How to store Fluimucil antibiotic it for inhalation. The use of the drug fluimucil - an antibiotic in the inhalation therapy of respiratory infections. Carrying out inhalation with Fluimucil - an IT antibiotic.
To treat a long, debilitating cough, doctors prescribe antibiotics. There are drugs that help solve the problem without harming the entire body. These drugs include the antibiotic Fluimucil IT, which acts on the site of the disease locally, using inhalation.
Antibiotic Fluimucil IT for inhalation
The drug has no analogues for complex treatment respiratory diseases, because it simultaneously has an antimicrobial and expectorant effect. Carrying out inhalations using a nebulizer helps deliver the drug in finely dispersed form to the problem area. Antibiotic Fluimucil IT:
If the pathogen is a virus. The most common viruses that cause this are rhinovirus. Bacterial sinusitis. If you are in the presence of bacteria. The most common are staphylococci and streptococci. Mycotic sinusitis. If infectious agent is a mushroom. Specific forms of fungal sinusitis.
Symptoms and signs of sinusitis
As a result, the fungus causes an allergic reaction with congestion of the nasal cavity and polyposis in the nostrils and sinuses. One of the most common fungi of this sinusitis is Aspergillus, which causes what is called aspergillosis or aspergillosis sinusitis.
- Allergic sinusitis from mushrooms.
- They block cavities and cause chronic inflammation.
- Invasive mycotic sinusitis.
- The fungus can spread to the eye and cause bulging and blindness.
- acts locally;
- penetrates deeply;
- moisturizes the mucous membrane;
- thins mucus;
- simplifies its removal;
- improves sputum secretion;
- promotes expectoration;
- cleanses the bronchi;
- acts anti-inflammatory.
Often, to solve problems of the nasal cavity, Rinofluimucil spray is used, which has an anti-inflammatory effect. If the cause of the disease is viruses, and the disease respiratory tract accompanied by a cough - Fluimucil-antibiotic IT is prescribed for inhalation. Thanks to local impact it does not harm the entire body. With the help of medicine, drainage in tuberculosis is improved. It is used to prevent complications after operations. Diseases treated with antibiotics:
Symptoms of chronic sinusitis
The pain is usually worse in the morning and in the area of the affected breasts, usually very intense. Jaundice syndrome causes pain in the cheekbones just below the orbits of the eyes, accompanied by toothache and headache. Spheroid sinusitis causes unreported headache and pain in posterior region skulls Secretion and droplets yellow mucus from the nose. Often nasal discharge, which has a typical color due to the presence of pus, tends to slide down the throat behind clogged nose. Fever and cold. General malaise and confusion.
How to Diagnose Sinusitis
- Frontal sinusitis is located on the forehead just above the eyebrows.
- Ethmoidal sinusitis causes pain in the forehead and between the eyes.
- Headaches are usually concentrated in the frontal region and in the affected area.
- A feeling of constriction in the affected area of the chest.
- Loss of smell.
- Hypoesthesia or loss of sensitivity in areas of the face.
- bronchitis;
- pneumonia;
- tracheitis;
- cystic fibrosis;
- broncholitis;
- sinusitis;
- sinusitis;
- otitis.
Composition of the medicine
Fluimucil antibiotic IT for inhalation is complex combined agent, which has an active ingredient – thiamphenicol glycinate acetylcysteinate. It is produced in the form of a lyophilisate - a powder of a special preparation technology. The kit consists of an ampoule with active substance, having a sulfurous odor, in dosages of 250 ml, 500 ml. To dilute the antibiotic, the package contains special bottles of water.
Children's dosage depends on age
Typically, a nerve fiber probe is inserted to visualize and inspect the nasal nodules and take samples of the fluid they contain, then undergo bacteriological analysis and possibly an antibiogram to determine what type of antibiotic will be used.
Drugs and treatment recommendations
The actor can use special diagnostic tests to be sure clinical picture, among which the most common studies are. It is especially useful to formulate correct diagnosis in forms caused by mycotic infections.
- Allergy tests.
- To determine if there is allergic component at the heart of the disease.
Pharmacology of the active components of the drug
Each of the main active ingredients Fluimucil-antibiotic IT for inhalation is aimed at solving its problems. The substance thiamphenicol is not used alone, in pure form. It prevents the proliferation of harmful microorganisms by blocking protein synthesis in cell walls. Valid on different types bacteria:
Today's medical recommendations show what needs to be done: this is pharmacological therapy, which in many cases guarantees complete healing or, according to at least, remission of irritating symptoms. In practice, we see the main types of medications used to treat the disorder.
