Instructions for use of Nise gel: composition, what it helps with, analogues and reviews. What you need to know about Nise ointment

Composition of Nise in tablets: 1 tablet 100 mg nimesulide . Calcium hydrogen phosphate, cellulose, corn starch, magnesium stearate, sodium carboxymethyl starch, talc, silicon dioxide as excipients.

Gel composition: 1 g contains 10 mg nimesulide . N-methyl-2-pyrrolidone, macrogol, propylene glycol, purified water, carbomer-940, isopropanol, butylated hydroxyanisole, thiomersal, potassium dihydrogen phosphate, flavoring as excipients.

Release form

• Dispersed tablets 50 mg.
• Tablets 100 mg.
• Gel 1% 20 g or 50 g in a tube.

pharmachologic effect

Anti-inflammatory , antipyretic , analgesic .

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

What is this medicine for? The active substance - nimesulide - is a non-steroidal anti-inflammatory drug, a derivative sulfonanilide . Wikipedia and pharmaceutical reference books contain a description of its action. Anti-inflammatory effect is caused by the suppression of the enzyme COX-2, which is involved in the synthesis of prostaglandins, which play a role in the development of inflammation and pain. At the same time, it also has other mechanisms of action: it affects the activity of cartilage metalloproteases, reduces the release of ROS by neutrophils, and reduces the formation of cytokines, which makes it promising in the treatment of rheumatological diseases.

Renders fast analgesic effect , the beginning of which is fixed after 15 minutes. after reception. Effective concentrations in plasma and synovial fluid are determined after 30 minutes. after reception. The analgesic effect of the drug is not inferior And and surpasses the effect Rofecoxib . It inhibits the formation of enzymes that destroy cartilage tissue, therefore it does not have a damaging effect on it. Unlike reduces the release of histamine, reducing bronchospasm. Its use is justified for bronchial asthma, when the use of other NSAIDs or acetylsalicylic acid .

Indications for use of the drug also include childhood. Only two nimesulide preparations ( And Nise ) are approved for use in children from 2 years of age, since they have a dosage form intended for them.

The predominant blocking of COX-2 and an unpronounced effect on COX-1 is determined by high level safety in relation to the gastrointestinal tract and explain the rare occurrence of other side effects. When taking nimesulide, the incidence of side effects from the gastrointestinal tract is less than when taking Diclofenac 2 times, 1.8 times, - 2.1 times.

Pharmacokinetics

Absorption is high. The maximum concentration is determined after 1.5–2 hours. Binding to albumin is 95%. Penetrates well into the source of inflammation, synovial fluid, and into the tissues of the female genital organs. Metabolized in the liver, and the main metabolite has similar activity. T1/2 is 1.5–4.7 hours, but the blocking of COX-2 still continues for up to 8 hours and up to 12 hours in the synovial fluid. At severe defeat kidney is prescribed with caution.

The gel components quickly penetrate into muscle tissue and into the joint cavity. The concentration reaches therapeutic levels, which causes analgesic and anti-inflammatory effects. The active component is found in small quantities in the bloodstream, therefore systemic impact has practically no effect. Clinical effect occurs in 4 weeks.

Indications for use of Nise

Indications for use of Nise tablets – symptomatic treatment:

• gouty And psoriatic arthritis ;
• osteochondrosis with pain syndrome;
• tendinitis , ;
• pain syndrome due to injuries postoperative period, thrombophlebitis , gynecological diseases;
• toothache and headache;
• fever of various origins.

Nise ointment is used for local treatment:

• lumbago ;
• rheumatoid arthritis ;
• psoriatic arthritis ;
• ANylosing spondylitis ;
• osteochondrosis with the presence of radicular syndrome;
• tenosynovitis ;
• sciatica ;
• ligament damage;
• myositis ;
• bruises and injuries.

Contraindications

• peptic ulcer in the acute stage;
• hypersensitivity;
• pronounced renal And liver failure ;
• pregnancy, lactation.

Use caution when prescribing to patients with arterial hypertension , , . Due to possible drowsiness There are restrictions when driving a car.

Side effects

Side effects of the tablets include nausea, vomiting, , pain in stomach area, , itching, bronchospasm . There is a risk of developing thrombocytopenia , drowsiness, petechiae , oliguria And hematuria , fluid retention.

Cream (gel) may cause local reactions in the form of a temporary change in skin color, itching, hives , peeling. When used on large areas of skin or when long-term use possible development of systemic reactions: stomach pain, heartburn , vomit, diarrhea , headache, fluid retention, blood changes, allergic reactions.

Instructions for use Nise (Method and dosage)

The drug has several release forms, the features of which will be discussed below.

Nise tablets, instructions for use

The usual dose for adults and children over 12 years of age is 100 mg twice daily. Nise tablets are best taken before meals with liquid. If there is discomfort in the stomach, the medicine is taken at the end of the meal. Dispersible (soluble) 50 mg tablets are convenient to use, which are dissolved in 5 ml of water before taking. The dosage may be adjusted according to various states: 50 mg for algodismenorrhea or 200 mg twice a day for severe pain, considering that the maximum dose is 400 mg per day.

If renal function is impaired, the dose is reduced. If symptoms of liver dysfunction appear (increased liver transaminases, itchy skin, nausea, vomiting, darkening of urine) the drug is stopped. After 2 weeks of use, biochemical indicators of liver function are monitored.

