such a concept as; what is it, is it produced in women or in men - these are the questions that often arise in such cases. Dehydroepiandrosterone sulfate in women is a hormone of youth that is responsible for many functions in the body of women and men.

DHEA hormone is an androgen, has no connection with puberty, is synthesized and secreted by the adrenal glands, and later by ovaries in women and testicles in men. The hormone DHEA is a ketothyroid hormone and is excreted in the urine.

Hormones in the female body are responsible for many processes, the menstrual cycle, genital area. A deficiency or excess of hormones will invariably affect appearance woman, her mood. The level of DHEA can be used to judge women's health, therefore, if there are any disorders in the body, it is necessary to carry out full examination, including taking a blood test for hormones.

DHEA (DHEA, DEA-SO4) is an abbreviation for the thyroid hormone dehydroepiandrosterone, which refers to. about 95% of this hormone, while paired female sex glands produce only 5% or not at all. Normally, male sex hormones, including dehydroepiandrosterone, are needed by a woman, since their role in the body is very significant. For example, sex life In a woman, her libido is directly related to DHEA, which, when interacting with testosterone, helps a woman experience sexual desire.

If, as a result of any disturbances (tumor, for example), the hormone DHEA begins to produce more than the required levels, this threatens with such consequences as:

  • infertility;
  • premature birth;
  • the appearance of the first signs of aging;
  • increased hair growth, etc.

Insufficient production of DHEA-SO4 leads to delayed sexual development. Most often this is due to a condition in which the adrenal glands cannot produce the hormone in sufficient quantities.

If changes in the levels of the hormone dehydroepiandrosterone sulfate are observed, it is necessary to consult doctors such as a gynecologist and endocrinologist.

Normal hormone levels

The normal range for DHEA in women is from 2700 to 11000 nmol/l. For men, this indicator is slightly different; the minimum level should not be lower than 5500 nmol/l.

In pregnant women, the level of dehydroepiandrosterone decreases with each trimester: from 3.12 nmol/l in the first trimester to 3.6 nmol/l by the end of pregnancy.

At birth, a baby's levels of the hormone DHEA are usually high. After a short period, this figure decreases sharply, which is the absolute norm, and then increases again.

Diagnostic measures

DHEA-S analysis is carried out using a sample taken venous blood. For the analysis, you will need blood serum (1 ml is enough), which can be stored for about 1 week at the appropriate temperature.

In order for your blood counts to be correct, on the eve of the test you must refrain from eating fatty foods and avoid drinking alcohol. If a person is taking synthetic hormones or other drugs (for example, Corticotropin, Clomiphene, Prednisolone, Dexamethasone, etc.), it is necessary to discontinue them several days before blood sampling or inform the doctor about them. Blood must be donated on an empty stomach; before taking the test, you should refrain from smoking and drinking coffee drinks. You are allowed to drink some water before taking the test.

Indications for a blood test for DHEA are the following disorders:

  • early puberty;
  • adrenogenital syndrome;
  • frequent miscarriages;
  • the presence of tumors in the area of ​​other organs;
  • menstruation disorders;
  • early signs of menopause;
  • alopecia or hirsutism;
  • infertility;
  • frigidity, etc.

DHEA testing should be done by the end of the first week menstrual cycle(5th, 6th, 7th day).

Hormone DHEA-sulfate

Thanks to the scientific development of synthetic hormones, most women can not only prolong youth, increase libido and experience the joy of motherhood, but also significantly improve their overall health. The hormone DHEA-S, produced in tablet form, is not prescribed to patients to improve sexual performance, but at the same time it is noted beneficial effect to testosterone, which increases sexual activity. Its use has a positive effect on work nervous system, improves the mind, memory and mood. In particular, its positive effect can be seen in people mature age.

There is another feature of the hormone: it dissolves fats accumulated as a result poor nutrition and other violations. This property of the hormone is actively used by nutritionists, cosmetologists, and athletes (the use of steroids is prohibited at competitions in elite sports). The drug produced in the form food additives studied on animals in which excess weight actually fell under the influence of the hormone, but for this it had to be administered in huge quantities. It follows from this that calling dehydroepiandrosterone a panacea for excess weight it is forbidden.

