Genferon radar candles. Method of use of the product in gynecological practice

The drug Genferon has an antimicrobial effect. It helps cure inflammation genitourinary organs person. This drug is active against many microorganisms of viral, fungal and bacterial origin.

The immunomodulatory effect is aimed at enhancing immune reaction, which allows you to successfully fight microbes that cause chronic inflammation in humans.

Description

The drug is produced in the form of small suppositories, which are inserted into the rectum or vagina. The shape of the candles is similar to an oval, one edge of which is slightly pointed. Suppositories produced are white or pale yellowish in color. They have a uniform structure on the inner surface. Genferon packages contain 5 or 10 pieces of medicinal suppositories.

Compound

Each suppository weighs about 1.60 g. It contains 3 active elements:

1. for alpha-2b type – 250,000, 500,000 or 1,000,000 IU. It has a negative effect on viruses and microbes. The immunomodulatory effect is achieved by enhancing the immune system response. Leukocytes, which are found on mucous tissues, under the influence of interferon, begin to more actively eliminate foci of infection.
2. Taurine – 0.01 g. It normalizes metabolic reactions and has a positive effect on tissue regeneration. Taurine has a pronounced antioxidant effect; it interacts with oxygen, due to the excessive accumulation of which the development of pathological conditions. Taurine increases medicinal qualities interferon.
3. Anestezin – 0.055 g. This is an anesthetic with local action. It prevents pain impulses from arising, blocking them in nerve endings. Anestezin has only a local effect; it is not absorbed into the blood plasma.

As additional substances, the manufacturer uses sodium citrate, dextran, polyethylene oxide, citric acid, Tween, purified water and solid fat.

pharmachologic effect

At rectal administration means a significant degree of influence of interferon is noticeable, due to which it is possible to achieve a pronounced immunomodulatory result. In the case of intravaginal use, quick release from bacteria and viruses on the affected area, but systemic action practically not expressed due to the poor ability of the vaginal mucosa to absorb substances for further distribution throughout the body.

The highest concentration of interferon in the blood is observed 6 hours after administration of the suppository. Active Ingredients medications are eliminated from the body through the kidneys 12 hours after using the suppository, so it is recommended to use the drug 2 times a day to maintain its effect.

Indications for use

Genferon can act as an independent agent or as one of the drugs complex therapy against inflammatory and infectious phenomena in urine excretory system. Its use is indicated for men, women (including during pregnancy) and children. Therapy based on this medicine used to eliminate:

• ureaplasmosis, mycoplasmosis, chlamydia;
• gardnerellosis, trichomoniasis;
• vaginal candidiasis;
• bacterial vaginosis;
• cystitis that has become chronic;
• cervicitis (disease of the cervical canal);
• bartholinitis (inflammatory process in the Bartholin glands);
• vulvovaginitis (inflammation in the vagina);
• adnexitis (inflammatory disease of the ovaries);
• erosive lesions of the cervix;
• urethritis (the process of inflammation in the urethra);
• balanitis (inflammation of the glans penis) and balanoposthitis (inflammatory disease affecting top part along with the foreskin).

Contraindications

The drug cannot be used if the patient’s body cannot tolerate interferon or other substances from the medication.

1. During exacerbations autoimmune diseases.
2. If you have allergies.
3. In the first three months of pregnancy.
4. At diabetes mellitus first type.
5. For childhood under six years old.

This medication can be used during lactation; it is important not to exceed the permissible dosage.

Rules for use and dosage

This medication is used differently in men, women and children. The following treatment regimens are recommended for women:

1. : assigned 1 supp. 2 times a day for 10 days. The drug is injected into the vagina. For a prolonged illness, place 1 suppository every other day, in this case the course of treatment increases to 2-3 months.
2. For acute vaginal inflammation, it is necessary to use one suppository vaginally after waking up (dosage 500,000 IU) and one suppository rectally at night (dosage 1,000,000 IU) together with the introduction of a fungicidal suppository into the vagina.
3. Pregnant women, in order to normalize local immunity during the treatment of urogenital infections, are prescribed 1 suppository (250,000 IU) of medication twice a day. The duration of therapy is 9-12 days. This treatment is suitable for 13-40 weeks of pregnancy; before the 13th week, such therapy is contraindicated.

In men, treatment of genitourinary diseases arising due to any infection is carried out with Genferon suppositories with the maximum possible dosage. The drug is injected into the posterior opening: you need to use one suppository twice a day for ten days. To increase the effectiveness of the medication, vitamin therapy with vitamins C and B can be carried out in parallel with the main treatment.

Treatment of children

The drug Genferon-Lite, which contains 125,000 IU of interferon, is suitable for treating young patients. This remedy is used for children from 7 to 15 years old. After reaching 15 years of age, adolescents can be treated with regular Genferon. For children under 7 years of age, Genferon is used only after prescription by a pediatrician.

This medication is usually prescribed to children when urinary tract infections occur or viral diseases. Suppositories are administered only into the rectum. Intratrauma should be avoided vaginal insertion suppositories for girls under seven years of age, as this can seriously disrupt the child’s microflora.

In the presence of acute infection caused by a virus, 1 suppository is administered twice a day anus(course – 6 days, with chronic stage illness – 10 days). After completion of treatment, to prevent reoccurrence infections, give 1 supp. into the anus before bedtime 1 time/2 days (duration preventive treatment– 1-2 months).

