Omeprazole doesn't help. Causes of withdrawal syndrome from omeprazole and other proton pump inhibitors
Omez for heartburn has gained great popularity as a medicine for the stomach.
There is a popular belief that this drug is a digestive enzyme that normalizes digestion and relieves heartburn.
Accordingly, it has no contraindications, and does not require a doctor’s prescription for use.
However, use of this medicine must be conscious and justified by correct diagnosis.
Purpose of the drug and principles of its action
The main task of this drug is to combat gastritis, gastric and duodenal ulcers.
The drug directly affects the glands and chemical reactions inside the stomach, limiting production of hydrochloric acid.
With heartburn, gastric juice, which is based on hydrochloric acid, for various reasons enters the lower parts of the esophagus.
Corroding the mucous membrane of its walls, the aggressive acid component gastric juice damages them, causes ulcers against a background of pain, burning behind the sternum.
Omez protects against heartburn by reducing stomach acidity. The active substance of the drug omeprazole, when interacting with the parietal cells of the inner part of the stomach, normalizes the acid balance.
On the other hand, this substance protects the gastric mucosa, enveloping it with a film that has healing properties. This promotes faster healing of the mucous membrane of the stomach walls.
Omez has an effective therapeutic effect for heartburn and the following diseases:
Peptic ulcer disease tends to worsen between seasons. Inclusion this drug in complex treatment, it effectively helps to get rid of heartburn, accelerates the healing of ulcers, and reduces discomfort with this pathology.
When prescribing medication, the dosage depends on the severity and severity of the disease.
The duration of the course of treatment is about a month, after which it is recommended to take a break.
To obtain a therapeutic effect, the drug should be taken regularly, strictly following the rules of administration.
Omez is used to treat gastritis with increased acidity. His active substance Omeprazole normalizes acid-base balance, eliminates discomfort, pain and heartburn.
In cases of eating fried, spicy and fatty foods, the use of this drug can effectively get rid of a burning sensation in the chest.
With cancer, patients often complain of nausea, heartburn, and periodic vomiting.
In such cases, many specialists conduct long courses of treatment with the drug with the consumption of large amounts of water. The drug is especially effective after a course of chemotherapy.
Dosage forms, dosages and rules for taking the drug
Omez is available in the form of powder and capsules of 10, 20, 40 ml. Such dosage forms facilitate the preparation of suspensions and their administration by children.
These medications effectively relieve heartburn symptoms.
Suspensions with 5% glucose are prepared as follows:
The resulting liquid is used for intravenous drips. This dosage form is the most effective and is used as prescribed by a doctor.
Taking the drug correctly will help detailed instructions on use, however, do not ignore the professional advice of a doctor.
It is the specialist who can select optimal dosage and develop a medication regimen tailored to your specific situation.
The active substance of the drug begins to act within 24 hours from the moment it enters the stomach.
The main thing in treatment is a long constant course of 1-2 months, since during this time the greatest activation of the drug occurs.
In case of severe attacks of peptic ulcer and exacerbation of gastritis, the number of doses is increased to twice a day.
In this case, the drug should be taken for the first time half an hour before meals, and the second time before bed on an empty stomach.
For interseasonal exacerbations, the medicine is taken for 1 to 4 months, one capsule before bedtime.
To prevent heartburn and severe pain You should start taking it either from the end of summer or from the end of winter. After taking the capsule, the effect of the drug begins within twenty minutes.
Side effects and contraindications
Complete nutrition with big amount vitamins, minerals, proteins, carbohydrates are the basis healthy image life.
Diet, regime, properly selected products and physical activity prevent pain, heartburn and other stomach problems.
Formed eating habits significantly prevent the occurrence of heartburn and gastrointestinal pathologies.
However, when problems with the digestive system, in particular heartburn, worsen, taking medications is often the only way out.
Omez is popular because of its price and effectiveness, however, it also has its limitations and contraindications.
Initially, the instructions for use warn that it is undesirable to use the medicine for pregnant women, people with individual intolerance, and children under 18 years of age.
In addition, elderly people and those with liver and kidney diseases should not take the drug.
When found benign tumors the use of the drug should be limited.
If the drug is used incorrectly, side effects are possible, which include a feeling of dry mouth, nausea, headaches, shortness of breath, and confusion.
In addition, constipation or diarrhea, allergic reactions, migraines, depression, decreased muscle tone and involuntary contraction may occur.
Thus, a popular “harmless” drug carries some hidden threats to the human body, so its use must be coordinated with a doctor. mandatory.
The main condition for its appointment is a correct diagnosis.
It is important that the effect of the drug is not hidden clinical picture illness, since in some cases early diagnosis for some pathologies it saves a person’s life.
The use of the drug Omez has great statistics and many reviews. The experience of many people suffering from heartburn speaks about its effectiveness.
What all reviews have in common is that the medicine should be taken systematically, strictly following the instructions and prescriptions of the doctor.
Only under this condition does this remedy confirm its effectiveness. Otherwise, there is practically no effect.
An informed person who knows about the therapeutic effect of the medicine and the correct use of the drug has a great advantage in the fight against heartburn and is confident in the future.
Omez for heartburn
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An antiulcer drug that also eliminates burning sensation in the stomach.
Composition and release form
The main active ingredient of Omez is omeprazole. Its content varies and is 10, 20, 40 mg. The substance can be presented in the form of capsules, powder (lyophilisate) for the preparation of an injection suspension. Therefore, the medicine can be taken orally or by intravenous drip.
An auxiliary substance for obtaining capsules is gelatin to create a shell and hold the white granular powder of omeprazole. "Omez" is offered in two forms:
"Omez" capsules can be used by children over 12 years of age.
Omeza capsules are available in three types:
Omez tablets are not available.
"Omez" is distinguished by a wide range of therapeutic and preventative care. It should be taken if you have one of the following diseases:
The drug is used in a number of gastrointestinal diseases.
In addition, Omez helps against heartburn.
Does it help?
The use of "Omeza" provides comprehensive supportive treatment for ulcerated mucosa on the walls of the gastrointestinal tract affected by the disease. The main therapeutic task of the drug is to suppress the increased secretion of gastric acid. As a result, the acidity of the digestive juice drops to normal value. The high efficiency of Omez allows you to achieve the desired effect within half an hour after administration and maintain it for 24 hours.
The antiulcer medicine works against enzymes (H-K-ATPase). To suppress them, a proton pump is formed in the parietal cells of the organ. As a result most of acid is not synthesized, which reduces the acidity of digestive juice. Moreover, the drug is effective against any irritant that causes ulcerative pathology. Its effectiveness lasts as long as possible.
With a single dose of Omez with a concentration of omeprazole 20 mg, a patient with an ulcer has stable intragastric acidity levels of 3 units. The value is maintained for 17 hours or more. Full recovery secretory function of the stomach is achieved 3-5 days from the start of therapy.
Together with the normalization of acidity, such unpleasant symptoms of ulcers disappear. Therefore, Omez helps with heartburn, burning and heaviness in the stomach after eating.
How to take Omez to treat heartburn?
Before treating heartburn with Omez, you should find out that a dosage of 40 mg of omeprazole is therapeutic, and 20 mg is prophylactic. Capsules should be taken in the evening 30 minutes before dinner. According to indications, the dosage can be increased to 80-120 mg for a single dose. This decision is based on the severity of the disease being treated and the failure of low-dose therapy.
The course of treatment with Omez depends on the type of disease, the severity of symptoms (heartburn) and the characteristics of the human body. Typically, the therapeutic course varies from 14 days to 2 months. for preventive purposes, aimed at preventing complications, and after therapy with non-steroidal, hormonal medications, it is recommended to take heartburn capsules for a course of up to 3 weeks.
Patients diagnosed with oncological pathologies of the gastrointestinal tract and ulcerative lesions of the mucous membrane have to take the medicine for a long time. The treatment course can last several months.
As the instructions say, it is unacceptable to discontinue the medication on your own. This may aggravate the course of the disease or neutralize the effect of therapy.
Side effects during treatment
The negative effect of omeprazole on the human body during treatment, according to the instructions, is manifested by the following general symptoms:
- low-grade body temperature;
- nasal congestion;
- allergies with skin manifestations;
- nausea;
- diarrhea;
- migraine attacks.
- clouding of consciousness with severe dizziness and spatial disorientation;
- tremors and convulsions caused by involuntary muscle contraction of the limbs;
- severe shortness of breath, oxygen starvation.
- there is hypersensitivity to the components;
- bleeding or obstruction of the gastrointestinal tract is detected;
- Pituitary tumors were diagnosed.
- children under 12 years old;
- pregnant and nursing mothers.
- with iron preparations, such as Ampicillin, Ketoconazole, Itraconazole due to a decrease in the absorption (bioavailability) of iron;
- with anticoagulants such as Phenytoin, Diazepam due to an artificial increase in their concentration and a decrease in excretion.