For children, the drug is prescribed at a rate of 3 mg/kg body weight 2–3 times a day. The maximum DM for children is no more than 5 mg/kg. The use of Nise tablets is contraindicated for children under 12 years of age. From 7 years of age, it is possible to take dispersible tablets, and for children from 2 years of age it is preferable to use children's syrup (suspension), which is available in 60 ml bottles and contains 50 mg of active substance per 5 ml. Children from 2 to 5 years old are prescribed children's Nise 2.5 ml 2-3 times a day, from 5 years old - 5 ml 2-3 times a day. Treatment lasts up to 5 days.

Gel Nise, instructions for use

Any cream, gel or ointment based on nimesulide has a pronounced analgesic effect. It is noted that the gel base is well absorbed and provides maximum diffusion of the components. Apply 3 cm of gel to the skin at the site of pain 2-3 times a day, spread thin layer, does not rub in. The course is no more than 10 days. The amount of gel may vary depending on the size of the skin area and the patient's reaction. The maximum dose is 30 g per day.

The drug should be applied to dry, intact skin. The gel should not be used under airtight bandages and should not come into contact with the eyes. After applying the gel, hands should be washed with soap. The use of the drug in tablets and gel form makes the treatment complex. There are injections with the same active ingredient - Nimulid. 2 ml ampoules contain 75 mg of the drug.

Overdose

Manifested by increased severity of adverse reactions. Drowsiness, apathy, nausea appear, sometimes gastrointestinal bleeding, spicy renal failure, blood pressure increases.
Treatment begins with gastric lavage, administration sorbents And osmotic laxatives .

Interaction

Increases nephrotoxic effect cyclosporines .

Application with GKS , other NSAIDs increase the risk of gastrointestinal bleeding.

Terms of sale

Tablets and suspension are available with a prescription. Gel without a prescription.

Storage conditions

At temperatures up to 25 °C.

Best before date

Gel - 2 years.

Tablets - 3 years.

Analogues of Nise

Level 4 ATX code matches:

Cheap analogues of tablets - (Replekfarm JSC, Macedonia) can be purchased for 68-94 rubles, (Medochemi, Cyprus) for 130-147 rubles.

Nise gel analogues: gels , Sulaydin , , Diclofenac .

Nise during pregnancy

Since NSAIDs cross the placenta, there is a possibility of developing congenital pathology in the fetus. Have the greatest teratogenic effect salicylates , indomethacin , aminophenazone .

The annotation for this drug also contains a warning about contraindications during pregnancy, since there is information that in newborns whose mothers took the tablet drug, nephrotoxic effect . Nimesulide can cause premature closure of the ductus botalus in the fetus. In a pregnant woman it can cause pulmonary hypertension , oliguria , peripheral edema And oligohydramnios . In addition, the risk of bleeding and uterine atony . The gel is also not recommended for use during pregnancy, despite low level systemic action.

The use of the drug is also contraindicated during breastfeeding. If necessary, breastfeeding is stopped. The use of the drug negatively affects female fertility, so its use is not recommended when planning pregnancy.

Nice and alcohol

Forum visitors are interested in the compatibility of this drug with alcohol. Indeed, not all instructions say this. Considering the hepatotoxic effect of alcohol and the drug (monitoring of liver function is necessary during long-term use), their simultaneous use is undesirable. In addition, the use of other hepatotoxic drugs (other NSAIDs, analgesics) should be avoided.

Reviews about Nise

Many users who are not familiar with the drug Nise are interested in what these tablets are for? Non-steroidal anti-inflammatory drugs, to which this drug belongs, combining analgesic, antipyretic and anti-inflammatory effects, are commonly used medications. These drugs are widely used for self-medication. There are many situations when we are forced to take painkillers, including - Nise tablets.

What is it most often taken for? this drug? Patients use it as a remedy for headaches, painful menstruation, for toothache, because this drug has a quickly onset and pronounced analgesic effect. Its effectiveness has been shown in multiple studies.

Reviews about Nise tablets are positive. The analgesic effect when taken orally occurs within 20 minutes and lasts 5 hours. However, you need to remember that Nise tablets for toothache should be used as an emergency treatment when it is not possible to immediately see a dentist. The drug Nise will not solve dental problems, but only temporarily relieves pain.

There are reviews of patients who took the drug long time regarding rheumatological diseases. It should be noted that the drug Nise has less gastro- and nephrotoxicity compared to other “traditional” NSAIDs due to the predominant inhibition of COX-2. An important factor is that nimesulide has a chondroprotective effect. All this allows you to take the drug for a long time without harm to health. Thus, the duration of continuous use of the drug in adolescents with juvenile arthrosis was 1-8 months, and no serious adverse reactions were observed. All unwanted reactions were reversible and eliminated by reducing the dose.

Reviews of Nise gel, often used for osteochondrosis, are also positive. Patients note a pronounced analgesic (pain quickly decreased) and anti-inflammatory effect. No skin changes were detected at the site of application of the gel. Gel Nise was used as monotherapy for moderate pain syndrome. In cases of severe pain, injections were prescribed, for example, Nimulid, and as a complementary therapy- ointment externally. The gel is used sparingly and is quickly absorbed without leaving a mark on the skin. It quickly penetrates into the periarticular tissues (the effect occurs after 30 minutes), and the duration of action is 4 - 6 hours. Since when local application concentration in the blood is very low, then systemic adverse reactions appear much less frequently.

