Glycine principle of action. Directions for use and dosage Glycine
Update: October 2018
Glycine is one of the most popular metabolic drugs prescribed to improve mental and physical abilities, and also as a sedative and light sleeping pills in pediatrics and for adult patients.
The action can be both calming and activating in relation to the central nervous system and varies depending on the time of taking the drug during the day - this is stated in the instructions for using Glycine.
However, you should immediately focus on the fact that all nootropic drugs, without exception, work only in pathologically changed tissues, directly improving metabolic processes in brain cells in case of disorders, but have no effect on healthy tissue. That is, using them to stimulate the mental activity of children and adults (as is often recommended) is, if not completely useless, then ineffective (see).
Pharmaceutical group: A drug to improve brain metabolism. According to the classification, ATX belongs to the group of nootropics and psychostimulants.
Composition of the drug, release form, price
- Active ingredient of the drug– glycine. 1 tablet of 100 mg contains 100 mg of glycine. Excipients of 100 mg tablets are: 1 mg magnesium stearate, 1 mg water-soluble methylcellulose.
- Release form: sublingual tablets with a sweetish taste, white with marble inclusions, flat-cylindrical with a chamfer shape.
In blister packs of 50 sublingual tablets, in a cardboard box.
Glycine tablets are also available in dosages of 150, 400 and 500 mg.
Price: Glycine No. 50, 100 mg: 29-36 rub.
Pharmacological action
Glycine is the simplest aminoacetic acid. It is part of protein molecules and biologically active compounds. Glycine is the basis for the synthesis of porphyrins, from which hemoglobin and myoglobin are subsequently synthesized, as well as purine bases. It regulates metabolic processes, activates and normalizes protective reactions of inhibition in the central nervous system, eliminates psycho-emotional stress, increases cognitive function and mental abilities. It has alpha1-adrenergic blocking, glycine- and GABA-ergic, antioxidant and antitoxic effects. Glycine regulates glutamate receptors, thereby achieving next steps drug:
- reducing conflict and aggressiveness;
- increasing the level of social adaptation;
- improvement and stabilization of mood;
- acceleration of falling asleep and improvement of sleep quality (see);
- reduction in severity, including those associated with menopause (see);
- reducing the severity of central nervous system disorders due to stroke and TBI;
- decrease toxic effect ethyl alcohol and medicines, inhibiting the activity of the central nervous system.
Pharmacokinetics- the drug quickly penetrates into biological fluids and body tissues, including brain matter. Without accumulating in tissues, it is completely metabolized to water and carbon dioxide.
Indications for use
The instructions for use of glycine indicate:
- Decreased performance, mental and physical;
- Stress and associated psycho-emotional tension;
- Overstrain of the central nervous system during periods of increased mental stress (exams, etc.);
- Deviant, contradictory accepted standards, behavior in adolescents and children;
- Perinatal damage to the central nervous system in infants;
- Ischemic stroke;
- Organic and functional diseases nervous system, accompanied by emotional instability, high excitability, falling mental performance and sleep disorders:
- neurosis-like conditions and neuroses
- vegetative-vascular dystonia
- recovery period after TBI (traumatic brain injury) and neuroinfections
- perinatal and other types of encephalopathies, including alcoholic and drug-induced.
This is written in the instructions for glycine, but the first 4 points should not be taken seriously. As a result of numerous studies, the effectiveness of nootropics (including glycine) for improving mental and physical performance, memory, has not been proven. Only 1 small study of glycine has shown that it has little effectiveness in CNS disorders, and not in severe cases. For example, in the USA, glycine is not used in these cases (the first 4 points); it is only occasionally used in psychiatric clinics to treat a number of patients.
Contraindications
Glycine is not prescribed if there are individual hypersensitivity reactions to the drug and its components.
Glycine for pregnant and breastfeeding women
It may be applicable for the treatment of these groups of women, but strictly as prescribed by a doctor.
Dosage
Glycine tablets are intended for sublingual resorption. You can dissolve the drug behind the cheek, or use a pre-crushed tablet in powder form.
- Nervous system lesions related to organic and functional changes and flowing with increased excitability, changes in emotional background, sleep disturbance: adults, 1 tablet (100 mg) of glycine twice or thrice a day for 7-14 days. The course of treatment can be extended up to 30 days. Repeated course use is possible 30 days after completion of the previous course.
- Sleep disorders: 0.5-1 tablet per 20 minutes of sleep.