Fluidizers are based on saline solution, which inhales, increasing humidity in the area of the paranasal cavities and favoring the fluidization of mucus. Decongestant sprays such as phenylephrine instead cause vasoconstriction and therefore immediately clear the nasal passages. However, sprays should be used for a limited period of time up to a maximum of 4-5 days, after which they become addictive and instead of freeing the nose, they block it. Decongestants reduce blood flow to the mucous membranes and, as a result, cause remission of congestion and empty cavities, promoting respiration. However, they increase arterial pressure as a side effect. Antihistamines are administered if there is an allergic component at the base of the sinusitis. They have a function as it gives the name of the counteracting histamine, which is one of the inflammatory chemical mediators and responsible for the allergic reaction. Antibiotics are used to fight infections or excessive bacterial infections. Antibiotics for mucous membranes and aerosols are also often prescribed. That is, with a special device, the drug is sprayed into the air in microscopic droplets and then inhaled by the patient. These medications allow fluidity and drainage while fighting infection. In general, cortisone sprays or pads. Nasal sprays, which can be: fluidizing and decongestant. . For chronic forms of the disease, therapy is always based on antibiotics, anti-inflammatory and nasal irrigation with saline solutions, but for pharmacological therapy It may be useful to coordinate, as recommended by a specialist, periodic inhalation cycles with sulfur water and bromine salt to reduce the risk of complications.
- coli;
- staphylococci;
- hemophilus influenzae;
- pneumoniae streptococcus;
- corynebacteria.
Another component that is included in Fluimucil-antibiotic IT for inhalation is acetylcysteine, a strong expectorant that helps thiamphenicol penetrate into tissues. With his help:
- the ability of bacteria to attach to the mucous membrane decreases;
- the proliferation of microorganisms is inhibited;
- sputum thins;
- its separation and removal is facilitated.
Surgical surgery for serious cases. In many cases chronic sinusitis resistant to any type of treatment and a small amount must be used surgical procedure to wash the sinuses, drain mucus and correct any defects that may be deviations from the septum or polyposis. The intervention, when feasible, is performed using endoscopic fiber optic instruments to be less invasive.
Natural and Alternative Remedies for Sinusitis Treatment
Sometimes a subject affected by sinusitis does not want to resort to traditional medicine; how to deal with it using alternative and homeopathic methods? Alternative medicines for the treatment of sinusitis are varied, below we list the most common ones natural remedies to combat this disease and buffer its annoying symptoms without resorting to medications.
Fluimucil - instructions for use for inhalation
When using an antibiotic for inhalation, it is necessary that the doctor prescribe the treatment, taking into account the course of the disease and the age of the patient. For effective action funds required:
- purchase medicine with the required dosage;
- choose the right inhaler for the procedures;
- dilute Fluimucil antibiotic taking into account the dosage;
- conduct the required number of sessions.
Selection and preparation of a nebulizer
Inhalations with Fluimucil IT are carried out using a nebulizer, which finely sprays the antibiotic, delivering it to the most remote areas of the diseased organ. When choosing a device for procedures, you need to keep in mind that the ultrasonic version of the device cannot be used. This is due to the fact that in nebulizers of this design the antibiotic is destroyed. This effect is produced by ultrasonic waves, which ensure atomization of the drug. It is recommended to use compressor devices in which the size of small droplets can be adjusted.
Complications, risks and consequences of sinusitis
Treats with thermal waters, which have proven effective in combating the symptoms of chronic forms of sinusitis. It belongs to the "ancient" Chinese medicine and uses needles that are inserted under the skin along certain lines called meridians, towards which the various organs" The meridians involved in the treatment of sinusitis include the lungs, bladder, intestines and liver. on the lung meridian the respiratory tract is released, which bladder facilitates the disintegration of mucous membranes, liver and intestinal detoxification, herbal remedies, herbs are used to prepare daily allowances in hot water or herbal teas using elderflowers in herbal teas as anti-inflammatory or even blackcurrant drops Eucalyptus, lavender and pine for inhalation Homeopathy Care should be carved out on the patient by a homeopath; Typically, Belladonna is used in acute forms, A sulfuric acid calcium and carbon dioxide in chronic forms. Acupuncture. . We've seen the causes and treatments, but what are the risks associated with this disease?