There is a convenient form of release for children - syrup, which is indicated for the treatment of symptoms of fever and inflammation that occur with infections of the upper respiratory tract. Russia has accumulated many years of successful experience in using dosage forms of nimesulide for children. Nise suspension is approved from 2 years of age and no serious adverse reactions were observed during its use. Different shapes Diclofenac is approved for use in children aged 6, 12, or 15 years. Meloxicam is used after 15 years, and some - after 18 years.

Nise price, where to buy

You can buy the drug with a prescription at any pharmacy.

How much do the tablets cost? Today, the price of Nise in tablets 100 mg No. 20 ranges from 198-225 rubles. The cost of the gel depends on the volume of the tube. Thus, the price of Nise gel 20 mg is 157-175 rubles, and ointment in a 50 mg tube can be purchased for 280-387 rubles.

• Online pharmacies in Russia Russia
• Online pharmacies in Ukraine Ukraine
• Online pharmacies in Kazakhstan Kazakhstan

WER.RU

Nisylat tablets 600 mg 20 pcs.

Nise gel 1% 20 g Dr. Reddy's Laboratories [Dr. Reddy's Laboratories]

Roxy Kids Organizer for toys and bath accessories Dino GreenRoxy Kids [Roxy Kids]

Belonging to the class of sulfonanilides. According to the classification, the drug belongs to the group of non-narcotic painkillers and anti-inflammatory drugs. The gel has a pronounced analgesic effect and is used for various types arthritis and other musculoskeletal disorders musculoskeletal system to eliminate pain.

Dosage form

The product is produced in the form of a gel intended for external use, sold in tubes of 20 and 50 grams.

Description and composition

The drug is produced in tubes of 20 and 50 grams. The product has a white or pale yellow color and a uniform consistency - the presence of foreign particles is unacceptable.

The drug contains the following substances:

• methyl salicylate;
• matanol;
• capsaicin.

The list of auxiliary components includes:

• distilled water;
• sodium benzoate;
• disodium salt of ethylenediaminetetraacetic acid;
• trometamol;
• hydroxytoluene;
• polyoxylcastor oil;
• monoethyl diethylene glycol ether;
• propylene glycol;
• diethyl phthalate;
• non-toxic gelling agent carbomer.

Pharmacological group

The gel belongs to the group of anti-inflammatory drugs non-steroidal type, latest generation. The main active component is, which has a local analgesic effect. The composition has a local antipyretic effect, removing heat from the affected areas.

Methanol has analgesic and antipruritic effects. Efficiency is due to the composition's ability to irritate nerve endings, receptors of the skin and mucous membranes. Provides the production and release of substances involved in the processes of pain regulation.

Methyl acylate ensures increased blood circulation in the affected areas. The component eliminates swelling and relieves inflammation. The product reduces the intensity painful sensations. Often, during use, allergic reactions occur that do not require stopping the use of the product.

Indications for use

The list of indications for use of the product is as follows:

• bursitis;
• synovitis;
• lumbodynia;
• arthritis;
• osteoarthritis;
• osteoarthrosis;
• tendenitis;
• nerve damage, various neuralgia;
• myalgia;
• defeats inner shells vaginas in women;
• Bekhterev's disease;
• rheumatism;
• damage to joints and tissues manifested against the background of metabolic processes;
• radiculitis;
• pain manifested in the spinal column.

for adults

The gel product can be used in patients belonging to these groups who do not have contraindications to the use of the composition.

for children

The use of the composition in pediatrics is prohibited. In the presence of acute indications the composition can be used for children over 7 years of age. The patient's well-being in this case should be constantly monitored. The occurrence of adverse reactions is a good reason for refusing to use the product.

Gel for external use is not recommended for use during pregnancy; the active component of the composition has the ability to be absorbed into the systemic bloodstream. Using the product can cause various developmental defects in a child. Use of the product during pregnancy is not recommended.

Contraindications

All medications have a certain list of contraindications for use, and the gel is no exception. The list of contraindications includes:

• hypersensitivity to the active or auxiliary components of the composition;
• ulcerative or erosive lesions Gastrointestinal tract;
• stomach bleeding;
• lesions of the epidermis at the site of application;
• infectious lesions skin;
• violation of the integrity of the skin at the site of use of the product;
• acute renal failure or its chronic course;
• pathologies of the hematopoietic organs;
• pregnancy period;
• childhood.

Increased caution is required when using the product in patients with the following lesions:

• hypertonic disease;
• heart rhythm disturbances;
• insulin-dependent diabetes;
• old age.

The use of the product in the presence of contraindications is unacceptable. In this case, the actions will cause significant harm.

Applications and dosages

Before using the product, rinse thoroughly clean water treated area. The area where the product is applied must be free of damage. A single dosage per day should not exceed 3 cm. Apply the product only to the area with severe pain. The drug should be absorbed on its own; you should not rub it into the skin. There is also no need to use bandages; it is important to provide air access.

for adults

The product is applied to previously prepared areas of the skin. The daily dose of use is 3-4 times a day. The maximum duration of therapy is 1-2 weeks.

for children

for pregnant women and during lactation

Use of the product during pregnancy and breastfeeding under strict ban. If there is an urgent need to use the composition during lactation, the issue of transferring the child to formula milk is decided.