- reflux esophagitis;
- gastroesophageal reflux disease;
- erosive and ulcerative processes, the course of which is explained by treatment with certain drugs, neuropsychic overload, stress;
- stomach or duodenal ulcer.
Severe side effects are as follows:
A negative reaction from using Omez can cause dizziness, convulsions, and shortness of breath.
If one of the symptoms appears, urgent medical attention is needed. In most cases, side effects develop due to individual intolerance to the active ingredient - omeprazole. Also, a negative effect is observed if you drink the drug for a long time and uncontrollably. Allergies are a serious reason for discontinuing the drug and looking for a safer alternative.
Pregnancy and lactation
"Omez" against heartburn is prohibited for use during pregnancy and breastfeeding.
Contraindications
The use of Omez is prohibited:
Drug interactions
Omez should not be taken at the same time:
There was no interaction between omeprazole and antacids when simultaneous administration.
Additional instructions
How to use Omeprazole for heartburn
Omeprazole is a medication designed to alleviate the condition of burning pain in the chest region of the body.
It has many analogues, the most famous of which are Omez and Ortanol, but, in fact, they are part of the same group of drugs with the active substance omeprazole.
Does Omeprazole help with heartburn or not, how long do the capsules suppress the mechanism that causes burning, how to take them and how much to pay to buy at the pharmacy? These questions are asked by all patients of the gastroenterologist who cannot get rid of the unpleasant sensation using improvised means.
How does Omeprazole treat heartburn?
Pharmacology describes the drug as a proton pump inhibitor. The principle of its effect on heartburn is due to the ability to inhibit the production of hydrochloric acid by gastric cells located in the mucous membrane of the main digestive organ.
By processing Omeprazole for heartburn, the body suppresses the transport of chlorine and hydrogen ions - particles involved in the formation of hydrochloric acid. The capsules reduce acidity and eliminate any adverse symptoms associated with its elevated levels. The drug acts quickly and relieves the condition for a long time.
In the annotation for Omeprazole, the indications for use are:
All of these diseases are accompanied by belching, heartburn, flatulence, and abdominal discomfort. Prescribing Omeprazole for other pathologies is advisable when the secretion of gastric juice increases. For example, with pancreatic adenoma, the body produces an excess of a substance that stimulates gastric secretion.
Doctors do not recommend drinking Omeprazole to relieve occasional heartburn. If the burning sensation does not go away for a long time and cannot be eliminated by changing your diet or lifestyle, you should consult a doctor. The purpose of the examination should be to exclude the development of a malignant tumor. Self-medication with Omeprazole is dangerous because the drug blurs the oncological picture and does not allow timely detection of a dangerous pathology.
Rules for using Omeprazole against heartburn
When purchasing a drug to combat a burning sensation, you should consider its dosage. 40 mg is a therapeutic dose, 20 mg is a prophylactic dose. How to take Omeprazole for heartburn?
Read more Traditional methods treating heartburn at home
Experts suggest drinking capsules in the morning and evening shortly before meals. IN special cases the dosage is increased to 80–120 mg per use of the drug. Doctors motivate this approach by the severity of a particular disease and the ineffectiveness of low doses.
How long can you take Omeprazole to relieve heartburn? For each disease, a course of therapy is developed separately. The patient can take the drug from 2 weeks to 2 months, which is explained by the peculiarities of the clinical picture. To prevent complications and after taking non-steroidal and hormonal medications, it is recommended to take heartburn medicine for no more than 3 weeks.
Patients suffering from peptic ulcers and oncological pathologies of the digestive system have to undergo treatment for a long time, up to several months. They should not adjust doses or discontinue the drug on their own.
As for contraindications to taking Omeprazole, the instructions for its use prescribe to refuse therapy with the substance omeprazole in the following cases:
- age up to 16 years;
- pregnancy and breastfeeding;
- hypersensitivity to capsule components;
- renal/liver failure and any dissonance in the activity of these organs.
Side effects of therapy include abdominal pain and intestinal upset, nausea and vomiting, drowsiness and emotional agitation, changes in blood counts and joint and muscle pain. In rare cases, taking Omeprazole causes swelling, blurred vision and general malaise. In general, the drug is well tolerated.
What is more effective for heartburn – Omeprazole or Omez
There is no fundamental difference between the drugs. Their composition is based on the same substance, but its auxiliary ingredients are not the same.
When buying Omez for heartburn, the consumer can note more high cost drug. Compared to Omeprazole, you have to pay 2 times more for Omez.
The patients themselves, who have tried both remedies on themselves, speak of their equivalent effectiveness in the treatment of diseases associated with increased acidity, and excellent tolerance by the body. The active substances quickly leave the capsule shell, after which they penetrate the gastrointestinal tract and are absorbed into the blood. Omeprazole reaches its maximum concentration within an hour. The symptoms accompanying gastric abnormalities disappear.
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Is it worth combining Omeprazole/Omez with alcohol? The instruction leaflet does not prohibit the consumption of alcohol during the period of drug treatment. However, it is not worth the risk, because the capsules are prescribed to eliminate pathologies in which drinking alcohol-containing drinks is strictly prohibited.
Each substance of a particular medicine works to maintain permissible level gastric secretion, accelerating the healing of erosive and ulcerative areas and preventing relapses of gastrointestinal diseases. By drinking alcohol, the patient injures the digestive mucosa, provokes complications and inhibits the healing process of pathological lesions.
Omeprazole is prescribed to pregnant women for health reasons. If the doctor insists on treatment during lactation, the baby must be switched to artificial feeding.
About the cost of Omeprazole
Manufacturers set the price for Omeprazole based on the number of capsules in the package, cost and form of production.
Which drug to give preference is the task of a specialist. Only a doctor is aware of the full effects of Omeprazole and its analogues. Thanks to his knowledge, he will be able to prescribe adequate therapy that will relieve heartburn in a short time.
Omeprazole really saves you from an unpleasant burning sensation, since it affects exactly the cause of its occurrence.
How to take omeprazole for heartburn?
Form of release of the drug and its effect on heartburn
Omeprazole is a time-tested drug widely used by gastroenterologists in the treatment of gastrointestinal diseases accompanied by increased secretion of gastric juice. In Russia, its manufacturers are the pharmaceutical companies Canonpharma Production, Ozon, AVVA-RUS and Sintez. The medicine is available in the form of hard, opaque capsules, the color of which may vary depending on the manufacturer. Inside the capsules there are spherical pellets (granules) of white or beige color. Capsules are packaged in blister packs of 10 pieces. Inside the cardboard box there are 2 or 3 blisters and instructions from the manufacturer.
The active ingredient of the drug is omeprazole, the dosage of which in each capsule is 20 mg. The list of auxiliary components of the drug includes gelatin, glycerol, sodium lauryl sulfate, nipazole, nipagin, titanium dioxide and water.
Heartburn is a concomitant symptom of diseases of the digestive system that develop as a result of increased production of gastric juice. The use of omeprazole can reduce daytime and nighttime secretion of gastric juice and thereby eliminate the main cause of heartburn. The clinical effect of the drug is observed when taken once a day. Maximum action active component occurs 4 days after the start of therapy. Omeprazole not only helps against heartburn, but also helps eliminate belching, nausea, reduces the intensity of pain in the stomach, and accelerates the healing of the affected area. inflammatory process mucous membrane digestive tract, prevents the development of peptic ulcers.
Instructions for use advise using Omeprazole orally. Capsules should be taken in the morning 30 minutes before breakfast, without chewing and with a small amount of water. If the patient is recommended to take the drug twice, the second dose should be taken 2 hours after dinner (best before bed). To achieve recovery, the use of Omeprazole should be combined with therapeutic diet. The daily dosage and frequency of taking the drug is determined by the doctor.
Omeprazole helps relieve heartburn after the first use, but in order to achieve a lasting clinical effect, the patient will need to undergo a full course of treatment with the drug. The duration of use of capsules depends on the disease that caused heartburn, and can range from 10 days to 6 months.
Contraindications and undesirable consequences of use
Omeprazole has limitations in use that the patient must take into account before starting treatment. Experts prohibit the use of the drug by persons suffering from individual intolerance to its components. Also, taking the drug is contraindicated for children under 16 years of age.
As a result of laboratory experiments, it was possible to establish that the use of omeprazole by pregnant women does not have an undesirable effect on the intrauterine development of the fetus. This fact allows the drug to be used during pregnancy under medical supervision. Omeprazole is found in breast milk, but does not pose a risk to the health of the baby. In this regard, the drug can be used during lactation in minimally effective doses. Elderly people and patients with severe renal or liver dysfunction should use Omeprazole for heartburn under the supervision of a specialist.
Adverse reactions during treatment medication are observed rarely and are reversible. The likelihood of their occurrence increases if the drug is taken in large doses or for a long period of time. long period. Adverse reactions to the drug usually manifest themselves as:
In addition to those listed adverse reactions, medical practice There are known cases when the use of Omeprazole in the fight against heartburn led to the patient developing painful sensations V abdominal cavity, alopecia, erythema multiforme, blurred vision, hyperthermia, peripheral edema, changes in blood composition (agranulocytosis, leukopenia, thrombocytopenia, pancytopenia). With long-term use of the drug, the development of granular cysts in the stomach is possible.
