Ovestin analogue - which drugs are similar in composition and action? The drug Ovestin and its inexpensive analogues. Which is better, Ovestin cream or estriol suppositories.

Among the short-acting drugs, Ovestin is distinguished. The active ingredient is estriol.

The component is considered a natural female hormone. In the endometrium it has a non-stimulating effect, in the vagina it is responsible for the regeneration of the epithelium.

Thanks to the effective action of the drug Ovestin, the normal pH environment is restored and the natural microflora is normalized.

The complex helps restore the pathological area, as well as increase local immunity.

The medicine is prescribed for infertility, urinary incontinence, as a preventive measure for complications, during an operating process with transvaginal access.

The medicine is sold at an affordable price, from 250-1370 rubles.

Russian-made analogues

Unlike the original medicine, similar versions of the drug Ovestin are cheaper. In Russia, medications containing estriol are available for sale in several options.

The selection of Russian-made medicines can be found in the table below:

Ukrainian substitutes

Unlike the original drug Ovestin, Ukrainian substitutes have a similar effect and have a medicinal effect on the development of genitourinary diseases.

They treat female organs and help cope with illness after surgery. Analogs go on sale at an average price: from 76 to 465 hryvnia.

• Folliculin
  The medicine is prescribed for insufficient ovarian function. Diseases include primary and secondary amenorrhea, infertility, and genital hypoplasia.

  The medication helps cope with postpartum weakness. Folliculin is prescribed for post-term pregnancy. The pharmacy sells the drug at a price of 76 hryvnia.

• Colpotrophin
  The medication eliminates urogenital disorders that appear after a lack of estrogen.

  The drug effectively copes with urinary incontinence, eliminates dryness and itching in the vagina. After removal of the ovaries, Colpotrophin is prescribed.

  The medicine has a healing effect on the vulva, as well as the vagina and perineum, which are damaged after childbirth.

  The drug is sold at an affordable price, it can be purchased from 220.00 to 465.80 hryvnia.

• Menostar
  The medicine serves as a prophylactic agent during postmenopausal osteoporosis in women, but taking into account that at least 5 years have passed since menopause occurred. The price of the drug is 120 hryvnia.

Other foreign analogues

In addition to the listed funds, there are foreign analogues of the drug Ovestin.

Modern pharmacology has presented similar medications that do not have inferior properties and are no different from Soviet manufacturers.

Similar preparations of the main remedy Ovestin contain the same substances that have an effective effect as the original product. The page presents the cheapest medicines that are available at pharmacy kiosks.

External data does not change; the country of origin tries to preserve the composition and affiliation of analogues.

The manufacturer sets the final price, so the drugs are not expensive. When choosing a medication, you need to pay attention to the side effects that are included in each medication instructions.

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• Latin name: Ovestin
• ATX code: G03CA04
• Active substance: Estriol
• Manufacturer: Organon (Netherlands)

Compound

Part Ovestin tablets active ingredient included estriol , as well as auxiliary ingredients: amylopectin , potato starch , lactose monohydrate , magnesium povidone , stearate , silica .

Part Ovestin candles active ingredient included estriol , and vitepsol S 58 as an additional ingredient.

Cream Ovestin accommodates estriol , as well as a number of additional ingredients: cetyl palmitate , octyldodecanol , cetyl alcohol , glycerol , polysorbate , stearyl alcohol , sorbitan stearate , chlorhexidine hydrochloride , lactic acid , sodium hydroxide , water .

Release form

Ovestin tablets have a white color, a flat, round shape with a beveled edge, and are marked on the surface of one side “ DG"above the number" 8 " and a dividing line; on the other side of the tablet there is the marking " ORGANON*».

Vaginal cream It has a homogeneous mass, a pure white or whitish hue, and has a specific odor.

Vaginal suppositories can have a color from white to cream, torpedo-shaped, uniform surface and longitudinal cut.

pharmachologic effect

The product contains a natural female hormone estriol . This is the so-called short-acting hormone. Consequently, it does not provide stimulation of proliferative processes in endometrium . The product accelerates the process of restoring the epithelium of the vaginal mucosa, as well as optimizing the pH environment and restoring the natural microflora of the vagina. As a result, the local level increases, and an obstacle to the development of pathological flora appears.

Pharmacodynamics and pharmacokinetics

The drug can be used in the presence of pathological symptoms that appear due to a lack of estrogen in the body. The drug is particularly effective in the treatment of urogenital disorders.

If there are atrophic changes vaginal mucosa, the drug helps restore the mucous membrane.