Side effects

Adverse reactions with the use of the gel are extremely rare. If the patient has hypersensitivity It is possible to develop allergies to the components of the product:

• peeling of the skin;
• itching of the skin;
• change in skin color;
• burning sensation.

Reactions of this nature do not require discontinuation of the drug and disappear on their own.

Adverse reactions from the following list occur extremely rarely, in particular with prolonged and improper use:

• a feeling of tightness behind the sternum;
• burning sensation in the larynx;
• digestive disorders;
• headache and migraine;
• dizziness;
• nausea and;
• delayed diuresis;
• anemia.

If any of the above symptoms occur, you should seek emergency medical attention. medical care. In some cases, emergency refusal to use the product and its subsequent replacement is indicated. IN in rare cases With prolonged use of the gel, renal failure develops, the symptom of which is disruption of the processes of removing fluid from the body.

Interaction with other drugs

It has the ability to enhance the effect of agents that inhibit the blood clotting process. Reduces the effectiveness of antihypertensive compounds and diuretics. It is not recommended to use in combination with. may increase the concentration of lithium in the patient's blood. Enhances the activity of cyclosporine.

special instructions

Scroll special instructions as follows:

1. The drug can be applied to intact skin.
2. Avoid contact of the composition with mucous membranes.
3. The drug is used externally only. After use, you should wash your hands; you can use disposable gloves for application.

The composition does not affect psychomotor reactions and the ability to concentrate.

Overdose

Cases of overdose are not recorded in the official medical practice. Development risk unwanted effects increases due to non-compliance with recommended doses and rules of use. An overdose is manifested by a general deterioration in health: nausea, clouding of consciousness. Often manifests itself elevated temperature. A specific antidote has not been found; if you suspect an overdose, you should contact a specialist as an emergency. If consumed orally, gastric lavage is performed, emergency hospitalization is indicated, and hemodialysis may be used.

Storage conditions

The drug is sold to the public through a network of pharmacies for free sale; a prescription from a doctor is not required. The product should be stored in its original packaging for two years from the date of issue. The room temperature should not exceed 25 degrees. Children's access to the place where medicines are stored should be limited.

Anti-inflammatory, antipyretic drug. Produced in India. Produced in the form of tablets, gel, suspension for children. Tablets are especially in demand. They have a quick effect and eliminate pain of any location. Taken for toothache, menstrual pain, back pain, muscle pain, headache. Active substances quickly penetrate the blood, spread throughout the body, and are localized at the site of pain. International name drug Nimesulide. Has enough high cost. For a pack of 20 tablets you will have to pay an average of 200 rubles. 60 ml of suspension for children costs about 350 rubles. A tube of gel with a capacity of 30 g sells for 160 rubles. Buyers often replace Nise prescribed by doctors with less expensive medicines– analogues.

Cheap tablets analogs of Nise

Take off pain syndrome medium degree, you can remove the fever with regular paracetamol, Ibuprofen, which are classified as cheap analogues of Nise. The drugs are available without a prescription. Approved for use almost from childhood. They do not irritate the mucous membranes of the stomach and intestines and have a low percentage of side effects.

With a similar active substance, the Indian-made drug Nimid Forte. For 10 pieces of tablets you will have to pay only 55 rubles.

You can replace Nise with Diclofenac. The cost of one package of 20 pieces is only 13.50 rubles. domestic production and 34.50 rub. Serbian

Analogue in gel form

Instead of Nise, you can use Diclofenac gel. A tube with a capacity of 30 g costs about 60 rubles. Gel for external use made in India with the same capacity - Nimid, can be bought for 65.44 rubles.

Analogues of Nise in gel form are:

Analogues of Nise in ointment form

You can use Diclofenac ointment. A tube with a capacity of 30 g costs about 28.00 rubles. Butadion ointment works in a similar way. The cost of a tube is 86 rubles.

• Ketonal;
• Ketoprofen;
• Clodifene;
• Olfen.

The drug Nise is recommended to be used after consultation with a doctor. Self-administration may cause side effects. You should not take medicine if you have problems with the gastrointestinal tract, internal bleeding, with renal and liver failure. At the same time, the drug is suitable for symptomatic treatment. Quickly eliminate bronchospasm, toothache, headache, menstrual pain. Take one tablet three times a day. The daily dose should not exceed 400 mg. The gel may cause an allergic reaction. For redness, burning of the skin, other unpleasant symptoms, treatment should be stopped.

Nise for menstrual pain should be used when the pain syndrome is severe. In other cases, it is better to use analgin or ibuprofen. If Nise is prescribed by a doctor, the issue of replacement should be discussed with him.

Cheap and effective analogues gel (ointment) Nise in wide range are present on pharmacy shelves, but how to truly choose effective remedy? is a question that interests many people. When looking for a drug with a pronounced anti-inflammatory, analgesic effect for the treatment of diseases of the musculoskeletal system, you need to carefully study the instructions for use, pay attention to the composition, indications, contraindications, as well as dosages and frequency of use. Having the necessary information about the drug, making a choice is much easier.

Among the large list of medications for topical use, doctors often prescribe Nise ointment or gel for the treatment of joint diseases. The drug has quick action, V complex therapy allows the creature to improve the patient’s condition, the mobility of diseased joints, and reduce the risk of complications.

