Set of immunoglobulin ige biochemical method. Accumulates in the upper layers of mucous membranes

Environment filled with various pathogens and allergens. When exposed unfavorable conditions Often people develop various allergic reactions. Behind immune function In the human body, a special protein is responsible - immunoglobulin E. When exposed to an allergen, it immediately reacts with it, performing a protective function. Often, after a blood test for immunoglobulin E, the doctor reports an increase in its value; let’s take a closer look at what this means.

IgE is produced by blood cells - B lymphocytes. The importance of this class of immunoglobulins is that they are the main indicator of allergies. When the body is exposed to any allergen, IgE comes into contact with it. Having formed a common complex, they attach to the membranes of mast cells and lead them to the process of degranulation, accompanied by the release of histamine, serotonin, and proteases. As a result, development occurs allergic reaction immediate type.

Norm and indications for research

Indications for studying the concentration of IgE are a large number of pathologies, for example, allergic rhinitis, bronchial asthma, helminth infection, dermatitis, urticaria and many others. To diagnose allergies, determining the concentration of total IgE is not enough, and therefore there is a need for research specific antibodies immunoglobulin E group for the identified allergen. Modern methods diagnostics make it possible to determine specific immunoglobulin in plasma for 600 or more allergens.

To assess the concentration of IgE and antibodies, a quantitative sample is performed. To do this, blood is taken from a vein in the morning, strictly on an empty stomach. You are allowed to drink water before taking the test. In a child, a study of immunoglobulin concentration has more important during diagnosis than in adults. Increased IgE content in children with allergies and hypersensitivity To a large number allergens are detected more often than, for example, in a child with hypersensitivity to a small number of allergens.

The norm for immunoglobulin E is taken to be different meanings depending on the age of the patient. The unit of measurement for IgE in the blood is designated kE/l. Concentration standards depending on age are as follows:

• children aged 1 to 3 months. – from 0 to 2 kE/l;
• children from 3 to 6 months. – from 3 to 10 kE/l;
• children aged 1 to 5 years – from 8 to 20 kE/l;
• children aged 6-14 years – from 10 to 50 kU/l;
• adolescents aged 15 years - up to 20 years - from 15 to 60 kE/l;
• adults - from 20 to 100 kE/l.

The first blood test for immunoglobulin E can be performed when the embryo has been developing for twelve weeks. It is during this period that IgE levels begin to increase. After the birth of a child, immunoglobulin concentration begins to rapidly increase. The increase in IgE concentration lasts until a certain age. In elderly people, the value decreases as much as possible, and subsequent diagnosis loses its relevance.

Reasons for increased immunoglobulin E

The development of hypersensitivity lies in the fact that when body tissues come into contact with external irritants, immunoglobulin E accumulates in the submucosal layer. Substances with increased sensitivity react with protein cells and a local inflammatory process begins due to increased output histamine and cytotoxins. As a result appear following symptoms: rhinitis, rashes on the skin and mucous membranes, bronchitis, asthma, anaphylactic shock.

If immunoglobulin E is elevated, this means that the person is infected and an allergic reaction is progressing, which can further cause local inflammation.

The importance of the diagnostic value of IgE blood concentration becomes less relevant after reaching 12 summer age. In adults, the level of immunoglobulin increases due to regular contact with environmental allergens. IN in this case increased sensitivity to one of the irritants does not cause a strong increase in protein compounds of the immune system.

• immunodeficiency states;
• bronchopulmonary aspergillosis;
• bronchial asthma combined with dermatitis and rhinitis;
• IgE myeloma;
• malignant tumors;
• leukemia of various etiologies;
• anemia.

IN in rare cases the study reveals excessive high content total immunoglobulin (from 2 to 50 thousand IU/l). A significant increase means that the person has hyper-IgE syndrome. The pathology is genetic and manifests itself with symptoms such as:

• frequent pneumonia;
• abscesses of the skin and mucous membranes;
• frequent rhinitis and inflammatory processes in the ears;
• osteoporosis, bone fragility;
• scoliosis;
• sinusitis;
• recurring candidiasis;
• chronic allergic dermatitis;
• dental diseases;
• pathologies of the autoimmune system.

Changes in concentration levels may be caused by certain medications. Therefore, two to three days before the test, it is recommended to avoid taking medications. Also, the overall picture of the study may be distorted as a result of eating before blood sampling, or drinking alcohol within 2-3 days before donating the material. In addition, it is not recommended to do exercises and other physical exercise. It is important to exclude stressful situations.

