Clindacin vaginal cream: instructions and recommendations for use, composition, review of analogues and reviews from women. Clindacin suppositories

*registered by the Ministry of Health of the Russian Federation (according to grls.rosminzdrav.ru)

Registration number:

P N000956/01

Active substance:

Clindamycin

Dosage form:

vaginal cream

Compound:

1 g of cream contains:

active substance: clindamycin phosphate in terms of 100% substance - 20 mg;

Excipients: sodium benzoate 40 mg, castor oil 100 mg, propylene glycol 440 mg, emulsifier EM 3398 100 mg, macrogol-1500 300 mg.

Description:

The cream is white to off-white with a yellowish or creamy tint.

A slight specific odor is allowed.

Pharmacotherapeutic group:

Antibiotic-lincosamide ATX:
J.01.F.F.01

Pharmacodynamics:

Antibiotic of the lincosamide group for vaginal use. The mechanism of action of the drug is associated with a disruption of intracellular protein synthesis in the microbial cell at the level of the 50S ribosomal subunit.

Clindamycin has a wide spectrum of action, has a bacteriostatic effect, and in higher concentrations it is bactericidal against some microorganisms. Active against microorganisms that cause bacterial vaginosis: Gardnerella vaginalis, Mobiluncus spp., Bacteroides spp., Mycoplasma hominis, Peptostreptococcus spp. Not sensitive to clindamycin Trichomonas vaginalis And Candida albicans.

Pharmacokinetics:

After a single intravaginal administration of 100 mg of clindamycin, an average of 4% of the administered dose is systemically absorbed. The maximum concentration of clindamycin in blood plasma is 20 ng/ml.

Indications for use

Bacterial vaginosis caused by microorganisms sensitive to the drug.

Contraindications

Hypersensitivity to clindamycin or lincomycin.

Carefully:

Clinical studies on the use of clindamycin in women in the first trimester of pregnancy have not been conducted, so the use of the drug is possible only when the expected benefit to the mother outweighs the risk to the fetus.

Use in the second and third trimesters of pregnancy is possible, since no adverse effects on the fetus have been detected.

It is unknown whether it stands out
clindamycin with mother's milk when used intravaginally, therefore, the benefits of using the drug during breastfeeding should be weighed against the possible risk to the baby.

Directions for use and doses

It is administered intravaginally using an applicator.

Instructions for using the applicator:

The disposable applicators included in the package are designed for precise dosing and insertion of Clindacin® cream into the vagina.

1. Open the tube of cream by removing the cap. Pierce the tube membrane with the back of the cap. Screw the plastic applicator onto the threaded neck of the tube.

2. By gently pressing on the opposite end of the tube, carefully squeeze the cream into the applicator. The applicator piston moves independently as the required volume is filled. The applicator is full when the piston reaches the stop. Unscrew the applicator and close the tube with the cap.

3. Lying on your back, pull your knees towards your chest. Holding the applicator horizontally, carefully insert it into the vagina as deeply as possible, trying not to cause discomfort.

4. Slowly pressing the plunger all the way, insert the entire volume of cream into the vagina.

5. Carefully remove the applicator from the vagina and throw it in the trash.

Side effect

It is possible to develop allergic reactions, irritation at the injection site, cervicitis, vaginitis, vulvovaginal candidiasis.

Overdose:

When using the drug intravaginally, an overdose has not been established.

Interaction

An antagonistic interaction has been observed between clindamycin and erythromycin.

There is cross-resistance between clindamycin and lincomycin.

Special instructions:

With prolonged use of the drug, excessive growth of microorganisms insensitive to it is possible, especially fungi of the genus Candida.

Considering the possibility of minimal systemic absorption of the drug (approximately 4%), the occurrence of diarrhea during the use of the drug cannot be excluded. In this case, the drug should be discontinued.

The effectiveness and safety of clindamycin when used intravaginally in children has not been established.

Effect on ability to drive:

Vaginal cream 2%.

Package:

20 or 40 g per aluminum tube. Each tube of 20 g along with 3 applicators and instructions for use or a tube of 40 g along with 7 applicators and instructions for use are placed in a cardboard pack.

Storage conditions:

In a place protected from light, at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Best before date:

Do not use after expiration date.