- Ischemic cerebral stroke : 1000 mg of the drug buccal or sublingual with 1 tsp. water during the first 3-6 hours; 1000 mg per day for the next 1-5 days; then - 1-2 tablets of glycine three times a day for another 30 days.
- Encephalopathies, consequences organic damage nervous system (central and peripheral): 1 tablet of glycine twice or thrice a day for 14-30 days. Courses are repeated 4-6 times throughout the year.
Instructions for use of glycine for children
The drug has a sweet taste, so children usually enjoy swallowing the tablets. If the tablet cannot be absorbed (newborns, early childhood), it is permissible to grind the required amount of the drug into powder and dilute it in a teaspoon of water.
- Children under three years old: 0.5 tab. (50 mg) of glycine taken twice or thrice a day for 7-14 days, then 50 mg once a day for 7-10 days. The daily dose for children under 3 years of age is 100-150 mg of glycine, and the course dose is no more than 2000-2600 mg.
- Children over 3 years old the drug is prescribed in an adult dosage: 1 tablet (100 mg) twice or thrice a day for 1-2 weeks, with a maximum increase in the course to 4 weeks.
Side effects of glycine
It is possible to develop hypersensitivity reactions in the form of a rash.
Overdose
No cases of overdose have been described. Possible: reduction blood pressure, dizziness and nausea.
Drug interactions
At simultaneous administration with drugs from the groups of anxiolytics, antipsychotics, anticonvulsants, hypnotics and antidepressants, glycine reduces the severity of the side effects of the former.
Special instructions
Prescribed with caution to persons managing vehicles and those involved in working with precision mechanisms.
Glycine analogues
Nootropics also include Piracetam (Nootropil, Piracetam, Lucetam), Noopept. Among herbal remedies We can highlight Ginkgo biloba (Bilobil, Memoplant, Ginkgo Biloba, Tanakan, Ginkum, Doppelherz ginkgo biloba with vitamins gr.B, Vitrum memory), which improves metabolic processes in neurons, as well as enhances the effect of nootropic drugs.
IN pharmacy points you can find Glycine: Glycine ozone, Glycine-Bio, Glycine Evalar, Glycine Forte, Glycine-Canon.
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100 pcs. 500 mg. 1100 rub. |
20 pcs. 50-80 rub. |
50 pcs. 17 rub. |
100 mg. 50 pcs. 30 rub |
30 caps. 150 rub. |
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Metabolic drug acting on cellular level, produced by many Russian companies. Glycine is based on an amino acid that in good condition health is synthesized in the cells of the body.
Like other drugs from the category of nootropics, Glycine acts only in cases of pathology. Healthy cells no additional stimulation is needed and taking the drug does not cause changes in the condition of the tissues.
Glycine is prescribed to stimulate mental activity and as a mild sedative with a hypnotic effect. This drug has amazing property. Depending on the admission different times days Glycine has different effects on the body.
To enhance activity brain activity The drug is taken in the morning. In the evening, when preparing for bed, Glycine can be safely taken as a sedative.
The drug was originally developed to relieve tension in people with alcohol addiction. It was successfully used by narcologists to recover from a drunken state. Further studies showed that Glycine has positive influence under stress and increased loads, even in childhood. Cardiologists recommend that their patients take glycine during VSD to improve the functioning of the heart muscle.
Composition, pharmacological properties and indications for use
A standard package of Glycine contains from 30 to 50 small, light-colored tablets with a sweetish taste. It is dispensed from pharmacies without a prescription, although it is not recommended to prescribe the drug yourself.
One tablet contains 100 mg of the active substance glycine in microcapsules. Additional components included:
How to take glycine for various diagnoses is written in detail in the instructions that necessarily accompany each package. medicine.
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Low cost and minimum quantity contraindications Glycine attracts patients and physicians when prescribing the drug.
Glycine is used in treatment in neurology, pediatrics and cardiology. It can be given to children with infancy. The drug is prescribed in the following cases:
Despite larger list conditions for which it is recommended to take Glycine, some recommendations are advertising in nature. The results of studies by drug manufacturers differ from the opinions of independent medical experts. Therapeutic effect at severe forms CNS diseases have not been proven in practice. And effectiveness in reducing mental and physical activity It has more of a placebo effect than a true strengthening agent.
Glycine is the simplest amino acid found in the structure of protein cells and compounds. Participating in the synthesis of porphyrins, glycine is necessary for the subsequent production by the body of such important substances as myoglobin and hemoglobin.