Contraindications and possible side effects of the medicine

Hormonal drugs can be not only useful (if the body produces insufficient hormones), but also dangerous, so taking them on your own is prohibited.

Since the hormone DHEA is the “mother” of thyroid hormones, including testosterone, by artificially increasing it in the body, you can achieve unpleasant consequences for a woman. In normal quantities, the hormone can improve the condition of the skin, making it smoother and more beautiful, prolong a woman’s menstrual cycle, improve the condition of hair and nails, strengthen joints and give a beautiful shine to the eyes - a symbol of youth and sexuality.

If it is in excess, the effect will be exactly the opposite: a woman will begin to grow hair in the area of ​​her face, legs, arms, and chest, while a bald spot may form on the top of her head (which happens to men under the influence of testosterone). At long-term use synthetic hormone can change the timbre of the voice and strengthen the muscles. There have been cases of the development of oncology in the mammary glands due to uncontrolled intake of DHEA sulfate.

When is the drug prescribed?

The hormone in certain dosages helps to cope with numerous problems of the body, in particular such as: chronic fatigue, reduced immunity, autoimmune diseases.

With the syndrome chronic fatigue the drug is indicated for mature women who note a significant improvement in their health and well-being 14 days after starting treatment. They experience a surge of strength, muscle activity and pleasant energy. Positive influence The hormone helps women improve their quality of life, increase productivity and get rid of the weakness inherent in older people.

Some pregnant women are also prescribed the drug in small quantities to prevent chronic fatigue. Pregnant women should not take the hormone on their own.

With reduced immunity associated with postoperative period, previous diseases, during the season increased risk get sick colds DHEA is prescribed. Through experiments, scientists have proven that when increased concentration in the body the hormone DHEA is treatable even chronic diseases related to the immune system.

During pregnancy, the hormone DHEA is produced by both the female body and the small body of the child, so it is very important to monitor the level of the hormone while carrying the baby.

Autoimmune diseases, caused by an incorrect reaction of the body to certain cells or organs, can cause serious harm to human health, since with an abnormal immune response, the body literally begins to eat itself from the inside. Sometimes this happens in thyroid gland women, which manifests itself in the form of destruction of thyroid cells increased activity immune functions.

DHEA sulfate is prescribed to women to combat this pathology, including during pregnancy, when other treatment methods are contraindicated. Therapy with a hormonal drug is carried out for 2.5 weeks, while further examination of patients shows significant improvements, and the disease itself can be “sent” into remission for a long time.

For the treatment of malignant tumors, the drug of the synthetic hormone DHEA is not prescribed, but at the same time it is noted that in all elderly people with normal indicator hormone, the risk of developing tumors is significantly reduced. It was noticed that when malignant neoplasms dehydroepiandrosterone is practically absent or its levels are very low.

Preventive measures

To avoid unpleasant changes in the body associated with an excess or deficiency of the hormone DHEA-S, it is necessary to pay attention to the appearance of symptoms such as menstrual irregularities (normally its duration should be about 30 days), lack of ovulation, and depressed mood.

Hair loss and brittle nails are often associated with vitamin deficiency, but the cause of this condition may be hormonal disbalance. If the cause of hair loss is not related to a cosmetic factor (incorrect and frequent dyeing, for example), then there is every reason to assume that there is a malfunction in the body, the cause of which can only be found out with the help of a specialist.

Aging female body- the process is natural, but it is completely undesirable when it begins prematurely. Therefore, if a woman (aged 37 years or earlier) notices a deterioration in the condition of her skin, the appearance of wrinkles, a decrease in the number menstrual blood, then you should immediately consult a doctor to take a course of hormonal replacement therapy, which will prolong a woman’s youth and eliminate premature aging.

From all of the above, only one conclusion follows: there is no need to fight attacks bad mood, depression, lack of normal libido on their own. After all, now, with the development modern medicine, All unpleasant signs and the symptoms can be corrected by improving the quality of life for yourself and your environment, which is affected by the emotional instability of a woman suffering from hormonal disorders.