Patients who often resort to taking Omeprazole for heartburn may develop addiction to its active substance and reduce its effectiveness. In this case, the patient is recommended to consult a doctor about replacing the drug with another heartburn remedy.
Interaction with drugs and release form
Omeprazole may interact with other drugs. Due to the inhibition of gastric secretions, it may reduce the absorption of caffeine, lidocaine, theophylline, diclofenac and metopropol, and also slow down the release of diazepam. The combination of omeprazole with clarithromycin and amoxicillin leads to an increase in their therapeutic effect.
In most patients, Omeprazole does not affect the ability to drive or perform work that requires concentration. The only exceptions are situations when it causes dizziness, drowsiness or blurred vision. Patients who have taken medication leads to the development of such adverse reactions, you should refrain from driving and working at potentially hazardous objects for the entire duration of its use.
Omeprazole is intended for over-the-counter sale. This product belongs to the category of inexpensive drugs. average cost it costs about 30 rubles for 30 capsules. Omeprazole is represented on the pharmaceutical market by a large number of structural analogues. You can replace this drug with Lorsek, Loseprazole, Losid, Omez, Omep, Omealox, Ornatol, Ultop, etc. The listed drugs are also widely used in the fight against heartburn, but they are more expensive than Omeprazole. The most accessible analogue The drug is Omez. Its price starts from 142 rubles for 30 capsules.
Omeprazole does not need special conditions storage It is recommended to keep the capsules at a temperature no higher than +25 °C in their original packaging. The drug is suitable for use for 3 years from the date of production.
Does Omeprazole help with heartburn?
Indications
Omeprazole is used to suppress the symptoms of diseases that are accompanied by heartburn. The list of such pathologies includes:
The listed diseases occur with signs of heartburn. Depending on the severity of the symptoms of the problem, the doctor determines the treatment regimen with Omeprazole.
Therapeutic effect for heartburn
In addition to its antisecretory properties, Omeprazole has a powerful antibacterial effect, that is, it inhibits activity and reproduction pathogenic flora in the digestive system. It is these pathogens that provoke the development of ulcers, gastritis and pancreatitis.
Omeprazole also helps with heartburn because it has regenerating agents. Often the symptom manifests itself due to damage to the walls of the esophagus against the background of ulcerative esophagitis and gastroreflux. At the same time, the remedy does not mask the signs of heartburn, but eliminates the cause that caused it.
Omeprazole is different quick action with severe heartburn. After taking the medicine, the patient feels relief within 40-45 minutes. Therapeutic action The inhibitor lasts for 24 hours.
Mechanism of action of the drug
After taking the drug, a number of processes occur in the digestive system, due to which a person’s heartburn completely disappears or its severity decreases:
Omeprazole should not be taken continuously for heartburn.. If the symptom does not disappear after a single dose of the drug, correction of diet and lifestyle, then you should consult a specialist. The doctor must rule out the development of a malignant tumor in the digestive system. With uncontrolled use of Omeprazole, there is a risk of drug overdose, accompanied by:
Methods of administration and dosage
How long can you take Omeprazole for heartburn? The answer to the question depends on the reason unpleasant symptoms. The medicine is produced in capsules of 20 mg and 40 mg. In the first case, capsules are prescribed to prevent signs of heartburn, in the second - for the treatment of diseases associated with a burning sensation.
In case of exacerbation of diseases of the gastrointestinal tract and their occurrence in a severe form, the medicine is prescribed in a dosage of up to 180 mg at a time. Capsules are drunk 30 minutes before meals or the same period of time after meals.
Duration of therapy depending on the severity of the symptom and its cause:
You cannot prescribe your own dosage. Incorrect calculations will lead to a lack of therapeutic effect or an overdose.
Contraindications for use
Not all patients can take Omeprazole for heartburn. Contraindications to treatment are:
To enhance the therapeutic effect, antacids for heartburn are taken together with the inhibitor.
Compared to other inhibitors, Omez and Omeprazole have a number of advantages:
Special instructions during treatment
In order for therapy to bring maximum benefit, you should adhere to the following basic recommendations:
There are other analogues of Omeprazole for heartburn - Omez and Ortanol. When purchasing analogue drugs, you should know that their price is almost 2 times higher than that of Omeprazole.
Other remedies that help with heartburn include:
Patient reviews
Patients mostly leave information on the Internet positive reviews about the use of Omeprazole for heartburn. Before inhibitor therapy, people are advised to undergo comprehensive examination body, since heartburn may indicate more dangerous diseases - malignant tumors in the digestive system. Taking Omeprazole in this case will distort the clinical picture of the disease and create difficulties for identifying oncology. For this reason, the drug should not be taken without a prescription from a specialist.
Another feature noted by patients is the possibility of addiction to Omeprazole. If you use the product constantly when heartburn occurs, its effectiveness will be lost.
Omeprazole is a popular and effective remedy for the treatment and prevention of diseases accompanied by heartburn. Due to the possibility of addiction to the drug and the development of side effects, you should consult your doctor before treatment. When using the medicine yourself, you need to read the instructions for its use. Exist certain rules use of medications, non-compliance with which leads to exacerbation of diseases of the digestive system.
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Omeprazole - instructions for use, analogues, reviews, price
The drug Omeprazole
A drug Omeprazole refers to the most modern antisecretory drugs used in the treatment of peptic ulcers and erosive-inflammatory diseases of the upper gastrointestinal tract. According to the mechanism of action, it relates to proton pump inhibitors .
Omeprazole suppresses the production of hydrochloric acid in the stomach and reduces its activity. This drug acquires its medicinal properties only after entering an acidic environment, which is precisely characteristic of the stomach.
After ingestion, the drug actively penetrates into special cells of the stomach responsible for the secretion of hydrochloric acid. It accumulates in them and thus regulates the production of gastric juice and pepsin (an enzyme that breaks down proteins).
Omeprazole has a bactericidal effect on the main “culprit” of gastritis and peptic ulcers – the microorganism Helicobacter pylori. That is why Omeprazole is necessarily included in the list of drugs that suppress Helicobacter pylori infection for stomach and duodenal ulcers.
With pathological reflux of gastric contents into the esophagus (reflux ulcerative and erosive esophagitis), the mucous membrane is inevitably damaged, and ulcerative defects form on it. Omeprazole, taken orally, can reduce the damaging effects of hydrochloric acid, restore the pH of gastric juice and significantly reduce the severity of the main symptoms of the disease.
Omeprazole not only significantly improves the well-being of patients, but also leads to sharp decline the likelihood of the disease returning and the development of its complications. Its action begins within 1 hour after ingestion and continues throughout the day. Omeprazole reaches its therapeutic maximum after 2 hours. The higher the dose of the drug, the stronger the inhibitory effect on the parietal (hydrochloric acid-producing) cells of the stomach.
Omeprazole is excreted from the body through the kidneys (up to 80%) and intestines (about 20%). In older people, as well as in chronic renal failure. the elimination of the drug from the body may be slowed down.
Release forms
In the pharmacy chain, the drug Omeprazole is sold in tablets, capsules and solutions for intravenous administration.
1. Enteric capsules contain 10 mg or 20 mg of the main active ingredient - omeprazole (7 capsules in a blister pack, a pack can contain from 1 to 4 blister plates); some manufacturers pack capsules in polymer jars of 30 or 40 pieces;
2. MAPS tablets (pellets), coated with 10 mg, 20 mg or 40 mg of active substance (No. 7, 14, 28);
3. Powder for infusion solutions in 40 mg bottles (5 bottles per package).
The drug is available only with a doctor's prescription.
Instructions for use of Omeprazole
Indications for use
Omeprazole has wide indications for diseases of the upper gastrointestinal tract. The drug is usually prescribed to adults and children over 5 years of age in the following cases:
1. IN complex treatment active phase peptic ulcer of the stomach and duodenum associated with Helicobacter pylori infection;
2. For the treatment of Zollinger-Ellison syndrome;
3. To relieve manifestations of gastroesophageal reflux (reflux of gastric contents into bottom part esophagus);
4. To eliminate uncomplicated heartburn that lasts more than 2 days during the week;
5. As course treatment endoscopically confirmed erosive esophagitis;
6. For the correction of hypersecretory disorders in the upper digestive tract;
7. For the treatment of gastropathy caused by taking non-steroidal anti-inflammatory drugs;
8. In the combined treatment of polyendocrine adenomatosis;
9. Prophylactically, to prevent relapse in chronic duodenal ulcers, aspirin and stress peptic ulcers.
Contraindications
The main contraindication for taking Omeprazole is intolerance to any of the components of the drug.
