How to drink femoston correctly and its possible side effects. How to drink femoston correctly and its possible side effects What are hormones

Femoston is an antimenopausal drug, combination drug for replacement hormone therapy in the body of women during menopause. Thanks to its components - estradiol and dydrogesterone - the drug allows you to survive the period of menopausal adjustment without significant lifestyle changes. Active active ingredients drugs - estradiol and dydrogesterone; the first compensates for the lack of estrogen in the female body during menopause, and the second ensures the onset of the secretion phase in the endometrium. The use of the drug femoston alleviates menopausal symptoms: nervousness, frequent change moods, excessive sweating, hot flashes, rapid heartbeat, headache, vaginal dryness, etc.

Indications:

Femoston is used for hormone replacement therapy for menopausal disorders resulting from natural menopause or as a result of surgery. Also used for the prevention of osteoporosis in women 40-45 years old.

Reception regimen:

Femoston is taken one tablet per day, preferably at the same time, regardless of meals. The tablets corresponding to each day are selected from the calendar package. The duration of taking the drug depends on the results of treatment and is determined by the doctor.

Release forms:

Femoston is produced in the form of round biconvex tablets, coated in different colors (white, grey, pink and yellow) depending on the composition of the active ingredients. For the convenience of taking the drug, the packaging is calendar (according to the days of administration), there are 28 pieces in a blister. There can be 1, 3 or 10 blisters in a cardboard pack.

Contraindications:

Femoston is contraindicated in pregnant and lactating women, women who are hypersensitive to the components of the drug, as well as those with estrogenic malignant neoplasms, breast cancer or suspicion of it, vaginal bleeding, venous thromboembolism, liver diseases.

Compound:

Femoston contains the active ingredients estradiol and dydrogesterone, excipients: lactose, hypromellose, corn starch, silicon dioxide, magnesium stearate. One tablet may contain 1 mg estradiol + 5 mg dydrogesterone or 1 mg estradiol + 10 mg dydrogesterone or 2 mg estradiol + 10 mg dydrogesterone, as noted different colors tablet shells for ease of administration by day of the cycle.

Taking hormonal medications lasts quite a long time. Long-term treatment forces a person to change his habits and monitor his health more carefully.

So that therapy can give positive result, you should discuss with your doctor in advance all possible nuances of nutrition, whether you can drink alcohol during this period or not.

It is impossible to predict how alcohol will behave along with taking Femoston tablets, because alcoholic beverages are the first thing that the doctor strongly recommends limiting.

Hormones are responsible for the vital functions of the human body. Their production occurs on the principle of replacement: if somewhere their level decreases, then a specific gland internal secretion begins active production. Where there are not enough hormones, the organ’s performance deteriorates, and where there is an excess, hyperactivity occurs. Neither one nor the other brings any benefit to a person. There are three types of hormone therapy available:

• blocking – inhibits the active work of the glands;
• stimulating – enhances endocrine glands with decreased activity;
• replacement – ​​used for complete absence certain type hormones.

Prescriptions of the drug Femoston

The drug Femoston is a hormone replacement therapy. Its composition is synthetic, active substances estradiol and dydrogesterone - analogues of the female sex hormones estradiol and progesterone.

Progesterone affects the growth, development of the fetus, and pregnancy. Estradiol is responsible for the psycho-emotional and vegetative background of a woman during menopause.

The doctor prescribes Femoston for women who have entered the stage of age-related changes and associated psycho-emotional disorders: rapid heartbeat, hot flashes, sleep disturbances, for the prevention of osteoporosis, which is a very common manifestation of menopausal changes

The drug is also prescribed to women who, for a number of reasons, have failed to become pregnant.

Before prescribing to a patient medicine the doctor will definitely collect full complex medical tests, will hold gynecological examination for hidden contraindications and identified diseases.

During direct administration of Femoston, it is recommended to conduct periodic examinations and pay attention to clinical changes in organism.

Forms of release of the drug

There are three types of medicine supplied to pharmacies:

• Femoston 1/10;
• Femoston 1/5 conti;

Any form of the medication is available in tablet form, intended for oral administration. The difference in labeling is due to the nominal dosage of active substances, which allows each woman to choose best option taking the drug.

The package contains 28 colored pills different colors: orange and pink for the 1/5 variety, white and gray are packaged in 1/10, for the 2/10 variety, the colors will be light yellow, pink.

The different color palette is not accidental - each color has a specific hormone assigned to it:

• white, pink contain estradiol;
• orange, gray and light yellow contain the hormone progesterone (dydrogesterone).

Accordingly, tablets are taken strictly according to color differentiation.

Features of taking Femoston tablets

Hormone replacement therapy with Femoston does not affect the management vehicle and, according to patients, it is well tolerated by the body.

However, you should use the drug with caution as it has several side effects. None of the forms of the medicine can be used during pregnancy or breastfeeding.

The medicine is prescribed with caution to patients suffering from renal failure, heart failure, and chronic liver diseases (Femoston 2/10).

• breast cancer;
• any forms of estrogen-dependent formations;
• internal bleeding;
• presence of thrombophlebitis;
• allergic intolerance to the components of the drug;
• threat of cerebrovascular accident.

The drug can be used in combination with other medications. However, it should be taken into account that medications containing St. John's wort will enhance the chemical and biological process of estrogen and progesterone. Together with antiviral anti-HIV drugs, the inducer reaction will increase, and simultaneous use with phenytoin and rifabutin, on the contrary, will significantly weaken the work of replacement therapy.