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Controlling your hormone levels can greatly improve your quality of life. Dehydroepiandrosterone (DHEA) is one of the most important hormones in the human body as it regulates the production of androgen and estrogen. Excessive amounts of DHEA in the body may be associated with hyperandrogen syndrome. To reduce DHEA levels, start eating right, exercising exercise and sleep at least 8 hours a day. Consult your doctor and ask him to monitor your performance over a period of time. Keep track of what medications you take then positive result And wellness won't keep you waiting long.

Steps

Doctor's appointment

    Consult your doctor. Make an appointment with your doctor or endocrinologist, a specialist in hormonal disorders. They will need your medical history and a blood test to check your DHEA levels. Take with you a sheet of paper with any questions you may have to make effective use of your visit.

    Eat foods with high content zinc or take a zinc supplement. Certain minerals, such as zinc, can reduce swelling and inflammation throughout the body. If you are suffering from frequent swelling along with high DHEA levels, try zinc to address this issue. Before you start taking any supplements, be sure to consult with your doctor. Foods high in zinc include:

    • meat, especially beef, pork, venison and dark meat chicken;
    • nuts;
    • beans;
    • whole grains;
    • yeast.

  1. Monitor ongoing illnesses. High levels of DHEA can have a direct impact on other aspects of your health, including other medical conditions during treatment. While you are trying to reduce high DHEA levels, you may want to consider taking a additional examinations for diabetes, liver disease or cancer. This is a proactive approach that will save good health for a long time.

    Beware possible interactions with other medications. Side effect Some drugs increase DHEA levels. If you are trying to lower your hormone levels, be sure to consult your doctor before taking new medications. Discuss and review with him the effects of the medications you are taking.

    • For example, diabetes medications such as Metformin are often associated with an increase in DHEA levels.

  2. Stop taking synthetic DHEA supplements. Talk to your doctor about gradually tapering off your prescription over-the-counter hormonal medications. It will be extremely difficult for you to lower your DHEA levels while you are taking medications that increase your DHEA levels.

    • Please note that on complete failure It may take months to come off the medications. Be patient and over time you will notice positive changes.

  3. Agree to the operation. If high DHEA levels are caused by a large tumor, your doctor may advise surgical intervention. Before agreeing to anything, discuss the risks and benefits of surgery with your doctor. On a positive note operation is rapid decline hormone levels.

Change your lifestyle

    Consult your doctor before making any changes to your lifestyle. If you want to try controlling your DHEA levels through diet and exercise, make an appointment with your doctor. Perhaps he will be able to advise something or point you in the right direction. Have him track your DHEA levels so you know what changes to make.

    Eat right. It is worth clarifying that food products themselves do not contain DHEA as such. But consuming certain foods can increase or decrease the production of DHEA and other hormones. If you want to lower your DHEA levels, avoid foods that raise them (wild yam, sugar, wheat and dairy). Instead, your diet should consist of foods that have anti-inflammatory properties, like tomatoes, olive oil and salmon.

    Get some exercise, but try not to overdo it. Training three times a week is great way keep DHEA levels under control. To get the most benefit from your workouts, do cardio and weight-bearing exercises.

    Maintain a healthy weight. Take a look at the body mass index chart to compare your weight in relation to your height and age. With excessive weight, DHEA is deposited in adipose tissue. The body also produces too much estrogen, DHEA, and other hormones.

    Get enough sleep. To better control your hormones, try to sleep at least 8 hours a day. Create a sleep schedule and stick to it.

    Reduce your stress levels. Human body very sensitive to stress, which can lead to increased production various hormones, including DHEA. To keep your DHEA levels under control, learn to relax. Try yoga to help you relax both at home and at work. Perform techniques deep breathing. Dine out at least once to enjoy fresh air. Go to the cinema with friends or take an art class.

    • Ask your doctor to monitor not only your DHEA levels, but also your blood pressure. By doing something relaxing, you will immediately notice clear improvements.

