What does Nise in tablets help with? Instructions for use

Active substance: nimesulide 100 mg.
Excipients: calcium hydrogen phosphate 75 mg, microcrystalline cellulose (type 114) 40 mg, corn starch 54 mg, sodium carboxymethyl starch 35 mg, magnesium stearate 3 mg, colloidal silicon dioxide 2 mg, talc 1 mg.

Description
White with a yellowish tint, round biconvex tablets with a smooth surface.

Pharmacodynamics. Non-steroidal anti-inflammatory drug (NSAID) from the sulfonanilide class. It is a selective competitive inhibitor of cyclooxygenase-2 (COX-2), inhibits the synthesis of prostaglandins at the site of inflammation. The inhibitory effect on COX-1 is less pronounced (less likely to cause side effects associated with inhibition of prostaglandin synthesis in healthy tissues). It has anti-inflammatory, analgesic and pronounced antipyretic effects.

Pharmacokinetics. Absorption when taken orally is high (food intake reduces the rate of absorption without affecting its degree). Time to reach maximum concentration (TCmax) - 1.5-2.5 hours. Communication with plasma proteins - 95%, with erythrocytes - 2%, with lipoproteins - 1%, with acidic alpha1-glycoproteins - 1%. Changing the dose does not affect the degree of binding. The maximum concentration value (Cmax) is 3.5-6.5 mg/l. Volume of distribution - 0.19-0.35 l/kg. Penetrates into the tissues of the female genital organs, where after a single dose its concentration is about 40% of the concentration in plasma. Penetrates well into the acidic environment of the inflammation site (40%) and synovial fluid (43%). Easily penetrates histohematic barriers.
Metabolized in the liver by tissue monooxygenases. The main metabolite, 4-hydroxynimesulide (25%), has similar pharmacological activity, but due to a decrease in molecular size, it is able to quickly diffuse through the hydrophobic COX-2 channel to the active binding site of the methyl group. 4-hydroxynimesulide is a water-soluble compound, the elimination of which does not require glutathione and conjugation reactions of phase II metabolism (sulfation, glucuronidation, etc.). The half-life (T1/2) of nimesulide is 1.56-4.95 hours, 4-hydroxynimesulide is 2.89-4.78 hours. 4-hydroxynimesulide is excreted by the kidneys (65%) and bile (35%), is subject to enterohepatic recycling.
In patients with renal failure (creatinine clearance 1.8-4.8 l/h or 30-80 ml/min), as well as in children and the elderly, the pharmacokinetic profile of nimesulide does not change significantly.

Directions for use and dosage:

Features of application:

Side effects:

Interaction with other drugs:

Contraindications:

Overdose:

Storage conditions:

List B. In a dry place, protected from light, at a temperature not exceeding 25 ° C. Keep out of the reach of children! Shelf life: 3 years. Do not use after the expiration date stated on the package.

Vacation conditions:

On prescription

Package:

Tablets 100 mg.
1, 2 or 10 PVC/aluminum blisters of 10 tablets, along with instructions for use, are packed in a cardboard box.

> Nise for children

Description of the medicine (not an instruction for use!):
Before using the medicine "Nise for children" Be sure to consult your doctor!

Age restrictions : The manufacturer strongly recommends prescribing Nise to older children - starting from the age of twelve.

Composition and type of dispensing in pharmacies : The active substance of Nise is Nimesulide. Excipients depend on the release form (tablets, suspension, gel).
Tablets for oral administration containing 0.1 g of Nimesulide and soluble tablets containing 0.05 g of Nimesulide are packaged in blister packs of 10 pieces and placed in cardboard boxes. 1 box can contain 1, 2 or 10 blister packs.
A suspension containing 0.01 g of Nimesulide per 1 ml is bottled in dark glass bottles with a capacity of 60 ml, equipped with a dosage cap, and packaged in cardboard boxes.

Indications for use :

• Pain syndrome: dental pain, postoperative and post-traumatic pain, neurogenic pain (sciatica, radiculitis, neuropathy, migraine);
• Fever, fever against the background of infectious and inflammatory diseases of any tissues and organs (at a temperature above 38.50C);
• Non-rheumatic, rheumatic and rheumatoid diseases of joints and ligaments (arthritis, arthrosis, spondylosis, myalgia, arthralgia).

Pharmacokinetics and pharmacodynamics: Nimesulide is almost completely absorbed from the intestine; simultaneous food intake reduces the rate of absorption, but does not affect the maximum concentration of the drug in the blood plasma, which is achieved on average one and a half to two and a half hours after administration.