In addition, the drug is not recommended to be taken during pregnancy. It has been clinically proven that taking Omeprazole, especially in the first trimester of pregnancy, can lead to malformations in the fetus. Therefore, the drug is prescribed only in extreme cases, when the benefits of its use significantly outweigh the side effects.
The drug penetrates well and quickly into the blood and breast milk. therefore, it is not prescribed during lactation.
Omeprazole helps reduce the acidity of gastric juice; therefore, it is not prescribed for gastritis with low acidity, atrophic gastritis.
Omeprazole is also contraindicated in patients with suspected oncological pathology of the stomach or duodenum. In this case, the drug can neutralize the existing symptoms and complicate the final diagnosis. There is evidence that Omeprazole in this pathology can stimulate the growth of an existing tumor.
Other contraindications include osteoporosis and a tendency to spontaneous bone fractures. Omeprazole leaches calcium from bones, so it can increase the effects of osteoporosis. In case of emergency, treatment with Omeprazole under the cover of calcium and vitamin D supplements is allowed.
Before prescribing Omeprazole, you must ensure that the patient does not have the following conditions:
Side effects
Side effects from taking Omeprazole are quite rare. As a rule, they occur with improper or prolonged use of the drug (more than 2-3 months in a row). In these cases, the most common disorder observed in the digestive system is nausea. bloating and abdominal pain. diarrhea or constipation. Some patients complain of headaches and dizziness. All symptoms usually go away on their own after discontinuation of the drug.
In addition, Omeprazole may cause:
Extremely rare side effects are enlargement and engorgement of the mammary glands, and decreased visual acuity. swelling on lower limbs. the formation of glandular cysts in the stomach, which are benign and reversible.
Treatment with Omeprazole
Due to the fact that incorrect or uncontrolled use of the drug can cause serious harm to the gastrointestinal tract, only a doctor can prescribe it.
How to take Omeprazole?
Omeprazole should be taken immediately before meals or during breakfast. If it is necessary to take the drug again during the day, it is usually prescribed in the evening.
Capsules should not be chewed or divided into pieces. The required dose of the drug is washed down with a small amount of clean still water.
If as remedy Omeprazole tablets (pellets) are used; they can be dissolved in acidified water, yogurt or juice (15-20 ml). The diluted drug should be drunk within 30 minutes.
Omeprazole dosage
The standard single dose of the drug is 20 mg, but it can be adjusted by the doctor depending on the severity of the disease and the general condition of the patient. Omeprazole is prescribed in courses of no more than 2 months, after which a break of several months is necessary.
At in serious condition patient, especially if he is in the intensive care unit, Omeprazole can be administered through a catheter directly into the stomach, or use sterile solutions for intravenous infusion. For administration through a catheter, it is necessary to dilute 20 mg of powder from the capsule in 30 ml of water, leave for 3-5 minutes and administer through a gastric tube. For intravenous drip administration 40 mg of sterile Omeprazole powder (1 bottle) is diluted in 100 ml of 0.9% sodium chloride solution or 5% glucose.
Omeprazole for children
The drug is usually not prescribed to children under 5 years of age. However, for Zollinger-Ellison syndrome and some other acute diseases of the upper digestive tract, the doctor may prescribe Omeprazole. In this case, the dose of the drug is calculated based on the child’s body weight.
1. For body weights up to 10 kg, the drug is prescribed at a dose of 5 mg per day.
2. With a weight of 10 to 20 kg, the daily dose of the drug is 10 mg.
3. If the child weighs 20 kg or more, a single dose of 20 mg of Omeprazole per day is allowed.
Omeprazole during pregnancy
Pregnancy is a contraindication for the use of Omeprazole. It is especially important to avoid taking the drug in the first trimester of pregnancy, because in this case, the risk of developing pathology increases sharply cardiovascular systems s in the fetus. During the remaining stages of pregnancy, Omeprazole is prescribed with great caution and only when positive effects from the drug outweigh the possible side effects.
Omeprazole for gastritis
Omeprazole is prescribed only for gastritis with high acidity! For normo- and hypoacid gastritis, Omeprazole is contraindicated and can provoke the development atrophic gastritis with zero acidity of gastric juice.
The maximum effect from a single dose of Omeprazole at a dose of 20 mg occurs on average after 1.5-2 hours. The therapeutic effect of the drug lasts from 18 to 24 hours, therefore, for gastritis, the daily dose of Omeprazole is 1 capsule (20 mg). The duration of treatment usually does not exceed 2–3 weeks. During this time, the acidity of the stomach is normalized and the main symptoms of gastritis are eliminated.
If gastritis is associated with Helicobacter pylori infection, then along with Omeprazole it is necessary to carry out mandatory antibacterial treatment according to one of the generally accepted regimens in this case (triple therapy).
Omeprazole for heartburn
Omeprazole effectively eliminates heartburn symptoms during various diseases gastrointestinal tract. However, taking it independently is allowed only as an exception, as an emergency aid. Its dose in this case should not exceed 10 mg per day. Therapeutic effect from Omeprazole develops after 4-5 days, and the full course of treatment should not exceed 14 days. Treatment with Omeprazole can be repeated no earlier than after 4 months.
If heartburn returns after treatment, you should consult a doctor for advice and examination. The same should be done for frequently recurring heartburn, especially if it occurs more than 2 days a week. In this case, appropriate treatment with Omeprazole in appropriate dosages will be prescribed.
Interaction of Omeprazole with other drugs
Omeprazole can change the effect of any drug (Ketoconazole, Itraconazole, Ampicillin, iron salts, etc.), the activity and absorption of which depends on the pH of the stomach.
Drugs that are transformed in the liver (Warfarin, Diazepam, Phenytoin, etc.) may, when interacting with Omeprazole, break down more slowly, increasing their concentration in the blood and tissues. Omeprazole also slows down the release of tranquilizers from the body (Sibazon, Diazepam, Elenium). In these cases, it may be necessary to reduce the dose of these medications.
Omeprazole may enhance the effect of anticoagulants indirect action and anticonvulsants (coumarins, Diphenin). When taking Clarithromycin and Omeprazole simultaneously, the effects are mutually enhanced.
Omeprazole enhances the negative effect of other drugs on the hematopoietic system.
Omeprazole analogues
Due to its popularity and high efficiency Omeprazole has many analogues and generic drugs (synonyms), which contain the same main active ingredient, but differ significantly in price.
The most popular analogues (synonyms) that are allowed in Russia:
There are also other analogs of Omeprazole that are not registered in the Russian Federation:
Antra MUPS, Prilosec, Lokit, Proseptin, Romesek are widely used in the European pharmacy market.
Price from 271 rubles. The analogue is 242 rubles more expensive
Instructions for use with Omeprazole
Registration number:
LP-001970Trade name: Omeprazole-Teva
International generic name(INN): omeprazole
Dosage form:
enteric capsulesCompound
Dosage 10 mg
1 capsule contains:
active substance omeprazole 10.00 mg;
Excipients: granulated sugar [sucrose, starch syrup] 48.00 mg, sodium carboxymethyl starch type A 2.10 mg, sodium lauryl sulfate 2.99 mg, povidone 4.75 mg, potassium oleate 0.644 mg, oleic acid 0.107 mg, hypromellose 3.00 mg, methacrylic acid and ethyl acrylate copolymer 20.455 mg. triethyl citrate 2.345 mg, titanium dioxide (E171) 0.75 mg talc 0.095 mg.
Cellulose capsule: carrageenan 0.15 mg, potassium chloride 0.2 mg, titanium dioxide (E171) 3.1912 mg, hypromellose 39.96 mg, water 2.30 mg, sunset yellow dye (E110) 0.3588 mg, iron oxide dye red (E172) 0.5888 mg, charming red dye (E129) 0.276 mg.
Dosage 20 mg
1 capsule contains: active substance omeprazole 20.00 mg;
Excipients: granulated sugar [sucrose, starch syrup] 96.00 mg, sodium carboxymethyl starch type A 4.20 mg, sodium lauryl sulfate 5.98 mg, povidone 9.50 mg, potassium oleate 1.287 mg, oleic acid 0.214 mg, hypromellose 6.00 mg , melacrylic acid and ethyl acrylate copolymer 40.91 mg, triethyl citrate 4.69 mg, titanium dioxide (E171) 1.50 mg, talc 0.19 mg.
Cellulose capsule: carrageenan 0.185 mg, potassium chloride 0.265 mg, titanium dioxide (E171) 3.60 mg, hypromellose 52.05 mg, water 3.00 mg, sunset yellow dye (E110) 0.468 mg charming red dye (E129) 0.096 mg , brilliant blue dye (E133) 0.336 mg.
Dosage 40 mg
1 capsule contains: active substance omeprazole 40.00 mg:
excipients: granulated sugar [sucrose, starchy molasses] 1912.00 mg, sodium carboxymethyl starch type A 8.40 mg, sodium lauryl sulfate 11.96 mg, povidone 19.00 mg, potassium oleate 2.576 mg, oleic acid 0.428 mg, hypromellose 12.00 mg , methacrylic acid and ethyl acrylate copolymer 81.82 mg triethyl citrate 9.38 mg, titanium dioxide (E171) 3.00 mg, talc 0.38 mg.