Combined use of Femoston with alcohol

Reception hormonal pills forces the endocrine system to work in a slightly different mode. The body can respond adverse reaction: migraine, nausea, cycle disorders. Excessive nervousness, exacerbation cholelithiasis, convulsions, swelling, liver dysfunction, Bladder. Especially Hard case will lead to stroke, Quincke's edema, hemolytic anemia.

The combination of Femoston and alcohol increases adverse reactions.

If you drink alcohol and take hormones at the same time, you can develop a number of serious complications. When absorbed into the blood, alcohol stimulates the production of prolactin. The person becomes overly excited, aggressive, signs appear depressive state, panic fear.

The compatibility of Femoston with ethyl alcohol will negate the therapeutic effect of the medication and increase the risk of developing osteoporosis. Menopausal complications, which the drug normalizes, will get out of control, increasing their effect. Additionally, problems with the thyroid gland will appear, weight will increase, and hirsutism will develop (hair growth will increase).

The most harmless of the side effects is a decrease in medicinal properties drug.

Rules for drinking alcohol

Nobody encourages you to give up alcoholic beverages without a categorical doctor’s prescription. You should take into account all the nuances and follow the rules of admission:

1. the maximum permissible dose of ethanol is 40 grams per week (100 grams of vodka, 400 grams of wine, 400 grams of beer);
2. break between pills and alcohol – 4.5 hours;
3. excess permissible norm more than 1.5 times, a justified reason to skip taking pills for 2 days.

Taking hormonal medications lasts quite a long time. Long-term treatment forces a person to change his habits and monitor his health more carefully.

In order for the therapy to give a positive result, you should discuss in advance with your doctor all possible nuances of nutrition, whether you can drink alcohol during this period or not.

It is impossible to predict how alcohol will behave along with taking Femoston tablets, because alcoholic beverages are the first thing that the doctor strongly recommends limiting.

Hormones are responsible for the vital functions of the human body. Their production occurs on the principle of replacement: if somewhere their level decreases, then a specific endocrine gland begins active production. Where there are not enough hormones, the organ’s performance deteriorates, and where there is an excess, hyperactivity occurs. Neither one nor the other brings any benefit to a person. There are three types of hormone therapy available:

• blocking – inhibits the active work of the glands;
• stimulating – strengthens the endocrine glands with decreased activity;
• replacement – ​​used in the complete absence of a certain type of hormone.

Prescriptions of the drug Femoston

The drug Femoston is a hormone replacement therapy. Its composition is synthetic, active substances estradiol and dydrogesterone - analogues of the female sex hormones estradiol and progesterone.

Progesterone affects the growth, development of the fetus, and pregnancy. Estradiol is responsible for the psycho-emotional and vegetative background of a woman during menopause.

The doctor prescribes Femoston for women who have entered the stage of age-related changes and associated psycho-emotional disorders: rapid heartbeat, hot flashes, sleep disturbances, for the prevention of osteoporosis, which is a very common manifestation of menopausal changes

The drug is also prescribed to women who, for a number of reasons, have failed to become pregnant.

Before prescribing a medicine to a patient, the doctor will necessarily collect a full range of medical tests and conduct a gynecological examination for hidden contraindications and identified diseases.

During direct administration of Femoston, it is recommended to conduct periodic examinations and pay attention to clinical changes in the body.

Forms of release of the drug

There are three types of medicine supplied to pharmacies:

• Femoston 1/10;
• Femoston 1/5 conti;

Any form of the medication is available in tablet form, intended for oral administration. The difference in labeling is due to the nominal dosage of active substances, which allows each woman to choose the optimal option for taking the drug.

The package contains 28 pills colored in different colors: orange and pink for the 1/5 form, white and gray are packaged in 1/10, for the 2/10 variety, the colors will be light yellow, pink.

The different color palette is not accidental - each color has a specific hormone assigned to it:

• white, pink contain estradiol;
• orange, gray and light yellow contain the hormone progesterone (dydrogesterone).

Accordingly, tablets are taken strictly according to color differentiation.

Features of taking Femoston tablets

Hormone replacement therapy with Femoston does not affect driving and, according to patients, is well tolerated by the body.

However, you should use the drug with caution as it has several side effects. None of the forms of the medicine can be used during pregnancy or breastfeeding.

The medicine is prescribed with caution to patients suffering from renal failure, heart failure, and chronic liver diseases (Femoston 2/10).

• breast cancer;
• any forms of estrogen-dependent formations;
• internal bleeding;
• presence of thrombophlebitis;
• allergic intolerance to the components of the drug;
• threat of cerebrovascular accident.

The drug can be used in combination with other medications. However, it should be taken into account that medications containing St. John's wort will enhance the chemical and biological process of estrogen and progesterone. Together with antiviral anti-HIV drugs, the inducer reaction will increase, and simultaneous use with phenytoin and rifabutin, on the contrary, will significantly weaken the work of replacement therapy.

Combined use of Femoston with alcohol

Taking hormonal pills forces the endocrine system to work in a slightly different mode. The body may respond with an adverse reaction: migraine, nausea, cycle disruption. Excessive nervousness, exacerbation of cholelithiasis, convulsions, swelling, disruption of the liver and bladder. A particularly severe case will lead to stroke, angioedema, and hemolytic anemia.