For diseases of the genital organs and excretory system, children are prescribed a ten-day course of rectal administration of the medication (1 supp. 2 times a day). The interval between use of the product should not be more than 12 hours. Treatment of children should be accompanied by vitamin therapy (C and A) and.

Overdose

No overdose of Genferon has been detected. If too many suppositories were administered at one time, it is necessary to stop administering suppositories for one day, and then continue normal treatment.

Adverse reactions

Usually the drug is easily tolerated by patients. Sometimes there are local allergies, which manifest themselves as a slight burning sensation of the vagina, this phenomenon disappears 48 hours after stopping treatment with Genferon. You should consult your doctor before continuing therapy.

When taking interferon, fatigue, mild fever, increased temperature, pain in the head and muscles, thrombocytopenia or leukocytopenia may occur if the body has received more than 10,000,000 IU of interferon during the day. However, at present, no cases with such severe adverse reactions. When body temperature increases, it is recommended to take 1-2 tablets of paracetamol once.

special instructions

Genferon suppositories are especially effective for simultaneous administration antibiotics and other drugs with antimicrobial action that are suitable for the treatment of urological diseases. The effect of anesthesin is enhanced by non-narcotic analgesics. Anestezin reduces the effect of sulfonamides against bacteria.

To avoid re-infection from a sexual partner, it is recommended to treat the couple together. Genferon can be used during menstruation. This product does not affect reaction speed, does not reduce attention, and, therefore, will not interfere with driving a car or performing dangerous work.

Opinions about the drug

The opinion of doctors and reviews of patients who were treated with Genefron suppositories:

I often prescribe Genferon suppositories to my patients. This good drug, which extremely rarely causes side effects, which is especially important for use during pregnancy. Of course, it cannot cure chlamydia or ureaplasmosis; in such cases, combination therapy of several drugs is needed. But Genferon works well in the treatment of thrush, vulvovaginitis, etc.

Maria Sergeevna, obstetrician-gynecologist

Genferon helps to quickly cure infectious diseases in children. Although children do not like the suppository form, it is thanks to it that the drug is quickly absorbed and begins to heal the body.

Svetlana Vladislavovna, pediatrician

During the examination, the gynecologist discovered a slight erosion and suggested not cauterizing it, but trying to use Genferon suppositories for 3 weeks. I put them on twice a day, as the doctor advised. The only negative I felt was that the candles dissolve too slowly. But after the end of treatment, the erosion disappeared, and this is the main thing!

Veronica, 34 years old

I treated cystitis with Genferon, which appeared to me 5 times a year. The drug did not cause any problems for me side effect, there was not even a burning sensation from the candles. I took Genferon for a long time, but it was worth it, because the cystitis went away.

Olga, 23 years old

Genferon was prescribed to me by a doctor for inflammation in the ovaries. It took about two weeks to light the candles. A couple of days after taking it it started strong burning sensation in the vagina, I had to stop the drug and be treated in other ways. Genferon did not suit me, it only caused an allergy. But the pediatrician prescribed this remedy to the child for inflammation in the urethra. Children's Genferon helped, although I was afraid of a side effect.

Natalya, 30 years old

Price

The cost of this product depends on the dosage of the active substance:

• pack of 10 pieces (125 thousand IU) - from 290 rubles;
• pack of 10 pieces (250 thousand IU) - from 350 rubles;
• pack of 10 pieces (500 thousand IU) - from 550 rubles;
• pack of 10 pieces (1 million IU) – from 770 rub.

Storage rules and dispensing in pharmacies

The medication retains its useful action at a temperature range from 2 to 9 C. The place where the drug is stored should be inaccessible to children. The medication should not be used after the expiration date, i.e. after two years. Genferon can be purchased at a pharmacy with a prescription.

Analogs

Genferon has the following analogues among drugs with similar effects:

1. – antiviral agent in the form of suppositories. It has a similar list of indications for use. It is allowed after the 14th week of pregnancy, as well as during lactation.
2. Kipferon - suitable for the treatment of the same diseases as Genferon. Kipferon is active against rotavirus, staphylococcal infection, also eliminates .
3. Transfer factor – capsules with an immunomodulatory agent. Has no contraindications. It has a beneficial effect on the DNA of the infected cell, due to which the disease quickly recedes.
4. Interferon and Giaferon completely coincide in composition and action with Genferon. There is a slight difference in treatment regimens. Suitable for children.
5. – increases the production of immunoglobulins, thereby increasing the body’s resistance to viruses and bacteria.

Genferon: instructions for use and reviews

Latin name: Genferone

ATX code: L03AB05

Active substance: recombinant human interferon alpha-2b (interferon alfa-2b) + taurine (taurine) + benzocaine (benzocaine)

Manufacturer: Biocad CJSC (Russia)

Updating the description and photo: 03.11.2017

Genferon is a local and systemic immunomodulatory drug with antioxidant, immunomodulatory, local anesthetic and antiviral effects.

Release form and composition

Genferon is produced in the form of suppositories: cylindrical in shape with a pointed end, homogeneous structure, from white to white with a yellow tint, the color may have a funnel-shaped depression or a hollow rod at the cut (5 pcs each in a strip pack, 1 or 2 packs in a cardboard box ).