Cellulose capsule: carrageenan 0.283 mg, potassium chloride 0.397 mg, titanium dioxide (E171) 5.40 mg, hypromellose 78.07 mg, water 4.50 mg, sunset yellow dye (E110) 0.702 mg, charming red dye (E129) 0.144 mg, brilliant blue dye (E133) 0.504 mg.
Composition of white ink used for inscription on capsules (for all dosages): shellac 11-13%, ethanol 15-18%, isopropanol 15-18%, propylene glycol 1-3%, butanol 4-7%, povidone 10-13%, sodium hydroxide 0.m5-0.1%, titanium dioxide (E 7) -32-36-%.
Description
Dosage 10 mg.
Hard opaque cellulose capsules No. 3 with an orange body and a red cap. “O” is written in white ink on the lid and “10” on the body.
Dosage 20 mg.
Hard opaque cellulose capsules No. 2 with an orange body and a blue cap. “O” is written in white ink on the cover and “20” on the body.
Dosage 40 mg.
Hard opaque cellulose capsules No. 0 with an orange body and a blue cap. “O” is written in white ink on the lid and “40” on the body.
The contents of the capsules are micropellets from white to white with a yellowish or pinkish tint.
Pharmacotherapeutic group:
gastric glands secretion reducing agent - proton pump inhibitor.ATX code: A02BC01
Pharmacological properties
Pharmacodynamics. Inhibits the activity of H + /K + -ATPase in the parietal cells of the stomach and thereby blocks the final stage of hydrochloric acid secretion. The effect of omeprazole on last stage the process of formation of hydrochloric acid is dose-dependent and provides effective inhibition of basal and stimulated secretion, regardless of the nature of the stimulating factor.
When taken daily, omeprazole provides rapid and effective inhibition of daytime and nighttime hydrochloric acid secretion. The maximum effect is achieved within 4 days. In patients with duodenal ulcer, taking 20 mg of omeprazole maintains intragastric acidity at a pH level of more than 3 for 17 hours.
The action of omeprazole together with antibacterial drugs leads to the eradication of Helicobacter pylori, which allows you to quickly relieve the symptoms of the disease and achieve high degree healing of damaged mucous membrane and stable long-term remission and reduce the likelihood of bleeding from the gastrointestinal tract (GIT), and also eliminates the need for long-term antiulcer therapy.
Pharmacokinetics
Suction and distribution. After taking the drug orally, omeprazole is quickly absorbed from the small intestine, the maximum concentration in the blood plasma (C max) is achieved after 0.5-3.5 hours.
Bioavailability is 30-40%, with liver failure- 100%. Binding to blood plasma proteins (albumin and acidic α1-glycoprotein) is about 90%.
Metabolism and excretion. (omeprazole is almost completely metabolized in the liver with the participation of the CYP2C19 enzyme system with the formation of six pharmacologically inactive metabolites (hydroxyomeprazole, sulfide and sulfone derivatives, etc.). It is an inhibitor of the CYP2C19 isoenzyme.
Half-life (T 1/2) - 0.5-1 hour, in case of liver failure - 3 hours. Clearance 300-600 ml/min.
It is excreted by the kidneys (70-80%) and through the intestines (20-30%) in the form of metabolites.
Pharmacokinetics in special clinical situations. In chronic renal failure, excretion decreases in proportion to the decrease in creatinine clearance.
In elderly people, the excretion of omeprazole decreases and bioavailability increases.
Indications for use
- peptic ulcer of the stomach and duodenum, incl. relapse prevention;
- gastroesophageal reflux disease (GERD), reflux esophagitis, incl. relapse prevention;
- erosive and ulcerative lesions of the stomach and duodenum associated with taking non-steroidal anti-inflammatory drugs (NSAIDs);
- erosive and ulcerative lesions of the stomach and duodenum associated with Helicobacter pylori (as part of combination therapy);
- Zollinger-Ellison syndrome and others pathological conditions associated with decreased gastric secretion. Contraindications
Hypersensitivity to omeprazole or any of the components of the drug; fructose intolerance; sucrose/isomaltose deficiency; glucose-galactose malabsorption; joint use with clarithromycin in patients with liver failure, atazanavir, St. John's wort; pregnancy, breastfeeding period; age up to 18 years.Carefully
Liver failure; renal failure; simultaneous use with clarithromycin.Use during pregnancy and breastfeeding
The use of omeprazole during pregnancy and breastfeeding is contraindicated due to insufficient data on efficacy and safety in this category of patients.Directions for use and doses
Inside, in the morning before meals or during meals, with a small amount of water; The contents of the capsule must not be chewed.
Adults
With exacerbation of gastric ulcer, duodenal ulcer and reflux esophagitis
20 mg 1 time per day. The course of treatment is 4-8 weeks. In some cases, it is possible to increase the dose to 40 mg per day.
With maintenance therapy for GERD to prevent relapses
10-20 mg for 26-52 weeks depending on the clinical effect, for severe esophagitis - for life.
In the treatment of erosive and ulcerative lesions of the stomach and duodenum associated with taking NSAIDs (including for the prevention of relapses)
10-20 mg per day.
For Zollinger-Ellison syndrome
The dose is set individually. The recommended starting dose is 60 mg once daily. If necessary, the dose is increased to 80-120 mg per day, in which case it should be divided into two doses.
Erosive and ulcerative lesions of the stomach and duodenum associated with Helicobacter pylori
20 mg 2 times a day in combination with antibacterial drugs for 7 days. In patients with gastric and/or duodenal ulcers in the acute stage, it is possible to extend monotherapy with omeprazole.
In elderly patients, no dose adjustment is required.
In patients with insufficient renal function, no dose adjustment is required.
In patients with liver failure, the maximum daily dose is 20 mg.
If you have difficulty swallowing a whole capsule, you can swallow its contents after opening or dissolving the capsule, or you can mix the contents of the capsule with a slightly acidified liquid (juice, yogurt) and use the resulting suspension for 30 minutes.Side effect
The frequency of side effects is classified in accordance with the recommendations of the World Health Organization: very often - at least 10%; often - at least 1%, but less than 10%; infrequently - not less than 0.1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely (including isolated cases) - less than 0.01%.
From the blood and lymphatic system: rarely - hypochromic microcytic anemia in children; very rare - reversible thrombocytopenia, leukopenia, pancytopenia, agranulocytosis.
From the immune system: very rarely - satiety, increased body temperature, angioedema, constriction of the bronchi, allergic vasculitis, fever, anaphylactic shock.
From the nervous system: often - headache, dizziness, insomnia, drowsiness, lethargy (the listed side effects tend to worsen with long-term therapy): rarely - paresthesia, confusion, hallucinations, especially in elderly patients or in severe cases of the disease; very rarely - anxiety, depression, especially in elderly patients or in severe cases of the disease.
From the side of the organ of vision: infrequently - visual disturbances, incl. decrease in visual fields, decrease in the acuity and clarity of visual perception (usually disappear after cessation of therapy).
Hearing and labyrinth disorders: infrequently - disorders of auditory perception, incl. "ringing in the ears" (usually disappears after cessation of therapy).
From the gastrointestinal tract: often - nausea, vomiting, flatulence, constipation, diarrhea, abdominal pain (in most cases, the severity of these phenomena increases with continued therapy); infrequently - taste perversion (usually disappears after cessation of therapy); rarely - a change in the color of the tongue to brown-black and the appearance of benign cysts of the salivary glands when used simultaneously with clarithromycin (the phenomena are reversible after cessation of therapy); very rarely - dry mouth, stomatitis, candidiasis, pancreatitis.
From the liver and biliary tract: infrequently - changes in liver enzymes (reversible); very rarely - hepatitis, jaundice, liver failure, encephalopathy, especially in patients with liver disease.
For the skin and subcutaneous tissues: uncommon - rash, itching, alopecia, erythema multiforme, photosensitivity, increased sweating; very rarely - Stevens-Johnson syndrome, toxic epidermal necrolysis.
From the musculoskeletal and connective tissue: infrequently - fractures of the vertebrae, wrist bones, femoral head (see section " special instructions"); rarely - myalgia, arthralgia; very rarely - muscle weakness.
From the kidneys and urinary tract: rarely - interstitial nephritis.
General disorders and disorders at the injection site: uncommon - peripheral edema (usually disappears after cessation of therapy); rarely - hyponatremia; very rarely - hypomagnesemia (see section "Special instructions"), gynecomastia.Overdose
Symptoms: blurred vision, drowsiness, agitation, confusion, headache, increased sweating, dry mouth, nausea, arrhythmia.
Treatment: carrying out symptomatic therapy, hemodialysis is not effective enough. A specific antidote is not known.Interaction with other drugs
When used simultaneously with omeprazole, the absorption of ketoconazole may be reduced.