The combination of Femoston and alcohol increases adverse reactions.

If you drink alcohol and take hormones at the same time, you can develop a number of serious complications. When absorbed into the blood, alcohol stimulates the production of prolactin. The person becomes overly excited, aggressive, signs of depression and panic appear.

The compatibility of Femoston with ethyl alcohol will negate the therapeutic effect of the medication and increase the risk of developing osteoporosis. Menopausal complications, which the drug normalizes, will get out of control, increasing their effect. Additionally, problems with the thyroid gland will appear, weight will increase, and hirsutism will develop (hair growth will increase).

The most harmless of the side effects is a decrease in the medicinal properties of the drug.

Rules for drinking alcohol

Nobody encourages you to give up alcoholic beverages without a categorical doctor’s prescription. You should take into account all the nuances and follow the rules of admission:

1. the maximum permissible dose of ethanol is 40 grams per week (100 grams of vodka, 400 grams of wine, 400 grams of beer);
2. break between pills and alcohol – 4.5 hours;
3. exceeding the permissible norm by more than 1.5 times is a justified reason to skip taking pills for 2 days.

Thank you

The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

Femoston is a hormone replacement therapy drug that is used to treat various natural changes in a woman’s body caused by the onset of menopause or removal of the ovaries (surgical castration). Femoston ensures the entry into the woman’s body of sex hormones, which, as a result of menopause or surgical castration, are produced by the ovaries and adipose tissue in insufficient quantities and, thereby, maintain normal condition and functioning various organs and systems. Femoston eliminates various disorders caused by deficiency of sex hormones, such as vegetative, psycho-emotional and sexual disorders, and also prevents ischemic heart disease and osteoporosis.

Types, names, release forms and composition of Femoston

Currently, three varieties of the drug Femoston are produced - these are Femoston 1/10, Femoston 2/10 and Femoston 1/5 (Conti). All three varieties are available in a single dosage form – pills for oral administration, and differ from each other only in dosage active ingredients. Femoston 1/5 tablets are correctly called “Femoston Conti 1/5”, but in everyday speech they are often referred to as “Femoston 1 5” or “Femoston Conti”. Tablets Femoston 1/10 and Femoston 2/10 are often written and called “Femoston 1 10” and “Femoston 2 10”. Femoston 1, Femoston 2 and Femoston 5 tablets do not exist. The types of Femoston tablets differ from each other only in the dosage of the active substance in the tablets.

All varieties of Femoston include estradiol (estrogen hormone) and dydrogesterone(progesterone hormone) in various dosages.

Femoston 1/5 is available in packs of 28 tablets, each of which contains 1 mg of estradiol and 5 mg of dydrogesterone. The tablets are orange-pink in color, have a round, biconvex shape and are engraved with “379” on one side and “S” on the other.

Femoston 1/10 Available in packs of 28 tablets. Each package contains 14 tablets of two types - white and gray. White tablets contain 1 mg of estradiol, and gray tablets contain 1 mg of estradiol + 10 mg of dydrogesterone. Both the white and gray tablets are round, biconvex in shape and have "379" engraved on one side.

Femoston 2/10 Available in packs of 28 tablets, of which there are two varieties - pink and light yellow. There are the same quantity of both types of tablets, that is, one pack contains 14 pieces, both pink and light yellow. Each pink tablet contains 2 mg of estradiol, and each light yellow tablet contains 2 mg of estradiol + 10 mg of dydrogesterone. Both types of tablets are the same size, round, biconvex shape and have "379" engraved on one side.

As auxiliary components, all types of tablets of the three varieties of Femoston (pink-orange, white, gray, pink, light yellow) contain the same substances, such as:

• Hypromellose;
• Magnesium stearate;
• Colloidal silicon dioxide;
• Lactose monohydrate;
• Talc;
• Titanium dioxide;
• Polyethylene glycol 400;
• Iron oxides black, red and yellow (to give color to tablets).

Therapeutic effect

All varieties of Femoston have the same therapeutic effect, and different dosages active hormones allow you to choose for every woman optimal drug, best suited for her.

Femoston is a combined, modern, low-dose hormonal drug, therapeutic effects which is caused by the constituents estradiol and dydrogesterone.

Estradiol, which is part of Femoston, is identical to the natural one normally produced by a woman’s ovaries. That is why it replenishes the deficiency of estrogen in the body when it is insufficiently produced during menopause or almost completely absent during castration syndrome. Estrogens in women in menopause or after removal of the ovaries ensure smoothness, elasticity and slow aging of the skin, slow down hair loss, and cause hair production. vaginal lubrication, preventing dryness and discomfort during sexual intercourse, and also prevent atherosclerosis and osteoporosis. In addition, estradiol eliminates specific manifestations of menopause or castration syndrome, such as hot flashes, sweating, sleep disturbances, excitability, dizziness, headaches, atrophy of the skin and mucous membranes, etc.

Dydrogesterone is a progesterone hormone that ensures endometrial growth in the second half menstrual cycle among women. When taken as part of Femoston, dydrogesterone reduces the risk of developing endometrial hyperplasia or cancer, which increases with the use of estrogens. This progesterone hormone does not have any other effects, and is included in Femoston specifically to reduce the risk of endometrial hyperplasia and cancer, which increases due to estradiol intake.