• Human recombinant interferon alpha-2 – 250 thousand, 500 thousand or 1 million IU;
• Taurine – 10 mg;
• Benzocaine – 55 mg.

Excipients: dextran 60000, Tween-80, sodium citrate, polyethylene oxide 1500, lemon acid, emulsifier T2, solid fat, purified water.

Pharmacological properties

Pharmacodynamics

The active component of Genferon is recombinant human interferon alpha-2b, synthesized by a strain of the bacterium Escherichia coli, modified using genetic engineering methods to introduce the human interferon alpha-2b gene into it.

Taurine normalizes metabolic processes and ensures tissue regeneration, and is also characterized by an immunomodulatory and membrane-stabilizing effect. The substance belongs to strong antioxidants, therefore enters into direct reactions with active forms oxygen, excessive accumulation of which increases the risk of developing pathological processes. Taurine ensures the preservation of the biological activity of interferon and enhances therapeutic effect Genferon.

Benzocaine (anesthetic) is a local anesthetics. It reduces permeability cell membranes for sodium ions, replaces calcium ions in receptors localized on the inner surface of the membrane, blocks the transport of nerve impulses. The active ingredient Genferon prevents the occurrence of pain impulses in the endings of sensitive nerves and their transmission along nerve fibers. Benzocaine has an exclusively local effect and does not enter the systemic circulation.

Pharmacokinetics

With rectal administration of Genferon, high bioavailability of interferon is observed, exceeding 80%, which explains both local and pronounced systemic immunomodulatory effects. When intra vaginal use due to the high concentration of this component at the site of infection and its fixation on the cells of the mucous membrane, a pronounced local antibacterial, antiproliferative and antiviral effect is observed. Since the vaginal mucosa has low absorption capacity, the systemic effect of interferon is negligible.

The maximum level of interferon in the blood serum is recorded 5 hours after the administration of Genferon. The removal of this substance from the body is mainly carried out by renal catabolism. The half-life is 12 hours, which determines the frequency of use of the drug 2 times a day.

Indications for use

According to the instructions, Genferon is indicated for use as part of the complex treatment of the following diseases/conditions:

• Acute bronchitis;
• Infectious and inflammatory diseases of the urogenital tract: chlamydia, genital herpes, ureaplasmosis, recurrent vaginal candidiasis, mycoplasmosis, gardnerellosis, human papillomavirus infection, trichomoniasis, bacterial vaginosis, cervical erosion, vulvovaginitis, cervicitis, bartholinitis, adnexitis, prostatitis, urethritis, balanitis, balanoposthitis;
• Chronic recurrent cystitis of bacterial etiology.

Contraindications

Hypersensitivity to the components of the drug is the only contraindication to its use.

Genferon is prescribed with caution to patients with allergic or autoimmune diseases in the acute stage.

Instructions for use of Genferon: method and dosage

Genferon is used intravaginally and/or rectally:

• Infectious and inflammatory diseases of the urogenital tract in men: rectally, 1 suppository (depending on the severity of the condition, 500,000 or 1,000,000 IU), 2 times a day for 10 days;
• Infectious and inflammatory diseases of the urogenital tract of women: rectally or intravaginally (depending on the nature of the disease), 1 suppository of 250,000, 500,000 or 1,000,000 IU (depending on the severity of the condition) 2 times a day, for 10 days daily. In case of prolonged illnesses, 1 suppository 3 times a week (every other day), duration – 1-3 months. For the treatment of a severe infectious-inflammatory process in the vagina - 1 suppository of 500,000 IU intravaginally in the morning and 1 suppository of 1,000,000 IU rectally at night, at the same time a suppository with antibacterial/fungicidal agents should be inserted into the vagina;
• Normalization of indicators local immunity in women during pregnancy 13-40 weeks during the treatment of infectious and inflammatory diseases of the urogenital tract: 1 suppository of 250,000 IU intravaginally 2 times a day, for 10 days daily;
• Chronic recurrent cystitis (as part of complex therapy) in adults: in case of exacerbation - in combination with a standard course antibacterial therapy 1 suppository 1,000,000 IU rectally 2 times a day for 10 days, then every other day for 40 days, at the same dose to prevent relapses;
• Acute bronchitis (as part of complex therapy) in adults: 1 suppository of 1,000,000 IU rectally 2 times a day for 5 days.

Side effects

The use of the drug may cause the development allergic reactions in the form of itching, skin rash, burning sensation in the vagina. Side effects are reversible and disappear within 72 hours after discontinuation or dose reduction.

There may be an increase in temperature after administration of the drug.

At daily dose 10 million IU there is a high probability of the following side effects:

• From the outside hematopoietic system: thrombocytopenia, leukopenia;
• From the central side nervous system: headache;
• Other: increased sweating, fever, loss of appetite, weakness, myalgia, arthralgia.

Overdose

Cases of overdose of Genferon in clinical practice almost unknown. In case of accidental single administration of suppositories in a larger quantity than was prescribed by the doctor, it is necessary to suspend further administration of the drug for at least 24 hours, after which you can return to the original treatment regimen.

special instructions

The drug can be used in the second and third trimester of pregnancy if the expected benefit to the mother outweighs the potential risk to the fetus.

To exclude urogenital reinfection, simultaneous treatment of the sexual partner is recommended.

It is possible to use the drug during menstruation.