As a result, under the influence of the drug, the level of resistance of vaginal tissue to inflammatory processes and infections increases. Women note that after taking the product, the manifestations of dryness And vaginal itching , dyspareunia , infections of the genitourinary system, and complaints associated with urinary incontinence .

When the drug is administered intravaginally, optimal bioavailability of the active substance is ensured at the site of its action. Estriol by absorption it enters the general circulation system. As a result, the concentration in the blood plasma increases significantly unconjugated estriol . The highest level of concentration of the substance in the blood plasma is observed 1–2 hours after its administration. Approximately 90% estriol contacts albumin in blood plasma.

Since estriol is an end product, it is mainly excreted in the urine in conjugated form. Only a small part of the drug (about 2%) is excreted from the body with feces, mainly in unconjugated form.

Indications for use

Indications for use Ovestin candles, and tablets And cream the following:

• treatment atrophic colpitis ;
• age-related changes in the vaginal mucosa of an atrophic nature, which arise due to estrogen deficiency;
• frequent urination , painful sensations when urinating;
• , which is associated with the cervical factor;
• for diagnostic purposes if the cytology smear results are unclear;
• preventive measures to prevent inflammation of the urogenital area;
• preventive measures to prevent complications after operations with access through the vagina.

Contraindications

Contraindications for candles, pills, Ovestin cream the following:

• intolerance to the components of the product;
• pregnancy period;
• breast cancer , suspicion of developing cancer or a history of breast cancer;
• estrogen-dependent malignant tumor ;
• bleeding from the vagina of unknown etiology;
• venous or arterial thromboembolism in the anamnesis;
• porphyria ;
• acute liver disease or changes in liver tests.

Side effects

Medicine in the form suppositories may cause local itching or irritation. There may be tenderness or tightness in the mammary glands. Such side effects, as a rule, are observed in the first days of using the drug, but sometimes their development indicates that too high a dose of the drug has been prescribed.

Acyclic bleeding was also noted, metrorrhagia , breakthrough bleeding.

The annotation for the drug notes that other side effects may develop during treatment with Ovestin. Such manifestations have been reported during treatment estrogen-progestogen , but there is not enough data to determine whether Ovestin is different in this.

We are talking about benign and malignant estrogen-dependent tumors, heart attacks and gallbladder diseases, skin and subcutaneous inflammatory processes,.

Instructions for use of Ovestin (Method and dosage)

If a patient is prescribed Ovestin during treatment, the instructions for use of the drug must be strictly followed.

The drug can be used as cream, pills, candles, and at the same time, regardless of the method of administration, it remains equally effective. When using any form of the drug, be it ointment tablets or suppositories, it is taken once a day.

Instructions for use Ovestin in the form of cream suggests that the product is administered before bedtime using a special applicator. Initially, it is used every day; if there is a noticeable improvement in the condition, you can switch to a twice-weekly administration regimen. The duration of treatment depends on the disease.

Pills, as a rule, are prescribed in a dose of 2-4 pcs. (4-8 mg) per day for one month, then the dose is reduced to 1-2 tablets (1-2 mg) per day. If a person has urinary incontinence, a higher dose of the drug may be prescribed.

Introduction suppositories indicated once a day, and when the symptoms gradually decrease, you can switch to administering suppositories twice a week.

Candles administered once a day, if symptoms improve, switch to more rare administration - 2 times a week.

If preparations are being made for surgery using a transvaginal approach, one suppository is administered every day, treatment begins two weeks before surgery. Further, after the manipulations, two more suppositories are administered per week for 14 days. Ovestin cream is used according to the same scheme.

If a dose of the drug was missed, and the interval between doses was no more than 36 hours, you should take the dose that was missed and continue treatment as usual. If the interval is more than 36 hours, then taking Ovestin continues according to the scheme.

Overdose

In case of an overdose of Ovestin, nausea and vomiting, as well as bleeding from the vagina, may occur.

In this case, symptomatic therapy is practiced.

Interaction

No adverse interactions with other drugs were noted.

However, it should be borne in mind that the pharmacological properties of Ovestin may determine the interaction with anticonvulsants and antiretroviral drugs, as well as with drugs that contain St. John's wort .

There is evidence that estriol can enhance the effect of a number of corticosteroids And theophylline .

Terms of sale

Ovestin is available with a doctor's prescription.

Storage conditions

Pills should be stored in a dark and dry place at a temperature between 2 and 30 °C.

