Zirgan eye gel: instructions for use and reviews. Antiviral eye gel "Zirgan": description, reviews

Instructions for use

Active ingredients
Release form
Compound

1 g of gel contains ganciclovir 1.5 mg. Excipients: benzalkonium chloride - 75 mcg, carbomer - 4.83 mg, sorbitol - 50 mg, sodium hydroxide - q.s. up to pH 7.4, purified water - up to 1 g.

Pharmacological effect

Antiviral drug for local application in ophthalmology. Ganciclovir is a nucleoside that inhibits the replication of human viruses herpes simplex Types 1 and 2. IN infected cells Ganciclovir is converted to the active form of ganciclovir, ganciclovir triphosphate. Phosphorylation occurs predominantly in infected cells, and the concentration of ganciclovir triphosphate in uninfected cells is 10 times lower. The antiviral activity of ganciclovir triphosphate consists of inhibition of viral DNA synthesis using two mechanisms: competitive inhibition of viral DNA polymerase and direct incorporation into viral DNA with disruption of chain termination and preventing its replication

Pharmakinetics

After instillation of the drug into the eye 5 times a day. within 11-15 days when treating superficial herpetic keratitis Ganciclovir plasma concentrations were very low: average 0.013 µg/ml (0=0.037)

Indications

Treatment of acute superficial keratitis caused by herpes simplex virus

Contraindications

Pregnancy; - period breastfeeding;- children under 12 years of age; - hypersensitivity to ganciclovir, acyclovir or any of the components of the drug

Precautionary measures

The patient should refrain from driving a car or operating complex machinery in case of any visual impairment during treatment with the drug

Use during pregnancy and breastfeeding

The drug is contraindicated during pregnancy and lactation. For women of childbearing age, the use of contraception is necessary. Due to genotoxicity demonstrated in animal experiments, men using Zirgan are advised to use reliable methods of contraception during treatment and for three months after its completion.

Directions for use and doses

The drug is instilled into the lower conjunctival sac of the affected eye, 1 drop 5 times a day. until complete re-epithelialization of the cornea, then - 1 drop 3 times a day, for 7 days. The duration of treatment should not exceed 21 days

Side effects

On the part of the organ of vision: the most common side effects are blurred vision (60%), eye irritation (20%), punctate keratitis (5%) and conjunctival hyperemia (5%)

Overdose

There is no evidence of overdose

Interaction with other drugs

Not found

special instructions

The medicinal product not intended for the treatment of cytomegalovirus infection of the retina. Efficacy against keratoconjunctivitis caused by other types of viruses has not been established. None special research was not carried out in patients with immunodeficiency. Benzalkonium chloride may cause eye irritation and discoloration of soft contact lenses. The drug should not come into contact with soft contact lenses. Contact lenses should be removed before using the drug and reinstalled no earlier than 15 minutes after instillation.

Zirgan is an antiviral drug that is used in ophthalmic practice; the medication is used topically. Let's take a look at its instructions for use.

Composition and release form

The drug Zirgan is presented as a colorless eye gel, it has a uniform consistency. Its active substance is ganciclovir in a dosage of 1.5 milligrams. The auxiliary components of the medication will be as follows: benzalkonium chloride, as well as sodium hydroxide, carbomer is added in the required amount, and sorbitol is also present, in addition, purified water.

The gel is placed in small tubes in an amount of five grams; a convenient tip and screw cap are included with the medicine. The medicine is packed in cardboard packaging. For sale medicine on prescription.

The drug is valid for three years from the date of release; after the container is opened, it can be stored for four weeks, after which the medicine will be lost therapeutic effect Therefore, its further use should be abandoned.

pharmachologic effect

The drug Zirgan is intended for local use in ophthalmology. The active compound ganciclovir is a nucleoside that inhibits the replication of herpes simplex viruses. Directly in infected cells active substance converted to ganciclovir triphosphate. The antiviral activity of the drug is to suppress the synthesis of viral DNA.

Indications for use

The medicine Zirgan is prescribed for the treatment of superficial keratitis occurring in acute form caused by the herpes simplex virus. Before using the gel directly, you will need to consult an ophthalmologist.

Contraindications for use

Among the contraindications to the use of an ophthalmic agent are the following conditions:

The gel is not used during pregnancy;
The drug is not prescribed in pediatrics, in particular before the age of twelve;
The drug is not prescribed during breastfeeding.

In addition, the gel is contraindicated if the patient has a hypersensitivity to the compound ganciclovir or to other components medication.

Application and dosage

The drug is used locally, and the gel is carefully applied into the lower conjunctival sac of the diseased eye, one drop at a time, the frequency of use can be up to five times a day, and treatment is carried out until the function of the cornea improves, and then the frequency of use of the medication is reduced to three times a day .

In general, the duration of therapy with Zirgan can last no more than 21 days, and before starting treatment it is necessary to consult with a qualified ophthalmologist.

Overdose

There is no information about an overdose of Zirgan. If the gel is accidentally ingested, then the patient should undergo gastric lavage, after which a doctor should be consulted, especially in a situation where the patient feels uncomfortable.

Side effects

While using the ophthalmic drug Zirgan, you may develop side effects directly from the organ of vision, while local manifestations will be as follows: most often the patient will notice some blurred vision, eye irritation is added, the development of punctate keratitis is possible, in addition, pronounced redness of the conjunctiva occurs.

No systemic side effects have been reported to date. If the listed symptoms are severe, in this situation it is recommended to consult an ophthalmologist in a timely manner.

special instructions

The drug Zirgan is not intended for the treatment of cytomegalovirus infection localized on the retina.

It is worth noting that the benzalkonium chloride included in the gel can lead to some eye irritation, in addition, the color of soft contact lenses changes, therefore, the drug should not be allowed to come into contact with the lenses.

During treatment with Zirgan, the patient is not recommended to drive a vehicle, as there may be a temporary disturbance in visual perception, which gradually disappears after the end of therapeutic measures.

If the gel loses its physical and chemical properties, that is, it becomes liquid or too thick, in addition, it changes color, and is also heterogeneous, and so on, in this situation, from using such dosage form worth abstaining. It is worth noting that the drug cannot be frozen.

Analogs

Analogs include the drug Ganciclovir, as well as the drug Cymevene.

Conclusion

We reviewed the drug Zirgan, instructions for use, application, indications, contraindications, action, side effects, analogues, composition, dosage. Treatment of eye diseases should be carried out after prior consultation with a qualified ophthalmologist. If side effects occur during therapeutic measures, then the patient should urgently consult a doctor regarding further use of the medication.

Farmila-Tea Pharmaceuticals S.p.A.

Country of origin

Italy

Product group

Sense organs /vision, hearing/

Antiviral agent

Release forms

  • 5 g - (1) - cardboard packs.

Description of the dosage form

  • Colorless eye gel.

pharmachologic effect

Antiviral agent. It is a synthetic analogue of guanine. Its chemical structure is similar to acyclovir. Inside the cell, ganciclovir is sequentially metabolized into its monophosphate form by cellular deoxyguanosine kinase and then into active ganciclovir triphosphate. Acting as a substrate and being incorporated into DNA, ganciclovir triphosphate competitively inhibits viral DNA synthesis. This leads to suppression of DNA synthesis by inhibiting DNA chain elongation. Ganciclovir inhibits viral DNA polymerase more actively than cellular polymerase. Active against cytomegalovirus, Herpes simplex virus types 1 and 2, Varicella zoster, Epstein-Barr virus. Clinical researches were carried out only for CMV infection.

Pharmacokinetics

After oral administration, it is slightly absorbed from the gastrointestinal tract. Bioavailability is 6-9%. Cmax in blood plasma after oral administration is achieved after 1.8 hours, with intravenous administration - within 1 hour. Distributed in all tissues, passes through the placenta. Vd is 0.74 l/kg. Plasma protein binding - 1-2%. Excreted in urine. T1/2 after oral administration is 3.1-5.5 hours, with intravenous administration - 2.9 hours.

Special conditions

Use with caution in patients with impaired renal function. This category of patients requires adjustment of the dosage regimen depending on the value of CC. During the treatment period, regular monitoring of peripheral blood patterns and renal function is necessary. Depending on the degree of neutropenia and thrombocytopenia, adjustment of the dosage regimen or temporary cessation of treatment is required until signs of hematopoietic recovery appear. The simultaneous use of ganciclovir with drugs such as dapsone, pentamidine, fluorocytosine, vincristine, vinblastine, adriamycin, amphotericin B, combinations of trimethoprim with sulfonamides is justified only if the expected benefit of therapy outweighs the potential risk. Ganciclovir should only be administered intravenously, because IM or SC injections cause severe tissue irritation. IV drip administration must be accompanied by an appropriate water load. In children under 12 years of age, ganciclovir is used in cases where the expected benefit of therapy outweighs the risk of side effects. When used in high doses, suppression of spermatogenesis in men and fertility in women is possible. Men and women of childbearing age should use reliable methods of contraception during treatment. Men are also recommended to use barrier methods contraception for 90 days after the end of treatment.

Compound

  • ganciclovir 1.5 mg Excipients: benzalkonium chloride - 75 mg, carbomer - 4.83 mg, sorbitol - 50 mg, sodium hydroxide - q.s. to pH 7.4, purified water to 1 g.

