Trental tablets for what and how. How long can you take Trental?
Trental is a remedy that effectively dilates blood vessels in many tissues of the body, stimulates blood flow and improves blood properties. Instructions for use presented in accessible form in this article, must be studied before starting to use the medicine. Additional data on the prices of the drug, the availability of Trental analogues in pharmacies in Russia, reviews from patients and doctors will allow you to choose the right dosage regimen and ensure the safety of therapy.
Compound
Active substance in medicine is Pentoxifylline. Its content in the composition of the drug depends on the form of release:
- Trental 100 mg and 400 mg tablets;
- Trental solution for injections and infusions - 20 mg of the active ingredient Pentoxifylline in 2 ml.
Auxiliary components in the composition of injection solutions:
- sterile water;
- NaCl.
Additional ingredients in tablets:
- lactose;
- starches;
- silicon salts;
- Mg stearate;
- talc;
- film formers (polymers).
Release form
Trental is produced by Sanofi (India) in two forms:
- Coated tablets white round shape. Packages may contain 20 or 60 tablets.
- Sterile transparent solutions for injection or infusion. Available in 5 ml ampoules. The packages contain 5 ampoules.
Each package includes instructions for using the product from the manufacturer.
pharmachologic effect
The effectiveness of the drug is ensured by the mechanism of action on blood vessels and blood in the human body. Trental is classified as pharmacological group drugs that are peripheral vasodilators (vasodilators). Main directions pharmacological action the medications are as follows:
- inhibition of the phosphodiesterase enzyme;
- increased accumulation of AMP in tissues and blood;
- decreased blood clotting;
- increased fibrinolysis;
- decreased blood viscosity;
- vasodilator effect;
- improving blood circulation;
- stimulation of oxygen supply to the body, especially the effect on the limbs and nerve tissues;
- slight dilatation of the blood vessels of the heart.
Indications for use
The diseases for which Trental is used, according to the manufacturer's instructions, are the following:
- encephalopathy due to atherosclerosis;
- ischemic stroke;
- encephalopathy due to impaired blood circulation in the brain;
- circulatory disorders in peripheral tissues due to diabetes mellitus, atherosclerosis or inflammatory processes;
- tissue nutritional disorders caused by pathological processes in the veins or blood circulation disorders - varicose veins, thrombophlebitis, trophic ulcers, gangrene, hemorrhoids, frostbite, gynecological diseases;
- endarteritis;
- Raynaud's disease;
- disturbances of blood circulation in the organs of vision;
- pathological lesions of microcirculation in the hearing organs.
Contraindications
Trental (as described by the manufacturer) is not prescribed in the presence of the following pathologies and conditions:
- allergy;
- massive bleeding;
- large-scale hemorrhages in the retina or brain;
- heart attack in the acute period;
- ulcers in the gastrointestinal tract;
- hemorrhagic diathesis;
- childhood.
Before you start taking Trental, it is important to exclude these contraindications for use.
Instructions for use
Methods of using tablets:
Trental tablets are used in adults only after meals. Take the medicine with at least 50 ml of water. The prescribed dose is not chewed, but swallowed whole. The duration of the appointment is determined by the doctor individually.
The recommended dosage is 2 to 4 tablets (100 mg) 2 or 3 times a day. It is advisable to distribute the prescribed amount of Pentoxifylline evenly throughout the day: before lunch (morning), at lunch (if necessary) and in the evening (after lunch).
The maximum dose of Trental per day is 1.2 g.
For patients with concomitant serious diseases of the heart, blood vessels, and kidneys, it is important to begin therapy with low doses of Trental.
Course of treatment with injection forms:
Most effective intravenous infusions for adults, which are much easier to tolerate by patients than other parenteral methods of administering Trental. The recommended dose is 100-600 mg of the drug, which must be diluted in 100-500 ml of NaCl, Ringer's, or 5% Glucose solutions. Administration time using a dropper is 100 mg/hour.