Treatment for elevated immunoglobulin E

To prescribe therapy, one blood test for IgE is not enough; it is necessary to conduct a number of other tests, including tests for allergens (pollen, food, household, fungal, epidermal). A contraindication to allergy testing is a child under three years of age. First of all, it is necessary to identify the allergen that causes the inflammation process and eliminate it. For more effective selection of treatment, consultation with such narrow specialists, as an otolaryngologist, gastroenterologist, immunologist.

Prescribed as therapy antihistamines(Erius, Suprastin and their analogues), enzymes and sorbents. For dermatitis, the course of treatment includes regular skin treatment using special means hygiene (A-Derma, Dermalex). Creams that have a softening effect (Atoderm, Excipial) effectively affect the condition of the skin. Elevated IgE needs to be treated comprehensively, which significantly speeds up the process of reducing concentrations. Treatment with increased concentrations of immunoglobulin is possible only after additional examinations and doctors' reports.

Based on the results of all examinations, the level of immunoglobulin E concentration in the blood is assessed, including over time, and appropriate therapy is prescribed, aimed at reducing IgE and eliminating the allergen. It is also important to carry out preventive measures Treatments for allergic diseases. Treatment may be difficult if it is necessary to determine the IgE level in a child under 6 months of age, since during this period the immune response is still poorly developed and the concentration of antibodies is insignificant.

Immunoglobulin E performs important function for humans – protects mucous membranes from substances that cause hypersensitivity and allergies. Protective function from external stimuli is important for both a child and an adult, since if a pathogen enters the body, then there is a high probability of developing a concomitant inflammatory process. It should be noted that if immunoglobulin E increases in the blood, there is no need to make independent attempts to reduce its concentration. The doctor should prescribe treatment based on complaints and examinations performed.

In adults, determination of the concentration of immunoglobulin E in blood serum has less diagnostic value than in children. Increased level immunoglobulin E is detected only in 50% of patients with atopic bronchial asthma. Most high values concentrations of immunoglobulin E in the blood are observed with hypersensitivity to a large number of allergens in combination with bronchial asthma, atopic dermatitis and allergic rhinitis. In case of hypersensitivity to one allergen, the concentration of immunoglobulin E may be within normal limits.

Allergic bronchopulmonary aspergillosis is accompanied by a significant increase in the content of immunoglobulin E in the blood. Its concentration is increased in almost every patient with allergic aspergillosis during the period of acute pulmonary infiltration. A normal immunoglobulin E level in patients with active lung disease excludes the diagnosis of aspergillosis.

Determination of immunoglobulin E is important for diagnosis rare disease- hyper-IgE syndrome. It is characterized by an increase in the concentration of immunoglobulin E in the blood to 2000-50,000 kU/l, eosinophilia, pronounced urticaria and hyperemia to inhaled allergens, pollen, food, bacterial and fungal allergens. Bronchial asthma for of this syndrome uncharacteristic.

When assessing the results of determining total immunoglobulin E, it should be borne in mind that in approximately 30% of patients with atopic diseases, the concentration of immunoglobulin E may be normal.

When is immunoglobulin E low?

Concentration of total immunoglobulin E in blood serum under certain pathological conditions

When diagnosing an allergy, it is not enough to state an increase in the concentration of total immunoglobulin E in the blood. To search for the causative allergen, it is necessary to identify specific antibodies of the immunoglobulin E class. Currently, laboratories are able to determine allergen-specific immunoglobulin E in serum to more than 600 allergens that most often cause allergic reactions in humans. However, the detection of allergen-specific IgE (to any allergen or antigen) does not yet prove that this particular allergen is responsible for clinical symptoms. Interpretation of research results should be carried out only after comparison with the clinical picture and detailed data. allergy history. The absence of specific immunoglobulin E in the blood serum does not exclude the possibility of participation in the pathogenesis of the disease by an IgE-dependent mechanism, since local synthesis of immunoglobulin E and sensitization of mast cells can occur in the absence of specific immunoglobulins E in the blood (for example, with allergic rhinitis). Antibodies of other classes that are specific for a given allergen, especially the immunoglobulin G class, may cause false-negative results.

A blood test for immunoglobulin E is prescribed to diagnose inflammation and immune responses caused by an irritating substance.