When used simultaneously with omeprazole, the bioavailability of digoxin increases by 10% due to an increase in pH.
Omeprazole may reduce the absorption of vitamin B12 with long-term use.
Omeprazole should not be used concomitantly with St. John's wort due to clinically significant interactions.
With simultaneous use of omeprazole and clarithromycin, their concentrations in blood plasma increase.
When administered simultaneously with omeprazole, the area of the modes of the concentration-time curve of atazanavir decreases by 75%, therefore their simultaneous use is contraindicated.
When used simultaneously with omeprazole, it is possible to slow down the excretion of warfarin, diazepam and phenytoin, as well as imipramine, clomipramine, citalopram, hexabarbital, disulfiram, since omeprazole is biotransformed in the liver with the participation of the CYP2C19 isoenzyme. Doses of these drugs may need to be reduced. When using omeprazole with caffeine, propranolol, theophylline, metoprolol, lidocaine, quinidine, erythromycin, phenacetin, estradiol, amoxicillin, naproxen, piroxicam and antacids, no clinically significant interaction has been established.special instructions
Before starting therapy, it is necessary to exclude the presence of a malignant process in the upper gastrointestinal tract, because Taking Omeprazole-Teva may mask symptoms and delay the correct diagnosis.
A decrease in gastric acidity, including when using proton pump blockers, increases the number of bacteria in the gastrointestinal tract, which increases the risk of gastrointestinal infections.
In patients with severe insufficiency Liver function requires regular monitoring of liver enzymes during therapy with Omeprazole-Teva.
Omeprazole-Teva contains sucrose and is therefore contraindicated in patients with congenital disorders of carbohydrate metabolism (fructose intolerance, sucrase/isomaltose deficiency, glucose-galactose malabsorption).
When treating erosive and ulcerative lesions associated with NSAID use, the possibility of limiting or discontinuing NSAID use should be carefully considered to increase the effectiveness of antiulcer therapy.
The drug contains sodium, which should be taken into account in patients on a controlled sodium diet.
The risk-benefit ratio of long-term (more than 1 year) maintenance therapy with Omeprazole-Teva should be regularly assessed. There is evidence of an increased risk of fractures of the vertebrae, wrist bones, and head of the femur, mainly in elderly patients, as well as in the presence of predisposing factors. Patients at risk of developing osteoporosis should ensure adequate intake of vitamin D and calcium.
There are reports of the occurrence of severe hypomagnesemia in patients receiving therapy with proton pump inhibitors, including omeprazole, for more than 1 year.
Patients receiving omeprazole therapy for a long time, especially in combination with digoxin or other drugs that reduce magnesium levels in the blood plasma (diuretics), require regular monitoring of magnesium levels.Impact on the ability to drive vehicles and operate equipment
Considering the possibility of undesirable effects on the central nervous system and the organ of vision, during treatment with omeprazole, care must be taken when driving vehicles and engaging in potentially hazardous activities that require increased concentration attention and speed of psychomotor reactions.Release form
enteric capsules 10 mg, 20 mg, 40 mg.
6 or 7 capsules in a blister made of aluminum foil/PVC/PVDC and polyamide film/aluminum foil/PVC.
5 blisters of 6 capsules each or 2 or 4 blisters of 7 capsules each along with instructions for use in a cardboard box.Best before date
2 years.
Do not use after the expiration date stated on the package.Storage conditions
Store at a temperature not exceeding 25°C.
Keep out of the reach of children.Conditions for dispensing from pharmacies
On prescription.Legal entity in whose name the RU was issued:
Teva Pharmaceutical Enterprises Ltd., IsraelManufacturer:
Teva Pharma, S.L.U., Polygon Industrial Malpica, Calle S, no. 4, 50016 Zaragoza: Spain Address for receiving complaints:
119049, Moscow, Shabolovka st., 10, bldg. 1
Inexpensive and effective
Advantages: Price, does not taste bad, available in all pharmacies
Disadvantages: none found
I have always had a weak digestive system. No matter what kind of treatment they prescribed to me, the drugs were simply at an exorbitant price, but it turned out that not everything is good, it is very expensive. Paid doctors prescribed mainly foreign drugs, but the pills didn’t always help - I just started vomiting. They treated him to the point where an ulcer appeared. And not in the stomach, but in the duodenum. When there was no longer any strength or means left to fight, I went to an ordinary clinic to see an ordinary doctor. The gray-haired grandfather prescribed Omeprazole. To be honest, I didn’t think that this could somehow help me, but I still took the pills as prescribed. After two weeks I almost didn’t remember what heartburn was, and after a month the abdominal pain went away and so far they haven’t appeared again. I continue to take these pills, as the doctor suggested, in courses, with breaks. I'm going to have a follow-up appointment soon and I really want to know how I'm doing.
Good for preventing peptic ulcers
Advantages: inexpensive, effective
Disadvantages: cumulative, must be taken according to a schedule, removes calcium from the body
Three years ago, my husband was diagnosed with a duodenal ulcer. Then we had a long course of treatment in a hospital, but then, when we were discharged, we had to undergo preventive courses of therapy every six months. Even if you follow a diet and correct mode work and rest cannot be avoided from pills. One of the drugs that my husband takes without fail is Omeprazole. Despite the fact that the instructions describe a lot of side effects, we avoided this. The drug is effective, noticeable immediately, traces of heartburn are gone. The course of treatment is usually 10-14 days, take a tablet thirty minutes before meals. The doctor said that Omeprazole removes calcium from the body, so he was required to drink regular calcium gluconate.
They helped a lot!
Advantages: Helps with ulcers, price, no side effects
Disadvantages: side effects
I suffered from stomach pain, one might say, constantly. But I just couldn’t decide to go to the doctor. It got to the point that during the last such attack I had to call an ambulance. They said it was gastritis initial stage ulcers already. The doctor said that I need to take Omeprazole for a month. As soon as I took the medicine for the first time, the pain stopped, and after a full month’s course I didn’t remember about it at all. I will say that the list of side effects certainly confused me greatly, but thank God, nothing strange happened to me when taking Omeprazole. In a word, I am satisfied with the medicine.
I've heard a lot good feedback
Benefits: Copes with diseases, reviews from friends
Disadvantages: None
I've heard about Omeprazole and it similar drugs, there are a lot of good reviews from friends or colleagues in the fight against GERD or other gastrointestinal diseases, but I myself have already gotten used to taking Rabeloc for these problems. It is also very effective, quite easy to use - one tablet a day is enough.
Helped with stomach pain
Benefits: Efficiency
Disadvantages: none found
I have never suffered from gastritis or ulcers, but like all people, I periodically have stomach pain, especially when I eat something harmful: fatty or spicy. That's how it is this time: I'm full fried meat and my stomach hurt, I couldn’t sleep at night. I didn’t know what to do, since I didn’t want to drink painkillers in this case, I drank activated charcoal, but it doesn’t relieve the pain. In the morning I called my sister, and she is an experienced gastritis sufferer, and she advised me to take Omeprazole. It is usually prescribed for ulcers, but her gastroenterologist advised her to treat gastritis with Omeprazole. You need to take 1 capsule a day, the pain subsided the very next day after taking the first tablet.