Femoston - indications for use

Indications for use for all three varieties of Femoston (1/10, 2/10 and 1/5) are the same:
1. Hormone replacement therapy for specific menopausal or castration syndrome in women, manifested by hot flashes, sweating, palpitations, sleep disturbances, excitability, nervousness, vaginal dryness and other symptoms of estrogen deficiency. Femoston 1/10 and 2/10 can be started to be used six months after the last menstruation, and Femoston 1/5 - only a year later;
2. Prevention of osteoporosis and increased bone fragility in women during menopause with intolerance to other drugs intended to maintain normal bone mineralization, prevent calcium deficiency and treat this pathology.

Instructions for use

Femoston 1/5 – instructions (how to take)

Femoston 1/5 should be taken one tablet every day, preferably at the same time, regardless of meals. After finishing the tablets from one pack, start the next one immediately, without taking any breaks.

If on some day a woman forgot to take another Femoston 1/5 tablet, but less than 12 hours have passed from the scheduled time, then she should take it as quickly as possible. If more than 12 hours have passed since the pill was supposed to be taken, then you need to skip it and next day Take the tablets as usual until the end of the pack. You should not take two tablets at once to compensate for a missed dose. If a woman forgot to take a pill, then while taking the current pack she has an increased risk of bleeding and spotting from the genital tract.

The duration of use of the drug is determined individually, based on the speed of normalization of the condition and the disappearance of menopausal symptoms. Usually the drug is taken for at least 3 to 6 months without interruption. In principle, Femoston 1/5 is suitable for long-term continuous use, that is, tablets can be taken for several years in a row without taking any breaks.

If Femoston 1/5 is ineffective for relieving the symptoms of menopause, then you can switch to Femoston 1/10 or Femoston 2/10, which contain a higher dosage of hormones. Depending on how you feel and the effectiveness of treatment, the dosage of Femoston can be changed again in the future.

If a woman is already taking any estrogen-progestagen drug (for example, Femoston 1/10, Femoston 2/10, Angeliq, Cliogest, Climodien, Indivina, etc.) and wants to replace it with Femoston 1/5, then she should first finish her drink Completely started packaging of the medicine. Then, without taking any break, the next day after taking last pill from the package of estrogen-progestagen drug, you should start taking Femoston 1/5 tablets.

If a woman is taking an estrogen-progestin drug (for example, Trisequence, Divisek, etc.) and wants to switch to Femoston 1/5, then this can be done any day. That is, it is not necessary to finish the started pack of estrogen-progestogen tablets, it is enough just to start taking Femoston 1/5 the next day.

Femoston 1/10 and Femoston 2/10 – instructions (how to take)

A pack of Femoston 1/10 contains 14 white and 14 gray tablets, and a pack of Femoston 2/10 contains 14 pink and 14 light yellow tablets, which are taken regardless of food. In each new pack of Femoston 1/10, first take all the white tablets, one piece per day, preferably at the same time. Then take all the gray tablets, 1 piece per day, also preferably at the same time. Do the same with Femoston 2/10, first taking all the pink tablets, one per day, and then the light yellow ones, also one per day.

After finishing one pack of Femoston 1/10 or Femoston 2/10, and opening a new one, again take all white tablets from 1/10 or pink tablets from 2/10, and then gray tablets from 1/10 or light yellow tablets from 2/10. 10, one piece per day. There are no breaks between packs, that is, after finishing one, start taking pills from a new one the next day.

Women who have not stopped menstruating should start taking Femoston 1/10 or Femoston 2/10 on the first day of menstruation. If the menstrual cycle is irregular, then before starting to take Femoston 1/10 or 2/10, you should take progestagen drugs (for example, Veraplex, Gestanin, Gormofort, Duphaston, Levonova, etc.) for two weeks, which will provide withdrawal bleeding in order to remove the uterine cavity of all remnants of the endometrium. If a woman’s menstruation stopped more than six months ago, then she can start taking Femoston 1/10 and 2/10 any day.

If a woman forgot to take a pill and less than 12 hours have passed since her usual dose, then she should take the missed pill. If more than 12 hours have passed since the usual dose, then the missed tablet is removed from the pack and thrown away, and the next day the next tablet is taken according to the schedule. You should not take two tablets at the same time in order to eliminate the omission. While taking a pack with a missed pill, a woman has an increased risk of bleeding from the genital tract.

The duration of use of Femoston 1/10 and Femoston 2/10 is determined individually, depending on the speed of normalization of the condition and relief climacteric syndrome. The drugs are suitable for long-term use and can be used for several years without interruption. If the treatment is not effective enough, you can replace the drug with another one or choose Femoston with a lower or higher dosage of hormones. Usually, hormone replacement therapy is started with Femoston 1/10, and then, depending on the reaction of the woman’s body, she is left on this type of drug or transferred to Femoston 1/5 or Femoston 2/10.

If a woman wants to switch to taking another drug with 2 or 3 types of tablets, then she should first finish the started pack of Femoston 1/10 Femoston 2/10. Then, without any break, the next day after taking the last tablet from the pack of Femoston 1/10 or Femoston 2/10 you need to start taking another drug.