When an antigen interacts with an antibody, the concentration of immunoglobulin E in the blood instantly changes. Thanks to immunoglobulin analysis, it is possible to diagnose pathologies such as urticaria, Quincke's edema, bronchial asthma and other diseases of allergic etiology, as well as problems with the gastrointestinal tract.

Clinical picture

WHAT DOCTORS SAY ABOUT EFFECTIVE METHODS OF TREATING ALLERGIES

Vice-President of the Association of Children's Allergists and Immunologists of Russia. Pediatrician, allergist-immunologist. Smolkin Yuri Solomonovich

Practical medical experience: more than 30 years

The article will introduce you in more detail to the class of immunoglobulins E and the need for testing.

This is interesting! The substance is produced by the fetus in the first trimester of pregnancy. When collecting blood from the umbilical cord and identifying it in the analysis increased concentration protein compound is stated high risk development of allergies after birth.

What is immunoglobulin E?

Total immunoglobulin E is an antibody produced by the immune system. Antibodies are responsible for maintaining immunity.

Protein compounds are produced by the submucosa and are formed in respiratory tract, on nasopharyngeal tonsils, tonsils, skin layer, gastrointestinal tract

Antibodies instantly react to a foreign substance, so there are more class E immunoglobulins in the body of a sick person than in healthy people.

Fact! The main function of the protein compound is to protect the surface mucous membranes from the effects of staphylococci, streptococci, mycoses and others. pathogenic microorganisms. The entry of harmful bacteria into the mucous membranes and into the blood provokes an inflammatory process and causes allergies in the form of dermatitis, swelling, and bronchial spasms.

What does immunoglobulin E show?

Immunoglobulins- special protein compounds that are synthesized by B lymphocytes. Thanks to special receptors, antibodies attach to highly specialized immune cells- mast cells and basophils - granular leukocytes responsible for the destruction of antigens in the body.

When prescribing a blood test, the doctor pays attention to the isolation of two types of immunoglobulins:

1. General;
2. Specific, providing information about a specific allergen.

Reference! When donating blood for total IgE, the total content of antibodies in the body is examined.

Immunoglobulin E is a specific indicator of an allergic reaction. Interaction with a foreign substance leads to a fight between antibodies and antigen, which leads to allergies with the following symptoms:

• runny nose with dry nasal congestion, clear, odorless mucous discharge, bouts of sneezing, increased sensitivity of the nasal mucosa;
• dermatitis with skin hyperemia, swelling of the skin, itching, burning;
• coughing attacks;
• bronchial asthma - chronic pathology caused by a decrease in the lumen of the bronchi with wheezing, coughing attacks, shortness of breath;
• anaphylaxis is an immediate immune response to an irritating substance.

Attention! At the first sign anaphylactic shock You should immediately call an ambulance - otherwise, attacks of suffocation lead to death.

Norms for the concentration of immunoglobulin E in the blood of children and adults

Quantity total IgE of an adult differs from children's indicators. Let us pay attention to the table, which presents the norms for the content of immunoglobulin E in the blood plasma of adults and children:

Note! The protein content in the child's blood gradually increases. IN adolescence protein substance is established in the analysis, and in older people the IgE content in the blood decreases.

What does an increased level of immunoglobulin E indicate?

Exposure to allergens provokes sharp increase IgE and indicates pathologies such as:

• inflammatory skin lesions;
• bronchial asthma;
• allergic rhinitis;
• allergic gastroenteritis;
• urticaria and Quincke's edema;
• anaphylactoid reactions.

The strongest allergens, due to which there is a noticeable increase in IgE in the analysis:

• dust mites;
• preservatives;
• foreign protein;
• pollen grains of highly allergenic plants;
• metal alloys;
• toxins.

• hyper-IgE syndrome;
• selective immunoglobulin A deficiency;
• underdevelopment of the thymus;
• myeloma - uncontrolled proliferation of white blood cells;
• primary (congenital) immunological deficiency - reduced platelet levels in the blood, eczema rash and other pathologies.

Reference! An analysis of the protein content in the blood is performed during tissue transplantation, when the host body acts as an irritant for the donor cells. When interacting structural and functional units, the skin, mucous membranes, and organs of the gastrointestinal tract are most often affected.