***For moderators who reject a question marked “contact your local therapist.” Answer: I contacted him more than once, he doesn’t prescribe anything other than opeprazole, and they don’t force me into any further examinations, that’s why I’m asking for advice here, where should I go and what could be the causes of my problems.” Good afternoon! I really ask for help with my strange stomach problems Background: In childhood, asthma and allergies were treated, the symptoms of asthma went away by the age of 15, gastritis began. At the age of 18, I had a stomach ulcer (it manifested itself as heartburn, there was no pain), since then I have had heartburn and stomach problems once for 8 years. , then gastrodudenitis and gastritis. Until the age of 22, inflammations occurred in February-April or October-November. Omeprazole 20 mg helped a lot, after 1 tablet you forget about heartburn, after a couple of weeks you stop drinking and are healthy. Then inflammations became frequent, it happened to the point of nausea. in a lying position, doctors wrote that there was cardia insufficiency and possibly a hernia. hiatus diaphragm (I don’t remember how they did an x-ray with barium). The attending physician did not test for Helicobacter, but gave 1 antibiotic + omeprazole for inflammation. So, for a year and a half, the symptoms were relieved (at the age of 23, they already happened more than 2 times a year, they were treated with antibiotics only in the spring and autumn). It seems I did an air test, there was no Helicobacter. Bottom line: in those days the symptoms were the same as for ordinary gastritis, the symptoms were standard (heartburn on an empty stomach, I ate and it went away, I drank omeprazole it went away, and more often antacids helped). At 24-25 years old, things became more complicated, the symptoms became more frequent, omeprazole 20 mg no longer helped to forget the symptoms in one dose and a short course of a couple of weeks. T.K. I moved, new doctor I immediately took a stool test for Helicobacter, which was negative, so I was forbidden to take antibiotics in the fall and spring. Heartburn has become regular at night, regardless of omeprazole, and there are almost no daytime symptoms. Having trouble sleeping due to acid or stomach contents in the throat. Gastroscopy with biopsy in July 2014 showed nothing but gastritis. Currently, since November, heartburn has been bothering me every night, I took omeprazole 20, the symptoms appeared and disappeared for a couple of days, and as a result the condition worsened. I bought a bed lift, sleeping with the headboard raised doesn't really help. Symptoms: after eating, violent belching (no smell), a lot of gas moving around the stomach, there is often a feeling that there is food in the stomach, the stomach is full (if you eat a little more than usual or some kind of hamburger), but the food does not pass into the intestines for about 2 hours. 3, very unpleasant. Based on observations, I found that food leaves immediately at the moment of transition to sleep, as soon as you start to fall asleep, the sphincter opens and relief comes. That's why I fought short nap if it happened during the day. Stomach spasms (nerves?) occur. At night dry throat from the Adam's apple area and above (from 12 o'clock at night, even when you are still awake and there is no heartburn), water does not help, it will only help if you accidentally smell the allergen and start sneezing, the mucous membranes are immediately moisturized. I often confuse this with heartburn, because my throat hurts in the morning, but I don’t understand why, because the acid in my mouth seems to disappear in the morning, after taking omeprazole 40 at night. I don’t agree with the doctor that it’s all about reflux. It’s difficult to objectively assess my symptoms, I’m already confused about them, and the doctor doesn’t prescribe daily ph-metry. The stomach and, it seems, duodenum, as far as I understand the anatomy, are “pulling” at night, the pain is not pronounced, nagging, very weak, it started a month ago. It hurts when pressed (the doctor did palpation) - area solar plexus- and up to just above the navel. All this is connected with long sleep as I noticed, when you wake up in the morning you feel a very strong activity of the stomach and intestines, everything there is rumbling, seething and thriving, and that’s when it bothers you. If you sleep during the day or evening for more than an hour and a half, the symptoms will be the same. Symptoms go away immediately after waking up (5-10 minutes), an irritated throat or when there is acid in the esophagus - after a couple of hours. THOSE. While awake, nothing bothers me (except for belching after eating), all the problems are only in my sleep, and there are often nightmares there. Over the past 5 days, the symptoms have become even stronger at night, despite omeprazole 40, the doctor did a general blood test and ultrasound abdominal organs, everything is normal, he prescribed me to drink omeprazole 40 twice a day. Although after 2 days of taking it, the activity in the stomach increased even more at night. Other symptoms include: red eyes in the morning, terrible itching in the ears (in the mornings and spontaneously in the afternoon), severe dandruff and itchy scalp if you don’t wash it for at least 2 days. A slight itching in the trachea during the day (it seemed to me that it was not the esophagus, because a sip of water does not help, but if you cough, it seems as if you were scratching it) - as a rule, a loratadine tablet relieves this itching after a couple of hours. At night you really want to eat, at 1 and 5 o’clock in the morning, you often wake up. Bottom line, maybe we’re not treating the right thing at all? Maybe it's a matter of bacterial imbalance in the intestines? Or allergies? Or is there something wrong with the nervous system (why are the symptoms mostly in sleep)? The doctor doesn’t really want to look for the cause, as I understand, omeprazole is easier to prescribe. But I don’t know what to do anymore, because you yourself see the symptoms are different from standard gastritis, etc. And yes, of course no alcohol, junk food I try not to eat, I make sure that I drink enough water for six months, although on the other hand I didn’t exercise at all for six months (usually when I took breaks from exercise, my mood immediately worsened, without happiness hormones, maybe this is also part of the problem). In general, I’m at a dead end, I’ve studied the entire topic of stomach problems over the past years, up and down, I read mostly academic articles (gastroscan.Ru), but I can’t compare the symptoms, while I see a lot possible reasons problems, what to take on is not clear, please direct me :) in the near future I will visit an allergist and have a chest x-ray. Thanks a lot.
The cause of gastric ulcers is its excessive acidity, an overly aggressive environment that provokes damage to the mucous membrane. To combat this phenomenon, various drugs are used pharmacological groups, among which a prominent place is occupied by the so-called proton pump inhibitors or proton pump inhibitors. The proton pump (alternatively called H+/K+-ATPase) is an enzyme that plays a major role in the secretion of hydrochloric acid by parietal (parietal) cells of the gastric mucosa. Thanks to his tireless work, H+ and Cl ions are released into the lumen of the stomach, which subsequently happily combine into hydrochloric acid. If this process takes pathological character, then it’s time to slow down the functioning of the proton pump, which is successfully accomplished by a drug such as omeprazole, with the direct participation of which the final stage of hydrochloric acid synthesis is blocked. Under such conditions, both stimulated and basal (without the presence of a stimulus) secretion of hydrochloric acid decreases.
The effect of omeprazole develops within 1 hour after administration, reaches its peak in the second hour and lasts for almost the whole day. In order to evaluate the full power of omeprazole, you should pay attention to specific figures: 20 mg of the drug is enough to maintain the intragastric pH in a patient suffering from duodenal ulcer at level 3 for 17 hours.
After discontinuation of omeprazole, secretion returns to normal within 3-5 days.
Omeprazole is available in enteric capsules, which should be swallowed without chewing, along with a small amount of liquid. The dose, frequency and duration of administration is determined by the specific disease. Thus, an acute duodenal ulcer requires taking 20 mg (1 capsule) of omeprazole per day for 2-4 weeks; in especially severe cases, the daily dose can be increased to 2 capsules. For acute gastric ulcers and erosive-ulcerative inflammation of the esophagus, 1-2 capsules of the drug per day are taken for 4-8 weeks. The duration of taking omeprazole is similar for erosive and ulcerative lesions of the digestive tract caused by taking non-steroidal anti-inflammatory drugs, however, the daily dose should not exceed 1 capsule in this case. For helicobacteriosis, the drug is taken 1 capsule 2 times a day for 1 week in combination with antibiotics. Omerpazole can be taken after the active phase of the disease has ceased in order to prevent relapses. In such cases, the drug is taken 1 capsule once a day for a long (up to six months) period of time.
It is very important (especially for gastric ulcers) to undergo an oncological examination before starting treatment in order to exclude the presence of malignant neoplasms. Otherwise, you can hide the symptoms of cancer, which can lead to untimely initiation of treatment.
Pharmacology
Omeprazole is an antiulcer drug, an inhibitor of the enzyme H + /K + -adenosine triphosphate (ATP) phase. Inhibits the activity of H + /K + - adenosine triphosphate (ATP phase (H + /K + -adenosine triphosphate (ATP) phase, also known as - " proton pump"or "proton pump") in the parietal cells of the stomach, thereby blocking the transfer of hydrogen ions and the final stage of hydrochloric acid synthesis in the stomach. Omeprazole is a prodrug. In the acidic environment of the parietal cell tubules, omeprazole is converted into the active metabolite sulfenamide, which inhibits membrane H + / K + - adenosine triphosphate (ATP) phase, connecting with it due to the disulfide bridge. This explains the high selectivity of the action of omeprazole on parietal cells, where there is a medium for the formation of sulfenamide. The biotransformation of omeprazole into sulfenamide occurs quickly (within 2-4 minutes). Sulfenamide is a cation and is not absorbed.
Omeprazole suppresses basal and stimulated by any stimulus secretion of hydrochloric acid at the final stage. Reduces the total volume of gastric secretion and inhibits the release of pepsin. Omeprazole has gastroprotective activity, the mechanism of which is not clear. Does not affect products internal factor Castle and the speed of transition of food mass from the stomach to the duodenum. Omeprazole does not act on acetylcholine and histamine receptors.
Omeprazole capsules contain film-coated microgranules, the gradual release and onset of action of omeprazole begins 1 hour after administration, reaches a maximum after 2 hours, and persists for 24 hours or more. Inhibition of 50% of maximum secretion after a single dose of 20 mg of the drug lasts 24 hours.
A single dose per day provides rapid and effective suppression of daytime and nighttime gastric secretion, reaching its maximum after 4 days of treatment. In patients with duodenal ulcers, taking 20 mg of omeprazole maintains pH = 3 inside the stomach for 17 hours. After stopping the drug, secretory activity is completely restored after 3-5 days.
Pharmacokinetics
Absorption is high. Bioavailability is 30-40% (in case of liver failure it increases to almost 100%), increases in elderly people and in patients with impaired liver function; insufficiency of renal function has no effect. TC max - 0.5-3.5 hours.
Possessing high lipophilicity, it easily penetrates the parietal cells of the stomach. Communication with plasma proteins is 90-95% (albumin and acidic alpha 1-glycoprotein).