Gel (ointment) Nise - medicinal product for external use with a pronounced analgesic and anti-inflammatory effect, which is widely used in the treatment of diseases of the musculoskeletal system. Application of ointment in complex treatment will help reduce the symptoms of diseases such as arthritis, arthrosis, gonoarthrosis, osteochondrosis and other pathologies in which there is damage and inflammation of the joints and periarticular tissues. Active component The drug is nimesulide, which belongs to the non-steroidal anti-inflammatory drugs from the sulfonanilide class.

The mechanism of action of the drug is to suppress the enzyme - cyclooxygenase type 2, which is involved in the synthesis of inflammatory mediators - prostaglandins. The use of Nise ointment or gel, as well as some of its analogs, allows you to inhibit prostaglandins, thereby relieving pain and eliminating inflammation.

Nise is produced for external use in tubes of 20 or 50 grams. You can buy the drug at any pharmacy in the city without a doctor's prescription. The cost of the ointment (gel) is about 250 rubles per package.

Prices for analogues of Nise gel are quite different and directly depend on the manufacturer, the composition of the drug, the supplier and the pharmacy chain itself.

Indications

The drug Nise gel, as well as its structural similar products with the same therapeutic effect are widely used in the complex treatment of the following diseases:

1. Arthritis of joints of different localization and etiology;
2. Osteoarthritis;
3. Osteochondrosis of the cervical, thoracic or lumbar region;
4. Bursitis;
5. Ankylosing spondylitis;
6. Post-traumatic pain;
7. Muscle pain;
8. Various infectious diseases small and large joints;
9. Neuralgia;
10. Myalgia.

Use Nise gel, like many of its analogues, can be used for other inflammatory and degenerative diseases musculoskeletal system, but before using any product you need consult a doctor.

Disease therapy affecting joints and periarticular tissue should always be carried out comprehensively and only after consultation with the attending physician.

List of analogues

Nise ointment (gel), like any other drug, has several analogues, which are divided into structural drugs that have an identical composition or drugs with a different composition but the same therapeutic effect. The list of such drugs is quite extensive, but in practice the following drugs are most often used:

• Sulaydin gel – a product for external use from the group of non-steroidal anti-inflammatory drugs. The active component of the drug is nimesulide 10 mg, which allows Sulaydin gel to be classified as a structural analogue of Nise ointment. The drug has the same mechanism of action and is widely used to treat joint diseases. The cost of Sulaydin gel is about 560 rubles per 30 ml.
• Nimulid gel – a drug with a pronounced analgesic and anti-inflammatory effect based on nimesulide. Used in the treatment of joint diseases in which there is inflammatory process. The price of the drug ranges from 140 to 250 rubles per 30g package.
• Diclofenac ointment – a common drug from the group of non-steroidal anti-inflammatory drugs, which contains the active component – ​​diclofenac. The medicine has an analgesic and anti-inflammatory effect and can be used in combination with other drugs. The cost of the gel is about 25 rubles per package of 30 grams.
• Ketonal gel – a drug based on ketoprofen, which has analgesic, anti-edematous and anti-inflammatory properties. The drug has a wide range of uses and is also quite well tolerated. The cost of the gel is about 320 rubles per 50 grams.
• Voltaren gel – means local action, the use of which allows you to eliminate pain, swelling and inflammation in the joints. The active component of the gel is diclofenac diethylamine. It is produced by a Swiss pharmaceutical company, which explains its high cost, which is about 450 rubles.
• Fastum gel – a drug based on ketoprofen with a powerful analgesic and anti-inflammatory effect. Widely used in the treatment of diseases of the joints and spine. The price of the medicine is from 270 rubles per 30 grams.

It is important to understand that any analogue of Nise ointment (gel) has its own contraindications, adverse reactions and features of use, therefore, before using any medicine, you need to study the instructions and consult with your doctor.

Analogs of the drug Nise are presented, in accordance with medical terminology, called “synonyms” - drugs that are interchangeable in their effects on the body, containing one or more identical active ingredients. When selecting synonyms, consider not only their cost, but also the country of production and the reputation of the manufacturer.

Description of the drug

Nise- NSAIDs. Selective inhibitor of COX-2 - an enzyme involved in the synthesis of prostaglandins - mediators of edema, inflammation and pain. The drug has anti-inflammatory, analgesic and antipyretic effects.

Reversibly inhibits the formation of prostaglandin E 2, both at the site of inflammation and in upward paths nociceptive system, including the pathways for pain impulses in the spinal cord.

Reduces the concentration of short-lived prostaglandin H2, from which prostaglandin E2 is formed under the action of prostaglandin isomerase. A decrease in the concentration of prostaglandin E 2 leads to a decrease in the degree of activation of EP-type prostanoid receptors, which is expressed in analgesic and anti-inflammatory effects.

It has a slight effect on COX-1 and practically does not interfere with the formation of prostaglandin E 2 from arachidonic acid under physiological conditions, thereby reducing the number of side effects of the drug.

The drug suppresses platelet aggregation by inhibiting the synthesis of endoperoxides and thromboxane A2, and inhibits the synthesis of platelet aggregation factor. Suppresses the release of histamine and also reduces the degree of bronchospasm caused by exposure to histamine and acetaldehyde.