Impact on the ability to drive vehicles and complex mechanisms

The use of Genferon does not affect the patient’s ability to drive vehicles and perform potentially dangerous species works that require high concentration of attention and significant speed of psychomotor reactions.

Use during pregnancy and lactation

Genferon can be used to normalize local immunity during pregnancy from 13 to 40 weeks as part of complex therapy for human papillomavirus infection, genital herpes, cytomegalovirus infection, chlamydia, mycoplasmosis, ureaplasmosis, bacterial vaginosis, often accompanied by itching, discomfort and painful sensations in area lower sections urogenital tract.

Clinical studies have confirmed the safety of intravaginal administration of Genferon at a dose of 250,000 IU for a period of 13–40 weeks. Safety of treatment with the drug in the first trimester of pregnancy this moment insufficiently studied.

Use in childhood

Age restrictions in official instructions are not available for the drug. However, doctors do not recommend using Genferon for children under 7 years of age (for this age category, including children infancy, the drug Genferon Light was developed in a dosage of 125 thousand). Genferon is approved for children over 7 years of age at a dosage of 250 thousand.

Drug interactions

The effectiveness of Genferon increases when used simultaneously with antimicrobial agents for the treatment of urogenital infections and antibiotics.

The effect of interferon is enhanced by vitamins E and C.

The effect of benzocaine increases when combined with anticholinesterase and non-steroidal anti-inflammatory drugs.

Benzocaine inhibits the antibacterial activity of sulfonamides.

Analogs

Analogs of Genferon are: Viferon, Vitaferon, Viferon-Feron, Kipferon, Laferon, Laferobion, Farmbiotek, Alfarekin, Alfarona, Bioferon, Herpferon, Grippferon, Virogel, Intron A, Lipoferon, Interoferobion interferon alfa-2b, Introbion interferon alfa-2b, Laferon Farmbiotek, Okoferon, Realdiron.

Terms and conditions of storage

Keep away from children. Store at temperatures between 2 and 8 °C.

Shelf life – 2 years.

Interferons are substances that cells make human body immune to viruses. Immediately after their discovery in the 20th century, drugs containing these biological molecules appeared. By adding vitamins, anti-inflammatory and other components to interferons, you can get effective means from many diseases. One of the striking examples is “Genferon”. The drug is active against a number of viruses, bacteria, and fungal microorganisms. What do the instructions for using Genferon suppositories say, and is this medicine safe?

"Genferon" is sold in pharmacies as rectal and vaginal suppositories; there are different dosages. A spray for nasal use is also provided. The drug is well tolerated, its use is almost never accompanied by side effects and gives significant results. Reviews of Genferon candles confirm their effectiveness.

Compound

The main effect of the drug is due to the human interferon alpha 2b included in the drug. Suppositories are available in the following dosage:

• 125 thousand IU;
• 250 thousand IU;
• 500 thousand IU;
• 1 million IU.

In addition to interferon, each suppository contains the following components:

• amino acid – taurine in the amount of 0.01 g;
• analgesic component– benzocaine or anesthesin in the amount of 0.055 g.

There is no anesthetic ingredient in the children's candles from the "Light" series. All suppositories contain macrogol, polysorbate, emulsifiers, sodium hydrogen citrate, citric acid, dextran, water and solid fat as forming components.

Operating principle

Rectal use of suppositories is comparable in speed of effect and subsequent concentration of the active substance in the bloodstream with injections. Rich Network blood vessels rectum and the special structure of the mucosa allow the drug to be quickly absorbed. "Genferon" is metabolized in the liver and kidneys, so these organs play a role in the elimination of the drug. Within 12 hours after administration of the suppository, the concentration of the active substance in the blood drops by half, so dosage regimens include the use of suppositories twice a day.

When administered vaginally, one portion of the substance enters the systemic circulation, the remaining acts locally. Therefore, when gynecological diseases it is better to use “targeted” supply of the drug to the lesion, and if it is necessary to increase the systemic antiviral response, it is necessary to use rectally introduction.

Candles must be stored at a temperature no higher than +4 ° C to prevent the destruction of interferon.

Interferon

Human interferon is produced special types Escherichia coli, to which the genes responsible for the production of this biologically active substance have been introduced. Interferon can cause the following actions:

• antiviral– stops the reproduction of viral particles by deactivating special enzymes and disrupting the interaction of pathogens with human cells;
• antibacterial– activates the immune system responsible for the destruction of pathogenic bacteria;
• immunomodulatory– increases the activity of T-helpers (a type of lymphocyte) B-lymphocytes, macrophages, as a result the immune system quickly recognizes pathogens, inactivates them and creates memory cells (immunity);
• antiproliferative– the drug is capable of stopping the division of viral cells, as well as chlamydia, ureaplasma and mycoplasma, therefore it is prescribed in complex treatment these infections.

Amino acid

Taurine has a general stimulating effect on the body, and also increases the activity of interferon, being a trigger in the composition of the drug "Genferon". Namely, the following effects can be observed:

• metabolism improves;
• the ability of cells to self-heal increases;
• tissue resistance to viruses and bacteria increases;
• harmful metabolic products - free radicals - are neutralized.

Analgesic component

Benzocaine and anesthesin act locally, blocking the conduction of nerve impulses through tissues. This achieves an analgesic effect, reducing the intensity of burning and itching, which is important in the treatment of gynecological diseases.