During the first passage of Nimesulide through the liver, its metabolites are formed, which have activity similar to Nimesulide. Subsequently, these metabolites are processed by the liver into inactive substances, a third of which is excreted in bile and excreted in feces, and two-thirds are removed from the body in urine. In children, the elderly and in patients with moderately severe renal failure, the excretion of Nimesulide remains virtually unchanged. Nimesulide and its active metabolites penetrate well into all organs and tissues, including the site of inflammation.

Instructions for use : For adults, the average therapeutic dose is 200 mg per day, the maximum therapeutic dose is 400 mg per day. These doses should be divided into two (for the maximum dose - four) doses.

For children weighing more than 40 kg, Nise is prescribed 100 mg twice a day (maximum daily dose).

For children weighing less than 40 kg, Nise is prescribed in a daily dose at the rate of 3 to 5 mg per 1 kg of the child’s body weight. The dose calculated in this way should be distributed over 2-3 doses. The maximum daily dose for children is 5 mg per 1 kg of body weight.

Children aged two to twelve years are prescribed either a suspension or soluble tablets. Children over 12 years of age can be prescribed regular tablets.

special instructions : Regular use of the drug for more than ten days is not recommended. With long-term use, monitoring of the functional state of the liver and kidneys is necessary. Nise should be used with caution by people employed in hazardous industries, as well as by vehicle drivers, as it can cause dizziness and drowsiness.

Nise is able to enhance the effect of drugs from the group of cardiac glycosides (digoxin and its analogues), diuretics, lithium drugs, drugs to reduce blood clotting, phenytoin, antitumor drugs, drugs for the treatment of non-insulin-dependent diabetes mellitus, NSAIDs.

Contraindications and side effects :

• Children under two years of age.
• Liver dysfunction, severe renal and heart failure.
• Hypersensitivity to Nimesulide or other components of the drug.
• During pregnancy and breastfeeding.
• Inflammatory and ulcerative diseases of the stomach and intestines.
• Blood clotting disorders, bleeding.
• Non-insulin-dependent diabetes mellitus (type II).

1. Gastrointestinal tract: irritation (nausea, heartburn, vomiting, pain), ulceration, bleeding, drug-induced hepatitis, diarrhea;
2. Nervous system: depression, drowsiness, dizziness;
3. Hematopoietic and hemostasis system: suppression of red bone marrow and decreased formation of all types of blood cells, decreased blood clotting.
4. Hypersensitivity reactions (allergy): rash, Quincke's edema, bronchospasm, anaphylaxis.

Reviews about “Nise for Children”:

Tanya They showed on TV how a child fell into a coma through this medicine

Olga The child has a hygroma of the right knee. Nise was prescribed by a rheumatologist. Unless there is a special case, I do not give the child serious medications. Therefore, I do not agree with the mother’s statement: let’s not be afraid. In our time, vitamins are also dangerous. But there are cases when taking such medications is necessary. In particular, many children begin to have convulsions from high temperatures. And in the case of cerebral palsy, children with high temperatures should not be allowed at all. Therefore, a doctor’s opinion is required

Catherine My daughter is 8 months old, sore throat, t39. She roared over her for 3 days, Nurofen’s temperature stopped decreasing on the second day, the child was really suffering. Nise was advised by a neighbor, they gave it to the baby when teething, but for a long time she did not dare to give it (the limit is up to 2 years, after all). I read the reviews here and decided to go. After 1.5 hours the child was sleeping with a normal temperature. The main thing is not to abuse it, the age limit was not set up without reason, and no one has canceled allergies to drugs. And so, in emergency cases, it can be used, I was satisfied with the drug, the baby at least had a rest from the fever.

Mariyka I gave my daughter half a tablet for lacunar tonsillitis at night; the temperature was 39, it was enough for 23 hours, but then in the evening it rose again to 37.8, I gave it another half - I probably shouldn’t have used it anymore at that temperature...

Oksana It is me again. I'm sorry, the drug for children is called nimulid

Oksana A wonderful drug.....for adults. But I wouldn’t give it to a child in tablet form. There is a good alternative for children, the same nise, but in syrup, it’s called nisemulide.

Alyona I have two children, 7 and 4 years old, we use Nise, nothing else helps.

Natalia It helps me and the children a lot, only FOR

Allochka The dentist also prescribed it for me when my wisdom teeth were coming through, I had such pain, I started drinking, the pain goes away literally after 10 minutes, but I shouldn’t abuse them, I only drank when I couldn’t bear it at all. Any pills cure one thing or cripple another.

Evgenia Can Nise be taken as an anti-inflammatory drug if the child does not have a fever and the inflammatory process does not go away?

Ramzizya It helps us a lot too.

Alexey They say Nise affects male potency, is this true?

Olya We, too, are always saved only by the whole family.

ghoul Since I was 2 years old I’ve been drinking Nise, nothing helps anymore, 1/4 now 1/2 once per illness when it’s really bad. There were no side effects

Natalia The child was eight months old, had bronchitis, a temperature in the forties, Efferalgan did not reduce it, the doctor advised Nise, in tablets, 1/4. It helped a lot. It does not reduce the temperature quickly, 1.5-2 hours, but the effect lasts for a very long time. Of course, we try to make do with drugs that are more adapted for children, but there are cases when it is worth giving Nise, in the end, you must agree that an elevated temperature for a long time in a child can be much more dangerous than the side effects of Nise, which are present in everyone without exception medicines.

Julia I am breastfeeding my baby. The tooth was pulled out, the gum was sewn up, the anesthesia wore off, the pain was hellish. I drank Nise, everything went away, now I’m wondering how it will affect the baby during feeding. Help.

Elvira great help for the whole family

Olga My knee hurt very much. It was impossible to get up without help and support. I took one tablet and three hours later the pain was gone. :

Alexei The headache is very rare, but quite severe. My brother has increased weather sensitivity. I am 15 years old. I don’t know how, but for me nise is the only salvation, it doesn’t have any negative effects. Maybe this is due to age, but for me it’s niz excellent product and always helps my brother

Alexander Otitis with wild pain, the prescribed drops don’t help, one pill and suddenly a magician arrived... a night of deep sleep, even sciatica doesn’t bother me.

Elena Nise is an ordinary drug, you just need to use it wisely.

Igor does it really help?

Love Nise is a monstrous pill. I drank them for 7 days and got so twisted that I had to go to the ambulance. The doctor said: “And we have idiots in medicine.....” I won’t write further. But I realized that not everything was as good as the doctor ordered. Nise is completely prohibited in my medicine cabinet.

Inna They release Ibuklin. The pharmacy said that it was being re-registered, but now it is available everywhere.

Saida Does anyone know if they make ibuklin?

taty I don’t understand why this group of drugs is considered in the antiviral group??? NSAIDs do not belong to the above group of drugs. Nise is a good drug, especially if alternatives like paracetamol and ibuprofen do not help...

Julia Although they say it’s harmful, I give Nise to my child. We are already 5 years old. The doctor prescribed it for the first time when he was three years old for a cold. I like the result - the child does not suffer. I myself even take children’s Nise for headaches.

Natalia My 13-year-old daughter was prescribed NIZ due to arthritis. When taken, increased fatigue, depression and irritability are observed. The doctor wanted to exempt me from school for the duration of the appointment, but we refused; apparently, we will have to take advantage of the exemption. Affects when doing homework. Intelligence slows down.

Irina A very effective drug, the main thing is not to abuse it. We use it from the age of 2, for 7 years, but only at a temperature of 38.5 and above.

Galina daughter is 2 years old. gets sick often. temperature up to 40. nise helps very well. but they say it is very harmful. so I try to do without it.

Ksenia Excellent tablets. The child is 1 year and 8 months old. I give from 9 months. always immediately knocks you down. The neighbor is afraid to give to her children; they are constantly in the hospital, they are given injections. What can you say about her, as soon as you sympathize with her mentality. GIVE YOUR CHILDREN NIZE DO NOT BE AFRAID, I give one fourth and it helps.

Natalia My son is 1.3 years old. When a baby's teeth are cutting T40! And not a single drug based on paracetamol or nurofen reduces it! You can pour even a bucket into a child - it will do no good. Nise in suspension in the recommended dose of 2 ml reduces the temperature immediately and permanently. When you have a cold, it goes away for a day or even a day. So what can we say about the dangers of this drug in a minimal dosage compared to the huge and useless amount of ml. other “recommended” children’s medications?!

Sergey My son is 11 years old. For about 4 years now, with the temperature rising above 38, we have been using Nise. Indeed, it does not give a positive effect soon, but for a long time.

Evgeniya My daughter is 4 years old. Since she was 2 years old, we have been lowering her temperature only with high water. It helps quickly and for a long time.

Svetlana Very effective tablets! But I heard somewhere that frequent use is harmful...

Olga My daughter is 9 years old. When the temperature rises, neither paracetamol, nor ibuprofen, nor even an injection of the “lytic mixture” helps. Nise always helps reduce the temperature. The only drawback is that it takes effect after 1.5 - 2 hours.

Irina They lowered my daughter’s temperature with Nimulid (the same Nise only in the form of a suspension). It begins to act after 2 hours, but it lowers the temperature for a long time - 12-24 hours, depending on the cause of the temperature increase. My daughter is 2 years old, so we try not to abuse this drug; we give it only when the temperature is above 39 degrees and paracetamol and ibuprofen do not reduce it.

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Anti-inflammatory analgesics sometimes have to be taken in long courses, so doctors advise choosing the safest and most effective drugs. The group of such drugs includes Nise, an effective pain reliever that rarely causes negative side effects. Before using it, it is important to carefully study the instructions.

Nise - tablet composition

The active ingredient of the described medication is nimesulide in an amount of 100 mg per pill. This substance is a non-steroidal chemical compound from the sulfonanilide group. It inhibits the production of enzymes that are involved in the synthesis of mediators of pain, swelling and inflammation. There are also auxiliary components added to Nise - the composition includes:

• calcium hydrogen phosphate;
• corn starch;
• microcrystalline cellulose type 114;
• sodium carboxymethyl starch;
• magnesium stearate;
• colloidal silicon dioxide;
• purified talc.

Nise tablets - what helps?

The pharmacological agent in question is prescribed only for symptomatic therapy; it does not affect the causes of the disease and its course. Nise tablets – indications for use:

• toothache and headache;
• pain in the postoperative period;
• arthralgia;
• post-traumatic pain;
• inflammation of soft tissues, tendons and ligaments;
• myalgia of rheumatic and other origins;
• febrile syndrome;
• neuralgia.

Medical studies have shown that nimesulide not only eliminates pain, swelling and inflammation, but also prevents damage to cartilage tissue and stops the destruction of collagen. Thanks to this action, there are a number of musculoskeletal pathologies for which Nise is also effective, the indications for use of which are as follows:

• articular syndrome during gouty exacerbations;
• rheumatoid and psoriatic arthritis;
• ankylosing spondylitis;
• radicular syndrome;
• osteoarthritis;
• tenosynovitis;
• spinal pain due to scoliosis and other diseases;
• osteoarthritis;
• tendinitis;
• radiculitis;
• pain due to osteoporosis.

How to take Nise tablets?

The presented drug acts quickly and effectively, but it is important to follow the recommendations for its use. It is advisable to first consult with a doctor before taking Nise - using the medicine in the wrong dosage can cause negative side effects. Additionally, it is necessary to clarify the duration of the therapeutic course.

The described medication is prescribed mainly to adults. Adolescents over 12 years of age with a body weight of 40 kg or more can take Nise tablets in a standard dosage – 100 mg. If the weight is less, the amount of nimesulide is calculated at 3-5 mg per 1 kg. The drug in question is not prescribed to children under 3 years of age. If the child has reached the specified age, it is allowed to use dispersible Nise - tablets for children that dissolve in water. They are available in a dosage of 50 mg of the active ingredient in each pill.

How to take Nise for toothache?

An anti-inflammatory agent based on nimesulide is used to relieve discomfort before and after dental procedures. In these situations, Nise is prescribed according to the classical scheme - tablets for toothache are taken 2 times a day, 1 piece (100 mg). The maximum daily dosage is 200 mg. Experts advise taking pills before meals, but if you experience discomfort in the stomach or intestines, it is better to use Nise tablets after a meal. The duration of the course is calculated individually, but should not exceed 15 days.

How to take Nise for osteochondrosis?

Back pain, inflammation and swelling are also effectively relieved by nimesulide. If osteochondrosis relapses, the standard method of taking Nise is prescribed - 100 mg 2 times a day. Similarly, tablets are used for symptomatic treatment of other musculoskeletal pathologies with pain syndrome. The duration of treatment is determined depending on the severity of clinical signs, mainly 7-12 days.

The presented pharmacological remedy helps with the problem in question, but not always. Nise painkillers are recommended only if an attack occurs against the background of:

• increased body temperature;
• inflammatory processes, such as meningitis;
• tension;
• overwork;
• stress;
• lack of sleep;
• changes in weather conditions;
• toothache;
• blows and bruises;
• surgical interventions;
• medical procedures;
• noise;
• blood pressure surges;
• osteochondrosis;
• pinched nerve roots and other factors.

Nise tablets are ineffective if the cause of the pain syndrome is. In this case, no anti-inflammatory non-steroidal medications will help. For migraine attacks, it is better to take medications that have a direct effect directly on the dilated blood vessels in the brain and block the sensitivity of the trigeminal nerve receptors. These medications include triptans.

How long does the Nise tablet last?

