The drug Mexidol side effects. Contraindications and possible reactions from the use of Mexidol

Original domestic antihypoxant and antioxidant direct action, optimizing the energy supply of cells and increasing the body's reserve capabilities



Mexidol tablets - official* instructions for use

*registered by the Ministry of Health of the Russian Federation (according to grls.rosminzdrav.ru)

Registration number:

LSR-002063/07 dated 08/09/2007

Tradename drug:

INN or group name: Ethylmethylhydroxypyridine succinate.

Chemical rational name: 2-ethyl-6-methyl-3-hydroxypyridine succinate.

Dosage form:

film-coated tablets

Compound:

Active substance: ethylmethylhydroxypyridine succinate - 125 mg, excipients: lactose monohydrate, sodium carboxymethylcellulose (carmellose sodium), magnesium stearate, shell: opadry II white (macrogol (polyethylene glycol), polyvinyl alcohol, talc, titanium dioxide).

Description:
The tablets are round, biconvex, film-coated, white to off-white in color.

Pharmacotherapeutic group:

antioxidant agent.

ATX code: N07XX

Pharmacological properties:

Pharmacodynamics:

Mexidol ® is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (shock, hypoxia and ischemia, disorders cerebral circulation, intoxication with alcohol and antipsychotics (neuroleptics)).
The mechanism of action of Mexidol ® is due to its antioxidant, antihypoxic and membrane protective effects. It inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Mexidol ® modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, transport of neurotransmitters and improve synaptic transmission. Mexidol increases the content of dopamine in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization cell membranes.
The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation.
Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. Has a hypolipidemic effect, reduces the content total cholesterol and low density lipoproteins.
The anti-stress effect is manifested in the normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, impaired learning and memory processes, reduction of dystrophic and morphological changes in various structures of the brain. Mexidol ® has a pronounced antitoxic effect in withdrawal syndrome. It eliminates the neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, autonomic functions, and is also able to relieve cognitive impairment caused by long-term use ethanol and its withdrawal. Under the influence of Mexidol, the effect of tranquilizing, neuroleptic, antidepressant, hypnotic and anticonvulsants, which allows you to reduce their doses and reduce side effects.
Mexidol ® improves functional state ischemic myocardium. In conditions coronary insufficiency increases collateral blood supply to ischemic myocardium, helps preserve the integrity of cardiomyocytes and maintain them functional activity. Effectively restores myocardial contractility in reversible cardiac dysfunction.

Pharmacokinetics:
Rapidly absorbed when taken orally. The maximum concentration at doses of 400 - 500 mg is 3.5 - 4.0 mcg/ml. Quickly distributed in organs and tissues. The average retention time of the drug in the body when taken orally is 4.9 - 5.2 hours. Metabolized in the liver by glucuron conjugation. 5 metabolites have been identified: 3-hydroxypyridine phosphate - formed in the liver and, with the participation of alkaline phosphatase, breaks down into phosphoric acid and 3-hydroxypyridine; 2nd metabolite - pharmacologically active, is formed in large quantities and is found in the urine 1 - 2 days after administration; 3rd - excreted in large quantities in the urine; 4th and 5th are glucurone conjugates. T1/2 when taken orally - 2.0 - 2.6 hours. It is quickly excreted in the urine, mainly in the form of metabolites and in small quantities - unchanged. The most intensive elimination occurs during the first 4 hours after taking the drug. The rates of urinary excretion of unchanged drug and metabolites have individual variability.

Indications for use:

  • Consequences of acute cerebrovascular accidents, including after transient ischemic attacks, in the subcompensation phase as preventive courses;
  • Mild traumatic brain injury, consequences of traumatic brain injury;
  • Encephalopathies of various origins (dyscirculatory, dysmetabolic, post-traumatic, mixed);
  • Syndrome vegetative dystonia;
  • Mild cognitive disorders of atherosclerotic origin;
  • Anxiety disorders in neurotic and neurosis-like conditions;
  • Coronary heart disease in the composition complex therapy;
  • Relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, post-withdrawal disorders;
  • Conditions after acute intoxication with antipsychotic drugs;
  • Asthenic conditions, as well as for the prevention of development somatic diseases under influence extreme factors and loads;
  • Impact of extreme (stress) factors.

Contraindications:

Acute hepatic and/or renal failure, increased individual sensitivity to the drug. Due to insufficient knowledge of the effect of the drug - childhood, pregnancy, breastfeeding.