The drug also inhibits the release of tumor necrosis factor alpha, which causes the formation of cytokines.

It has been shown that nimesulide is able to suppress the synthesis of interleukin-6 and urokinase, thereby preventing the destruction cartilage tissue. Inhibits the synthesis of metalloproteases (elastase, collagenase), preventing the destruction of proteoglycans and collagen of cartilage tissue.

It has antioxidant properties and inhibits the formation of toxic oxygen breakdown products by reducing the activity of myeloperoxidase. Interacts with glucocorticoid receptors, activating them through phosphorylation, which also enhances the anti-inflammatory effect of the drug.

When applied topically, it causes a weakening or disappearance of pain at the site of application of the gel, incl. pain in the joints at rest and during movement, reduces morning stiffness and swelling of the joints. Helps increase range of motion.

List of analogues

Note! The list contains synonyms of Nise having similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, and well-known companies from of Eastern Europe: KRKA, Gedeon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Release form(by popularity)	price, rub.
Nise
1% 20g gel (D - r Reddy's Laboratories Ltd. (India)	198.30
Tab 100 mg N20 (D - r Reddy's Laboratories Ltd. (India)	221
1% 50g gel (D - r Reddy's Laboratories Ltd. (India)	326.30
Actasulide
Ameolin
Aponil
Tab 100 mg No. 20 (Medokemi Ltd (Cyprus)	133.10
Aulin
Kokstral
Mesulid
Naisulide
Nemulex
100 mg No. 4 gran.d / pr.susp.inward (K.O. Rompharm Company S.R.L. (Romania)	119
100 mg No. 10 granules for preparation. suspensions orally (K.O. Rompharm Company S.R.L. (Romania)	185.70
100 mg No. 1 gran.d / pr.susp.inward (K.O. Rompharm Company S.R.L. (Romania)	545.60
Nimegesik
Nimesan
100 mg No. 20 tab (Shreya Life Sciences Pvt. Ltd. (India)	172.40
Nimesil
Granules for suspension 100 mg pack 2 g N1 (Laboratory Guidotti S.p.A. (Italy)	28
Nimesulide
Tab 100 mg No. 20 (Ozone LLC (Russia)	31.20
Tab 100 mg N20 (Replekfarm JSC (Macedonia)	44.30
Nimesulide Canon
Granules for cooking. susp. for oral administration 100 mg, 30 pcs. (Kanonpharma, Russia)	343
Granules for cooking. susp. for oral administration 100 mg, 2 pcs. (Kanonpharma, Russia)	407
Nimesulide*
Nimesulide-LekT
Nimesulide-MBF
Nimesulide-C3
Nimesulid-Teva
100mg No. 20 TB	145.40
Nimesulide-Trivium
Nimesulide-Pharmaplant
Nimika
Tab dispersant 100 mg N20 (Ipka Laboratories Limited (India)	219.30
Nimulid
100 mg No. 10 lozenge tablet (PANACEA BIOTEC (India)	132.30
Suspension 50mg / 5ml 60ml (PANACEA BIOTEC (India)	149.70
Gel 1% 30g (PANACEA BIOTEC (India)	237.90
Tab lingual. 100 mg N20 (PANACEA BIOTEC (India)	249.30
Tab 100 mg N30 (PANACEA BIOTEC (India)	326.50
Novolid
Prolid
Sulaydin
Florida

Reviews

Below are the results of surveys of site visitors about the medicine Nise. They reflect the personal feelings of the respondents and cannot be used as an official recommendation for treatment with this drug. We strongly recommend that you contact a qualified medical specialist to select a personal course of treatment.

Visitor survey results

Nine visitors reported effectiveness

Your answer about side effects »

Ten visitors reported cost estimates

	Participants		%
Dear	8		80.0%
Not expensive	2		20.0%

Your answer about the cost estimate »

Thirteen visitors reported frequency of intake per day

How often should I take Nise?
Most respondents most often take this drug 2 times a day. The report shows how often other survey participants take this drug.

	Participants		%
2 times a day	7		53.8%
1 per day	4		30.8%
3 times a day	1		7.7%
4 times a day	1		7.7%

Your answer about the frequency of intake per day »

Nine visitors reported dosage

	Participants		%
51-100mg	5		55.6%
6-10mg	2		22.2%
101-200mg	1		11.1%
11-50mg	1		11.1%

Your answer about dosage »

Three visitors reported an expiration date

How long does it take to take Nise to feel an improvement in the patient’s condition?
Survey participants in most cases felt an improvement in their condition after 5 days. But this may not correspond to the period after which you will improve. Check with your doctor for how long you need to take this medicine. The table below shows the results of the survey on the initiation of effective action.

	Participants		%
5 days	1		33.3%
1 day	1		33.3%
> 3 months	1		33.3%

Your answer about the start date »

Six visitors reported appointment times

When is the best time to take Nise: on empty stomach, before, after or during meals?
Site users most often report that they take this medication after meals. However, your doctor may recommend a different time for you. The report shows when the remaining patients surveyed take their medication.

Your answer about the reception time »

87 visitors reported the patient's age

Your answer about the patient's age »

Visitor reviews

Official instructions for use

There are contraindications! Before use, read the instructions

Nise ®

(Nise)

Registration number:

P No. 12824/03 - 040411
Tradename drug: Nise ®
International generic name drug: Nise.

Dosage form:

pills
Compound
Each tablet contains:
Active substance: Nise 100 mg.
Excipients: calcium hydrogen phosphate 75 mg, cellulose
microcrystalline (type 114) 40 mg, corn starch 54 mg, sodium carboxymethyl starch 35 mg, magnesium stearate 3 mg, colloidal silicon dioxide 2 mg, talc 1 mg.
Description
White with a yellowish tint, round biconvex tablets with a smooth surface.

Pharmacotherapeutic group:

non-steroidal anti-inflammatory drug (NSAID).
CodeATX:M01AX17.

Pharmacological properties

Pharmacodynamics
Non-steroidal anti-inflammatory drug (NSAID) from the sulfonanilide class. It is a selective competitive inhibitor of cyclooxygenase-2 (COX-2), inhibits the synthesis of prostaglandins at the site of inflammation. The inhibitory effect on COX-1 is less pronounced (less likely to cause side effects associated with inhibition of prostaglandin synthesis in healthy tissues). It has anti-inflammatory, analgesic and pronounced antipyretic effects.
Pharmacokinetics
Absorption when taken orally is high (food intake reduces the rate of absorption without affecting its degree). Time to reach maximum concentration (T max) - 1.5-2.5 hours. Communication with plasma proteins - 95%, with erythrocytes - 2%, with lipoproteins - 1%, with acidic alpha glycoproteins - 1%. Changing the dose does not affect the degree of binding. The maximum concentration value (Cmax) is 3.5-6.5 mg/l. Volume of distribution - 0.19-0.35 l/kg. Penetrates into the tissues of the female genital organs, where after a single dose its concentration is about 40% of the concentration in plasma. Penetrates well into the acidic environment of the inflammation site (40%) and synovial fluid (43%). Easily penetrates histohematic barriers.
Metabolized in the liver by tissue monooxygenases. The main metabolite, 4-hydroxynimesulide (25%), has similar pharmacological activity, but due to a decrease in molecular size, it is able to quickly diffuse through the hydrophobic COX-2 channel to the active binding site of the methyl group. 4-hydroxynimesulide is a water-soluble compound, the elimination of which does not require glutathione and phase II metabolic conjugation reactions (sulfation, glucuronidation, etc.).
The half-life (T1/2) of nimesulide is 1.56-4.95 hours, 4-hydroxynimesulide is 2.89-4.78 hours. 4-hydroxynimesulide is excreted by the kidneys (65%) and bile (35%), is subject to enterohepatic recycling.
In patients with renal failure (creatinine clearance 1.8-4.8 l/h or 30-80 ml/min), as well as in children and the elderly, the pharmacokinetic profile of nimesulide does not change significantly.

Indications for use

- rheumatoid arthritis;
- articular syndrome during exacerbation of gout;
- psoriatic arthritis;
- ankylosing spondylitis;
- osteochondrosis with radicular syndrome;
- osteoarthritis;
- myalgia of rheumatic and non-rheumatic origin;
- inflammation of ligaments, tendons, bursitis, including post-traumatic inflammation
soft tissues;
- pain syndrome of various origins (including in the postoperative period, with
injuries, algodismenorrhea, toothache, headache, arthralgia, lumbar ischialgia).
The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

Contraindications

Hypersensitivity to active substance or auxiliary components; complete or incomplete combination bronchial asthma, recurrent polyposis of the nose or paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including a history); erosive and ulcerative changes in the gastric mucosa and duodenum(DPK), active gastrointestinal bleeding, cerebrovascular or other bleeding; inflammatory diseases intestines (Crohn's disease, nonspecific ulcerative colitis) in the acute phase; hemophilia and other bleeding disorders; decompensated heart failure; liver failure or any active liver disease; anamnestic data on the development of hepatotoxic reactions when using nimesulide preparations; concomitant use of potentially hepatotoxic substances; alcoholism, drug addiction; severe renal failure (creatinine clearance less than 30 ml/min), progressive kidney disease, confirmed hyperkalemia; period after coronary artery bypass surgery; pregnancy, lactation period; children under 12 years of age (for this dosage form, see section “Special instructions”).
Carefully
Ischemic disease heart disease, cerebrovascular disease, congestive heart failure, dyslipidemia/hyperlipidemia, diabetes, peripheral arterial disease, smoking, creatinine clearance less than 60 ml/min. Anamnestic data on the development of ulcerative lesions of the gastrointestinal tract, the presence of infection Helicobacter pylori, old age, long-term use of NSAIDs, frequent alcohol consumption, severe somatic diseases, concomitant therapy anticoagulants (for example, warfarin), antiplatelet agents (for example, acetylsalicylic acid, clopidogrel), oral glucocorticosteroids (for example, prednisolone), selective inhibitors serotonin reuptake (for example, citalopram, fluoxetine, paroxetine, sertraline).

Directions for use and doses

The minimum effective dose should be used for the shortest possible short course. The tablets are taken with enough water, preferably after meals. Adults and children over 12 years of age, take 1 tablet orally 2 times a day. If you have illnesses gastrointestinal tract It is advisable to take the drug at the end of a meal or after a meal. The maximum daily dose for adults is 200 mg. Patients with chronic renal failure require reduction daily dose up to 100 mg.