T1/2 - 0.5-1 hour (for liver failure - 3 hours), clearance - 500-600 ml/min. Almost completely metabolized in the liver with the participation of the CYP2C19 enzyme system, with the formation of 6 pharmacologically inactive metabolites (hydroxyomeprazole, sulfide and sulfone derivatives, etc.). It is an inhibitor of the CYP2C19 isoenzyme. Excretion by the kidneys (70-80%) and bile (20-30%) in the form of metabolites.
In chronic renal failure, excretion decreases in proportion to the decrease in creatine clearance. In elderly patients, excretion decreases.
Release form
Gelatin capsules, with a white body and a yellow cap; the contents of the capsules are spherical microgranules, coated, white or white with a creamy tint.
10 pieces. - contour cell packaging (3) - cardboard packs.
Dosage
Orally, capsules are usually taken in the morning, without chewing, with a small amount of water (immediately before meals).
For exacerbation of peptic ulcer, reflux esophagitis and gastropathy caused by taking NSAIDs - 20 mg 1 time per day. For patients with severe reflux esophagitis, the dose is increased to 40 mg once a day. The course of treatment for duodenal ulcer is 2-4 weeks, if necessary - 4-5 weeks; for gastric ulcers, for reflux esophagitis, for erosive and ulcerative lesions of the gastrointestinal tract caused by taking NSAIDs - for 4-8 weeks.
Reduction of symptoms of the disease and scarring of the ulcer in most cases occurs within 2 weeks. For patients who do not experience complete scarring of the ulcer after a two-week course, treatment should be continued for another 2 weeks.
Patients resistant to treatment with other antiulcer drugs are prescribed 40 mg per day. The course of treatment for duodenal ulcer is 4 weeks, for gastric ulcer and reflux esophagitis - 8 weeks.
For Zollinger-Elisson syndrome - usually 60 mg 1 time per day; if necessary, the dose is increased to 80-120 mg/day (the dose is divided into 2 doses).
To prevent relapses of peptic ulcer - 10 mg 1 time per day.
To eradicate Helicobacter pylori, “triple” therapy is used (within 1 week: omeprazole 20 mg, amoxicillin 1 g, clarithromycin 500 mg - 2 times a day; or omeprazole 20 mg, clarithromycin 250 mg, metronidazole 400 mg - 2 times a day). day; either omeprazole 40 mg once a day, amoxicillin 500 mg and metronidazole 400 mg - 3 times a day)
or “double” therapy (for 2 weeks: omeprazole 20-40 mg and amoxicillin 750 mg - 2 times a day or omeprazole 40 mg - 1 time a day and clarithromycin 500 mg - 3 times a day or amoxicillin 0.75-1.5 g -2 times a day).
For liver failure, 10-20 mg is prescribed once a day (for severe liver failure, the daily dose should not exceed 20 mg); in case of impaired renal function and in elderly patients, no dosage adjustment is required.
Overdose
Symptoms: confusion, blurred vision, drowsiness, dry mouth, nausea, tachycardia, arrhythmia, headache.
Treatment: symptomatic. Hemodialysis is not effective enough. There is no specific antidote.
Interaction
May reduce the absorption of ampicillin esters, iron salts, itraconazole and ketoconazole (omeprazole increases gastric pH).
Being inhibitors of cytochrome P450, it can increase the concentration and reduce the excretion of diazepam, indirect anticoagulants, phenytoin (drugs that are metabolized in the liver via cytochrome CYP2C19), which in some cases may require a reduction in the doses of these drugs. May increase plasma concentrations of clarithromycin.
In the same time long-term use omeprazole at a dose of 20 mg 1 time per day in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol, cyclosporine, lidocaine, quinidine and estradiol did not lead to a change in their plasma concentrations.
Strengthens the inhibitory effect on the hematopoietic system and other drugs.
There was no interaction with concomitantly taken antacids.
Side effects
From the digestive system: diarrhea or constipation, abdominal pain, nausea, vomiting, flatulence; in rare cases - increased activity of liver enzymes, taste disturbances, in some cases - dry mouth, stomatitis, in patients with previous severe liver disease - hepatitis (including jaundice), impaired liver function.
From the nervous system: in patients with severe concomitant somatic diseases- headache, dizziness, agitation, depression, in patients with previous severe liver disease - encephalopathy.
From the musculoskeletal system: in some cases - arthralgia, myasthenia, myalgia.
From the hematopoietic system: in some cases - leukopenia, thrombocytopenia, agranulocytosis, pancytopenia.
From the outside skin: rarely - skin rash and/or itching, in some cases photosensitivity, multiforme exudative erythema, alopecia.
Allergic reactions: urticaria, angioedema, fever, bronchospasm, interstitial nephritis and anaphylactic shock.
Other: rarely - visual disturbances, malaise, peripheral edema, increased sweating, gynecomastia, formation of gastric glandular cysts during long-term treatment(a consequence of inhibition of hydrochloric acid secretion, is benign, reversible).
Indications
- peptic ulcer of the stomach and duodenum (in the acute phase and anti-relapse treatment), incl. associated with Helicobacter pylori (as part of combination therapy);
- reflux esophagitis (including erosive).
- hypersecretory conditions (Zollinger-Ellison syndrome, stress ulcers of the gastrointestinal tract, polyendocrine adenomatosis, systemic mastocytosis);
- gastropathy caused by taking non-steroidal anti-inflammatory drugs.
Contraindications
- childhood;
- pregnancy;
- lactation period;
- hypersensitivity.
With caution: renal and/or liver failure.
Features of application
Use during pregnancy and breastfeeding
Contraindicated during pregnancy and lactation.Use for liver dysfunction
With caution: liver failure. For liver failure, 10-20 mg is prescribed once a day (for severe liver failure, the daily dose should not exceed 20 mg);Use for renal impairment
With caution: renal failure. If renal function is impaired, no dosage adjustment is required.Use in children
Contraindicated for children.special instructions
Before starting therapy, it is necessary to exclude the presence of a malignant process (especially with a stomach ulcer), since treatment, masking symptoms, can delay the correct diagnosis.
Taking it with food does not affect its effectiveness.
Omeprazole is the name of both the medicine and its active ingredient. This drug is used to reduce the acidity of gastric juice. Omeprazole is the basis of such drugs as Omez, Ultop and Nexium. This substance penetrates the cells lining the stomach and, acting inside them, stops the production of hydrochloric acid. Both basal, that is, constant, background secretion and acid secretion, which is caused by some stimulating reasons, such as food intake, stops. Also, Omeprazole protects the cells themselves from aggressive influences.Important features of this drug are:
- rapid onset of effect – already an hour after administration;
- the end of the dose does not lead to a sharp increase in the production of hydrochloric acid - a “rebound”;
- a decrease in the acidity of gastric contents leads to the destruction of Helicobacter, which is the cause of peptic ulcers - the substances secreted by this microorganism are not neutralized by hydrochloric acid and begin to “poison” the bacteria themselves.
Omeprazole is produced in capsules. The instructions for the drug warn that under no circumstances should they be opened or chewed, since the active substance must come out of the shell in the stomach. Typically, take this remedy once, in the morning, perhaps during breakfast. It is not necessary to drink plenty of Omeprazole capsules. IN critical conditions and if it is impossible to swallow, in a hospital this drug can be administered through an IV or directly into the stomach. Such treatment can only be contraindicated if you are individually intolerant to Omeprazole. This drug can be prescribed to pregnant women only for health reasons. Breastfeeding women should stop breastfeeding.
Side effects and overdose of Omeprazole
Omeprazole is enough safe drug, which is well tolerated by patients. But still, it has a systemic effect and can cause undesirable reactions from the nervous system and hematopoiesis. Some patients experience muscle pain, urinary dysfunction, and dermatological reactions. Allergic manifestations are also likely: urticaria, bronchospasm, anaphylactic shock. Decrease or complete cessation The secretion of hydrochloric acid can also negatively affect the functioning of the digestive system itself - causing vomiting and loss of appetite. In rare cases, liver dysfunction.In case of an overdose of Omeprazole, disturbances in the functioning of the nervous and cardiovascular systems and digestion occur. Treatment is symptomatic, that is, it depends on the complex and strength of the observed lesions.
Reviews about Omeprazole
Patients with various lesions gastrointestinal problems associated with hyperacidity, this medicine is often discussed. And many are very pleased with the effectiveness of Omeprazole and leave good reviews about it. For example, one man said this: “I took Omeprazole for two weeks - subjectively, my health was restored. I didn't notice any side effects. The final verdict will be made by the doctor."But there are also reviews from people who took this medicine with difficulty - they felt headaches, weakness, nausea. There are also reports about allergic reactions, however, not as dangerous as bronchospasm, but, in any case, even the appearance of an itchy rash is a reason to stop taking the drug.
In conclusion, it is worth saying that Omeprazole is a well-known and very effective medicine. But, before you start drinking it, you need to undergo examination by a gastroenterologist, where it will be determined accurate diagnosis. And the decision to prescribe this drug, as well as to stop it, can only be made by a doctor.
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