Its effect on the nervous system is regulatory. This amino acid during metabolism normalizes the body's response to irritation. By influencing glutamate receptors, glycine increases the stress resistance of the central nervous system. It is this property that is used in medicine for a sedative effect in cases of high stress.
Pharmaceutical glycine practically does not accumulate in tissues. It easily penetrates body fluids at the cellular level, performing its functions. The drug decomposes to an absolutely safe state. The end result of the decomposition is carbon dioxide and water. This feature protects the body from the effects of additional chemicals to the excretory system.
Directions for use and dosage
The release form of the drug is very convenient for oral administration. The taste does not cause them negative emotions. The tablets must be dissolved, which even a child can do. According to the instructions for the drug, the dosage and time of administration depend on the patient’s condition and biological rhythms. There is a selective effect of the drug at different times of the day, for example:
A specialist should decide whether Glycine can be given to children. You should not prescribe treatment for any condition of your baby on your own.
Modern psychologists allow the use of the drug in children with increased excitability. Glycine is usually prescribed between the ages of 12 and 15 years if the child suffers from sudden changes mood, reluctance to concentrate on classes. At the same time, both children and parents need to drink the drug. High level Tensions in the family when children enter the period of adolescence are difficult for adults to bear.
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The child can be given no more than 1 tablet in the morning and before bedtime. For children under three years of age, Glycine is diluted with water in an amount of no more than 50 mg. The course of treatment is from 2 to 4 weeks. Children over three years of age may be prescribed adult dosage. In some cases, the drug is recommended for reduced level hemoglobin as a regulator of synthesis.
Side effects and combination with alcohol
The instructions for the drug do not indicate possible side effects from use.
But this indicates the absolute safety of the drug. Like any nootropic drugs, Glycine can cause allergic reactions on the skin in the form of rash, redness and itching. Especially often such side effects happen in children.
For people suffering from unstable blood pressure, taking Glycine may have a negative impact on their health. Although there is no mention that the drug increases or decreases blood pressure in the annotation.
The drug can reduce concentration. Therefore, you should drink it with caution while driving a car.
Unlike most sedatives and sleeping pills, Glycine can be taken even in a state of alcohol intoxication, according to drug experts. Its antioxidant properties contribute to the rapid removal of alcohol breakdown products from cells. With regular use of the drug in a dosage of 3 tablets per day, a decrease in the effects of alcohol intoxication is observed.
Glycine analogs
Basic active ingredient The drug is included in many other medicines. Based on glycine the following are produced:
- Doppelhertz glycine (Germany).
- Glycine forte "Evalar" (Russia).
- Glycine "Ozone" (Russia).
Glycine-like effects have nootropic drugs different from it in composition:
Despite the widely advertised qualities of Glycine, there is no evidence of its effectiveness in reducing physical and mental activity does not exist. Most experts say that positive reviews patients are based on self-deception. When deciding to take a medicine, do not forget about the need to consult a doctor.
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Glycine is a drug and active substance that is considered nonessential amino acid, is a white crystalline fine powder; it dissolves quite easily in water.
Pharmacological action glycine
The active substance glycine helps to normalize metabolic processes occurring in the body, has an anti-stress and nootropic effect, in addition, it has antiepileptic and sedative effect.
This compound freely penetrates into many biological fluids and tissues human body, including in the brain. The active substance is quickly destroyed by the so-called glycine oxidase; this process occurs directly in the liver.
Glycine is a neurotransmitter of the so-called inhibitory type of action; in addition, it is considered a regulator of metabolic processes in the spinal cord and brain. Normalizes both the processes of inhibition and excitation in the nervous system, improves mental performance, normalizes sleep, helps eliminate depressive state and increased irritability.
This substance is effective as an auxiliary drug in the presence of epileptic seizures in a patient. It has a multicomponent so-called anti-ischemic effect, which is expressed in a decrease in the content of toxic products in the nervous system, such as aldehydes, ketones and some other compounds formed in biochemical reactions when acute ischemia occurs.
Indications glycine
I will list when the drug glycine is indicated for use, these will be the following conditions:
In the presence of stressful conditions;
With emotional lability;
With psycho-emotional stress;
This active substance is prescribed for increased excitability;
In the presence of neurosis-like conditions;
A remedy is prescribed for vegetative-vascular dystonia;
With the consequences of traumatic brain injury;
With neuroinfection;
In some forms of encephalopathy, including those of alcohol origin;
In case of sleep disturbance;
In the presence of ischemic stroke acute nature.
The drug glycine is prescribed to increase a person’s mental performance, including the drug used by adolescents with deviant (deviation from the norm) forms of behavior.
Contraindications glycine
Among the contraindications, only hypersensitivity to glycine can be noted; there are no other cases when the drug cannot be used.
Glycine intake and glycine dosage
A medicinal product containing glycine is recommended to be taken sublingually (under the tongue), for psycho-emotional stress, for decreased mental performance, as well as attention and memory, for delayed mental development The drug is usually prescribed at a dose of 0.1 gram up to two or three times a day for two weeks or one month. The daily dose should not be more than 0.3 grams.
With lesions of the nervous system of a functional or organic nature, which are accompanied by sleep disturbances, increased excitability, in addition, emotional lability, as well as children under three years of age, the medicine is usually prescribed at a dose of 0.05 grams per dose up to three times a day for a week or one month, while daily dose varies from 0.1 to 0.15 grams. If necessary, the therapeutic course can be repeated.
A glycine-based drug reduces the severity of some toxic effects of antidepressant drugs, anticonvulsants, as well as neuroleptics.
Side effects of glycine
In some cases, the patient may develop an allergic reaction to the use of drugs containing the active substance glycine. In this case, the patient should consult a specialist.
Glycine overdose
Currently, there are no cases of overdose of the drug Glycine. If the drug is consumed simultaneously in large quantities, in this situation it is recommended to urgently begin the procedure of gastric lavage using boiled water, and the patient must drink at least one liter of liquid.
After which, especially if general health deteriorates, the patient is recommended to consult a qualified doctor.
Special instructions
It is worth noting one feature that during the surgical intervention on prostate gland, in particular with transurethral resection, the patient is usually given local applications using glycine, which can enter the systemic circulation and negatively affect body functions such as the heart, kidneys and lungs, especially in people with cardiovascular pathology.
Preparations containing glycine
The active substance glycine is contained in the drug of the same name. It is produced pharmaceutical industry in the form of sublingual tablets. It is recommended to store them out of the reach of children; the medication should be used no later than the expiration date indicated on the package.
Conclusion
The use of the drug Glycine should be carried out on the recommendation of the treating doctor. If an allergy to this medication occurs, the patient should consult a doctor.
"Glycine" is a drug that has a beneficial effect on metabolic processes in the human brain. It is part of various biological active substances, the protein composition of body tissues is no exception. In addition, glycine is a neurotransmitter, directly involved in the transmission of information along nerve fibers.
Under the influence this drug performance and mood are significantly improved, which has a good effect on a person’s adaptation in the work team and in the family. It also has a beneficial effect on sleep, relieves the effects of experienced neuroses on internal organs, central nervous system and circulatory systems.
The drug "Glycine", which occurs extremely rarely, is prescribed for stroke and various brain injuries, as it significantly reduces negative consequences. It is used to treat chronic alcoholism, to restore normal operation brain and relief of consequences after the toxic effects of alcoholic beverages. It reduces the need for oxygen in brain tissue, thereby improving the processes of memorizing new material and developing cognitive abilities.
The drug "Glycine": side effects. Taking this drug is contraindicated in the presence of individual intolerance to its components. No cases of drug overdose have been identified. Allergic reactions may occur as a side effect. A positive side effect of this drug is that it reduces the intensity of the side effects of other drugs that have a direct effect on the central nervous system, including sleeping pills and sedatives.
It occurs quite rarely, but it can be very difficult to predict how it will proceed. this process. Mild manifestations of allergic reactions are possible in the form of a rash accompanied by itching, and there are more severe cases, accompanied by Quincke's edema or even anaphylactic shock. It is worth considering that with continued use of the drug, the allergic reaction intensifies, so if you are allergic to Glycine, you must immediately stop taking the drug and consult a doctor.
In individual cases, it is possible that increased sleepiness, which is accompanied by a slight dilatation of blood vessels, which provokes severe headache. Since the drug "Glycine" (the side effects of which are caused by individual intolerance) is strong sedative, then in case of an overdose, a state of apathy occurs and performance decreases. Due to excessive central nervous system suppression, slight loss of coordination and thirst may also occur.
Hypotensive patients should be very careful when using the drug, since glycine tends to slightly lower blood pressure levels. This decrease, in turn, leads to weakness, dizziness, and darkening of the eyes. When pressure drops, complaints of heaviness in the head are possible.