The table provides indicators of total IgE during pathological changes in organism:

Reduced immunoglobulin E

The level of antibodies responsible for maintaining the immune system not only increases, but also decreases. A sharp decrease in the amount of protein in the blood indicates Louis-Bart syndrome - a neurodegenerative hereditary disease. The disease is formed due to defects in T-lymphocytes - red blood cells.

Interesting! At sluggish illness the analysis shows a moderate level of protein in the blood, with acute process immunoglobulin in the blood is off the charts. The disease and the presence of allergens can only be diagnosed by a doctor.

How to get tested?

When taking an analysis for the content of protein cells, you should adhere to the same rules characteristic of any biochemical analysis blood.

Preparation for analysis involves:

• Blood is donated strictly on an empty stomach in the morning, that is, at least 8 hours must pass after eating. It is permissible to drink non-carbonated water before taking the test;
• 2 days before the analysis, it is advisable to exclude salted, smoked, fried foods, and alcoholic beverages;
• It is advisable not to abuse tobacco smoking 24 hours before the test;
• Avoid 2-3 days before blood collection stressful situations, severe physical and mental stress;
• upon admission medical supplies warn the attending physician or laboratory technician to avoid distortion of the analysis;
• On the day of the test, it is not advisable to conduct an ultrasound examination, fluorography, or physiotherapeutic measures - take the test on another day.

Important! If you have doubts about an increased or decreased concentration of immunoglobulin E, it is permissible to retake the blood test in another laboratory.

How to lower immunoglobulin levels?

To reduce the concentration of serum IgE, it is prescribed complex treatment, which includes taking medications - orally and locally and traditional medicine.

Drug therapy

The doctor prescribes treatment taking into account the reason that led to the increase in the number of antibodies, individual characteristics body and age of the patient.

1. Antiallergic drugs that act on H-1 histamine receptors and suppress the action of the antigen - Telfast. Most often, experts recommend taking new generation antihistamines, because the drugs have a minimum side effects, quickly coping with allergy symptoms;
2. Local therapy in the form of non-hormonal creams, gels, ointments that promote skin regeneration - Bepanten, Belosalik, Akriderm. For severe lesions of the epidermis, the use of glucocorticosteroids of various hormonal activities is recommended - depending on the severity of the inflammatory process - Advantan, Lokoid, Prednisolone;
3. Drugs to enhance immunity - Arbidol, Amiksin. Currently, the immunity of allergy sufferers is strengthened through the gradual introduction of allergens, which makes it possible to achieve long-term remission;
4. If helminthiasis is present, antihelminthic medications are prescribed - Pirantel, Vermox, Mebendazole.

Alternative medicine treatment

Facilities traditional healers will not cure pathology, but help improve analysis and are part of complex therapy. To lower immunoglobulin levels, the following folk recipes are used:

• decoction of herbal tea - St. John's wort, yarrow, chamomile petals, dandelion root - 1/3 cup before each meal;
• mixture eggshells And lemon juice— take 1 teaspoon 3 times a day;
• dandelion and burdock decoction - 1/2 cup before breakfast, lunch, afternoon snack, dinner.

Cost of analysis

The price for an analysis of the content of immunoglobulin in blood plasma is on average 650 rubles. Blood sampling is priced separately - the cost is about 210 rubles.

On the base budgetary institution Immunoglobulin testing is rarely performed due to the lack of reagents and necessary equipment, so doctors at budget clinics have to cooperate with private centers.

Video

One of the varieties of complex proteins are glycoproteins, the molecules of which are characterized by a combination of the protein part itself with sucrose or lactose. Such proteins are important element cell membranes animals and plants. A class of glycoproteins is present on the surface of B-lymphocytes, having the property of forming bonds with proteins or polysaccharides - parts of the cells of microorganisms that have entered the body, possibly representing a danger, and are called immunoglobulins (antibodies). Sometimes in the results of blood tests you may see the item “total immunoglobulin E”. What is it and what specific role does it play in human body and how important is it?

Specificity of immunoglobulin E

When antigens, cell fragments of microbes, viruses or other microorganisms that are an allergen in the body attach to immunoglobulin E, ARNT occurs. As a result, inflammatory mediators are released into the blood, leading to allergic manifestations such as itching, burning and rashes.

Immunoglobulin E is elevated: what does this mean?

The concentration of IgE in the blood of a person without pathologies is quite small, even almost absent, and its share among all immunoglobulins is within a thousandth of a percent. Since any allergy leads to a sharp increase in immunoglobulin E, the level of such antibodies in the blood increases noticeably.