Directions for use and dosage:

Orally, 125 - 250 mg 3 times a day; the maximum daily dose is 800 mg (6 tablets).
Duration of treatment - 2 - 6 weeks; to relieve alcohol withdrawal - 5 - 7 days. Treatment is stopped gradually, reducing the dose over 2-3 days.
Initial dose - 125 - 250 mg (1 - 2 tablets) 1 - 2 times a day with gradual increase before receiving therapeutic effect; the maximum daily dose is 800 mg (6 tablets).
The duration of therapy in patients with coronary heart disease is at least 1.5 - 2 months. Repeated courses (on the recommendation of a doctor) are preferably carried out in the spring and autumn periods.

Side effect:

Individual adverse reactions may occur: dyspeptic or dyspeptic in nature, allergic reactions.

Interaction with other drugs:
Mexidol is combined with all drugs used to treat somatic diseases. Enhances the effect of benzodiazepine drugs, antidepressants, anxiolytics, anticonvulsants and antiparkinsonian drugs. Reduces the toxic effects of ethyl alcohol.

Special instructions:

During the treatment period, care must be taken when driving vehicles and engaging in other potentially dangerous species activities requiring increased concentration attention and speed of psychomotor reactions.

Overdose:

In case of overdose, drowsiness may develop.

Release form:

Film-coated tablets, 125 mg. 10 tablets in a blister pack made of PVC film and aluminum foil or 90 tablets in a food-grade plastic jar. 1, 2, 3, 4, 5 blister packs or 1 plastic jar together with instructions for use in a cardboard pack. For hospitals. Film-coated tablets, 125 mg. 450 and 900 tablets in a plastic jar made of food grade plastic along with instructions for use in corrugated cardboard boxes.

Storage conditions:

Store in a dry place, protected from light, at a temperature not exceeding 25 °C. Keep out of the reach of children.

Best before date:

3 years. Do not use after the expiration date indicated on the pack.

Vacation conditions: On prescription

Manufacturer:

A: CJSC "ZiO-Zdorovye", 142103, Moscow region, Podolsk, st. Zheleznodorozhnaya 2
B: CJSC "ALSI-Pharma", CJSC "ALSI Pharma", 129272, Moscow, Trifonovsky deadlock, 3,

Organization accepting complaints:
LLC "NPK "Pharmasoft" 115280, Moscow, Avtozavodskaya st., 22

Comments(visible only to specialists verified by the MEDI RU editorial team)

Pharmaceutical analogues group*

*Analogues are not equivalent replacements for each other

Mexidol is an antioxidant drug that realizes its effects through the inhibition of free radical processes. It also has membrane protective properties and can have nootropic, mild anticonvulsant, vasoactive and anxiolytic effects.

The drug can increase resistance to damaging influences (hypoxia, ischemia, shock, cerebral circulatory disorders, intoxication alcoholic drinks or antipsychotics). The drug blocks lipid peroxidation, which can cause cell damage. The activity of membrane enzymes and receptor complexes is also modulated, which improves the functioning of brain cell membranes. Taking Mexidol improves the functioning of synapses, enhances the mechanism of compensatory glycolysis and reduces the inhibition of oxidative processes in the Krebs cycle under conditions of low oxygen content in cells.

Mexidol is able to reduce platelet aggregation, thereby improving the rheological properties of blood. Stabilizes blood cell membranes during hemolytic processes. Has a mild lipid-lowering effect.

In addition to the effects described above, Mexidol is able to stabilize disturbed vegetative processes, restore sleep, improve memory, and reduce morphological and dystrophic disorders in brain structures. It has a good antitoxic effect during alcohol abuse, including during abstinence. Reduces the manifestations of acute alcohol intoxication, normalizes behavior, and relieves cognitive impairment due to chronic alcohol consumption. Mexidol can enhance the effect of tranquilizers, antidepressants, antipsychotics, sleeping pills and anticonvulsants, which, when taken together, can help reduce drug dosages and reduce possible side effects.

Pharmacokinetically, Mexidol tablets are well absorbed when taken orally. It is quickly distributed throughout organs and tissues, the average duration of action of Mexidol is about 4-5 hours. Metabolized in the liver into 5 metabolites, pharmacologically active metabolites are determined in the urine for up to 48 hours.

The half-life after oral administration is 2.5 hours. It is excreted in the urine, mainly in the form of metabolites, and also, slightly, unchanged. The most intense elimination is observed in the first 4 hours after administration.