Side effects

The frequency of side effects is classified depending on the frequency of occurrence of the case: often - (1-10%), sometimes (0.1-1%), rarely (0.01-0.1%), very rarely (less than 0.01% ), including individual messages.
Allergic reactions: rarely - hypersensitivity reactions; very rarely - anaphylactoid reactions.
From the central nervous system: infrequently - dizziness; rarely - a feeling of fear, nervousness, nightmares; very rarely - headache, drowsiness, encephalopathy (Reis syndrome).
From the skin: uncommon - itching, rash, increased sweating; rarely: erythema, dermatitis; very rare: urticaria, angioedema, swelling of the face, multiform exudative erythema, including Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).
From the urinary system: infrequently - swelling; rarely - dysuria, hematuria, urinary retention, hyperkalemia; very rarely - renal failure, oliguria, interstitial nephritis.
From the gastrointestinal tract: often - diarrhea, nausea, vomiting; infrequently - constipation, flatulence, gastritis; very rarely - abdominal pain, stomatitis, tarry stools, gastrointestinal bleeding, ulcer and/or perforation of the stomach or duodenum. From the liver and biliary system: often - increased liver transaminases; very rarely - hepatitis, fulminant hepatitis, jaundice, cholestasis. From the hematopoietic organs: rarely - anemia, eosinophilia; very rarely - thrombocytopenia, pancytopenia, purpura, prolonged bleeding time From the respiratory system: infrequently - shortness of breath; very rarely - exacerbation of bronchial asthma, bronchospasm. From the senses: rarely - blurred vision.
From the cardiovascular system: infrequently - arterial hypertension; rarely - tachycardia, hemorrhages, hot flashes. Other: rarely - general weakness; very rarely - hypothermia.

Overdose

Symptoms: apathy, drowsiness, nausea, vomiting. Gastrointestinal bleeding, increased blood pressure, acute renal failure, and respiratory depression may occur.
Treatment: Symptomatic treatment of the patient and supportive care are required. There is no specific antidote. If an overdose occurs within the last 4 hours, it is necessary to induce vomiting and ensure that activated carbon(60-100 g per adult), osmotic laxatives. Forced diuresis and hemodialysis are ineffective due to the high binding of the drug to proteins.

Interaction with other drugs

The effect of medications that reduce blood clotting is enhanced when used simultaneously with nimesulide.
Nise may reduce the effect of furosemide. Nise can increase the possibility of attack side effects at simultaneous administration methotrexate.
Plasma lithium levels increase when lithium and nimesulide are taken simultaneously.
Nise may increase the effect of cyclosporine on the kidneys.
Use with glucocorticosteroids and serotonin reuptake inhibitors increases the risk of gastrointestinal bleeding.

special instructions

Since Nise ® is partially excreted by the kidneys, its dose for patients with impaired renal function should be reduced, depending on creatinine clearance. Given reports of visual disturbances in patients taking other NSAIDs, treatment should be stopped immediately if any visual disturbance occurs and the patient should be examined by an ophthalmologist.
The drug may cause fluid retention in tissues, so patients with high blood pressure and with cardiac impairment, Nise ® should be used with extreme caution.
Patients should undergo regular medical monitoring if they, along with nimesulide, take medications that are characterized by an effect on the gastrointestinal tract.
If signs of liver damage appear (itching, yellowing of the skin, nausea, vomiting, abdominal pain, dark urine, increased levels of liver transaminases), you should stop taking the drug and consult your doctor. The drug should not be used simultaneously with other NSAIDs.
The drug can change the properties of platelets, but does not replace the preventive effect of acetylsalicylic acid in cardiovascular diseases. The use of the drug may adversely affect female fertility and is not recommended for women planning pregnancy.
After 2 weeks of using the drug, monitoring is necessary biochemical parameters liver functions.
This dosage form is contraindicated for children under 12 years of age, but if it is necessary to use nimesulide in children over 7 years of age, 50 mg dispersible tablets and suspension can be used in strict accordance with the instructions for medical use attached to them.
Since the drug may cause drowsiness, dizziness, and blurred vision, caution must be exercised when driving or engaging in other potentially dangerous activities. dangerous species activities requiring increased concentration attention and speed of psychomotor reactions.

Release form

Tablets 100 mg. 1, 2 or 10 PVC/aluminum blisters of 10 tablets, along with instructions for use, are packed in a cardboard box.

Storage conditions

List B.
In a dry place, protected from light, at a temperature not exceeding 25°C.
Keep out of the reach of children!

Best before date

3 years.
Do not use after the expiration date stated on the packaging.

Vacation conditions

On prescription.

Manufacturer

Dr. Reddy's Laboratories Ltd., 7-1-27, Ameerpet, Hyderabad - 500016, Andhra Pradesh, India
Address of production place
Dr. Reddy's Laboratories Ltd.
1. Plot No. 42, 45 and 46, Bachupally Village, Qutbullapur Mandal, Ranga Reddy District, Andhra Pradesh, India
2. Village Khol, Nalagarh Road, Baddi Consumer claims should be sent to the following address: Representative office of the company "Dr. Reddy" with Laboratories Ltd.: 115035, Moscow, Ovchinnikovskaya embankment, 20, building 1, Solan district, Himachal Pradesh , India

The information on the page was verified by physician-therapist E.I. Vasilyeva.