That's why if the immunoglobulin E level is elevated, this indicates the presence of an allergic disease.

The concentration of immunoglobulin E often directly depends on the severity of the disease process or the stage of the disease. Maximum level this substance is typical in the presence of diffuse neurodermatitis, atopic bronchitis or hay fever. If this disease is hereditary in nature in combination with hypersensitivity to allergens, then the test result will also have high rate immunoglobulin E level.

What does an immunoglobulin E test show?

The result of an immunoglobulin e test shows its level in the blood, which allows us to draw a conclusion about the presence (if IgE level is elevated) or absence (if IgE is normal) in a person various types allergies or helminth infections, in particular:

• Atopic dermatitis;
• Systemic anaphylaxis;
• Allergic rhinitis;
• Allergic gastroenteropathy;
• Hives;
• Atopic bronchial asthma;
• Mycosis;
• Helminthiases;
• Monoculosis;
• Cirrhosis of the liver;
• Immunodeficiency.

However, not always normal level These antibodies indicate that the person does not suffer from allergies, for example, about 30% of patients have normal IgE levels.

Moreover, the result of the analysis does not immediately determine the cause of the allergic reaction. To do this, you should be tested for specific immunoglobulin E. In this case, a special method is used, which consists in determining the quantitative ratio of specific antibodies to a specific allergen or their group. For greater reliability, it is advisable to compare the results with skin tests.

Specificity of immunoglobulin M

Immunoglobulin M is an indicator of humoral immunity provided by B lymphocytes, which from brain stem cells differentiate not into the thymus, but into other places, for example, in The lymph nodes or pharyngeal tonsils. This protein is the first to be produced in response to acute infection, and provide primary immunity.

An important feature is also that since antibodies of this class are the largest among all immunoglobulins, during pregnancy they cannot reach the fetus.

Immunoglobulin M is elevated, what does this mean?

If immunoglobulin M (IgM) in the blood has a high concentration, then this is a sign of acute infectious process, For example:

In the opposite case, with low immunoglobulin m, we are talking about either diseases that deplete the immune system, or chronic viral infection. Moreover, the reason low level IgM may be congenital deficiency due to selective deficiency of this immunoglobulin, agammaglobulinemia, monoclonal gammopathies (not IgM) or acquired deficiency, which occurs, for example, in lymphoma, after radiation therapy, splenectomy, as a result of gastroenteropathy, protein loss due to burns.

The human immune system produces special compounds called immunoglobulins or antibodies. They identify the infection and then form immune complexes with its antigens and remove them, and also remain in the body for a long time (or even for life) to prevent future diseases.

In particular, it has long been known about one of the classes of immunoglobulins, called common immunoglobulin E, what it is immune system to protect against allergens, a sufficiently high concentration in the body indicates a tendency to allergic pathology(atopy).

Video: how to take tests for immunoglobulin E

In this video, immunologist Elena Nikolskaya will tell you what the inscription “Immunoglobulin E total” means in the test results:

Immunoglobulin analysis is a mandatory element differential diagnosis. Based on research results, doctors identify allergic diseases and inflammatory processes. The special table shows optimal values for every age.

It is important to know what immunoglobulin E shows. The norm in children differs in different periods life depends on the time of year. Why are the indicators changing? What does increased and reduced level lgE? How to treat? The answers are in the article.

Immunoglobulin E: what is it

A special protein is found on the membranes of plasma cells. The substance is present in small quantities in the blood plasma; during an acute immune response, the active release of serotonin, histamine, and heparin occurs, and the number of antibodies increases sharply. The task of lgE is to destroy foreign information that has entered the body. Antibodies produced by immune reaction, lead to the death of antigens.

Immunoglobulin E - the cause lightning-fast reaction Type 1, in which life-threatening signs appear (pronounced swelling of the tissues and larynx). It is the IgE level that allows you to determine your susceptibility to allergic diseases. Immunoglobulin E is also involved in the formation of anthelmintic immune defense.