Before using the nebulizer you should:
- disinfect the device;
- Wash the hands;
- prepare a mask for breathing through the nose;
- make a solution for inhalation;
- pour the antibiotic into a special container using a pipette or syringe;
- mask, attach the compressor after filling the medicine.
Storage conditions and periods
The most common complications of sinusitis are the passage of infection from the nasal passages to neighboring organs, such as the orbital cavities and eyes or meninges. These are all events that require urgent medical intervention, as the consequences may jeopardize the patient's vision or even life.
A serious complication, but unfortunately rare, is subdural empyema, which is a collection of pus caused by bacteria infecting the meninges. Among less serious complications is the passage of infection during inner ear with otitis and labyrinthitis. And so the retention purulent fluid inside the ear, ear blockage, balance problems and dizziness, swelling lower jaw.
How to dilute Fluimucil solution
For adults and children, the preparation of the solution is no different. Fluimucil-antibiotic IT for inhalation has a difference only in dosage. The solution is diluted in a glass container. For children, you should take half the amount of powder. The finished product should be stored on the refrigerator shelf for no more than a day. Adults require:
It can then be purchased without a prescription, but is used appropriately to ensure its effectiveness and reduce its unwanted effects. For getting additional information and consultation, contact your pharmacist. Consult your doctor if the disorder does not improve after short period treatment.
What medications or foods may affect how the medication works?
This medicine is contraindicated in children under 2 years of age. Pregnancy and lactation. Tell your doctor or pharmacist if you have recently taken any other medicines, including those without a prescription. Laboratory interactions with drugs.
- take 500 ml of powder in an ampoule;
- add 4 ml clean water from the kit;
- use the solution in 2 doses.
Side effects
Cough medicine Fluimucil IT shows excellent results in the treatment of diseases accompanied by severe manifestations. Antibiotic use may have side effects. Doctors observe patients:
The presence of a sulfuric odor does not indicate any change in the drug, but contains active substance. When it can be used only after consulting a doctor. Patients with bronchial asthma should be monitored closely during therapy; if bronchospasm occurs, treatment should be discontinued immediately. It is advisable to consult a doctor, even if these disorders occurred in the past. This requires special care when using medicine in patients with peptic ulcer or due to peptic ulcer disease, especially in the case of simultaneous administration other medicines have a known effect of gastrolily.
- stomatitis;
- reflex cough;
- rhinitis;
- nausea caused by the smell of the medicine;
- allergies;
- drowsiness;
- runny nose;
- bronchospasm.
Contraindications
The use of the IT antibiotic fluimucil for inhalation is not indicated for all patients. The drugs should not be used by patients diagnosed with blood diseases. Inhalations are contraindicated in the following cases:
What kind of nebulizer is needed for inhalation?
What to do during pregnancy and lactation. Consult your doctor if you suspect you are pregnant or want to plan to become pregnant. Effect on the ability to operate and use equipment. If you have a known sugar intolerance, consult your doctor before taking this medication. In the case of diabetic patients or after a low calorie diet, it should be borne in mind that the preparation of the container and sugar amounts to approximately one teaspoon of coffee for each sachet.
- pregnancy;
- bronchial asthma;
- infant feeding;
- stomach ulcers;
- kidney diseases;
- insufficient age - children under 3 years old;
- liver failure.
Registration number: P N012977/01-051114
Be careful not to exceed the dosage indicated without your doctor's advice. The duration of therapy is 5-10 days. Consult your doctor if the disorder occurs repeatedly or if you notice any changes in its functions.
Fluimucil inhalation during antibiotic treatment
Dissolve the contents of the sachet in a glass containing a little water, mix with a needle and a teaspoon. This is a pleasant solution that can be drunk straight. What to do if you take an overdose of medication. Overdose may cause gastrointestinal symptoms such as nausea, vomiting and diarrhea.
Tradename: Fluimucil®-antibiotic IT
International patented (or group) name.
Thiamphenicol glycinate acetylcysteinate
Chemical name. 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-aminoacetyloxymethyl-2-(4-methylsulfonylphenyl)ethyl] acetamide acetylcysteinate
Dosage form: lyophilisate for the preparation of solution for injection and inhalation.
Compound
1 bottle contains: active substance thiamphenicol glycinate acetylcysteinate - 810 mg (in terms of thiamphenicol - 500 mg) and excipient disodium edetate 2.5 mg.