The duration of the analgesic and anti-inflammatory effect depends on the nature of the discomfort, its intensity and cause. Nise 100 mg tablets block discomfort for 0.5 days. The degree of pain relief gradually decreases, because nimesulide begins to be eliminated from the body after 2-5 hours. The maximum analgesic effect is observed 20-25 minutes after taking the tablet.

How many times a day can I take Nise?

The recommended frequency of use of the medication in question is limited to two times. In extremely rare situations, the doctor may allow you to take Nise tablets more often - the use of an anti-inflammatory drug is allowed in a maximum daily dosage of 400 mg. Exceptional cases when nimesulide is prescribed 4 times a day occur in surgical practice. After some operations, the severity of the pain syndrome is too intense, and in order to avoid a state of shock, the analgesic will be used in an increased dose.

How long can you take Nise tablets?

The duration of symptomatic therapy should correspond to the specific situation. Only a specialist decides how many days Nise can be taken. The maximum recommended duration of treatment is 15 days. More often, nimesulide is used until swelling and signs of inflammation disappear - 7-10 days or less. For headaches, menstrual pain, and toothache, the medication is used for 2-3 days or once.

Can Nise be taken with alcohol?

There are no direct instructions regarding the simultaneous use of nimesulide and the consumption of alcoholic beverages. Nise tablets help against headaches and fever associated with a hangover, quickly and effectively relieving the condition. Doctors just do not recommend using the described drug in parallel with strong drinks and on the eve of parties. Nise and alcohol are poorly compatible, because ethanol can retain fluid in the body. Along with it, nimesulide accumulates in the digestive system, which can provoke dangerous consequences.

Nise tablets - side effects

The presented pharmacological agent is rarely accompanied by negative concomitant phenomena. Most tablets are well tolerated, less than 5% of patients cannot take Nise - side effects include:

• dizziness;
• nervousness;
• feeling of unreasonable fear;
• nightmares;
• drowsiness;
• swelling of the face;
• encephalopathy in the form of Reis' syndrome;
• headache;
• Lyell's syndrome;
• immune hypersensitivity reactions;
• skin rash (urticaria, eczema, dermatitis);
• anaphylactic shock;
• increased sweating;
• exudative erythema multiforme;
• angioedema;
• Stevens-Johnson syndrome;
• toxic epidermal necrolysis;
• dysuria;
• hyperkalemia;
• urinary retention;
• hematuria;
• renal failure;
• interstitial nephritis;
• severe swelling of the extremities;
• oliguria;
• nausea;
• constipation;
• gastritis;
• flatulence;
• diarrhea;
• vomit;
• stomatitis;
• pain in the epigastric region;
• tarry soft stools;
• exacerbation of peptic ulcer, perforation of the stomach or duodenum;
• internal bleeding;
• hepatitis, including fulminant form;
• cholestasis;
• drug-induced jaundice;
• increased transaminase levels;
• eosinophilia;
• anemia;
• pancytopenia;
• increased duration of bleeding;
• thrombocytopenia;
• purpura;
• exacerbation of bronchial asthma attacks;
• dyspnea;
• bronchospasms;
• arterial hypertension;
• tides;
• tachycardia;
• blurred vision or deterioration in its clarity;
• hemorrhage;
• general weakness, decreased performance;
• a sharp decrease in body temperature.

People with certain medical conditions are at higher risk of developing these problems. In such situations, it is necessary to use Nise with extreme caution; side effects are more often observed in the following pathologies:

• dysfunction of the kidneys and bladder;
• eye diseases;
• high blood pressure;
• cardiovascular diseases;
• severe liver damage.

Nimesulide is capable of chemical reactions with other non-steroidal anti-inflammatory drugs, so the simultaneous use of Nise and similar analgesics may lead to undesirable side effects. It is not recommended to take the medication while planning pregnancy. The drug has been found to have a negative effect on female fertility.

Nise tablets - contraindications

• a combination of recurrent nasal polyposis, paranasal sinuses or bronchial asthma and intolerance to acetylsalicylic acid or other non-steroidal painkillers;
• hypersensitivity to nimesulide or auxiliary ingredients of the drug;
• cerebrovascular, active gastric, intestinal or other bleeding;
• Crohn's disease in relapse stage;
• nonspecific ulcerative colitis during an exacerbation;
• decompensated heart failure;
• erosive or ulcerative lesions of the mucous membrane of the duodenum and stomach;
• hemophilia and other pathologies that alter blood clotting;
• any active liver disease, including failure;
• alcoholism;
• hyperkalemia;
• severe renal failure with creatinine clearance less than 30 ml/min;
• period after coronary artery bypass surgery;
• hepatotoxic reactions when prescribing drugs containing nimesulide;
• concurrent use of potentially hepatotoxic chemicals.