Change your habits

  1. Beware of the natural decline in hormone levels as you age. DHEA levels typically reach highest performance at the age of 20, when a person becomes mature in a hormonal and physical sense. After this, a natural decline in DHEA levels begins, which drops to almost zero by the age of 90. Talk to your doctor about how to manage age-related decline in DHEA while taking independent measures, such as changes in diet.

Dehydrepiandrosterone sulfate (DHEA-sulfate, DHEA-S) is a non-pubertal androgen synthesized and secreted by the adrenal glands and is a ketosteroid.

DHEA sulfate is synthesized primarily as a sulfate ester from cholesterol sulfate ester. The majority of DHEA sulfate is catabolized and typically only 10% of the steroid is excreted in the urine.

DHEA sulfate is secreted at a rate of 10-20 mg/24 hours (35-70 µmol/24 hours) in men and 3.5-10 mg/24 hours (12-35 µmol/24 hours) in women, without a circadian rhythm . It does not bind to specific plasma proteins (SHBG or CBG) and, therefore, their concentration does not affect the level of DHEA sulfate. However, DHEA sulfate binds to serum albumin.

In addition to DHEA sulfate, dehydrepiandrosterone (DHEA) is present in the circulating blood, which is formed partly in the adrenal cortex and partly in the gonads at a rate of 1/4 and 1/2 of the rate of DHEA sulfate secretion in men and women, respectively. Because the metabolic clearance of DHEA is very rapid, its concentration in the circulating blood is lower than the level of DHEA sulfate.

Due to the high concentration of DHEA sulfate in the blood, long period half-life and high stability, as well as the fact that its source is mainly the adrenal glands, DHEA sulfate is an excellent indicator of androgen secretion.

Why is it important to take Dehydroepiandrosterone Sulfate (DHEA-S)?

Dehydroepiandrosterone sulfate is produced almost entirely in the adrenal cortex, in men - a certain amount in the gonads (5%). In women, it is not produced in the ovaries. The level of this hormone is an indicator of androgen synthetic activity of the adrenal glands. The hormone has a weak androgenic effect, however, during its metabolism in peripheral tissues, testosterone and dihydrotestosterone are formed. The clearance rate of dehydroepiandrosterone is low. This indicator is used in the diagnosis of hyperandrogenic conditions in women (hirsutism, baldness, disorder reproductive function), as well as to assess androgen status in cases of delayed sexual development. During pregnancy

Dehydroepiandros terone sulfate is produced by the adrenal cortex of the mother and fetus and serves as a precursor for the synthesis of placental estrogens.

Its level in the blood of pregnant women decreases moderately. In children, the content of dehydroepiandrosterone increases during puberty, and then gradually decreases with age.

The determination of DHEA-S04 in the blood as a marker of androgen production by the adrenal glands replaces the determination of 17-CS in daily urine. This eliminates errors associated with incomplete sample collection, impaired renal function, and the interference of many drugs with 17-KS. The test is often used in conjunction with the determination of testosterone and SHBG (sex hormone binding globulin).

For what diseases is dehydroepiandrosterone sulfate (DHEA-S) given?

  • adrenal tumors;
  • differential diagnosis of ovarian diseases;
  • osteoporosis;
  • delayed puberty.

If women have elevated testosterone levels, then by determining the concentration of DHEA sulfate, it is possible to determine whether this is due to adrenal disease or ovarian disease. DHEA sulfate levels increase only in diseases of the adrenal glands, such as androgen-producing tumors, adrenal hyperplasia, Cushing's syndrome of hypothalamic-pituitary origin with 21-hydroxylase or 11-beta-hydroxylase deficiency.

To check/improve the performance of which organs should you take Dehydroepiandrosterone sulfate (DHEA-S)?

Adrenal glands.

How to prepare for the Dehydroepiandrosterone Sulfate (DHEA-S) test?

On the eve of the study, it is necessary to exclude fatty foods and alcohol from the diet. Smoking should be avoided one hour before blood collection. During collection, the subjects must be at rest, sitting or lying down, on an empty stomach.

Dehydroepiandrosterone sulfate (DHEA-S) donation material

  • blood serum;
  • blood plasma (use test tubes with EDTA or heparin);