If a woman wants to switch to taking Femoston 1/10 or Femoston 2/10 from any other drug containing only one type of tablet, then this can be done at any time. That is, you don’t need to finish a pack of another drug, it’s enough just any day instead old tablet drink the first pack of Femoston 1/10 or Femoston 2/10.

special instructions

All three varieties of Femoston are contraindicated for use during pregnancy and breastfeeding. If pregnancy occurs accidentally while taking Femoston, you should immediately stop taking the drug. The issue of continuing pregnancy should be decided individually with a gynecologist.

Since estrogens promote fluid retention in the body and the formation of edema, all three types of Femoston should be used with caution in women suffering from kidney disease, renal or heart failure. During the entire period of use of any type of Femoston, kidney and heart function should be monitored and the woman’s condition should be monitored.

Femoston 2/10 should not be used by women suffering from acute or chronic liver diseases at any stage. And Femoston 1/10 and Femoston 1/5 can be used for liver diseases, but only after liver test parameters (AST, ALT and alkaline phosphatase activity) are normalized.

When using Femoston, a risk assessment should be carried out at least once a year and useful action, as well as correlate them with each other and, on the basis of this, make a decision on continuing or stopping hormone replacement therapy. Taking any type of Femoston continues as long as the benefits outweigh the risks.

Before starting to use any type of Femoston, it is necessary to carefully find out all existing and past diseases, as well as conduct an examination of the condition of the genital organs and mammary glands. If there are any benign neoplasms in the uterus, ovaries or mammary glands, then Femoston cannot be taken. If any nodes or lumps form in the chest while taking medications, you should immediately consult a doctor.

During the entire period of taking Femoston, women suffering in the present or having suffered in the past the following diseases, must visit a doctor at least once every three months:

• Endometriosis;
• High risk of thrombosis or thromboembolism;
• Presence of breast cancer in blood relatives (mother, sister, grandmother, etc.);
• Hypertonic disease;
• Hepatocellular adenoma;
• Cholelithiasis;
• Severe obesity (BMI over 30);
• Migraine;
• Severe headache;
• Systemic lupus erythematosus;
• Bronchial asthma;
• Porphyria;
• Epilepsy;

In women who have suffered from the listed diseases in the past or present, their symptoms may intensify while taking Femoston. If a woman has the listed diseases, the risk of developing complications of hormone replacement therapy increases significantly, such as breast cancer, thromboembolism, ischemic disease heart disease, heart attack, stroke, etc., and that is why this category of women needs to constantly monitor their condition by visiting a doctor at least once a quarter.

You should be aware that taking Femoston or any hormone replacement therapy drug containing estrogen slightly increases the risk of developing endometrial and breast cancer. Therefore, women who have not had their uterus and mammary glands removed should be careful and wary of possible cancer endometrium during the entire period of taking Femoston. The risk of developing cancer increases the longer you take Femoston. In addition, while taking Femoston in women, the risk of coronary artery disease and stroke increases. However, the risk of developing stroke and ischemic heart disease is more influenced by the woman’s age and her existing chronic diseases, but it does not depend at all on the duration of use of Femoston.

The risk of venous thromboembolism increases most significantly during therapy with any type of Femoston in women. Moreover, the risk of thromboembolism is highest during the first year of treatment, and in subsequent years, on the contrary, it decreases. Therefore, women who have increased risk venous thromboembolism, can take Femoston only under the supervision of a doctor and under close supervision. If any of the blood relatives has a thrombolytic defect (for example, deficiency of antithrombin, protein C, protein S, etc.), then the woman should not take Femoston.

Since any extensive surgery is accompanied by a risk of thromboembolism, then 4–6 weeks before the procedure it is necessary to stop taking Femoston. It will be possible to resume taking Femoston only after motor activity is completely restored after the operation.

During the entire period of Femoston therapy, the concentration of triglycerides, thyroid-binding globulin, corticoid-binding globulin and sex hormone-binding globulin, as well as alpha-1-antitrypsin and ceruloplasmin in the blood may increase. However, this does not lead to an increase in the concentration of circulating active hormones.

Femoston does not improve mental abilities and is not a contraceptive drug.

At the beginning of treatment with any type of Femoston, a woman may develop breakthrough bleeding or spotting. If bleeding or spotting occurs, you should discontinue Femoston, consult a doctor and undergo an examination to identify tumors or endometrial hyperplasia.

If jaundice, migraine-like headaches, liver dysfunction, severe increase in blood pressure, pregnancy or symptoms of troboembolism (painful swelling of the legs, sharp chest pain, shortness of breath, blurred vision) develop, you must immediately stop taking the drug and consult a doctor.

Overdose

Cases of overdose with Femoston 1/5 have not been registered, however, theoretically, if this happens, there may be an increase in side effects.

An overdose of Femoston 1/10 and Femoston 2/10 is possible, and it is manifested by the development of nausea, vomiting, drowsiness and dizziness. There is no specific antidote, therefore, in case of an overdose of Femoston, it is necessary to perform a gastric lavage, give the woman a sorbent (for example, activated carbon, Polyphepan, Polysorb, etc.) and then, if necessary, eliminate various symptoms, supporting normal work vital organs.

Impact on the ability to operate machinery

Any type of Femoston does not affect the ability to operate machinery, however, women who take hormone replacement therapy drugs should be careful when driving a car or working with machinery and machines.