When is it useful to use

"Genferon" can be used for any disease if it is assumed to be of a viral or bacterial nature. Genferon Light suppositories are more often used for children due to the lower dose of the drug and the absence of an anesthetic in the composition. Cases for use are as follows:

• rotavirus;
• ARVI and influenza;
• at temperature during teething;
• chickenpox.

The use of Genferon suppositories in gynecology includes the following list of pathologies:

• STIs – chlamydia, ureaplasmosis, mycoplasmosis, trichomoniasis, herpes, human papillomavirus (especially with HPV types 16 and 18);
• nonspecific inflammation– vaginitis, cervical erosion, adnexitis;
• recurrent thrush– for the treatment and prevention of new episodes of the disease;
• disturbance of vaginal flora– bacterial vaginosis (gardnerellosis).

The drug is prescribed in treatment regimens for dysplasia, especially with signs viral infection, as well as endometriosis. It is effective to use "Genferon" in the treatment of cystitis, urethritis, and prostatitis in men. The drug is used in the treatment of hepatitis, cytomegalovirus infection, including during pregnancy.

For whom the drug is contraindicated

Genferon suppositories should not be used when hypersensitivity to any component of the drug, as well as in case of ever recorded allergy to analogue drugs. It is necessary to refrain from rectal use in case of exacerbation of hemorrhoids.

Contraindications for use are autoimmune diseases, since the drug can compromise the exacerbation or progression of diseases. For example, with autoimmune thyroiditis, glomerulonephritis, diabetes mellitus, scleroderma.

"Genferon" during pregnancy is allowed only from the 12th week according to indications. There are no previous data on the safety of use. During use during lactation, it is recommended to stop breastfeeding.

Instructions for use of "Genferon"

Depending on the purpose of therapy, the methods of using the drug differ slightly. The main points in treating women are as follows:

• standard scheme– one suppository in the vagina twice a day for ten days (for gynecological diseases and sexually transmitted infections);
• evening suppository - if necessary (if there are other suppositories) can be placed rectally;
• for recurrent processes– after the main treatment, it is necessary to lay one suppository for three months;
• for diseases not related to the genital organs– suppositories should be placed rectally;
• during menstruation– you should switch to rectal use.

Men and children should use one suppository into the rectum in the morning and evening.

Nasal spray "Genferon" is used in men, women and children after 7 years - twice a day, one injection for the prevention and treatment of colds.

Complications of taking

The side effects of Genferon do not differ in frequency of occurrence - usually suppositories and spray are well tolerated. The following symptoms are rarely observed:

• headache;
• increased fatigue;
• weakness in muscles and joints;
• decreased appetite;
• increased sweating;
• locally – itching, burning, increased discharge;
• increase in temperature on the first day of admission.

If you suspect a side effect, you should first exclude these symptoms as manifestations of the underlying disease. Reviews from doctors indicate that the drug is well tolerated when administered to patients. No cases of overdose have been identified.

Analogs

Among the drug analogues for the main active ingredient, interferon, the following drugs can be distinguished:

• "Viferon";
• "Interferon";
• "Kipferon";
• "Laverobion".

"Genferon" is a drug with antiviral and antibacterial activity, stimulates the immune system and helps fight infection. But the indications for the use of Genferon are determined only by the doctor, as well as the regimens, as well as the duration of treatment.

Answers to frequently
questions asked:

• What is Genferon ®?
• How does Genferon ® work?
• How to use Genferon ®?
• Does Genferon ® ® affect spermatogenesis? If yes, then how (does it increase the activity of sperm, does it increase their concentration)?
• The doctor prescribed me 500,000 IU for the treatment of vaginal candidiasis in the Genferon ® complex 2 times a day. But I mistakenly purchased 1,000,000 IU. If I use a large dose, how could it negatively affect my body? Or can you just put half a candle?
• I was prescribed a 20-day course of treatment with Genferon ® suppositories. But during these 20 days I should have my period, do I need to stop the course? So what should we do then?
• Is it possible to prescribe Genferon ® for acute inflammation? prostate gland or only in a chronic, non-aggravated process?

What is Genferon ®?

Genferon ® is a unique drug obtained as a result of many years of research by Russian scientists at the Center for Engineering Immunology. It is a combination of recombinant human interferon alpha-2b, taurine and anesthesin, available as vaginal and rectal suppositories.

Genferon ® 500,000 IU, 1,000,000 IU is produced by the Russian biotechnology company Biocad in accordance with international quality standards (GMP) and ISO 9001: 2000, which is a guarantee of effective and safe treatment.

Is it safe and advisable to use Genferon ® with an elevated level of the CA-125 tumor marker in the blood?

If the content of the CA 125 tumor marker is slightly increased during inflammatory processes of the pelvic organs, including against the background of urogenital infections, treatment with Genferon ® is indicated for the purpose of immunomodulation and achieving antiviral and indirect antibacterial effects. It is recommended to use Genferon ® with caution during exacerbation of autoimmune diseases, which in in rare cases may be the cause of an increase in the content of CA 125. In any case, the decision to prescribe the drug Genferon ® should be made by the doctor after a comprehensive examination of the patient. Fact higher level tumor marker CA 125 cannot be a contraindication to the use of the drug Genferon®, prescribed to correct immunological imbalance and prevent the development of infectious complications, which does not have negative influence on the course of the underlying disease.

For what diseases is Genferon ® used?