Indications

Mexidol tablets are used very widely in neurological practice, in particular for the following conditions:

    • ACVA (hemorrhagic and stroke), as well as their consequences.
    • TBI().
    • Abstinence.
    • Poisoning with antipsychotics.
    • Asthenia.
    • within the framework of asthenia.
    • Dizziness of various origins (with vascular diseases brain).

Contraindications

There are a number of contraindications to the use of the drug:

  • Acute renal failure.
  • Allergic reactions to the drug.
  • Pediatric practice.
  • Pregnancy and lactation.

It is also undesirable to use Mexidol for significant liver dysfunction.

Mode of application

Mexidol tablets are taken orally, regardless of meals. Doses are 1-2 tablets (125-250 mg) three times a day. Maximum dosage 6 tablets (or 0.8 grams). The course of treatment is 1-2 months. Repeated courses are possible 2-3 times a year.

For alcohol withdrawal and antipsychotic poisoning, the course of treatment can be 7-10 days.

Side effects

Side effects when taking Mexidol tablets are quite rare. Sometimes there is individual poor tolerance in the form of nausea and other dyspeptic complaints. Also, as with any drug, hypersensitivity reactions are possible with Mexidol.

Overdose

Mexidol tablets are safe to use; cases of overdose are extremely rare. In case of overdose, it is possible to develop general weakness or drowsiness.

special instructions

When taking Mexidol tablets, you should remember the following special instructions:

  • When used with antidepressants, benzodiazepines, anxiolytics, anticonvulsants, their effects should be expected to increase. Toxic effect ethanol, when used together, decreases.
  • When taking Mexidol, caution should be exercised when driving or performing potentially hazardous work, requiring quick reaction and attention.

Storage conditions

Mexidol tablets should be stored in a dark, dry place at temperatures no higher than 24-25 degrees Celsius. The storage period should not exceed 3 years.

Analogs

Mexidol tablets are an original medicine. Generic drugs, the active ingredient of which is alsoate, are drugs such as Mexifin, Mexicor, Metostabil, as well as some other drugs that are not widely used on the market.

Video commentary by the author

Price

Mexidol tablets are dispensed from pharmacies with a doctor’s prescription. Found in almost all pharmacies. Average prices do not vary widely due to various factors and make up:

  • Pack of 30 tablets 233-290 rubles.
  • Pack of 50 tablets 350-475 rubles.

Prices are approximate. An analysis of the drug market for 2019 has not yet been carried out.

Do not self-medicate to avoid tragic consequences. Before using Mexidol tablets, consult your doctor!

Mexidol is a Russian drug with an antioxidant effect, used in cardiology and neurology. Available in the form of tablets and solution for injection. The use of the drug has some features, depending on the form of the drug, the age of the patient and his diagnosis. Read about all the nuances of using Mexidol in this article.

The medicine is based on ethylmethylhydroxypyridine succinate. It is a membrane protector – a substance that protects the body’s cells from various pathogenic influences (mainly from the destructive effect free radicals).

Belongs to the group of antioxidant drugs. INN (international generic name) – . Latin name- Mexidolum.

Mechanism of action and properties

Ethylmethylhydroxypyridine succinate allows you to normalize the oxygen supply to tissues and the process of its absorption. Improves memory, reduces the harm of exposure to toxins (especially against the background of alcohol), increases the body's resistance to the occurrence of pathologies associated with oxygen deficiency.

According to clinical data, the drug has a positive effect on blood vessels when atherosclerotic changes occur, platelet aggregation and when problems with cerebral hemodynamics occur.

The product has the following effects on the body:

  • antihypoxic: increases resistance to hypoxia, improves the utilization of oxygen circulating in the body;
  • nootropic: affects brain mental functionality;
  • anxiolytic: reduces anxiety, nervousness, unreasonable feelings of fear, restlessness;
  • stress-protective: protects life support systems from harmful, negative impact psycho-emotional nature;
  • antiepileptic: relieves tremors, muscle cramps of various origins.

How does Mexidol act on the blood?

Mexidol has antihypoxic, membrane-protective, nootropic, anticonvulsant, and anxiolytic effects. Capable of improving blood supply to the brain, cerebral metabolism, blood microcirculation and its rheological properties.

Allows you to reduce platelet aggregation, stabilize function and improve the condition of blood cell membranes in the event of hemolysis. Has a lipid-lowering effect, reduces the content of lipoproteins and cholesterol, endogenous intoxication, enzyme toxemia (with a diagnosis of acute pancreatitis).