For patients in in serious condition it is possible to administer the drug by drip over 24 hours. The dosage for this regimen should be calculated at 0.6 mg per 1 kilogram of weight per hour.
Maximum daily dose regardless of the administration technique - 1.2 g.
In some cases, intravenous injections are prescribed slowly at lying down sick. The dose is 5 ml of Trental. The frequency of administration is selected individually.
The duration of therapy is selected by the treating doctor taking into account the dynamics of the disease. After the patient’s condition improves, it is recommended to continue taking Trental tablets.
Some doctors (usually neurologists) use an administration method such as electrophoresis with Trental (ampoules) to the affected area with impaired blood flow (especially sites of injury in sports or areas affected by osteochondrosis). The time and frequency of application is selected individually.
Overdose
Frequent consequences of exceeding the dose of Trental are the following:
- dizziness;
- nausea;
- hypotension;
- increased body temperature;
- tides;
- increased excitability;
- cardiopalmus;
- heart rhythm disturbances;
- convulsions;
- vomit " coffee grounds", which indicates bleeding from the stomach and intestines.
Methods for preventing overdose symptoms are careful monitoring of the patient's condition and correct dose selection. Treatment is symptomatic.
Side effects
Possible side effects of using Trental are the following:
- hypotension;
- heart rhythm disturbances;
- hypertension (rare);
- thrombocytopenia;
- aplastic form of anemia;
- headaches and dizziness;
- convulsions;
- dyspepsia;
- skin rash of an allergic nature;
- increased bleeding;
- bile stagnation;
- sleep disorders;
- visual disturbances;
- retinal detachment;
- hypoglycemia.
It is possible to prevent and reduce the likelihood of side effects correct selection dose and monitoring the patient's condition.
Interaction with other tools
The combination of Trental with the following groups of drugs enhances the effectiveness of the drugs:
- insulin;
- blood thinners;
- antihypertensive drugs;
- Theophylline;
- Ciprofloxacin;
- Cimetidine.
During pregnancy and lactation
There is no reliable data in official instructions about the safety of using Trental during pregnancy. Pentoxifylline is excreted in breast milk, so if you need to take Trental when breastfeeding(Gv) During lactation, breastfeeding should be temporarily stopped.
With alcohol
When Trental interacts with alcohol, it increases Negative influence ethanol on the body, especially on the stomach and intestines, which can provoke unwanted reactions. During Trental therapy, it is important to exclude alcohol due to low level compatibility.
Analogs
Drugs that can replace Trental without loss of effectiveness
(generics) are as follows:
- Agapurin;
- Latrain;
- Pentoxifylline from different manufacturers, including domestic analogues Russian (cheap);
- Pentoxipharm;
- Pentilin;
- Pentotren.
The list of such drugs includes synonyms of Trental, which are substitutes for medicine if necessary.
Important! Replacement is carried out only by the attending doctor.
Best before date
Ampoules have a shelf life of 3 years from the date of production. The tablets are stored for 4 years. The end of this period is a contraindication to the use of the medicine.
Terms of sale and storage
Trental can be purchased in pharmacies only with a prescription issued to Latin and contains international name active substance in Latin.
The product should be stored under the following conditions:
- temperature no more than 25⁰С;
- out of reach of children;
- away from direct rays.
special instructions
If the patient develops allergic reactions, it is important to immediately stop using the drug. It is important to monitor the dosage of hypoglycemic agents in people suffering from diabetes mellitus.
During therapy with Trental, blood counts should be monitored to prevent the development of anemia.
The drug may cause dizziness. Before driving, it is important to find out the patient’s reaction to the drug.
Price
The cost of Trental is influenced by the form of release and the number of doses in the package:
- 5 ml ampoules No. 5 cost from 155 rubles;
- tablets 100 mg No. 60 - from 480 rubles;
- tablets 400 mg No. 20 - from 630 rubles;
- tablets 400 mg No. 60 - from 1500 rub.
Some human diseases are accompanied by a deterioration in the blood supply to tissues, in which case it is necessary to prescribe medications to eliminate this problem. One of the most accessible and strong drugs, improving blood circulation, is Trental.
Description of the drug, composition
What is a medicine like Trental prescribed for and what is it? This is a vasodilating drug with a long-lasting effect, dilating capillaries and improving blood flow and microcirculation. Medicine Available in the form of tablets and solution with the active substance pentoxifylline. In addition to this, the composition contains:
- talc;
- titanium dioxide;
- povidone;
- macrogol;
- magnesium stearate;
- hyaetellosis;
- hypromellose.
The drug is easily adsorbed in the gastrointestinal tract and excreted through the kidneys and intestines. The half-life is about one and a half hours. It is recommended to store the tablets at room temperature for no more than four years.
Most of the composition is excreted through the kidneys, so people with renal failure you should take the medicine carefully.
Indications for use
Medicines of this type used in the treatment of many diseases. Trental's indications for use are as follows:
The drug helps in complex therapy and treats weakened blood supply to tissues. The dosage depends on the indication, type of disease and degree of its development.
Instructions for use
If the doctor prescribed Trental tablets, why and how to take them this medicine? Its dosage is usually set individually. The standard dosage regimen involves a gradual increase in dose and is as follows:
When prescribing a drug, everything is taken into account possible deviations and the patient's pathology. One of the most important factors application is also the type of disease being eliminated.
If you need to take other medications, you should check their compatibility and consult your doctor.
Contraindications
Due to the fact that the drug Trental is vasodilator, it has limitations in use, mainly associated with pathologies of cardio-vascular system. Among its main contraindications:
Other restrictions include pregnancy and breastfeeding, children's and adolescence under eighteen years of age, drinking alcohol. The medication should be taken with extreme caution in case of arrhythmia and hypotension, liver dysfunction, after surgical operations, at high risks heavy bleeding, in old age. In this case, the dosage is usually reduced, and if serious side effects and complications occur, the medication is stopped.
Side effects
Trental is strong medicine, which has many possible side effects:
If the dosage is exceeded, the risk of side effects increases. With large and systematic overdoses, these phenomena may intensify over time and require symptomatic treatment. In this case, the drug should be stopped immediately, and then the respiratory function should be normalized and arterial pressure. If necessary, it is important to consult a doctor.
Analogs
When individual intolerance Trental and other restrictions are prescribed by analogue drugs of domestic and imported origin.
Concentration of active ingredient analogue drugs Trentala varies.
Trental is a drug that reduces blood viscosity and improves microcirculation. Pentoxifylline, which is part of the drug and at the same time is the main active substance, reduces platelet aggregation, restores platelet elasticity and improves fibrinolysis, reducing the concentration of fibrinogen in plasma. Therefore, in this article we will take a detailed look at the instructions for using Trental, its price, reviews and cheap analogues.
Features of the drug
Composition of Trental
- In one tablet trental contains 100 milligrams of pentoxifylline and excipients (lactose; starch; talc; colloidal silicon dioxide; magnesium stearate). Each tablet is coated with an enteric coating consisting of methacrylic acid copolymer; sodium hydroxide; macrogol (polyethylene glycol) 8000; talc; titanium dioxide (E171). Trental 400 uses different excipients than 100 mg, namely: povidone (PVP); hyaetellose (hydroxyethylcellulose); talc; magnesium stearate.
- Solution for infusion in an amount of one milliliter includes 20 milligrams of the main substance (pentoxifylline) and excipients (sodium chloride, distilled water).
Dosage forms
- Pills Available in two types: 100 and 400 milligrams. They have a round, biconvex shape. Trental 400 has an oblong biconvex shape, and on one side is the inscription: “ATA”.
- Ampoules with medicine are made of transparent glass and have a blue rim at the top. Ampoules are packed in cardboard box, each of them contains 5 milliliters of trental. The solution for infusion is colorless and almost transparent.
In pharmacies in our state you can buy trental in tablets and ampoules at prices ranging from 140 to 1770 rubles. The price depends on the dosage and form of the drug. The region where the medicine is sold also plays an important role in pricing.
pharmachologic effect
Pharmacodynamics
Trental improves blood fluidity (that is, its rheological properties). Due to the active substance, it affects the pathological changes in red blood cells, reducing platelet aggregation and reducing the viscous structure of the blood. In this regard, blood circulation in hard-to-reach places and areas of poor circulation is significantly improved. At the same time, there is a slight expansion coronary vessels and a weak myotropic vasorelaxant effect, as well as a decrease in total peripheral resistance.
A xanthine derivative (pentoxifylline) inhibits phosphodiesterase and accumulates cAMP in blood cells and smooth muscle blood vessels. If symptoms are disturbed cerebral circulation the medicine is very effective. The drug also copes well with occlusive lesions of peripheral arteries. This is reflected in the elimination of seizures in calf muscles, increasing walking distance and disappearing constant pain in the lower extremities.
Pharmacokinetics
After using tablets or intravenous solution active substance Absorbed extremely quickly and practically without residue. Pentoxifylline is actively metabolized in the liver and red blood cells. Various groups metabolites are formed due to the oxidation and breakdown of the main active substance (pentoxifylline).
The pharmacological activity of the metabolites is in no way inferior to pentoxifylline. The main substance, together with its metabolites, do not bind to proteins contained in blood plasma.
The half-life occurs 96 minutes after taking the tablets; if the drug was administered by infusion, the half-life will begin after 70 minutes. The drug is excreted through the kidneys in the form of unconjugated water-soluble metabolites, but about 4-5% are excreted in the feces. In people with impaired liver and kidney function, there is a slower half-life and elimination.
Indications
Indications for use of the drug Trental:
- cerebrovascular accidents;
- memory impairment;
- consequences ;
- ischemic and;
- impaired concentration;
- circulatory disorders in choroid and in the retina of the eye;
- violations peripheral circulation atherosclerotic genesis;
- diabetic angiopathy;
- "intermittent" claudication;
- postthrombotic syndrome;
- trophic disorders (trophic leg ulcer, gangrene);
- frostbite;
- otosclerosis;
- hearing loss;
- degenerative changes due to vascular pathology inner ear.
It is not advisable to give the drug to children, since there is no confirmed data on the effects of trental on the child’s body. Pregnant women are also not recommended for treatment with this medicine; doctors do not have enough data on its effects during pregnancy.
The main active ingredient trental in small quantities can penetrate into breast milk. Therefore, during breastfeeding, the attending physician should carefully analyze the decision to prescribe the drug to a nursing mother.
Instructions for use
The regimen and dosage of use of trental are determined by the attending physician depending on the severity of the disease:
- Pills taken orally without chewing during or immediately after meals, with plenty of water. If the dosage of the tablets is 100 mg, then I take them 3 times a day, one pill. Over time, your doctor will advise you to increase the dose to two or three tablets at a time. The maximum single dose is 400 mg. The daily dosage should not exceed 1200 mg.
- Solution for infusion administered intravenously by dropper. The dosage is calculated for the administration of two 5 ml. ampoules twice a day (evening and morning). In particular severe cases the IV is placed three times a day. After the infusion, your doctor may prescribe two Trental 400 mg tablets.
It is important to remember that for patients suffering from renal failure, daily dosage the drug is reduced.
Contraindications
- massive bleeding;
- extensive hemorrhages in the retina;
- acute;
- severe atherosclerotic lesions;
- uncontrolled;
- under 18 years of age;
- pregnancy;
- lactation period (breastfeeding);
- hypersensitivity to the components of the drug;
- hypersensitivity to other methylxanthines.
Should be used with caution when:
- arterial hypotension (risk of decreased blood pressure);
- renal dysfunction in CC< 30 мл/мин (риск кумуляции и increased risk development of side effects);
- severe liver dysfunction (risk of accumulation and increased risk of side effects);
- increased tendency to bleeding;
- disorders of the blood coagulation system (risk of developing more severe bleeding);
- after recent surgical interventions.
Side effects
When using trental in large doses The following side effects were identified:
- headache;
- anxiety;
- sleep disorders;
- convulsions;
- facial skin hyperemia;
- rushes of blood to the face and upper chest; ;
- vomit;
- diarrhea.
special instructions
- During treatment with Trental, blood pressure should be constantly monitored.
- To prevent hypoglycemia in patients with diabetes mellitus, it is necessary to periodically adjust the dose.
- Smoking reduces the therapeutic effectiveness of the drug.
If you are interested in Trental 100 tablets, then the instructions for use, reviews, my story about why and how to take them will fill the cup of interest in the drug... I will consider this pharmaceutical drug in detail!
Trental - composition and release form
The pharmaceutical industry produces the medicine in tablet forms of 100 milligrams. The active ingredient is pentoxifylline. As auxiliary compounds, one can note the presence of starch, sodium hydroxide, silicon dioxide, talc, lactose, in addition, magnesium stearate, titanium dioxide, macrogol 8000, a copolymer of the so-called methacrylic acid.
To purchase Trental tablets, you will need a prescription from a doctor. The shelf life of the pharmaceutical drug is four years; it must be stored in a place where small children have no access.
Trental - action
The drug Trental has a vasodilating (vasodilating) effect. The main component is pentoxifylline, which improves microcirculatory processes and also dilates blood vessels.
The drug suppresses phosphodiesterase, has a positive effect on the so-called rheological properties of blood, normalizes microcirculation, and also increases the concentration of ATP and cAMP in platelets in red blood cells. Due to expansion coronary arteries the flow of oxygen to the myocardium increases, resulting in an antianginal effect.
The drug normalizes blood oxygenation by dilating the blood vessels of the lungs. The pharmaceutical drug Trental increases the tone of the so-called respiratory muscles, in particular the diaphragm, as well as the intercostal muscles. The medicine affects the bioelectric brain activity, increases the concentration of ATP.
In the area of impaired blood supply, the medicine normalizes microcirculation. For so-called intermittent claudication, this medication helps eliminate pain syndrome at rest, in addition, it relieves a person from cramps in the calf muscles that occur at night, and also contributes to a longer walking distance.
The active substance of the drug is well absorbed and metabolized in the body. The half-life averages one and a half hours. 90 percent of the drug is excreted by the kidneys, in addition, through the intestines.
Trental - indications for use
Indications for the use of pharmaceuticals are the following conditions, accompanied by a violation of the so-called peripheral circulation and a violation of trophic processes in tissues:
Obliterating endarteritis;
The so-called intermittent claudication in diabetic angiopathy;
Frostbite;
Trophic ulcers shins;
Gangrene;
Varicose veins veins;
Postthrombotic syndrome;
Raynaud's disease;
Cerebral atherosclerosis;
Cerebrovascular accident;
Otosclerosis;
Neuroinfection viral origin;
Encephalopathy;
After a myocardial infarction;
With ischemic heart disease;
Bronchial asthma;
Impotence of vascular origin.
Used in ophthalmology for acute disorder blood supply in the retina and in the so-called membrane of the eye.
Trental - contraindications for use
The drug Trental is not used for porphyria, lactation, acute heart attack, intolerance to so-called xanthine derivatives, with massive bleeding, during pregnancy, with retinal hemorrhages, with hemorrhagic stroke.
Trental - side effects
Trental causes the following: adverse reactions: convulsions, anxiety is added, dizziness is noted, headache is recorded, sleep disturbance is characteristic, excessive brittleness of nails is recorded, in addition, swelling, “flushes” of blood to the face, skin hyperemia.
Other adverse reactions will be as follows: cholestatic hepatitis, exacerbation of cholecystitis is observed, intestinal atony is characteristic, loss of appetite occurs, in addition, dry mouth, impaired visual perception, falling blood pressure, pancytopenia.
In addition, hypofibrinogenemia, urticaria, leukopenia, as well as thrombocytopenia, increased liver enzymes, progression of angina are observed, cardialgia, arrhythmia, and tachycardia are not excluded. During development similar manifestations You should consult your doctor.
Trental - application and dosage
The pharmaceutical drug Trental is taken orally, the dose is prescribed by a doctor. Take the medicine with water, taking 100 mg three times a day.
Trental - drug overdose
An overdose of the drug is expressed in the form of tonic-clonic convulsions, accompanied by agitation, drowsiness, weakness, tachycardia, fainting, decreased blood pressure, vomiting, and dizziness. IN similar situation emergency gastric lavage is performed, in addition, enterosobrents are administered to the patient, and if necessary, the patient is hospitalized.
special instructions
Inhaling tobacco reduces therapeutic effect this medicine.
Trental - reviews
The medicine Trental has a positive effect according to many patients. Only a few expressed a neutral opinion about this pharmaceutical product. In general, the drug is effective.
Trental - analogues
Pentoxifylline, Vazonit, Pentamon are analogues of the drug Trental.
Conclusion
Before taking the medication Trental 100, the patient should consult a doctor.
A person’s normal well-being largely depends on the health of blood vessels. Trental is a remedy that will help maintain for as long as possible healthy condition vessels. Next, we will talk about the cases in which Trental is indicated for use, and how to take this remedy correctly.
Indications for the use of Trental droppers and tablets
Trental is one of the most popular and effective angioprotectors. The main effect of this drug is vasodilation. Thanks to this, blood circulation in the vessels becomes more intense, all tissues and organs receive oxygen in sufficient quantities, which helps to normalize their work. One of the most important benefits of Trental is its ability to thin the blood and prevent the formation of deadly blood clots.
In general, the indications for the use of Trental are determined by its main active ingredient - pentoxifylline. It is this component that affects red blood cells, ensuring their elasticity, promoting the accumulation useful substances in the walls of blood vessels, tissues and organs. At the same time, the activity of pentoxifylline does not affect changes in heart rate in any way.
The main indications for use of the drug Trental 400 are as follows:
- One of the main indications is encephalopathy.
- Trental helps with peripheral circulatory disorders of atherosclerotic origin, manifested by problems such as, for example.
- The drug is also prescribed for trophic disorders: ulcers, gangrene, eczema, burns, frostbite.
- With the help of Trental you can fight circulatory disorders in the retina.
- Sometimes sexual dysfunction can occur due to insufficient blood circulation (one of the most striking examples is vascular impotence). Trental will help you cope even with such problems.
- Another indication is Raynaud's disease.
- The drug is prescribed for pathologies respiratory organs. Very often Trental is used to treat bronchial asthma, obstructive bronchitis, emphysema and other similar serious diseases.
- This medication is actively used to treat atherosclerosis and various changes caused by pathologies of the vessels of the inner ear, including hearing loss.
- Frequent severe headaches and dizziness can also be cured with Trental 400. The drug is often prescribed for absent-mindedness, impaired concentration, and memory loss.
- The medication promotes rapid rehabilitation of the body after a stroke.
Features of treatment with Trental
Today you can find Trental in tablets and special injection solutions over the counter in pharmacies. Select the most suitable form Only a specialist can treat and prescribe dosage. The standard dose is two to four tablets two or three times a day. The time of taking the drug does not matter, but it is advisable to take the tablets after meals. The product does not need to be chewed. Take the tablets with a sufficient amount of water. After exposure, the drug is eliminated from gastrointestinal tract almost completely.
Trental injections are indicated for use once or twice a day, depending on the patient’s health condition. Sometimes Trental tablets are prescribed in parallel with injections. In this case, the daily dose of the drug should not exceed 1200 mg.
There are, of course, patients for whom Trental can only harm:
- You should not take the drug if you are hypersensitive to its components.
- Trental is contraindicated for pregnant and nursing mothers.
- It is forbidden to take medication when.