Interaction with other drugs

Drugs that enhance the activity (inducers) of microsomal liver enzymes (for example, barbiturates, Phenytoin, Rifampicin, Carbamazepine, Rifabutin, Oxcarbazepine, Topiramate, Felbamate, Nevirapine, Efavirenes, etc.) reduce the severity of the effects of Femoston. The drugs Ritonavir and Nelfinavir, despite the fact that they are inducers of microsomal oxidation, do not reduce the effects of Femoston.

Any herbal preparations containing St. John's wort or its parts accelerate the excretion of Femoston components, and thereby weaken its therapeutic effect.

Femoston slows down the elimination of Tacrolimus, Fentanyl, Theophylline and Cyclosporine A from the body, so the dosages of these drugs should be reduced in order to prevent overdose and poisoning.

Femoston when planning pregnancy

IN last years Practicing gynecologists often prescribe the combination Femoston + Duphaston to women experiencing problems conceiving. Femoston is not indicated for use in the treatment of infertility, but in practice it is prescribed to women to normalize hormonal levels and increase the thickness of the endometrium, which significantly increases the likelihood of pregnancy. In such situations, doctors use pharmacological properties drug to achieve a certain effect in conditions that are not an indication for use. This practice of using drugs for other purposes is found all over the world and is called off-label prescriptions. Let's consider why Femoston promotes pregnancy and in what cases its use is justified in case of difficulties with conception.

Since Femoston contains natural estrogens and progesterone hormone, it has the ability to replenish estrogen deficiency and enhance the growth of the endometrium, making it thicker, denser and more blood-filled. Replenishing estrogen deficiency helps restore ovulation, and an additional dosage of progesterone improves the growth of the endometrium, making it thick enough for attachment ovum. This means that Femoston can help women who are unable to conceive due to too much pregnancy to become pregnant. thin endometrium or existing estrogen deficiency.

However, Femoston therapy is not very effective, since pregnancy occurs in only half of the woman after stopping the drug, since there is no ovulation during the course of treatment. In addition, Femoston causes numerous side effects, which are poorly and difficult to tolerate. Therefore, many gynecologists consider the use of Femoston to treat infertility unjustified. This category of doctors believes that in such situations women should take special drug, containing estrogens, and in the second half - Duphaston.

When planning a pregnancy, Femoston is usually prescribed in a dosage of 2/10, and it is recommended to take it according to the instructions, that is, one tablet per day, regardless of meals, preferably at the same time. Women need to drink all the tablets in the pack. And first they take all 14 tablets Pink colour, then 14 light yellow tablets. After finishing taking pills from one pack, the next one is started without any break, and so on until the course of therapy is completed. Quite often, in addition to Femoston, doctors prescribe Duphaston, which should be taken only in combination with light yellow tablets from each pack, that is, in the second half of the menstrual cycle. This means that at first the woman takes only pink tablets from each pack, and then light yellow Femoston + Duphaston tablets.

Femoston should be taken on the first day of the next menstrual cycle. If menstruation is irregular, it is recommended to start taking pink pills Femoston on the day of the expected start of menstruation.

Side effects of Femoston

Different types of Femoston can provoke the same side effects with different frequencies. In addition, some side effects are unique to one form or another of Femoston. Therefore, we present the side effects of each type of Femoston indicating the frequency of their occurrence in the table.

Incidence of side effects	Side effects of Femoston 1/5	Side effects Femoston 1/10	Side effects of Femoston 2/10
Common (more than one in a hundred women, but less than one in ten)	Migraine; Headache; Asthenia; Nausea; Stomach ache ; Bloating; Spasms in the calf muscles; Tension and tenderness of the mammary glands; Uterine bleeding ; Pain in the pelvis; Changes in body weight (decrease or increase).
	Spotting		Spotting
Uncommon (more than one in a thousand women, but less than one in a hundred)	; Contact lens intolerance; Impaired liver function, manifested by jaundice, asthenia and pain in the upper abdomen; Increase in breast size.
	Premenstrual syndrome	Breast tension syndrome before menstruation
	Very rare (occurs in less than one woman in 10,000)	Hemolytic anemia; Allergic reactions; Chorea; Myocardial infarction; Stroke; Vomit; Quincke's edema; Erythema nodosum multiforme; Vascular purpura; Chloasma or melasma; Worsening of the course of porphyria.

Contraindications to the use of Femoston

All Femoston drugs (1/5, 1/10 and 2/10) have absolute and relative contraindications for use. TO absolute contraindications refer to conditions in which drugs cannot be used under any circumstances. TO relative contraindications include conditions in which the use of Femoston is undesirable, but possible under close medical supervision and with caution.

Absolute contraindications to the use of all three types of Femoston are given in the table.

Absolute contraindications to the use of Femoston 1/5	Absolute contraindications to the use of Femoston 1/10 and Femoston 2/10
Cerebrovascular disorders	Existing or recently transferred arterial thromboembolism(for example, heart attack, stroke, ischemic heart disease, etc.)
	Untreated endometrial hyperplasia
	Porphyria
	Known or suspected progestogen-dependent tumors, such as meningioma
Pregnancy or suspected pregnancy
Breast-feeding
Detected breast cancer
Suspicion of breast cancer
Previous history of breast cancer
Endometrial cancer detected or suspected
Bleeding from the genital tract of unknown cause
Acute deep vein thrombosis or pulmonary embolism in the past
Hypersensitivity to the components of the drug
Acute or chronic liver diseases in the present or in the past (the drug can be used after normalization of laboratory parameters of liver function)
Detected thrombophilic disorders (deficiency of protein C or S or antithrombin)
Age under 18

Relative contraindications are the same for all three forms of Femoston, and these include the following diseases or conditions that a woman currently has or has had in the past:

Pregnancy;

The appearance of any side effect.