Mexidol helps reduce the viscosity of the membrane and increase its fluidity. Thins the blood and strengthens vascular walls. On admission active component The drug is absorbed into the patient's body within half an hour. Four hours later, ethylmethylhydroxypyridine succinate is detected in the blood plasma. The substance is removed naturally, with urine.

Prices, forms, components

There are two forms of drug production:


The approximate cost in Moscow and the Moscow region is presented in the table (Table 1).

Table 1 - Cost of Mexidol

In Moscow and the Moscow region the most high price for the drug. In the regions you can purchase it at a more attractive price.

Therapy rules

Only a specialist can choose the correct dosage. The daily number of tablets/ampoules and duration of therapy depend on the patient’s diagnosis. Therefore, it is strictly unacceptable to use Mexidol for self-medication. Even a minimal deviation from the permissible dose of the drug can lead to an overdose and dangerous consequences.

When does it apply and what are the restrictions?

Indications for use of the solution:

Also Mexidol in injection form used when acute intoxications antipsychotic drugs and to relieve withdrawal symptoms from alcohol poisoning.

Indications for use of tablets:

  • TBI and its consequences;
  • discircular, dismetabolic, post-traumatic, mixed encephalopathy;
  • vegetative dystonia;
  • cognitive impairment of atherosclerotic nature light form;
  • disruptions in cerebral circulation and their consequences;
  • ischemia;
  • asthenic condition;
  • somatic diseases and their prevention;
  • psycho-emotional disorders;
  • relief of abstinence against the background alcohol addiction, with pronounced vegetative-vascular and neurosis-like disorders.

The tablet form can be used to eliminate the consequences caused by intoxication with antipsychotic drugs.

Contraindications:

  • liver diseases;
  • disorders of the kidneys;
  • intolerance to the components of the composition.

Experts say that this moment There is no clinical data on the effect of the drug on the health of children, adolescents, pregnant and lactating women. Therefore, therapy with Mexidol should be carried out with extreme caution and only as prescribed by a doctor.

Dosage of the tablet form of Mexidol (125 mg)

The optimal dosage is one or two tablets three times a day. The maximum permitted daily dose should not exceed 750 mg of the active ingredient. The drug should be taken after meals with a glass of big amount water.

It is recommended to start therapy with a minimum dose - no more than two tablets 1-2 times a day. Then the dosage is gradually increased, at the discretion of the doctor (depending on the patient’s body’s response to the action of the drug, the therapeutic effect).

The average duration of therapy is two weeks, the maximum is six. When using Mexidol to relieve withdrawal symptoms due to alcoholism, treatment can last a maximum of 7 days. At coronary disease heart - long-term treatment, at least two months. It is forbidden to abruptly stop taking Mexidol. The dosage must be reduced slowly.

Intravenous jet and drip administration

The medicine is administered intramuscularly or intravenously. The dose is prescribed individually for each patient. However, the technology for preparing the solution is identical - the ampoule must be diluted in 200 ml of sodium chloride.

The initial stage of treatment is the minimum dosage of the drug. In most cases, 100 mg is prescribed 2-3 times a day. If the patient does not have negative reaction for Mexidol, not available adverse reactions, the dosage can be gradually increased. However, the maximum amount of administered medication is no more than 800 mg per day.

Administration of Mexidon is possible in two ways:

  1. Jet.
  2. The solution is administered slowly, the procedure should take approximately 7-8 minutes. Drip. This method

used in hospitals. Administration of the drug through a dropper - 50 drops per minute. The table shows dosage calculations medicinal product

depending on the diagnosis (Table 2). The table provides information for general information. It should not be taken as instructions for use.

Table 2 - Dosage of Mexidol solution depending on the specific pathology Diagnosis Volume of a single drug administration, mg Number of procedures per day
Permitted duration of treatment 300 3-4 Traumatic brain injury
2 weeks Circulatory disorders in the brain

300 (drip).

 100 (intramuscular)

1 (drip).

 3 (intramuscular).
Cognitive impairment alarming symptoms, dizziness 100 3 10-14 days
Encephalopathy 200 2 Traumatic brain injury
Heart attack 100 3 14 days
Glaucoma 200 2 Traumatic brain injury
Abstinence due to alcoholism 200-300 2 7 days
Drug intoxication 100-200 1 10 days
Pancreatitis 400 2 1 Week

Some treatment features

The drug is used for many circulatory disorders, both cerebral and peripheral vessels, as well as in neurological and autonomic disorders. Let's look at some of the features of using the drug.