Candles And cream should be stored in a dark and dry place at a temperature between 2 and 25 °C.

Best before date

The shelf life of Ovestin is 3 years.

special instructions

You cannot carry out therapy with high doses of the drug for a long time (no more than a few weeks).

If long-term treatment is necessary, regular examination of the mammary glands and examinations by a gynecologist should be carried out, careful monitoring coagulograms .

During treatment postmenopausal symptoms Hormone replacement therapy is practiced only in the presence of severe symptoms that worsen the quality of life.

A woman should be aware of exactly what changes in the mammary glands that appear during treatment that need to be reported to the doctor.

If factors appear that are a contraindication to treatment, or other negative changes in health status, it is necessary to stop treatment with the drug.

Because estrogen can cause fluid retention in the body, the health of people with heart failure and kidney disease should be carefully monitored.

Ovestin's analogues

Analogues of Ovestin in Russia are drugs Dimestrol , Hormoplex , Tephastrol . They also contain . However, the patient should not be interested in the price of analogs, but in the effectiveness of their effect on the body. Therefore, you should definitely consult your doctor about what you can replace Ovestin with.

For children

Ovestin ointment for children is used only as directed by a doctor. The remedy is sometimes used for synechiae in children. With this diagnosis, the cream for children is used only according to the scheme and in the dosage prescribed by the doctor.

During pregnancy

During pregnancy, Ovestin is not prescribed to women.

Reviews about Ovestin

Reviews about Ovestin candles that women leave when visiting the thematic forum are mostly positive. There is a positive effect of the product as a supporting agent during menopause. Patients also leave reviews of Ovestin cream and tablets, noting that these drugs can reduce the intensity of unpleasant symptoms and help treat a number of diseases. It is also noted that the ointment is easy to use. Reviews from doctors indicate that treatment with Ovestin is predominantly effective.

Less common are reviews of how the cream was used for children. Parents note that Ovestin should be used strictly according to doctor’s recommendations for treating children. Sometimes women report a burning sensation when using suppositories at first. However, this side effect quickly disappears.

Ovestin price, where to buy

Buy Ovestin tablets possible at a price of 800-900 rubles for 30 pcs. Price Ovestin candles on average is 1000 - 1100 rubles. Price Ovestin cream 15 g - 1100-1300 rubles.

The drug is intended for the symptomatic treatment of genitourinary disorders associated with estrogen deficiency. It has a high cost. For this reason, many patients ask the doctor to replace the product with cheaper Ovestin analogues with identical pharmacological properties.

The active substance of the drug is hormone estriol has a selective effect and is responsible for important biochemical processes in the body.

Helps restore epithelial tissue of the vagina and cervix. Does not have a systemic effect. Most often used in hormone replacement therapy.

In the form of a cream, it can be prescribed for a long period of time with subsequent transition to suppositories.

Structural cheap analogs of Ovestin

1. Ovipol Clio (Moldova). Eliminates urogenital syndrome. Normalizes the parameters of the physiological vaginal environment. This cheap analogue of Ovestin suppositories promotes the rapid restoration of endometrial mucous tissue.

Relieves irritation and itchy reactions due to excessive discharge (leucorrhoea). Activates blood circulation of the epithelium. Prescribed for:

• Narrowing of the vagina.

• Atrophic vaginitis.

• Incontinence due to hormonal deficiency.

• In rehabilitation therapy after vaginal surgeries.

• In the complex treatment of genitourinary infections.

Widely used for atrophy of the lower urinary tract.

• Vag candles. 0.5 mg No. 15 - 540 rub.

2. Orniona (Russia). Contains natural female hormone estriol. Intended for the correction of genitourinary disorders resulting from estrogen deficiency.

It has a local short-term effect that does not cause withdrawal symptoms. Has no systemic effect.

Increases the resistance of epithelial cells to infections. The Russian cheap analogue of Ovestin cream is prescribed:

• In case of urination problems.

• Not severe urinary incontinence.

• During the postmenopausal period to eliminate discomfort in the genital area.

In a short time:

• Eliminates urogenital symptoms associated with hormonal deficiency.

• Helps restore the mucous layer of the uterus.

• Vaginal cream. 0.1% 15 g - 610 rub.

3. Estrocad (Germany). Prescribed for estrogen deficiency. Restores the pH of the vaginal environment. Improves the quality of cervical mucus. Is the standard for use when:

• Ulcerative lesions on the cervix.

• Urethrocystitis.

• Atrophic colpitis.

Prevents urinary incontinence.