Genferon ® 500,000 IU and Genferon ® 1000,000 IU are used as part of complex therapy for infectious and inflammatory diseases of the urogenital tract in adults: genital herpes, chlamydia, ureaplasmosis, mycoplasmosis, recurrent vaginal candidiasis, gardnerellosis, trichomoniasis, papillomavirus infections, bacterial vaginosis, cervix, cervicitis, vulvovaginitis, bartholinitis, adnexitis, prostatitis, urethritis, balanitis, balanoposthitis, and also as part of complex therapy acute bronchitis in adults and as part of complex therapy for chronic recurrent cystitis of bacterial etiology in adults.

How does Genferon ® work?

Genferon ® – combination drug, the effect of which is determined by the components included in its composition. Has local and systemic effects. Interferon alpha-2b has antiviral, antibacterial and immunomodulatory effects. Under the influence of interferon alpha-2b, the activity of natural killer cells, T-helper cells, phagocytes, as well as the intensity of differentiation of B-lymphocytes in the body increases. Activation of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of primary pathological foci and ensures restoration of production secretory immunoglobulin A.

Interferon alfa-2b also directly inhibits the replication and transcription of chlamydia viruses. Taurine, included in the suppository, increases the biological effect of IFN due to its antioxidant and membrane-stabilizing properties, and also significantly accelerates the epithelization of damaged tissues due to a pronounced reparative effect. Benzocaine prevents the occurrence of pain impulses in the endings of sensory nerves, blocks their conduction along nerve fibers, thereby stopping the subjective manifestations of the disease (pain, itching, burning sensation, etc.), relieving the patient of suffering, which significantly improves the quality of life during treatment.

How to use Genferon®?

For infectious and inflammatory diseases of the urogenital tract in women. 1 suppository (Genferon ® 500,000 IU or Genferon ® 1,000,000 IU depending on the severity of the disease) vaginally or rectally (depending on the nature of the disease) 2 times a day every day for 10 days. For prolonged forms, 1 suppository 3 times a week, every other day, for 1-3 months.

For infectious and inflammatory diseases in men. Rectally, 1 suppository (Genferon ® 500,000 IU or Genferon ® 1,000,000 IU, depending on the severity of the disease) 2 times a day for 10 days.

For what purpose is taurine included in the drug?

The amino acid taurine increases the biological effect of interferon due to its antioxidant properties and at the same time ensures the regeneration of damaged tissues. It has been established that interferon in combination with taurine shows more pronounced antiviral activity than in combination with other antioxidants. It is for this purpose that taurine is included in the composition of the drug Genferon®.

What are the possible side effects when using Genferon ®?

The drug Genferon ® is well tolerated by patients. Allergic reactions (itching and burning sensation in the vagina) are possible. These phenomena are reversible and disappear within 72 hours after cessation of administration. Continuation of treatment with Genferon® is possible after consultation with a doctor.

What are the contraindications for the use of Genferon ®?

Individual intolerance to interferon and other substances included in the drug Genferon ® 500,000 IU, 1,000,000 IU.

I am interested in the drug Genferon ®, which was prescribed to my wife. It contains human recombinant Interferon alpha-2b. What is this interferon made of? Is it made from blood or is it synthetic? This is important for us because... Due to religious beliefs, we do not accept the use of blood products.

Interferon alpha-2b, which is part of the suppositories Genferon ® 500000, 1000000 IU, is recombinant. This means that it is obtained using genetic engineering methods from coli- a microorganism present in the intestines of any person. In production antiviral drug Genferon® is used by Escherichia coli bacteria into which the human interferon gene has been introduced. Due to this, bacteria become capable of large quantities produce human protein.

After repeated purification, interferon obtained from a culture of bacterial cells becomes completely free of any impurities of bacterial origin. Recombinant interferon is completely identical to natural interferon, but blood products are not used at any stage of its production.

Please tell us whether Genferon ® (500,000 IU) affects the effect of contraceptives? I have been using Nuvaring for a long time. And accordingly, is it possible to conduct sex life as usual while using Genferon ® or should you abstain for this time, or maybe there are special recommendations? (The doctor prescribed treatment for ureaplasmosis 2 times a day, morning and evening, for 10 days).

Antiviral drug Genferon ® 500,000 IU, 1,000,000 IU. does not contain substances that reduce the effectiveness of contraception when using Nuvaring. However, it should be remembered that when treating any urogenital infection, you should use a condom until laboratory confirmation of cure for you and your sexual partner.

Typically, this test is performed 4 weeks after the start of treatment. Otherwise, re-infection is possible. In addition, gynecologists recommend abstaining from sexual intercourse during the entire course of treatment with antiviral drugs for local application, including when using vaginal suppositories.

Does Genferon ® affect spermatogenesis? If yes, then how (does it increase the activity of sperm, does it increase their concentration)?

No, interferon drugs do not directly affect spermatogenesis. However, if spermatogenesis is impaired due to chronic infection(most often herpetic or chlamydial) or develops against the background of prostatitis, the use of the drug Genferon® gives a good clinical effect.

Does Genferon ® affect prostate secretion levels?

Normalization of these indicators occurs if their violation was caused by an infectious process, the elimination of which is much more successful when using the drug Genferon ®. If this is, say, some kind of hereditary defect, there will be no effect.

Please tell me whether taking Genferon ® is effective during exacerbation chronic pyelonephritis together with antibacterial therapy? If yes, is it better to administer suppositories rectally or vaginally and in what dosage, for how many days?

Yes, according to data clinical trials, the use of the drug Genferon ® 500,000, 1000,000 IU can increase the effectiveness of treatment of pyelonephritis. Rectal administration is advisable for a systemic immunomodulatory effect.

The drug is used according to the standard regimen - Genferon ® 1,000,000 IU 2 times a day for 10 days; then a prolonged regimen of use of the drug Genferon®, when after these 10 days the drug is prescribed once every 2 days at night for 20 days.

My doctor prescribed me 500,000 IU 2 times a day for the treatment of vaginal candidiasis in the Genferon® complex. But I mistakenly purchased 1,000,000 IU. If I use a large dose, how could it negatively affect my body? Or can you just put half a candle?

Health hazards of using the drug Genferon ® in the dosage specified in the instructions for medical use does not carry – in order for it to appear potential opportunity development of side effects, the dose of interferon should be many times higher. It is strictly not recommended to split the candle, as accurate dosing is not guaranteed.

Menstruation does not require discontinuation of the drug Genferon ®. When heavy discharge during menstruation, you can temporarily switch from vaginal to rectal administration of Genferon ® suppositories (these suppositories are universal, both vaginal and rectal use are possible, while vaginal administration is more pronounced local effect, and in case of rectal – systemic).

Is it safe and advisable to use Genferon ® with an elevated level of the CA-125 tumor marker in the blood?

Since an increased level of the tumor marker CA 125 can be detected not only in ovarian cancer (most often), but also in a number of inflammatory diseases, mainly of the upper parts of the urogenital tract, endometriosis, benign gynecological tumors, some autoimmune processes, hepatitis, cirrhosis of the liver, pancreatitis, pericarditis , as well as in physiological conditions female body– menstruation and pregnancy, it is quite difficult to answer your question unambiguously in the absence of specific data. If we're talking about O malignant neoplasm, then interferon-alpha drugs have a proven inhibitory effect on tumor growth, having antiproliferative, immunomodulatory and antimutagenic effects, and are quite widely used in the treatment malignant tumors. However, the doses of interferon-alpha used to achieve a noticeable antitumor effect in these drugs significantly exceed those in the drug Genferon ®.

If the content of the CA 125 tumor marker is slightly increased during inflammatory processes of the pelvic organs, including against the background of urogenital infections, treatment with Genferon ® is indicated for the purpose of immunomodulation and achieving antiviral and indirect antibacterial effects. It is recommended to use Genferon® with caution during exacerbation of autoimmune diseases, which in rare cases can cause an increase in the content of CA 125. In any case, the decision to prescribe Genferon ® should be made by a doctor after a comprehensive examination of the patient. The fact of an increased level of tumor marker CA 125 cannot be a contraindication to the use of the drug Genferon®, prescribed to correct immunological imbalances and prevent the development of infectious complications, which does not have a negative effect on the course of the underlying disease.

Should the base for the candle melt completely (there have been cases when the candle came out almost in its original form)?

When using suppositories, it is very important to follow the established rules and shelf life of medications. The physico-chemical properties of the drugs Genferon ® and Genferon ® light ensure the dissolution of the Genferon ® suppository at a temperature of 37 degrees Celsius and above for 5-10 minutes. The insolubility of the Genferon ® suppository may be due to the expiration date or improper storage, namely, non-compliance with temperature conditions (storage at too high or low temperatures). Suppositories must be stored in the refrigerator at a temperature of +2 to +8 degrees. Hypothetically, this situation is also possible if the suppository is inserted shallowly into the vagina (for example, into the vestibule).

Patients can be advised to follow the following technique: insert Genferon ® suppositories in a lying position, deep into the vagina, try not to change body position for 5 minutes after administration. Avoid heavy ones physical activity(weight lifting) within an hour after administration of the drug.

Is it possible to prescribe Genferon® for acute inflammation of the prostate gland or only for a chronic, non-aggravated process?

The effectiveness of the antiviral drug Genferon® has been proven specifically for chronic prostatitis. However, due to the fact that chronic prostatitis is often the outcome acute process, in some cases, immunocorrection as a component may be appropriate combination therapy acute prostatitis in order to reduce the risk of chronicity of the process, but it all depends on the specific clinical situation.

It is very inconvenient that after use you need to lie down, as the candles melt.

Unfortunately, it is very difficult to avoid partial leakage of the suppository after its insertion. However, it is mainly the suppository base that flows out, while the main active ingredients are absorbed. In addition, suppositories, as a dosage form, have a large number of advantages: 1. Rapid supply of medicinal substances to big circle blood circulation during rectal administration, as well as the absence of inactivation of substances by digestive juices (When taking peros, passage through the liver is 100%, and with rectal absorption in phase I, 20% of the absorbed substance enters the liver).2. Minimal risk of developing influenza-like syndrome characteristic of injectable drugs interferon. 3. No problem of taste or smell of drugs, the possibility of prescribing various medicinal substances pharmacological groups with a variety of physical and chemical properties. 4. Simplicity and painlessness of administration and use of Genferon® suppositories. 5. The possibility of topical application allows you to create an adequate concentration medicinal substance for urogenital infections directly at the site of inflammation, which increases the effectiveness of therapy.

Are allergic reactions to interferon possible?