On a note:

• the main physiological function of lgE is to protect mucous membranes and skin from external influence by activating mast cells and plasma factors;
• substance produces small part plasma cells;
• in the normal state, the level of immunoglobulin E is up to 0.5 mg/l, no more;
• with increased sensitization to many types of irritants and confirmed allergies, the IgE level increases;
• in some diseases the indicators exceed the permissible values ​​by 5-7 times or higher. Average values ​​at bronchial asthma- from 120 to 1200, with atopic dermatitis- from 80 to 14000, with allergic rhinitis- from 120 to 1000 kE/l.

Norm indicators in children

The table shows the values ​​of an important indicator allergic inflammation:

It is important to know: analysis of the IgE level is the main, but not the only element of diagnosis. Doctor analyzes Clinical signs diseases, clarifies the duration of manifestation of negative symptoms. To confirm the diagnosis and clarify the type of allergen, an immunoblotting reaction, comparison of the results with a pediatric allergen panel, or skin testing is required.

IgE immunoglobulin is elevated: reasons

In most cases, an excess of total immunoglobulin E in the blood serum indicates the development of allergic diseases. Doctor conducting a fence venous blood, compares the results with the table value.

It is important not only to clarify the level of the allergy indicator, but also to find out clinical picture diseases, study negative symptoms in detail. Increased performance develop not only against the background of hypersensitivity of the body after contact with an allergen, but also with other types of diseases.

A high level of lgE indicates the development of the following diseases of an allergic nature:

• bronchopulmonary aspergillosis of allergic origin;
• atopic;
• negative reaction to certain foods;
• drug allergies;
• allergic gastroenteropathy.

Increased levels in the absence of signs of allergy are one of the signs of the development of the following diseases:

• thymic aplasia;
• helminthic infestations;
• myeloma;
• hyper-lgE syndrome.

On a note! According to the results of research, doctors found that when food allergies, the body's sensitivity to pollen microparticles of some plants, the level of immunoglobulin E increases more actively than with a pronounced reaction to mold spores and house dust. With a negative response to one type of allergen, the indicators often remain within the reference values ​​or are slightly increased.

Decreased results: probable reasons

Deviation from the norm is possible with the following diseases:

• Louis-Bar syndrome;
• hypogammaglobulinemia of hereditary nature;
• some types of neoplasms.

How to prepare for the test and donate blood

Accurate test results make it possible to diagnose many diseases. Before taking blood, the doctor will explain how to act correctly so as not to blur the picture of the pathology. Parents should know what reasons prevent the true result from being established.

How to prepare for an immunoglobulin test? Three important rules:

• 4-5 days before the test, adjust your diet: give up fried, salty, spicy, steam, stew, bake. Basic Requirement- dishes should not irritate the intestinal mucosa.
• A week before the test, penicillin antibiotics are discontinued: potent drugs often increase lgE levels. Avoidance of the use of phenytoin is mandatory: this substance often underestimates immunoglobulin E levels.
• To confirm or refute the development of an allergic reaction, donate blood from a vein strictly on an empty stomach. Drinking water or any other type of liquid is also prohibited: the results will be inaccurate.

It sometimes takes a lot of time to clarify the diagnosis and identify the allergen. If there is a suspicion of need, during which it is excluded specific product, observe the reaction, after a while again include the expected stimulus in the menu, monitor the body’s response.

Certain actions help return the lgE level to normal:

• identifying the allergen, stopping contact with the irritating substance, refusing certain medications. If you are hypersensitive to components or animal fur, more careful care of your pet and home will be required;
• for prevention skin reactions, disorders of the gastrointestinal tract, damage to the conjunctiva and nasal mucosa, children should use less frequently. In case of an acute reaction to individual species food will have to exclude some items from the menu;
• Strengthening the immune system is an essential part of allergy prevention. The level of immunoglobulin E will be normal with a decrease in sensitization of the body. Well-known pediatrician Dr. Komarovsky recommends giving babies and older children calcium gluconate. The product, proven over the years, has a positive effect on the condition of capillaries, increases protective forces growing organism;
• elements of prevention: walks on fresh air, moderate physical activity, healthy sleep, varied diet, vitamin and mineral complexes.

If immunoglobulin E levels deviate from the norm, it is important to find out what diseases are causing the level of allergic inflammation indicator to be reduced or increased. For differential diagnosis, the patient should consult an immunologist, allergist, or infectious disease specialist. To correct IgE levels, doctors prescribe a set of preventive measures. If you are hypersensitive to irritants, it is important to limit or eliminate contact with allergens.

Find out everything you need to know about the blood test for immunoglobulin E after watching the following video: