Weight loss drug Orsoten. The reverse side of the drug Orsoten: side effects and contraindications for use

Composition and release form of the drug

Capsules from white to white with a yellowish tint; contents of capsules - microgranules or a mixture of powder and microgranules, white or almost white; The presence of compacted agglomerates that easily crumble when pressed is allowed.

* 100 g of semi-finished granules contain: orlistat - 53.1915 g, microcrystalline cellulose.

Excipients: microcrystalline cellulose.

Composition of the capsule body and cap: hypromellose, water, titanium dioxide (E171).

7 pcs. - contour cell packaging (3) - cardboard packs.
7 pcs. - contour cell packaging (6) - cardboard packs.
7 pcs. - contour cell packaging (12) - cardboard packs.
21 pcs. - contour cellular packaging (1) - cardboard packs.
21 pcs. - contour cell packaging (2) - cardboard packs.
21 pcs. - contour cell packaging (4) - cardboard packs.

pharmachologic effect

Lipase inhibitor. When taken orally, orlistat inhibits gastric and pancreatic lipases. As a result, the breakdown of dietary fats is disrupted and their absorption from the gastrointestinal tract is reduced. When used systematically, this effect leads to a decrease in body weight in obese patients. Orlistat is practically not absorbed from the gastrointestinal tract and therefore has virtually no resorptive effect.

Indications

Obesity (in combination with a moderate calorie diet).

Contraindications

Chronic malabsorption syndrome, increased sensitivity to orlistat.

Dosage

Take 120 mg orally with each main meal or within an hour after meals, usually no more than 3 times a day. If your meal is low in fat, you can skip orlistat.

Side effects

Maybe: oily discharge from the rectum, “greasy” stools, frequent bowel movements, urgency to defecate, fecal incontinence.

Drug interactions

It has been shown that orlistat leads to a decrease in the absorption of beta-carotene and α-tocopherol from the gastrointestinal tract.

special instructions

It must be borne in mind that the frequency and severity side effects increase with increasing fat content in food. By reducing the fat content in food, the likelihood of side effects decreases. It is recommended that the amount of fat consumed per day be distributed fairly evenly across all meals.

During treatment, as body weight decreases, it is possible to improve the course of the symptoms that often accompany obesity. pathological processes, incl. , diabetes mellitus, lipid metabolism disorders.

Pregnancy and lactation

Orlistat is used with extreme caution during pregnancy and lactation.

Orsoten was developed as a result of a fundamentally new approach to the control and reduction of body weight: it removes about 30% of fat deposits from the body naturally.

It is launched on the market by the world-famous pharmaceutical company KRKA, which in itself already guarantees its quality.

In this article we will look at why doctors prescribe Orsoten, including instructions for use, analogues and prices for it medicine in pharmacies. Real REVIEWS People who have already used Orsoten for weight loss can be read in the comments.

Composition and release form

Clinical and pharmacological group: a drug for the treatment of obesity – an inhibitor of gastrointestinal lipases.

Modern unique composition For fast weight loss Available in an easy-to-take capsule form. Inside the yellow-white gelatin-coated containers are microscopic granules or a mixture of granules and powder of the active substance.

• 1 capsule contains 120 mg of the active ingredient (orlistat). As auxiliary components in the production of this pharmacological agent Purified water gelatin, hypromellose, microcrystalline cellulose and titanium dioxide are used.

Capsules are supplied in blister packs (7 pieces or 21 pieces each).

What does Orsoten help with?

Orsoten is prescribed for long-term therapy obese patients with a body mass index (BMI) ≥30 kg/m2 or overweight (BMI ≥28 kg/m2), including patients with risk factors associated with obesity, in combination with a moderately low-calorie diet.

It is possible to prescribe Orsoten simultaneously with hypoglycemic drugs and/or a moderately low-calorie diet for type 2 diabetes mellitus with obesity or overweight.

Clinical data

The World Organization of Gastroenterology classifies orlistat as moderate effective means to combat obesity.

In the conducted clinical studies the drug caused a significant decrease in body weight in 75% of volunteer patients. Over 12 weeks of treatment, patients were able to lose up to 5% of their original weight. Better results (up to 10%) were observed in those who combined the drug with a hypocaloric diet and physical activity.

During the tests, other positive effects therapy. In particular in patients with hypertension observed persistent decline blood pressure:

• systolic (“upper”) - on average by 12.9 mm Hg. Art.,
• diastolic (“lower”) - by 7.6 mm Hg. Art.

All volunteers showed an improvement in lipid metabolism. After 24 weeks from start treatment course the level in the blood decreased total cholesterol and low-density lipoprotein (LDL) levels.

A number of studies have shown that orlistat helps prevent the onset or slow the progression of type 2 diabetes. In patients with impaired glucose tolerance, tissue sensitivity to insulin improved when taking it. In patients with already developed diabetes, treatment made it possible to reduce the doses of hypoglycemic agents taken.

pharmachologic effect

The effectiveness of Orsoten in getting rid of extra pounds is dictated by the active substance in its composition - orlistat. This is a drug that is used in medicine and dietetics specifically for weight loss. It is this substance that, when it enters the gastrointestinal tract, carries out all the necessary work there:

• blocks the activity of lipase, an enzyme that processes fats;
• as a result, fats are not absorbed by the body, as they remain undigested by lipase;
• the body begins to consume existing fat, including visceral fat, stored “in reserve”;
• no fat in the body - no extra pounds.

The mechanism of action of Orsoten is very simple, but it is precisely in this simplicity that it is brilliant. By affecting a minimum of processes occurring in the body, it causes minimal damage to it.

Instructions for use

The capsule is washed down with water, taken orally immediately before each main meal, during meals, or no later than 1 hour after meals. If a meal is skipped or if the meal does not contain fat, then orlistat can be skipped.

• Exceeding the dose healing effect does not increase. Clinical trials showed that excess active substance within 5 days they are eliminated naturally. The duration of the course of treatment is determined by the doctor, usually it ranges from 2-3 months to 2 years. If during the first 60-70 days the weight loss is less than 5%, stop taking the drug.

Dose adjustment is not required for elderly patients or patients with impaired liver or kidney function. The safety and effectiveness of orlistat in children and adolescents under 18 years of age has not been established.

Contraindications

According to the instructions, Orsoten cannot be prescribed for:

• cholestasis;
• increased level of sensitivity to the components included in the drug;
• chronic malabsorption syndrome;
• pregnancy and lactation;

and also under the age of 18 years.

Side effects

Orsoten may cause some side effects - for the most part from the gastrointestinal tract. In descending order of likelihood of their occurrence, these may be:

• flatulence;
• bloating;
• dyspepsia;
• spontaneous oily discharge from the rectum;
• frequent urge to defecate;
• fecal incontinence.

IN in rare cases may be observed general weakness, abdominal pain, headache, violation menstrual cycle, allergic reactions(itching, urticaria). Side effects usually appear on initial stage treatment and then disappear.

Overdose

Doctors' reviews of Orsoten do not contain information about cases of overdose with this drug.

Taking a single dose of orlistat 800 mg or up to 400 mg three times a day for two weeks was not accompanied by significant adverse reactions.

special instructions

During therapy, it is recommended to take multivitamin complexes to ensure adequate nutrition. Patients should adhere to dietary recommendations. Nutrition should be balanced, moderately low in calories and contain no more than 30% of calories in the form of fat. Daily consumption fats should be distributed over three main meals.

Orsoten is effective for a long-term course of weight control (reducing weight, maintaining it at an appropriate level and preventing re-gain of body weight). Therapy improves the profile of risk factors and diseases that accompany obesity (including impaired glucose tolerance, hypercholesterolemia, arterial hypertension, hyperinsulinemia, type 2 diabetes), and a decrease in the amount of visceral fat.

As a result of weight loss in patients with diabetes mellitus Type 2 usually shows improvement in compensation carbohydrate metabolism, which may allow reducing the dose of hypoglycemic drugs.

Development risk side effects from the outside digestive system may increase when taking Orsoten on a diet rich in fat. Therapy is canceled if, within 12 weeks from the start of taking the drug, body weight has not decreased by more than 5% of the original.

Interaction with other drugs

When using Orsoten simultaneously with:

• pravastatin – its bioavailability and lipid-lowering effect increases;
• fat-soluble vitamins - K, D, E, A - their absorption is impaired. Therefore, vitamins must be taken before bed or two hours after taking Orsoten.
• warfarin and other anticoagulants - the level of prothrombin decreases, the INR increases, and, as a result, hemostatic parameters change;
• cyclosporine – the concentration of cyclosporine in plasma decreases. In this regard, regular monitoring of the level of cyclosporine in the blood is recommended.

It should also be kept in mind that losing weight can lead to improved metabolism in diabetics. Therefore, this category of patients may require a reduction in the dose of oral hypoglycemic drugs.

Orsoten Slim (active ingredient orlistat) - a medicine for correction overweight body, which is an inhibitor of gastrointestinal lipases. It is necessary to immediately make a reservation that Orsoten Slim is not biologically active additive, as they write about it on a number of Internet forums: this is the real medicinal product from the Slovenian pharmaceutical company KRKA, the closest relative of orsoten (the difference between them is only in the content of the active substance: 60 mg versus 120 mg). Orsoten Slim differs from the notorious sibutramine in significantly less adverse reactions. The therapeutic activity of the drug hero of this article manifests itself exclusively in the bowels of the stomach and small intestine, where orlistat interacts with gastric and pancreatic lipases, inactivating the latter to such an extent that they lose the ability to break down dietary fat (triglycerides) into easily absorbed free fatty acids and monoglycerides. And since triglycerides are not absorbed into the gastrointestinal tract, a certain calorie deficit develops, which, in turn, has a positive effect on body weight control. Orsoten Slim at a dose of 60 mg 3 times a day blocks the absorption of about a quarter of everything consumed edible fat. Therapeutic effect The drug is limited only to the gastrointestinal tract, which is an undoubted advantage, since the absence of a systemic component in its action reduces the likelihood of adverse reactions. The pharmacological activity of Orsoten Slim leads to the fact that the fat content in the small intestine increases 24-48 hours after its use. oral administration(because fat stops being absorbed). After stopping the drug, the fat content returns to the initial values ​​within 48-72 hours. Therapy with Orsoten Slim will be effective only in combination with lifestyle and diet correction (daily aerobic exercise and low calorie diet with limiting saturated animal fats). Orsoten slim will do little without getting rid of the plume bad habits: in this case, continuing to abuse the unhealthy patient risks getting digestive disorders.

Moreover, it is necessary to limit not only fats, but also “fast” carbohydrates, since they readily transform into body fat. Weight loss associated with taking Orsoten Slim is accompanied by other positive phenomena, such as a decrease in the level of total and “bad” cholesterol (low-density lipoproteins), a decrease in waist circumference. If, after three months of regular pharmacotherapy with Orsoten Slim, the weight stubbornly continues to remain the same or decreases by less than 5%, you should consult a doctor to decide on the advisability further treatment. It is important that the patient must start a “diet” and exercise even before starting the medication course, without stopping following healthy image life and after its end. The diet during treatment should include no more than 30% fat. Daily intake of the three main nutrients - proteins, fats and carbohydrates - should be evenly distributed between breakfast, lunch and dinner. Effects of Orsoten Slim in persons suffering from renal and liver failure, have not been sufficiently studied, however, given the minimal absorption of the drug in gastrointestinal tract, no dose adjustment is required in such patients. The doctor must warn the patient about increased risk side effects when consuming food with high content fat Therapy with Orsoten Slim may lead to impaired absorption fat-soluble vitamins. In this regard, vitamins A, D, E and K are recommended to be taken before bed. Taking the drug by patients with diabetes mellitus is often accompanied by an improvement in metabolic control, which may require adjustment of hypoglycemic drugs. Getting rid of excess fat deposits may be accompanied by normalization of blood pressure, and, therefore, the opportunity to reduce the dose of antihypertensive drugs taken.

Pharmacology

Gastrointestinal lipase inhibitor long acting. The therapeutic activity of orlistat is realized in the lumen of the stomach and small intestine and consists in the formation of a covalent bond with the active serine site of gastric and pancreatic lipases. Inactivated in this way, the enzyme loses its ability to hydrolyze dietary fat in the form of triglycerides into absorbable free fatty acids and monoglycerides. Undigested triglycerides are not absorbed, and the resulting caloric deficit may positive influence for body weight control. Orlistat at a dose of 60 mg 3 times a day blocks the absorption of approximately 25% of dietary fat. The therapeutic effect of orlistat is realized without its systemic absorption. The effect of orlistat leads to the fact that the concentration of fat in the intestinal contents increases within 24-48 hours after its oral administration. After discontinuation of orlistat, the concentration of fat in the intestinal contents usually returns to baseline levels within 48-72 hours.

In adult patients with a BMI ≥28 kg/m2, orlistat at a dose of 60 mg 3 times a day is effective in combination with a hypocaloric, low-fat diet. In this case, the main loss of body weight occurs during the first 6 months of treatment.

The reduction in body weight caused by the use of orlistat at a dose of 60 mg 3 times a day is accompanied by another beneficial effect: a decrease in the concentration of total cholesterol, LDL cholesterol, and a decrease in waist circumference.

Pharmacokinetics

Suction

Studies in volunteers with normal and increased weight bodies showed that the degree of absorption of orlistat is minimal. The concentration of unchanged orlistat in blood plasma is below the limit quantification(below 5 ng/ml) 8 hours after oral administration of orlistat at a dose of 360 mg. In general, when used in therapeutic doses The determination of unchanged orlistat in blood plasma is sporadic, and its concentration is extremely low (less than 10 ng/ml or 0.02 μmol/l), and there are no signs of cumulation, which indicates a minimal degree of absorption.

Distribution

Vd cannot be determined because orlistat is minimally absorbed and has no established systemic pharmacokinetics. The binding of orlistat to plasma proteins is more than 99% (mainly to lipoproteins and albumins). Orlistat can penetrate into red blood cells to a minimal extent.

Metabolism

Metabolism of orlistat occurs mainly in the walls of the stomach and small intestine.

Removal

Approximately 97% of the dose is excreted through the intestines, 83% of this amount is excreted as unchanged orlistat. Cumulative renal excretion of all orlistat-containing substances is less than 2% of the administered dose. The time to achieve complete excretion (through the intestines and kidneys) ranges from 3 to 5 days.

Release form

Hard gelatin capsules, size No. 3, white body, cap light yellow color; the contents of the capsules are microgranules or a mixture of powder and microgranules of white or almost white color; The presence of compacted agglomerates that easily crumble when pressed is allowed.

Excipient semi-finished granules: microcrystalline cellulose.

Excipients: microcrystalline cellulose - 22.2 mg.

Composition of hard gelatin capsules No. 3: capsule body - titanium dioxide (E171) - 0.58 mg, gelatin - 28.22 mg; capsule cap - titanium dioxide (E171) - 0.19 mg, iron oxide yellow (E172) - 0.04 mg, gelatin - 18.97 mg.

21 pcs. - contour cell packaging (2) - cardboard packs.
21 pcs. - contour cell packaging (4) - cardboard packs.

Dosage

Take 60 mg orally (1 capsule) 3 times a day, immediately before, during or within 1 hour after each meal. Take the capsules with water.

If a meal is missed or the meal did not contain fat, orlistat should be omitted.

Within 24 hours, you can take no more than 3 capsules of 60 mg of Orsoten ® slim.

The course of treatment should not exceed 6 months.

If after 12 weeks of using the drug Orsoten ® slim there is no weight loss (no more than 5% of the initial weight), the patient should consult a doctor to decide on the advisability of further use.

Diet and exercise are an important component of a weight loss program. It is recommended to begin a dietary program and exercise before starting therapy with Orsoten ® slim.

While using the drug Orsoten ® slim, the patient should receive a moderately hypocaloric diet with a balanced content nutrients, in which approximately 30% is fat (for example, with a calorie content of 2000 kcal/day, food should contain no more than 67 g of fat). Daily intake of fats, carbohydrates and protein should be distributed between three main meals. Diet program and physical exercise should be continued after the use of Orsoten ® slim is discontinued.

Data on the use of orlistat in elderly patients are limited.

The effects of orlistat in people with impaired liver and/or kidney function have not been studied, however, given that the absorption of orlistat is minimal, dose adjustment is not required in elderly patients and in patients with impaired liver and/or kidney function.

Overdose

When using orlistat at a dose of 800 mg once and at a dose of up to 400 mg 3 times a day, daily, for 15 days, as in patients with normal weight body and in obese patients, no significant adverse reactions were identified. When using orlistat 240 mg 3 times a day for 6 months, no increase in the frequency of adverse reactions was noted.

Symptoms: Most reports of orlistat overdose in the post-marketing period either lack specific information about adverse reactions or describe unwanted reactions, which do not differ from those observed when using recommended doses of orlistat.

Treatment: in case of overdose, consult a doctor. In case of significant overdose of orlistat, it is recommended to monitor the patient for 24 hours. Based on data from studies in humans and animals, all systemic effects of orlistat due to lipase inhibition are usually quickly reversible.

Interaction

With the simultaneous use of cyclosporine and orlistat, a decrease in the concentration of cyclosporine in the blood plasma is observed, which may be accompanied by a decrease in its immunosuppressive activity. The simultaneous use of Orsoten ® slim and cyclosporine is contraindicated.

With simultaneous use of warfarin or other oral anticoagulants and orlistat, changes in MHO values ​​may occur.

The use of orlistat may impair the absorption of fat-soluble vitamins (A, D, E and K).

Due to the lack of pharmacokinetic interaction data, it is not recommended to use orlistat concomitantly with acarbose.

When used simultaneously with orlistat, a decrease in the concentration of amiodarone in the blood plasma was observed after a single use. Clinical relevance This effect in patients taking amiodarone is unclear. The simultaneous use of orlistat and amiodarone is possible only on the recommendation of a doctor.

Orlistat does not interact with amitriptyline, phenytoin, fluoxetine, sibutramine, phentermine; atorvastatin, pravastatin, fibrates; biguanides; digoxin, nifedipine, losartan; oral contraceptives and ethanol.

Side effects

Classification of the frequency of side effects (WHO): very often (≥1/10); often (from ≥1/100 to<1/10); нечасто (от ≥1/1000 до <1/100); редко (от ≥1/10 000 до <1/1000); очень редко (от <1/10 000), включая отдельные сообщения.

When using orlistat, reactions from the gastrointestinal tract are usually observed and are associated with the pharmacological action of the drug.

From the digestive system: very often - oily discharge from the rectum, release of gases with some discharge, imperative urge to defecate, steatorrhea; often - abdominal pain, fecal incontinence, loose stools, increased bowel movements.

During post-marketing use of orlistat, the following adverse reactions were observed (frequency unknown).

From the hematopoietic system: decreased concentration of prothrombin; increase in INR in patients taking orlistat concomitantly with anticoagulants.

From the digestive system: slight rectal bleeding, diverticulitis, hepatitis, cholelithiasis, increased activity of liver transaminases and alkaline phosphatase.

From the skin: bullous rash.

Allergic reactions: itching, rash, urticaria, angioedema, bronchospasm, anaphylaxis.

Indications

• for weight loss in patients over 18 years of age with excess body weight (BMI ≥28 kg/m2) in combination with a moderate hypocaloric diet low in fat.

Since it is not known whether orlistat is excreted in breast milk, Orsoten ® slim should not be used during breastfeeding.

Use for liver dysfunction

The effects of orlistat in people with impaired liver function have not been studied, however, given that the absorption of orlistat is minimal, no dose adjustment is required in patients with impaired liver function.

Use for renal impairment

The effects of orlistat in people with impaired renal function have not been studied, however, given that the absorption of orlistat is minimal, no dose adjustment is required in patients with impaired renal function.

Use in children

Contraindicated in children and adolescents under 18 years of age.

special instructions

Patients should be instructed to adhere to the dietary recommendations they receive. The likelihood of side effects from the gastrointestinal tract is higher if a particular meal or diet as a whole is characterized by a high fat content.

Treatment with Orsoten ® slim may impair the absorption of fat-soluble vitamins (A, D, E and K). For this reason, multivitamins should be taken before bed.

Since weight loss may be accompanied by improved metabolic control in patients with diabetes mellitus, those receiving hypoglycemic drugs should consult a doctor before using Orsoten ® Slim and, if necessary, adjust the dose of hypoglycemic drugs.

Weight loss may be accompanied by an improvement in blood pressure and a decrease in cholesterol concentrations. Patients taking medications for hypertension or hypercholesterolemia should consult a doctor when using Orsoten ® Slim and, if necessary, adjust the dose of these medications.

Patients taking amiodarone should consult their doctor before starting therapy with Orsoten ® slim.

Cases of rectal bleeding have been reported in patients using orlistat. If this phenomenon occurs, the patient should consult a doctor.

Impact on the ability to drive vehicles and operate machinery

Orsoten ® slim does not affect driving or operating technical devices that require increased concentration and speed of psychomotor reactions.

The instructions for using Orsoten tablets for weight loss say that they are safe and allow you to achieve the desired results in shaping your silhouette much faster and easier in combination with traditional weight loss methods. There are two types of the drug - Orsoten and the Slim version, which contains a smaller dose of the active substance and acts more gently and more slowly on the body.

Orsoten is an innovative development in the field of nutrition; capsules contain a specially selected combination of components that blocks the absorption of fats from foods and removes them from the body.

Results appear after a couple of weeks. By taking only one pill and no pills, you can lose up to 5 kg in a month. It is important to adhere to the dosage requirements contained in the instructions and drink the specified number of tablets. Losing weight will not be burdensome for the body, because it will not be subject to stress, as if you were on a diet or training intensively.

Orsoten capsules contain 120 mg of the main component orlistat and a number of additional substances that accelerate the loss of extra pounds - talc, magnesium stearate, microcrystalline cellulose. You can purchase packaging of various sizes. Standard packaging contains 3, 6 or 12 blisters. You should buy the amount you need to drink during your weight loss course.

Effect of the drug

When taking pills, forget about counting how much fat you consumed that day. The active substance blocks the entry of fats into the body. Orlistat does not enter the bloodstream, but acts in the stomach and small intestine, preventing the absorption of fats by the walls of the digestive organs and promoting their elimination naturally. This is why Orsoten and similar weight loss products are so effective.

You are allowed to eat everything and not worry about the fats contained in the food in the form of extra centimeters.

Soon, to maintain balance, the body will need to use its own fat reserves, without relying on their supply from the outside. Taking pills for a long time can cause you to lose a lot of weight. The instructions for use contain important information about how long the capsules can be taken - you should not take the drug for longer than the specified time, otherwise it will harm the body.

How to take it correctly

How to take Orsoten correctly to lose weight without harm to health? Each package contains detailed instructions for use, which indicate that you need to drink capsules three times a day, one piece an hour after or during meals. Why is it important to take the pills this way? Fats enter the body during meals and are processed within the next hour after eating. And the effect of the drug is based on blocking the intake of fats along with foods. If you take capsules at other times, arbitrarily, you will not achieve the effect.

The instructions also contain the recommended course of administration, but only the doctor prescribes the required number of days when the drugs should be taken. An increase in dosage must be discussed with a medical professional - do not arbitrarily change the number of capsules.

No drugs can block too much fat. Therefore, you should not lean on fatty foods in the hope that Orsoten will cope.

Eat balanced meals that contain no more than 30% fat. It is recommended to eat three times a day, with lunch being the most high-calorie meal. To obtain the effect, it is advisable to follow the following recommendations for use:

1. Go to three meals a day and take 3 capsules of the product per day. If you eat two or once a day, then take the number of tablets according to the number of meals.
2. The permissible dose is 3 capsules per day. Exceeding it will not lead to accelerated weight loss, but to health problems.
3. If the effectiveness of using the drug over 12 weeks resulted in a decrease in body weight by 5%, then stop the course of treatment.
4. While taking the medication, it is recommended to adhere to a balanced diet, where the amount of fat is moderate, and periodically do physical exercise, for example.
5. Important: Orsoten and alcohol are not compatible! Compatibility with any alcoholic beverages is negative and will reduce the effect of the drug to zero.

Orsoten is harmless, but it is not recommended to take the medicine for too long a time and in too large quantities - this is a medical drug, so side effects appear as the dose increases. We recommend taking it in short courses over two years to achieve the desired result if your weight is much higher than normal.

Contraindications

Taking Orsoten is limited by a number of contraindications. It is not recommended to take tablets if:

• Bladder problems;
• Pregnancy or lactation period;
• Individual intolerance to the components of the drug;
• You are on a strict diet, and your body does not receive enough of the necessary substances.

Side effects

Spontaneously increasing the dosage or duration of the course will lead to unpleasant consequences:

• Increased concentration of prothrombin in the blood and INR level;
• Increased gas formation, dull abdominal pain, diarrhea, rectal discharge;
• Skin rashes and other allergic reactions;
• The appearance of bleeding;
• Exacerbation of kidney and liver diseases.

To prevent negative effects on the liver, it is recommended to take Essenicale Forte in parallel.

If you experience side effects or feel worse, stop taking the drug and contact your healthcare professional to determine whether you can continue taking the medication. Some unpleasant symptoms appear to a small extent in the first week of taking Orsoten and then disappear.

Price

The medicine can be purchased at a pharmacy without presenting a prescription from a doctor. The average price for 21 tablets is approximately 650 rubles. This amount is calculated for a weekly dose of the drug, if you drink one capsule three times a day. A package containing 42 tablets will cost 1000 rubles, which is much more profitable than two packages of 21 capsules. The cost of the product is rather high, but you can save a lot if you purchase it from online pharmacies that periodically organize promotion days or provide discounts to customers.

Reviews from people losing weight – is it worth accepting?

Reviews of those losing weight say that orsoten does not affect the functioning of the central nervous system, does not disrupt the functioning of the digestive tract and does not cause side effects if the drug is taken according to the specified dose and for a strictly prescribed period of time by the doctor. This is an easy and affordable way to lose weight that does not cause any negative changes in the body.

Doctors and nutritionists confirm the effectiveness of Orsoten and recommend taking it to those who cannot give up fatty foods or for whom exercise is contraindicated.

Orsoten is not the only such drug for losing weight. If you cannot find this medicine in pharmacies in the city, you should ask about "", "Xenalten", "Orlimax" or "Alli" - their principle of action is similar to Orsoten, they also block the absorption and absorption of fats and promote rapid weight loss without effort. The drugs also contain orlistat, which explains the similar effect of the drugs.

Your feedback on the article:

These capsules are often called a miraculous salvation from extra pounds and fat. Indeed, this drug is one of the latest developments by professional nutritionists, which, when taken regularly, removes fat from the body daily, thereby making your figure slim and beautiful.