Femoston - analogues

Femoston does not have synonymous drugs that contain the same active substances in identical dosages. However, the domestic pharmaceutical market has quite wide range various drugs analogues of Femoston, which have a similar therapeutic effect, but contain other active substances. Below is a list of Femoston analogs that have the same anti-menopausal effect and contain a combination of estrogen and progesterone hormones as active components:
1. Activel tablets;
2. Angelique tablets;
3. Gynodian Depot solution for injection;
4. Divitren tablets;
5. Indivina tablets;
6. Clymene tablets;
7. Climodien tablets;
8. Kliogest tablets;
9. Pauzogest tablets;
10. Triaklim tablets;
11. Trisequence tablets;
12. Eviana tablets;
13. Revmelid tablets;
14. Cyclo-Proginova dragee.

To eliminate the symptoms of menopause, you can use not only hormonal agents, but also various herbal and biological active additives to foods that contain only natural plant and animal ingredients. Such non-hormonal analogues of Femoston for their anti-menopausal effect include the following drugs:

• Inoclim;
• Klimadinon UNO;
• Klimalanin;
• Livial;
• Femiwell;
• Feminal;
• Estrovel, etc.

• Date: 04/30/2019
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Femoston 1 10 is a drug that is prescribed to reduce the effects of hormonal shifts during menopause. The main active ingredients included in the composition are the hormones estradiol and dydrogesterone.

Replenishment of estradiol deficiency

Functions of estradiol in a woman’s body:

• takes part in the regulation of all stages of the menstrual cycle;
• has a positive effect on metabolism, promotes the absorption of iron and copper;
• strengthens bones, maintains the elasticity of ligaments;
• promotes elasticity cartilage tissue, which is especially important for joints;
• interacts with thyroxine, a hormone thyroid gland, and maintains its adequate volume in the blood;
• stabilizes thermoregulation processes;
• gives elasticity to the walls of blood vessels, ensures a sensitive response of blood vessels to an increase or decrease blood pressure;
• does the job nervous system and a more coordinated psyche;
• participates in the regulation of the sweat glands.

All metabolic processes in the body are closely interconnected and influence each other. Estradiol is the main hormone from the estrogen group, which affects the formation of mammary glands and organs reproductive system. Estrogens are synthesized in women yellow body, a gland that enters the follicular apparatus of the ovary. The pituitary gland and adrenal glands also take part in the synthesis.

For female body Menopause is a radical restructuring of all systems, especially reproductive. During this period, changes occur in many metabolic processes, which affects not only appearance, but also on women’s health. With age, the synthesis of estradiol occurs more slowly, and by the age of 45-55 it ends. A lack of sex hormones, including estrogens, leads to the following consequences:

• the woman is gaining weight;
• hair falls out and becomes sparse and thin;
• nails become brittle;
• calcium deficiency causes senile osteoporosis, increasing the likelihood of injuries and fractures;
• in cartilage tissue the water balance changes and minerals;
• the cartilaginous discs of the joints lose their elasticity, the smoothness of movements and mobility of the joint decreases;
• sweating increases;
• spontaneous redness of the face and neck, hot flashes occur;
• consistency in the functioning of the circulatory system is disrupted, hypertension often develops;
• the skin becomes dry, flabby and thin;
• the production of vaginal mucus changes, women complain of itching and dryness of the vagina;
• disturbances in the functioning of the nervous system and psyche appear;
• the psyche becomes labile, the woman cannot control her emotional condition and behavior and mood changes abruptly and unpredictably;
• a disorder of the nervous system provokes insomnia, high level anxiety;
• sexual desire and cognitive abilities decrease.

The greatest danger to life comes from imbalances of minerals in the bones. Fractures after menopause take a long time to heal and tissue regeneration occurs with complications.

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Unfavorable changes in appearance and deterioration in health lead patients to depressive syndrome and big clinical depression. Women aged 45 to 55 years are at increased risk of becoming dependent on alcohol. This is due sedative effect, which provides alcohol. Habituation develops gradually, but it brings great harm both psyche and general condition health. In order to remove at least part of the sharp and unpleasant manifestations menopause, Femoston is prescribed 1 10. This drug has side effects, therefore, the use should be agreed with a gynecologist and/or endocrinologist.

Therapeutic effects of the product

The drug does not cancel age-related changes and the aging process is not the elixir of immortality or eternal beauty. What are the indications for use of Femoston 1 10:

• used to reduce the intensity of menopausal symptoms;
• applied as prophylactic from bone fragility and osteoporosis.

Femoston is available in tablets for oral administration. The dosage is selected only by the doctor on an individual basis, since the drug has restrictions on administration.

In order for the doctor to determine which dosage is optimal for a particular patient, a series of tests will be required. Analyzes are prescribed according to the profile:

• cardiology and phlebology;
• gynecology;
• endocrinology;
• if indicated, examination by a surgeon or orthopedist.

Femoston tablets should be washed down with pure drinking water. For the patient’s health, it is important to follow the dosage schedule chosen by the doctor. Specific names diagnostic measures prescribed by the doctor. The drug is taken over a long course and will need to be re-examined annually to monitor side effects.