1 ampoule of solvent: water for injection 4 ml.
Description.
Bottle contents:
White or light yellow lamellar mass with a slight sulfuric odor.
Ampoule contents:
Transparent colorless liquid odorless and tasteless.
Pharmacotherapeutic group combined antibiotic (antibiotic + mucolytic)
ATX code .
Pharmacological properties
Pharmacodynamics
Thiamphenicol glycinate acetylcysteinate is a complex compound that combines the antibiotic thiamphenicol and the mucolytic acetylcysteine. After absorption of thiamphenicol, glycinate acetylcysteinate is split into acetylcysteine and thiamphenicol.
Thiamphenicol is a derivative of chloramphenicol, the mechanism of action is associated with inhibition of bacterial cell protein synthesis. Thiamphenicol has wide range antibacterial action, effective in vitro against bacteria, most often causing infections respiratory tract: gram-positive (Streptococcus pneumoniae, Corynebacterium diphtheriae, Staphylococcus spp., Streptococcus pyogenes, Listeria spp., Clostridium spp.) and gram-negative ( Haemophilus influenzae, Neisseria spp., Salmonella spp., Escherichia coli, Shigella spp., Bordetella pertussis, Yersinia pestis, Brucella spp., Bacteroides spp.).
Acetylcysteine, by breaking the disulfide bonds of mucoproteins, quickly and effectively dilutes sputum and pus, reduces their viscosity and promotes discharge. Acetylcysteine facilitates the penetration of the antibiotic thiamphenicol into lung tissue and inhibits the adhesion of bacteria to the epithelium of the respiratory tract.
Pharmacokinetics
Thiamphenicol is rapidly distributed in the body, accumulates in the tissues of the respiratory tract in therapeutic concentrations (tissue/plasma concentration ratio is about 1). Maximum plasma concentration is achieved 1 hour after intramuscular administration. The half-life is about 3 hours, the volume of distribution is 40-68 l. Plasma protein binding up to 20%. Excreted by the kidneys via glomerular filtration, 24 hours after administration, the amount of unchanged thiamphenicol in the urine is 50-70% of the administered dose. Penetrates through the placental barrier.
Acetylcysteine is quickly distributed in the body after use, the half-life is 2 hours. In the liver it is deacetylated to cysteine. In the blood, a mobile equilibrium of free acetylcysteine and its metabolites (cysteine, cystine, diacetylcysteine) is observed, free and bound to plasma proteins. Acetylcysteine penetrates into the intercellular space and is predominantly distributed in the liver, kidneys, lungs, and bronchial secretions. It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine), a small part is excreted unchanged through the intestines. Penetrates through the placental barrier.
Indications for use
Fluimucil® antibiotic IT is used for the treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug and accompanied by mucostasis.
Diseases of the upper respiratory tract and ENT organs: exudative otitis media, sinusitis, laryngotracheitis.
Lower respiratory tract diseases: spicy and Chronical bronchitis, prolonged pneumonia, lung abscess, emphysema, bronchiectasis, cystic fibrosis, bronchiolitis, whooping cough.
Prevention and treatment of bronchopulmonary complications after thoracic surgical interventions(bronchopneumonia, atelectasis). Prevention and treatment of obstructive and infectious complications of tracheostomy, preparation for bronchoscopy, bronchoaspiration.
With accompanying nonspecific forms respiratory infections to improve drainage, including cavernous lesions; for mycobacterial infections.
Contraindications
Hypersensitivity to one of the components of the drug; anemia, leukopenia, thrombocytopenia.
Carefully
For liver failure and chronic renal failure.
In children of the first two years of life due to age characteristics kidney function.
Use during pregnancy and lactation
During pregnancy the drug is prescribed only when the potential benefit to the mother outweighs the potential risk to the fetus.
If necessary, prescribing the drug during lactation should be stopped breast-feeding for the duration of treatment.
Directions for use and doses
Fluimucil® antibiotic IT is administered intramuscularly and used for inhalation, instillation, and cavity rinsing.
Inhalation: adults - 250 mg 1-2 times a day; children - 125 mg 1-2 times a day.
Remove the protective aluminum cap from the bottle;
- immediately before inhalation, open the ampoule with the solvent;
- using a syringe, introduce the contents of the ampoule into a closed bottle with the drug, mix thoroughly;
- using a syringe from a closed bottle with a solution, draw the required volume of solution prescribed by the doctor;
- pour the solution into the nebulizer (inhaler) tank;
- use nasal nozzles or a mask to inhale for 5-10 minutes.
The prepared solution for inhalation can be used within 24 hours when stored at a temperature of 5 ° C (in the refrigerator).
Endotracheal: through a bronchoscope, endotracheal tube, tracheostomy - 1-2 ml of solution (for adults, dissolve in 4 ml of water for injection - 500 mg of dry matter, for children - 250 mg).
Local: for insertion into the paranasal sinuses, as well as for washing cavities after surgical interventions in the nasal area and mastoid process, 1-2 ml of solution (for adults, dissolve in 4 ml of water for injection - 500 mg of dry matter, for children - 250 mg).
For diseases of the nasopharynx and ear, instill 2-4 drops into each nasal passage or external auditory canal.
Intramuscular: adults - 500 mg 2-3 times a day; for children under 3 years old - 125 mg 2 times a day; for children from 3 to 7 years - 250 mg 2 times a day; for children from 7 to 12 years old - 250 mg 3 times a day; for children from 13 to 15 years old - 500 mg 2 times a day; for children from 16 to 18 years old - 500 mg 2 or 3 times a day.
For patients with a creatinine clearance of 20-50 ml/min, the dose is 500 mg 2 times a day; with creatinine clearance 5-19 ml/min - 500 mg 1 time per day.
For premature and newborn babies up to 2 weeks average dose- 25 mg/kg per day.
If necessary, the dose can be increased by 2 times (in the first 2-3 days of treatment in particularly severe cases).
Do not increase the dose in premature and newborn children, as well as in patients over 65 years of age.
The course of treatment is no more than 10 days.
Side effect
For systemic and local routes of administration - allergic reactions.
At intramuscular injection possible slight burning at the injection site, reticulocytopenia, anemia, leukopenia, neutropenia, thrombocytopenia, nausea, vomiting, diarrhea.
At long-term use possible neuritis optic nerve, peripheral neuropathy.
At inhalation administration- reflex cough, local irritation of the respiratory tract, stomatitis, rhinitis, nausea. Laryngeal edema and bronchospasm are possible (mainly in bronchial asthma), in which case bronchodilators are prescribed.
Overdose
Symptoms: changes in bacterial flora, superinfections. Strengthening possible side effect drug (except allergic reactions). Maintenance therapy is recommended.
Interaction with other drugs
The simultaneous administration of antitussives may increase sputum stagnation due to suppression of the cough reflex.
It is not recommended to mix with other aerosol medications.
special instructions
During treatment, peripheral blood patterns should be monitored. If the number of leukocytes (less than 4 thousand/μl) and granulocytes (by more than 40%) decreases, the drug is discontinued.
The dose of thiamphenicol should be reduced in moderate to severe renal failure. In addition, patients with moderate to severe renal impairment are recommended to be treated separately with antibacterial mucolytic agents.
Fluimucil® IT antibiotic solution should not come into contact with metal and rubber surfaces.
For inhalation it is recommended to use compressor nebulizer, it must be adjusted so that the spray particle size is 3-20 microns. It is advisable to use a nebulizer made of glass or plastic. If the nebulizer has metal or rubber parts, they must be washed with water after use.
Effect on ability to drive vehicles and work with machinery
Fluimucil® antibiotic IT does not affect the ability to drive vehicles and other mechanisms.
Release form
Lyophilisate for the preparation of solution for injection and inhalation 500 mg.
810.0 mg of lyophilisate for the preparation of a solution for injection and inhalation in colorless glass vials (type I), sealed with a chlorobutyl rubber stopper and an aluminum cap for rolling.
4.0 ml of water for injection in clear glass ampoules (type I).
3 bottles of lyophilisate complete with 3 ampoules of solvents in a plastic tray along with instructions for use in a cardboard box.
Storage conditions
At temperatures from 15 °C to 25 °C.
Keep out of the reach of children.
Best before date
Lyophilisate for the preparation of solution for injection and inhalation 500 mg (bottles) 3 years
Solvent: water for injection (ampoules) 5 years
Set 3 years
Note: The shelf life of the kit is determined by the component with the shortest shelf life.
Do not use after the expiration date indicated on the package.
Conditions for dispensing from pharmacies
On prescription.
Manufacturing company
Zambon S.P.A., Italy
36100, Via della Chimica 9, Vicenza, Italy