ZIRGAN indications for use

  • Treatment of acute superficial keratitis caused by herpes simplex virus

ZIRGAN contraindications

  • Neutropenia ( absolute number neutrophils less than 0.5×109/l, thrombocytopenia (platelet count less than 25×109/l), severe renal dysfunction, congenital and neonatal cytomegalovirus infection, pregnancy, hypersensitivity to ganciclovir or acyclovir.

ZIRGAN side effects

  • From the hematopoietic system: neutropenia, thrombocytopenia, anemia, eosinophilia. From the side of the central nervous system: obsessive states or nightmares, ataxia, coma, confusion, insomnia, dizziness, headache, nervousness, paresthesia, psychosis, seizures. From the outside digestive system: nausea, vomiting, dry mouth, abdominal pain, anorexia, diarrhea, flatulence, changes in laboratory parameters of liver function. From the outside of cardio-vascular system: arrhythmia, arterial hypertension or hypotension. Allergic reactions: fever, skin rash, itching, urticaria. From the urinary system: hematuria, increased creatinine and urea in the blood plasma, increased urea nitrogen in the blood. Local reactions: inflammation, pain, phlebitis at the injection site. Other: hypoglycemia, dyspnea, alopecia.

Drug interactions

Probenecid and other drugs that inhibit renal tubular secretion or reabsorption may reduce the clearance of ganciclovir and increase its half-life. With simultaneous use of ganciclovir with dapsone, pentamidine, fluorocytosine, vincristine, vinblastine, adriamycin, amphotericin B, combinations of trimethoprim with sulfonamides, additive toxicity may develop. Concomitant use zidovudine and ganciclovir increases the risk of developing neutropenia. With the simultaneous use of ganciclovir and a combination of imipenem and cilastatin, generalized seizures are observed.

Storage conditions

  • store at room temperature 15-25 degrees
  • keep away from children
Information provided

For diseases of the visual organs, ointments, drops and other medications are used local action. "Zirgan" is an eye gel that has antiviral properties. The composition of the drug includes elements that are capable of attacking viral cells in a short period of time, destroying them. Before using the medicine, you should consult an ophthalmologist.

Composition and properties

Eye gel "Zirgan" ("Virgan") is a medication that has an antiviral effect that can fight Herpes Simplex, Epstein-Barr, and Varicella Zoster viruses.

The active component is ganciclovir - an element that is close in structure to acyclovir and is synthetic similar drug guanine. The medicine is produced in plastic tubes, 5 g each, equipped with dispensers in the form of tips and stands for proper storage medications in original packaging. Auxiliary components are:

  • sorbitol;
  • benzalkonium;
  • water;
  • carbomer, etc.
The action of the drug is aimed at eliminating the virus.

Ganciclovir is a nucleoside. It can inhibit the replication of human herpes simplex viruses types I and II. Upon penetration into diseased areas, transformation occurs in the cells active ingredient before your active state- ganciclovir triphosphate. Activity against viruses consists of the ability to inhibit the synthesis of viral DNA polymerase with subsequent inclusion in the pathogen gene and the effect on chain termination, which prevents its replication. As a result, the ability to reproduce is stopped and herpes does not spread in the body, but is transferred to latent form. Thanks to the auxiliary components, the gel acquires the necessary consistency, is successfully released during use and is able to fight viruses.

Indications

Zirgan eye gel is used to treat acute superficial keratitis caused by the herpes simplex virus, accompanied by the following symptoms:

  • blepharospasm - narrowing of the eye slit;
  • photophobia;
  • itching in the eye area;
  • feeling of a foreign body;
  • lacrimation;
  • cutting pain in the eye.

Contraindications


A person may not tolerate the drug due to his own characteristics.

The drug "Zirgan" should not be used in the following situations:

  • personal intolerance to ganciclovir;
  • period of pregnancy, lactation;
  • cytomegalo therapy viral infections retina;
  • age up to 12 years.

In case of immunodeficiency, the drug should be used with extreme caution. During pregnancy and breastfeeding, Zirgan should not be used. Experiments have shown that this drug is characterized by genotoxicity. As a result, all people in reproductive condition must take this fact into account when using the medication and for the next 3 months after therapy. During this period, proven contraceptives must be used.

Instructions for use

Zirgan gel is available only by prescription, so before using it you must consult an ophthalmologist. Instructions for use indicate that the medication is administered into the lower conjunctival sac 1 drop up to 5 times a day. Therapy must be carried out until the cornea is completely restored. In the next 7 days, this ointment should be administered three times a day, 1 drop. The total duration of the course of therapy is up to 3 weeks.

When treating with Zirgan gel, it is advisable to drink a lot of fluids to speed up the elimination of all components of this drug from the body.