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Contraindications for use

For safe use drug, you must carefully read all accompanying documentation. Femoston, the instructions for which contain this information, is not prescribed:

• if pregnancy is suspected;
• with confirmed pregnancy;
• during breastfeeding;
• if breast cancer is suspected or detected;
• for endometrial cancer of the uterus or other malignant tumors reproductive organs;
• at uterine bleeding outside the planned menstrual cycle;
• at varicose veins veins;
• with thrombophlebitis, thromboembolism, thrombosis of deep or superficial vessels;
• in case of cerebrovascular accident;
• for any liver disease in acute or chronic form;
• in case of individual allergy to any component of Femoston 1 10.

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The instructions for use also indicate which positive and negative side effects are most often observed when using Femoston 1 10:

• weight loss;
• strengthening bones and joints;
• muscle pain and cramps;
• enlargement and tenderness of the mammary glands;
• headache, dizziness and nausea;
• indigestion and accumulation of gases in the intestines.

Femoston, whose contraindications are due to its effect on circulatory system, is not completely safe drug, and its effect on women's health in the long term has not yet been studied. Recent studies have found that long-term use increases the risk of breast cancer. Therefore, all women taking Femoston 1 10 need to visit preventive examinations see a mammologist and examine your breasts yourself every month.

Side effects

At the age of 45-55 years health care required somewhat more often than before. For patients who plan to undergo examinations in other areas, it will be useful to know that Femoston 1 10 affects the results:

• blood biochemistry, analysis of sex hormones and thyroid hormones;
• blood test for glucose levels.

With caution, Femoston 1 10 is prescribed to those patients who have ever suffered or are currently suffering from the following diseases:

• decreased tone blood vessels, arterial hypertension;
• migraine of unclear etiology;
• multiple sclerosis, otosclerosis and atherosclerosis;
• epilepsy;
• diabetes mellitus, which causes complications on the cardiovascular system;
• tendency to form blood clots and emboli;
• hemoglobinopathy.

If while taking Femoston 1 10 occurs bad feeling, dizziness, spots flashing before the eyes, fainting or weakness, you need to consult a doctor and adjust the dose, or choose another drug. If you feel very unwell, call an ambulance.

Course of use and combination with other medications

In order for the drug Femoston 1 10 to show its best qualities, you need to use it in accordance with the doctor’s recommendations. General recommendations, suitable for any clinical picture:

1. It is best to choose the same time of day for your appointment.
2. The daily dosage is selected by the doctor.
3. The first time you take it, you feel absolutely normal: you can’t start taking it during a cold, headache, or an attack of insomnia.
4. In case of a non-standard cycle, the course is adjusted by the doctor.
5. If the patient’s menstruation has not yet stopped, then the start of administration should coincide with the beginning of the cycle.
6. If menstruation ended more than a year ago, the intake may not be coordinated with the previous cycle.
7. If the cycle is not regular, Gestagen therapy is first administered, and only then Femoston 1 10 is prescribed.

Any interference with work endocrine system justified only if the potential benefit is greater than potential harm. The attending physician must honestly inform the patient about all possible consequences use of Femoston 1 10, so that a sharp malaise does not come as a surprise and does not lead the patient into confusion. Femoston contains dydrogesterone and estradiol. This composition affects not only hormonal background, but has an indirect effect on all body systems, including the cardiovascular system. Femoston 1 10 is excreted by the kidneys and affects the liver, so patients with chronic or acute diseases these internal organs no medicine is prescribed. If the patient experiences one or more of the following list of symptoms, she should contact an endocrinologist as soon as possible, and if her condition seriously worsens, call an ambulance:

• swelling of the feet;
• swelling of the face;
• heaviness or pain in the chest;
• numbness skin and soreness of the limbs;
• breathing problems, shortness of breath;
• drowsiness, lethargy and decreased concentration;
• decreased blood pressure, weakness and dizziness;
• lightheadedness and fainting;
• tachycardia or bradycardia (slow heartbeat).

Compatibility with other medications that the patient is taking should be discussed with the attending physician. According to the instructions, alcohol does not interact with the drug, but a recommendation can be given: do not take Femoston 1 10 with alcoholic beverages in order to avoid unpredictable consequences.

Estradiol and dydrogesterone in combination with alcohol and general mental lability can have a powerful effect on a woman’s behavior. Until the bones and joints are strengthened, it is better to refrain from dancing and revelry. Some patients experience an acute reaction to interference with the endocrine system. For what symptoms should you discontinue the drug and choose another remedy:

• severe migraine to the point of intolerance;
• sharp and powerful boost blood pressure;
• disturbances in liver function, the appearance of jaundice;
• pregnancy;
• deterioration of the condition of blood vessels in the legs, development varicose veins or thrombophlebitis.

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During the course of the drug, pregnancy is rare, but after stopping the course, if the woman is still menstruating, pregnancy may occur. Therefore, Femoston 1 10 is used to plan pregnancy in women older than middle age. During the first month of use, some patients experienced uterine spotting bleeding outside the planned cycle. If such a symptom appears, you need to consult a gynecologist, and then:

• do an ultrasound and get tested;
• adjust the dose of the drug;
• if this does not stop the bleeding, then choose another drug.

Femoston 1 10, the instructions indicate this information, does not affect driving or operating equipment, and usually does not reduce concentration and vigilance.