IFNα, which is part of the drug Genferon ®, was obtained by genetic engineering and has a high degree of purification from protein impurities (purity >95%), which minimizes the risk of developing sensitization. Data from preclinical studies indicate that Genferon® 500,000 IU, 1,000,000 IU suppositories do not have sensitizing activity (Weigle index ≤ 1.0). Determined that medicinal product does not have skin-sensitizing activity and local irritating effect.

According to the results of clinical trials, including in pregnant women, the use of the drug Genferon ® was not accompanied by the development of allergic reactions in any of the cases. The realization of an allergy is possible only in rare cases of individual intolerance to recombinant human interferon-α-2b or other substances included in the suppository.

Is it possible to use antibiotics and Genferon ® simultaneously?

Genferon ® 500,000 IU, 1000,000 IU does not enter into unwanted interactions with antibacterial drugs On the contrary, due to its indirect antibacterial effect as part of complex therapy for urogenital infections, it demonstrates synergy with antibiotics. According to the results of numerous clinical trials, Genferon ® as part of complex therapy for infectious and inflammatory diseases does not cause the development side effects. In particular, high degree frequency of complete elimination infectious agent is consistent with the literature data on the increased sensitivity of pathogens to antibacterial therapy under the influence of interferon, which helps to increase the effectiveness of combination therapy.

Is it possible to drink alcohol while using Genferon ® suppositories?

The ability of ethanol to have a direct myelosuppressive effect on bone marrow hematopoiesis is widely known, which can lead to the development of cytopenic syndrome (leuko-, thrombocytopenia, anemia) and significantly aggravate the course infectious process. In addition, ethanol stimulates the processes of free radical oxidation of lipids and increases the lability of cell membranes, which leads to an increase in endotoxicosis and the formation of multiple organ dysfunction. Determined that increased content ethanol in the blood aggravates the severity of the disease and is accompanied by an increase in the level of adrenocorticotropic hormone, aldosterone, cortisol, interleukin-1β and the helper subpopulation of T-lymphocytes.

Although special research There has been no interaction between the drug Genferon ® and ethanol; we strongly recommend that you refrain from drinking alcohol during interferon therapy with Genferon ®. Moreover, Genferon® is almost always used in complex therapy in parallel with taking antibacterial and/or direct antiviral agents, the effectiveness of which, in turn, may be reduced when taken together with alcohol.

Genferon suppositories (price and detailed description drugs are presented on medical websites) are immunomodulatory, antiviral medicine, which has antimicrobial activity. This remedy is used primarily for the treatment inflammatory processes V genitourinary tract in women, men, and children.

What pharmacological effect do Genferon suppositories have? Reviews about the drug.

In the role active substances this drug are taurine, interferon alpha2, and anesthesin. Their complex action has an extremely positive influence on immune system, it exhibits antibacterial and antiviral effects. The antimicrobial activity of Genferon suppositories is transmitted to many pathogenic microorganisms, like fungi, bacteria, viruses, mycoplasmas and others. Among other things, the drug promotes the activation of leukocyte activity, it eliminates inflammatory foci, has a strong antioxidant effect and eliminates pain impulses. In addition, some reviews indicate that this remedy reduces burning sensation, pain and itching.

Release form of the drug Genferon and its composition.

Genferon is available in the form of suppositories (suppositories), which are intended for rectal or vaginal administration. They are cylindrical in shape, usually colored White color(sometimes slightly yellowish). Genferon is packaged in five or ten suppositories with a dosage of 250,000, 500,000, 1,000,000 IU of interferon; there is also the drug Genferon Light, which contains 125,000 IU of the active substance.

Genferon suppositories contain three main components: human interferon alpha2, taurine, and an anesthetic local remedy(either anesthesin or benzocaine). The excipients are polysorbate, dextran, macrogol, T2 emulsifier, sodium hydrogen citrate, solid fat, citric acid and purified water.

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Why are Genferon suppositories prescribed? Instructions for use and indications.

The main indications for the use of Genferon:

mycoplasmosis; urogenital chlamydia; genital herpes; vaginal candidiasis in chronic form; gardnerellosis; viral papillmatosis; ureaplasmosis; trichomoniasis; women's diseases genital organs, such as levvovaginitis, adnexitis, cervical erosion, cervicitis, bartholinitis, etc.; male sexual diseases such as prostatitis, balanitis, urethritis.

Genferon light is also prescribed as an additional medicine in the complex therapy of all kinds of viral diseases.

How to use Genferon suppositories correctly? Instructions for use.

The drug dosage regimen depends on the age and gender of the patient. Let's consider how women are advised to use Genferon suppositories. The instructions are as follows: depending on the severity of the disease of the urinary and reproductive systems, the severity of complaints, as well as the duration of the disease, the drug can be used in a dosage of 250 thousand, 500 thousand and 1 million IU. Suppositories should be administered twice a day into the rectum or vagina (taking into account the location of the inflammation). The course of treatment lasts at least ten days.

If inflammatory disease lasts for a long time genitourinary system, then after completing the main course, it is advisable to continue treatment with Genferon suppositories for another one to three months, one suppository every three days. For vaginal sanitation, normalization of the microbial biocenosis of the vagina, as well as for the treatment of inflammatory processes and infections, pregnant women can use Genferon one suppository of 250 thousand IU twice a day for ten days.