It helps women in menopause cope with urogenital atrophy.

Relieves the inflammatory process of the mucous membrane of the vagina and external genitalia caused by infectious pathogens.

Eliminates negative manifestations in the vaginal area, such as dryness, burning, discomfort.

• Vaginal suppositories 0.5 mg 10 pcs. - 540 rubles.

Related Posts

"Ovestin" refers to short-acting hormonal drugs, which include estriol, a natural female hormone. It has a non-stimulating effect on proliferative processes in the endometrium, regenerates the epithelium of the mucous membranes in the vagina, restores the normal pH environment and natural microflora.

The complex restores the development of the pathological sphere and increases local immunity.

Indications for use of "Ovestin":

• In order to prevent possible complications during surgery with transvaginal approaches.
• With atrophic age-related changes in the vaginal mucosa, occurring due to hormonal imbalances (deficiency of the hormone estrogen), manifested by a feeling of discomfort, pain during sexual intercourse, and excessive dryness.
• When diagnosing infertility associated with cervical factor.
• To improve urinary function or urinary incontinence.
• For additional diagnosis of smears for pathological changes with unclear results.
• For preventive purposes - to prevent inflammatory processes in the female genital organs.

Methods of using the drug:

"Ovestin" is used both topically (cream, suppositories) and internally (tablets). Regardless of the method of administration, the effectiveness of treatment does not change. The medicine, regardless of the form of release, is used only once a day. For urinary incontinence, in some cases the dose of the drug may be increased.

The cream must be administered at night using a special applicator.

The course of treatment depends on the severity of the symptom and improvement of the condition. Gradually the doses are reduced; it is enough to use the product once or twice a week. The next time you miss taking the medication, take the required dose after 12 hours, then continue treatment according to the recommended regimen.

Possible adverse reactions:

• Nausea.
• Feeling of burning, itching, irritation in the vaginal area.
• Increased blood pressure, headaches.
• Pain or discomfort in the mammary glands.

Contraindications for use:

• Porphyria.
• Pregnancy period.
• Exacerbation of liver diseases.
• Venous and arterial thromboembolism.
• Sensitivity to the constituent components of the drug.
• Vaginal bleeding of unknown etiology.
• If you suspect breast cancer or have an existing cancer.
• Endometrial cancer or suspicion of its presence.

"Ovestin" enhances the effect of theophylline and corticosteroids, this must be taken into account when taking such medications simultaneously. If the dose is exceeded, vaginal bleeding, vomiting, and nausea may occur.

Analogues of the drug "Ovestin"

"Ovipol Clio"

It is used in the treatment of atrophy of the mucous membranes of the genitourinary tract caused by a deficiency of the hormone estrogen. Used in postoperative and preoperative therapy during menopause, to relieve symptoms of the postmenopausal period, infertility, discomfort in the vagina, dyspareunia, frequent urination, diagnosing poppies by cytology from the vagina.

"Elvagin"

Hormonal drug, release form - cream. It is an analogue of the natural female hormone – estriol. Used to correct the deficiency of this hormone in the body, especially during menopause. It has an effective effect in the treatment of various urogenital disorders. Relieves disorders of epithelial atrophy, restores the natural microflora of the vaginal environment, preventing inflammatory and infectious diseases.

"Estriol"

The drug is a hormonal suppository. Used for therapeutic treatment of atrophic changes in the vagina and urinary tract associated with hormonal imbalances, especially during menopause. It is used in preparation for surgical intervention with transvaginal access and after surgery.

"Estrovagin" and "Estrocad"

Medicines are completely similar to all of the above analogues.

Any of the hormonal analogues of Ovestin are practically the same in application, use in treatment, have the same contraindications and possible side effects. At the same time, the prices for such drugs are much lower.

Real reviews from the drug

Alla, 51 years old: “After menopause, I was afraid of sexual activity. During sexual intercourse I felt terrible discomfort, dryness, and quite severe pain. Relations with her husband became cool. I was prescribed Estrocad, literally on the second day I felt relief, and a week later all the unpleasant symptoms disappeared!

Vera, 32 years old: “They discovered a fissure in my vagina and prescribed Ovestin.” The pharmacist recommended buying a cheaper analogue - Ovipol Clio. Everything went away, healed, I don’t remember the problem anymore!”

Vera, 58 years old: “I’ve been taking the hormonal drug Elvagin for more than ten months. It suited me perfectly, I forgot about hot flashes, I feel great. At the same time, not only did I not gain weight, but I also lost weight!”