For VSD, migraine and headache

Autonomic disorders are associated with hypoxic processes and affect the functioning of almost all human systems and organs. The brain and heart are primarily affected, which leads to the development of symptoms characteristic of VSD.

To stop these phenomena, Mexidol is often used today, aimed at supplying cells suffering from hypoxia with oxygen. As a result of this, blood flow is normalized, the functioning of cell membranes is stabilized, toxins are eliminated, stress resistance is increased, and stress is removed. negative manifestations VSD, in particular migraine-type headaches.

It is worth remembering that not every form of VSD is an indication for taking the drug. Greatest benefit It is effective in cases of cardiological type of pathology, as well as the presence of serious vascular and neurological disorders.

The dosage of the drug for VSD is calculated as follows:

  1. For mild manifestations of VSD, migraines and headaches, the tablet form is prescribed, one or two tablets up to three times a day.
  2. In case of severe symptoms, in particular with panic attacks, a solution of the drug is prescribed intramuscularly up to three times a day, 0.05-0.1 g of the drug.

For osteochondrosis

The use of Mexidol is indicated for severe forms osteochondrosis, when disturbances in blood flow, and therefore metabolism, become critical. The drug has pronounced antioxidant properties, which allows you to remove toxins formed as a result of degenerative processes in the vertebrae.

The medicine is prescribed intravenously up to 300-400 mg per day, depending on the patient’s condition. As the severity of negative symptoms decreases, the dosage is reduced and the drug is discontinued. The duration of therapy is two weeks.

During pressure surges

Mexidol is not special means to normalize blood pressure, but it can affect its level. It is impossible to say unequivocally whether this drug lowers or increases blood pressure; rather, it is worth talking about its normalization, that is, the drug can change the pressure both up and down, stopping autonomic disorders.

Most often, the drug is taken for low blood pressure, but can also be prescribed for the treatment of hypertension. The effect of the medicine is explained by the fact that the level of dopamine in the brain increases, blood flow normalizes, mental processes improve, and hypoxic manifestations are relieved.

It is worth understanding that if there is a surge in blood pressure after taking the drug, the patient may, in addition to a slight decrease or increase, experience emotional agitation, even insomnia.

Treatment with drugs for blood pressure disorders must be carried out extremely carefully, since Mexidol can also cause a reverse reaction in the body, in particular, an even greater increase in blood pressure, which will further aggravate the patient’s condition.

Application in sports

Mexidol is actively used in sports practice, as it normalizes metabolism and promotes the elimination of toxins formed during the destruction of proteins and fats and the deactivation of free radicals. The drug promotes better oxygen supply to tissues and regulates the functioning of the central nervous system, which helps increase the body's endurance, which is especially important for athletes.

The drug should be prescribed exclusively sports doctor. The limitation may be impaired kidney function. The standard dosage is one or two tablets up to 3 times a day. The duration of therapy depends on the athlete’s condition. Beginner course therapy is a week, but can be extended to four weeks.

Side effects and precautions

The drug is quite well tolerated by the body, side effects rarely occur. They manifest themselves in the form of nausea, dry mouth or an allergic reaction.

During Mexidol therapy, it is necessary to limit driving and work at hazardous sites. Under the influence of the drug, the speed of psychomotor reactions and concentration of attention may be reduced.

Mexidol is prescribed with extreme caution to patients with bronchial asthma. There is a high risk of increased attacks and severe allergic reactions.

Interaction with alcoholic beverages

As mentioned above, Mexidol is used to relieve withdrawal symptoms due to alcoholism. But this does not mean that it is allowed to drink alcohol during therapy.

The medicine does not reduce harmful harmful influence alcohol on the human body when taken during therapy!

Combining the drug with alcohol can cause dangerous side reactions. IN in this case Mexidol will not reduce harmful effects alcohol, and will increase it several times. The main impact will be on the nervous, cardiovascular systems and liver.

Many patients are convinced that drinking alcohol occasionally, in minimum quantities It is not dangerous during treatment with Mexidol. However, doctors argue that with such a treatment regimen one should not expect any positive therapeutic effect.

As a result, the patient is unable to receive vital succinate. This situation can lead to severe consequences not only for health, but also for life.

Can I take it during pregnancy?