In this article, we suggest learning in more detail about Orsoten for weight loss, how it works, whether it has analogues, and so on.

pharmachologic effect

Orsoten is an effective drug in the fight against extra pounds, which contains the active ingredient orlistat. It is this substance that, when it enters the digestive tract, performs the following functions:

• Blocks the work of lipase, an enzyme that is responsible for processing fats.
• Prevents the body from absorbing fats.
• Stimulates the processing of existing fat (including visceral fat, accumulated “in reserve”).

The mechanism of action of Orsoten diet pills is very simple, but precisely because of this simplicity it is very effective. The drug affects a minimum of processes in the body and causes virtually no harm to it. When the drug is taken orally, absorption of orlistat is negligible. Approximately 96% of the dose taken is excreted unchanged in the feces. Within 3-5 days, orlistat is completely eliminated from the body.

Indications for use

Orsoten is not a folk remedy for self-medication, therefore it is prescribed, like any drug, only by a specialist. Indications for its use may include:

• If the treatment of any disease requires mandatory or immediate weight loss.
• Obesity with a BMI (body mass index) of more than 30 kg/m².

Often, Orsoten tablets for weight loss are prescribed in conjunction with a low-calorie diet, if the person losing weight has a disease such as type II diabetes mellitus, as well as along with hypoglycemic drugs.

Method of use of the drug Orsoten

The instructions for using Orsoten diet pills are not complicated and will not require much effort and time from you. If you decide to try this drug, here are a few rules for its use:

• Consult your dietitian or healthcare professional before taking.
• Orlistat is taken one capsule three times a day, with a single dose not exceeding 120 mg.
• Take each capsule with a glass of water.
• Take the drug immediately before a meal or with food, or, in extreme cases, an hour after a meal, but not later.
• If for any reason you missed taking a capsule, then the next time you take the medicine, do not increase its dose under any circumstances.
• If you use Orsoten for weight loss, be sure to include a small amount of fat in your diet.
• Treatment with the drug can last up to two years.

Only if you strictly follow the instructions will Orsoten work and help you achieve the desired results.

Side effects of the drug and contraindications for use

Despite the fact that orlistat, which is part of Orsoten, does not in any way affect the body systems and its internal organs, a number of problems can arise if the drug is used incorrectly. This weight loss product is contraindicated:

• During pregnancy.
• During lactation.
• Under the age of 18.
• For chronic malabsorption (a condition in which the body loses nutrients).
• If someone who is losing weight has an individual intolerance to Orsoten.
• With cholistasis (malfunction of the gallbladder).

Complications may also appear in the following cases:

• If you ignore the instructions for using the drug.
• If the dosage is incorrect.
• In case of non-compliance with the diet.

Studies of the drug have shown the possibility of side effects such as disturbances in the gastrointestinal tract and allergies. Typically, these reactions of the body are weakly expressed and, as a rule, are transient. Such phenomena occur mainly at the initial stage of treatment (in the first three months from the start of taking the drug). With prolonged use of Orsoten, the number of cases of side effects decreases. Also encountered during therapy are: loose stools, flatulence, discharge from the rectum with an oily composition, a feeling of discomfort in the abdomen and rectum, damage to the gums and teeth, and fecal incontinence.

Analogues of the drug Orsoten

The most common structural analogues of this drug include Orsoten slim for weight loss. The difference between Orsoten slim and Orsoten is the dosage of the main active ingredient. The first drug contains 60 mg of orlistat, and the second - 120 mg.

Orsoten slim for weight loss is also intended for oral use. The tablets must be taken during meals or after meals (no later than an hour after finishing the meal). It is recommended to follow a diet low in fat. The course of therapy with the weight loss drug Orsoten Slim should not exceed 6 months. In general, the dose and duration of treatment are prescribed by the doctor.

Orsoten for weight loss - reviews from doctors

The best nutritionists and doctors of various specialties expressed their opinions about this drug. So, according to their reviews, Orsoten for weight loss has the unique ability not to affect the central nervous system, which cannot be said about many other means of the same focus. Another important advantage of Orsoten is absolute safety. The drug was certified and only after that was allowed onto the market.