Drivers should also be attentive to the use of the drug, since in individual cases there may be a decrease in concentration and inhibition of motor reactions.
The drug "Glycine", the side effects of which manifest themselves individually, may have an adverse effect on the embryo or fetus, as a result of which they develop birth defects. Also, the drugs taken tend to penetrate into the child’s body along with mother’s milk, so nursing mothers, no less than pregnant women, need to be careful when using the drug.
It is not advisable for hypotensive patients to take the drug before a long trip or before work, since even a slight decrease in pressure can lead to fainting, especially in hot weather. summer days.
Taking into account all the side effects, "Glycine" is a beneficial agent, which, however, should be prescribed exclusively by the attending physician.
Glycine instructions for use in adults are a detailed summary of how to take a substance that improves metabolic processes in the brain. Taking glycine allows you to calmly tolerate, regulates sleep and improves cognitive abilities such as thinking and learning.
How does glycine work?
Glycine (aminoacetic acid) is an amino acid that regulates and improves metabolism in nerve cells(neurons), including a positive effect on the transmission of nerve impulses through neurons. It has an inhibitory effect on the central nervous system, which helps relieve stress, anxiety and fear. Antioxidant (suppression of toxic free radicals formed during metabolism) and antitoxic (for example, from drinking alcohol) prevents damage and premature aging neurons.
Glycine is produced:
- in the form of sublingual tablets of 100 mg; excipients: magnesium stearate and water-soluble methylcellulose (Biotiki, Ozon, Russia);
- in the form of capsules for oral administration, 400 mg (VIS, Russia);
- in the form of capsules for oral administration, 500 mg (Solgar, USA);
- in the form of capsules doppelgerts active glycine + B-vitamins (glycine - 500 mg, vitamin B1 - 1.7 mg, vitamin B12 - 3.0 mcg, vitamin B6 - 2.0 mg), (Queisser Pharma, Germany);
- in the form of lozenges glycine forte (glycine 250 mg), (Ozone, Russia).
Glycine improves metabolism in neurons, relieves nervous tension, calms, improves mood, relieves anxiety and aggressiveness, increases the body’s adaptive capabilities and general performance, reduces cravings for alcohol. After the course of treatment, vegetative-vascular manifestations decrease, normalization blood pressure(BP), recovering heart rate. Glycine for adults is especially useful for patients after traumatic brain injuries and strokes, as it has the ability to restore injured neurons.
Who is glycine indicated for?
Glycine (instructions for use by adults) is prescribed for impaired mental performance, high neuropsychic stress, stress, behavioral disorders and adaptation in children and adolescents.
Glycine also used in the composition rehabilitation therapy after traumatic brain injuries, strokes, neuroinfections and severe stress, in the treatment of perinatal (in the second half of pregnancy, during childbirth and in the first week after birth) lesions of the nervous system. Glycine is widely used in the treatment of chronic alcoholism.
Glycine is used for any diseases that are accompanied by asthenia: irritable weakness, anxiety, bad mood, decreased mental performance, difficulty falling asleep and night sleep.
Contraindications and side effects of glycine
A contraindication for the use of glycine is only increased sensitivity to it of the patient's body. From side effects glycine, only allergic reactions are known, which are rare and manifest themselves in the form of an itchy rash.
Is it possible to overdose on glycine?
An overdose of glycine (consequences in adults) is rare, however, this possibility exists if several packages of the drug are accidentally consumed. Since glycine is an amino acid and is a component of protein, its overdose manifests itself in the form of protein poisoning: weakness, lethargy, drowsiness, decreased blood pressure, and decreased heart rate. An overdose of Glycine is especially dangerous for people suffering from severe kidney disease.
Immediately after taking large quantity tablets, you need to rinse your stomach and take a few tablets activated carbon. If the pills were taken a long time ago and symptoms of overdose appear, you should immediately call an ambulance.
Glycine dosage regimen
Glycine tablets are taken under the tongue, placed behind the cheek or in powder form (by rubbing the tablet). Capsules are taken orally during meals. The dosage of glycine and the duration of its administration depend on the patient’s condition. The standard dosage is one tablet 2-3 times a day for 2-4 weeks. The doctor, at his discretion, can increase both the dose and duration of taking the drug. But self-administration of glycine does not provide for changes in dosage.
When glycine is prescribed, the instructions for use in adults must be followed, but the doctor, at his discretion, can change the dosage of the drug
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