Doctors strongly do not recommend using the drug for pregnant women. At the moment, the positive/negative effect of Mexidol on the health of a pregnant woman and the development of the fetus has not been precisely determined. To avoid negative influence medicinal components It is recommended to choose a safer therapy.

At breastfeeding It is not advisable to prescribe the drug. However, in case emergency when a woman’s health is under serious threat, Mexidol is prescribed in minimum dosage. During the course of treatment, breastfeeding should be stopped.

Use in children

Despite warnings that the drug should be used with caution in patients younger than age group, Mexidol is actively used in pediatrics. The effect of the medicine on children's body has not yet been sufficiently studied, however, experienced doctors take responsibility for the health of children and include Mexidol in the therapeutic course.

Indications and dosage

For young patients, the drug is prescribed for circulatory disorders in the brain and for pathologies nervous system. According to statistics, the recovery process for children after traumatic brain injuries is significantly accelerated. Also available positive reviews on the use of the drug in the treatment of psychoemotional disorders.

It has been noted that in children, aggression and nervousness decrease, cognitive abilities increase (memory improves, concentration and learning ability increase).

The medicine is used to eliminate hypoxia in newborns. Babies with this pathology are in dire need of the help of antioxidant drugs that help eliminate the problem associated with a lack of oxygen. In this case, Mexidol is very effective. Despite all the advantages, the use of Mexidol as prophylactic absolutely unacceptable!


For very young patients, it is allowed to add medicine to complementary foods (after crushing the tablet).

Reviews from parents

What do parents who entrusted the health of their children to Mexidol think? Here are some reviews:

Tatyana, Nastya’s mother (1 year):"On scheduled inspection At the neurologist, the doctor discovered that my daughter had increased tone, uncharacteristic for this age. He prescribed complex treatment - the drugs Mexidol and Pantogam. I was afraid to give Mexidol to a child, since the instructions clearly stated that the drug was undesirable for children.

But still I decided to trust an experienced specialist. She gave crushed tablets 3 times a day. A month later, we visited the doctor again, who noted that the child had obvious improvements. I also want to note that there are no negative consequences We didn’t observe anything during treatment.”

Alena, mother of Christina (7 years old):“My girl suffered a severe head injury. The doctor prescribed Mexidol for us. I warned the doctor in time that the baby was suffering from seizures bronchial asthma. After this, the doctor performed a test. As it turned out, it is dangerous for us to take Mexidol. Prescribed alternative treatment."

When treating children, it is necessary to be extremely careful when prescribing medications. It is important to notify the doctor about any problems your child has. chronic diseases. You also need to strictly follow the treatment regimen prescribed by the specialist.

Similar drugs

Mexidol - very expensive remedy, therefore may not be available to many patients. In this case, generic drugs that have a similar effect, but are more affordable, will help. According to experts, in the Top 5 best analogues includes Neurox, Mexicor, Cerecard, Mexifin and Ethoxidol.

Available only in the form of a solution for injection. The basis of the drug is ethylmethylhydroxypyridine succinate. It is an antioxidant drug, used for:


Prohibited for use during pregnancy and lactation, with pathologies of the kidneys and liver, hypersensitivity to components. Contraindicated in children and adolescents under 16 years of age.

It is administered intravenously or intramuscularly. The initial dosage is no more than 2 ampoules 1-2 times a day. The dose can be gradually increased, but should not exceed 800 mg per day. Depending on the patient’s diagnosis, Neurox can be used from 5 to 14 days. The price is indicated in the table (Table 3).

Table 3 - Approximate cost of the drug

The table shows average prices in Moscow. Depending on the region, the cost of the drug may vary slightly.

It is sold in the form of capsules for oral administration and solution for injection. The basis of the drug is succinate. An antioxidant agent used in the treatment of ischemia, stroke, encephalopathy, and cognitive disorders. Contraindications – liver and kidney diseases, pregnancy and lactation, children’s and adolescence(up to 18 years old), increased sensitivity to the components of the composition.

Treatment with capsules begins with a minimum dose of 100 mg three times a day. The dosage may be gradually increased at the discretion of the attending physician. But the daily dose should not exceed 800 mg.

Therapy with a solution requires careful individual approach. The duration of treatment should not exceed 7-10 days. The optimal dosage is 200 mg twice or thrice a day. Cost of the drug: 140 rubles for 20 tablets of 100 mg, 350 rubles for 10 ampoules (2 ml).

– another analogue drug based on the substance ethylmethylhydroxypyridine succinate. Available in the form of a solution for intravenous/intramuscular injection.

Prescribed when anxiety states against the background of a neurosis-like disorder, vegetative-vascular dystonia, encephalopathy, mild cognitive disorders, acute pathologies of cerebral circulation, ischemia, and heart attack.

The drug is contraindicated in liver failure, disorders of the kidneys, a tendency to develop allergic reactions, pregnancy, lactation. Available age restrictions(not recommended for treatment of patients under 18 years of age).

Doctors insist that Cerecard cannot be used independently at home! Introduction medicinal substance must be carried out by an experienced specialist. Before use, the drug must be diluted in a sodium chloride solution. The recommended dosage is one ampoule three times a day. Approximate cost: for 10 ampoules of 2 ml - 350 rubles, for 5 ampoules of 5 ml - about 220 rubles.

– membrane-protective medicine, active ingredient – ​​ethylmethylhydroxypyridine succinate.

Indications for use:

  • neurosis-like state;
  • vegetative-vascular dystonia;
  • ischemia;
  • heart attack;
  • cerebral circulatory disorders;
  • abstinence due to alcohol dependence.

The drug is contraindicated in case of hypersensitivity to the composition, severe violations kidneys and liver, lactation, pregnancy. Not recommended for use in patients under sixteen years of age.

It is produced in the form of a solution and goes on sale in ampoules. One ampoule is prescribed 1 to 3 times a day. The duration of treatment is a maximum of 14 days. You can buy 10 ampoules (2 ml) for about 290 rubles, 5 ampoules (5 ml) for 280 rubles.

Refers to inhibitors of the free radical process, which is based on the substance ethoxydol (malate) ethylmethylhydroxypyridine. Prescribed for the treatment of cognitive disorders, encephalopathy, ischemia and stroke.

Contraindicated for:


Prescribed with caution to children and elderly patients. Available in the form chewable tablets. The tablet must be chewed thoroughly, then washed down with plenty of water. The optimal dosage is one tablet three times a day.

Price for Ethoxidol: 20 tablets of 100 mg can be purchased for approximately 650 rubles, 50 tablets of 100 mg - for 1,450 rubles.

Mexidol or Cereton: which is better?

Experts identify another medicine that belongs to the group nootropic drugs. We are talking about Cereton. As an active active ingredient The substance is choline alfoscerate.

Indications for use:

  • degenerative, involutional brain disorders;
  • cognitive disorders;
  • pseudomelancholic state in elderly patients;
  • psychoorganic syndrome.

Many argue that Cereton is a powerful competitor to Mexidol. However, if you pay attention to the indications for the use of Cereton, you can note a narrower scope of use of this drug.

It belongs to the group of nootropic drugs and has a slightly different effect on the body. Also, the two drugs have a different composition base. Therefore, it is not entirely advisable to compare Cereton and Mexidol.

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Mexidol is a synthetic antioxidant. It has a pharmacological effect on three levels at once: metabolic, vascular and neuronal.

Due to the targeted effect of the drug on all parts of pathogenic free radical oxidation, it is successfully used to treat many psychoneurological and cardiovascular diseases.

About the drug, composition, release form

The drug is available in two forms - tablets and solution for injection. Mexidol tablets contain 125 mg of ethylmethylhydroxypyridine succinate. They white, coated, available in 30 or 50 pieces per package.

Except active substance(Mexidolum) the drug contains auxiliary components: potato starch, White clay, Tween-80, octadecanoic acid, calcium stearate (E-572), methylcellulose, talc and titanium dioxide. Liquid form The drug is available with a dosage of 50 mg/ml in ampoules of 2 or 5 ml.

The active component of the drug is Mexidol (the chemical name is ethylmethylhydroxypyridine succinate). This neuroprotector has the following pharmacological effects:

  • inhibits free radical oxidation of lipids (antioxidant effect);
  • has a membrane-stabilizing effect (membrane-protective effect);
  • reduces the likelihood of cell damage during ischemia (antihypoxic effect);
  • has anticonvulsant activity;
  • has a nootropic and anxiolytic effect;
  • reduces the concentration of cholesterol and “bad” lipoproteins (hypolipidemic effect);
  • has an anti-stress effect.

Thanks to its chemical structure, Mexidol helps to normalize the structural and functional elements of cell membranes, restore neurotransmitter balance, improve the energy balance of cells, reduce membrane viscosity and increase their fluidity.

Mexidol - what does it help with?

What Mexidol helps with is easy to understand pharmacological effects— the drug is prescribed for both prevention and treatment of many conditions. Usually these are diseases associated with disturbances in the functioning of the nervous or cardiovascular systems. Mexidol is prescribed in the following situations:

  1. Prevention and treatment of circulatory disorders in the brain (chronic and acute);
  2. Rehabilitation after head injuries;
  3. Various encephalopathies;
  4. Syndrome vegetative-vascular dystonia;
  5. Neuroses and anxiety states;
  6. Complex therapy of atherosclerosis with cognitive disorders;
  7. Complex therapy of coronary heart disease;
  8. Poisoning with antipsychotic drugs;
  9. Withdrawal syndrome;
  10. Open-angle glaucoma;
  11. Prevention of the occurrence of pathologies against the background of regular extreme loads;
  12. Influence of stress factors.

Mexidol is used to treat diseases that are accompanied by neurodegeneration, for example, stroke, and. It has an anti-amnesic effect and helps improve memory and thinking abilities, which is why Mexidol is used in people old age and in patients with cognitive disorders.

The drug can be used in complex treatment with anticonvulsants, since it potentiates their effect and allows them to be reduced in dosage.

Considering what Mexidol helps with, it should be noted that the drug can also be used in healthy people with increased emotional, mental or physical activity, to save the body's resources.

Instructions for use of Mexidol for various diseases

Mexidol solution is administered intramuscularly or intravenously, the dosage is selected depending on the pathology, condition of the patient and his individual characteristics.

For intravenous drip infusions, administration of the drug should be slow - no faster than 60 drops per minute, jet administration should last 5-7 minutes.

  • A single dose should not be higher than 250 mg, and a daily dose should be 800 mg.

Complex therapy with Mexidol injections for cerebrovascular accidents begins with the administration of 200-400 mg intravenously every day, and from the 5th day it changes to intramuscular administration of 100 mg three times a day. Course duration – 2 weeks.

Treatment after head injuries involves intravenous administration 200 - 500 mg of the drug daily 3 times for 15 days. Discirculatory encephalopathy is treated with Mexidol for about a month, the first half of the month is administered intravenously at 100 mg 3 times a day, and the second half is administered intramuscularly 1 time a day.

When treating cognitive disorders in elderly people, 100-300 mg of the drug is administered intramuscularly for two to four weeks.

  • According to the instructions for use, Mexidol in tablet form is taken 125-250 mg 2-3 times a day. Daily dose should not be higher than 800 mg.

On average, therapy lasts 7-14 days, the dosage is gradually increased, and then gradually reduced towards the end of therapy. At combination treatment for coronary heart disease, the drug is taken for 1.5-2 months.

special instructions

The medicine may cause difficulty concentrating and drowsiness. Therefore, during therapy you should avoid driving vehicles and doing work that requires quick reactions.

It is important to remember that Mexidol enhances the effect of some anticonvulsant and sedative medications, so the doctor must adjust their dosage to avoid unwanted effects.

Side effects of Mexidol, contraindications

Taking Mexidol can cause the appearance side effects. The most common complaints are nausea and dry mouth, but other adverse effects may also occur:

  • drowsiness;
  • dizziness;
  • changes in blood pressure;
  • allergic reactions;
  • sleep disorders;
  • increased sweating;
  • feeling of anxiety and emotional tension.

The drug should not be taken if the liver or kidneys are insufficient, in childhood, pregnant and breastfeeding women, as well as in the presence of hypersensitivity to the components of the drug. Overdose causes drowsiness and is treated with detoxification therapy.

Mexidol analogues, list of drugs

Analogues Russian drug Mexidol are:

  • Armadin,
  • Venokor,
  • Dinar,
  • Zamexen,
  • Meximidol,
  • Mexiprim,
  • Nikomex,
  • Elfunat.

Remember that a doctor’s consultation is required, but if you are going to use an analogue of Mexidol already prescribed, the instructions for use, price and reviews do not apply to analogues and cannot be used as a guide for treatment. When replacing Mexidol, consultation with the attending physician is required; it is possible to change the treatment regimen, dosage, etc.

According to doctors, Mexidol is a low-toxic drug that has a large therapeutic range and virtually no side effects. He shows high efficiency in the treatment of neurological, mental and cardiovascular diseases. It can be used to treat chronic and acute processes, and also used to support the body during increased mental and physical stress.