Conditions for dispensing from pharmacies:

On prescription

Registration Certificate Holder:

Owner of the Registration Certificate: AKRIKHIN KhFK, OJSC

Clindacin - new instructions for use of the drug. You can read the pharmacological action, side effects, prices in pharmacies for Clindacin. Useful reviews about Klindacin -

Antibiotic of the lincosamide group for local use in gynecology.
Drug: CLINDACIN®

Active substance of the drug: clindamycin
ATX coding: G01AA10
KFG: Antibiotic for local use in gynecology
Registration number: P No. 000956/01
Registration date: 10/26/07
Owner reg. holder: Chemical and pharmaceutical plant AKRIKHIN OJSC (Russia)

Vaginal cream 2% from white to white with a yellowish or creamy tint, a slight specific odor is acceptable. 5 g (1 dose) clindamycin phosphate 100 mg
Excipients: sodium benzoate, castor oil, 1,2-propylene glycol, polyethylene oxide (as an emulsifier).
20 g - aluminum tubes (1) complete with applicators (3 pcs.) - cardboard packs.
40 g - aluminum tubes (1) complete with applicators (7 pcs.) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

Pharmacological action of Clindacin

Antibiotic of the lincosamide group for local use in gynecology. The mechanism of action of the drug is associated with a disruption of intracellular protein synthesis in the microbial cell at the level of the 50S ribosomal subunit. Has a bacteriostatic effect; in higher concentrations against some microorganisms - bactericidal.
Has a wide spectrum of action. Active against microorganisms that cause bacterial vaginosis: Gardnerella vaginalis, Mobiluncus spp., Bacteroides spp., Mycoplasma hominis, Peptostreptococcus spp.
Trichomonas vaginalis and Candida albicans are resistant to the drug.

Pharmacokinetics of the drug.

Suction
After a single intravaginal administration of 100 mg of clindamycin, an average of 4% of the administered dose is systemically absorbed.
Cmax in blood plasma averages 20 ng/ml.

Indications for use:

Bacterial vaginosis caused by microorganisms sensitive to the drug.

Dosage and method of administration of the drug.

The recommended single dose is 100 mg clindamycin (1 full applicator). The drug is administered intravaginally (using an applicator) 1 time/day before bedtime for 3-7 days.
Rules for using the applicator
Remove the cap from the cream tube and screw the plastic applicator onto the threaded neck of the tube. Roll the tube from the opposite end and squeeze the cream into the applicator. The applicator is full when the piston reaches the stop. Then you need to unscrew the applicator from the tube and screw on the cap.
Lying on your back, you should horizontally insert the applicator into the vagina as far as possible, but so as not to cause discomfort. Slowly pressing the plunger all the way, insert the cream into the vagina. You should then carefully remove the applicator from your vagina and throw it away.

Side effects of Clindacin:

From the reproductive system: irritation of the vulva at the site of drug administration, cervicitis, vaginitis, vulvovaginal candidiasis.
Other: allergic reactions.

Contraindications to the drug:

Hypersensitivity to clindamycin or lincomycin.

Use during pregnancy and lactation.

Clinical studies on the use of clindamycin in women in the first trimester of pregnancy have not been conducted, therefore the use of Clindacin in the first trimester of pregnancy is possible only when the expected benefit to the mother outweighs the risk to the fetus. Use in the second and third trimesters of pregnancy is possible, since no adverse effects on the fetus have been detected.
It is not known whether clindamycin is excreted in human milk, therefore, if it is necessary to prescribe Clindacin during lactation, the potential benefits of its use for the mother should be weighed against the possible risk to the infant.

Special instructions for the use of Clindacin.

With long-term use of Clindacin, excessive growth of microorganisms insensitive to it, especially fungi of the genus Candida, is possible.
Given the possibility of minimal systemic absorption of the drug (approximately 4%), it is necessary to keep in mind the possibility of developing diarrhea during the use of Clindacin. In this case, the drug should be discontinued.
It is not recommended to use Clindacin simultaneously with other intravaginal agents.
Use in pediatrics
The effectiveness and safety of Clindacin in children have not been established.

Instructions
on medical use of the drug

Registration number:

LSR-006667/08

Trade name of the drug: Clindacin ®

International nonproprietary name:

Clindamycin

Dosage form:

vaginal suppositories

Compound:

1 suppository contains: active substance - clindamycin phosphate in terms of clindamycin - 100 mg and excipients: semisynthetic glycerides (such as "Estarinum", "Vitepsol" or "Suppotsir").

Description.
White or white with a yellowish tint, cylindrical-conical suppositories. There are no inclusions on the longitudinal section; the presence of an airy and porous rod and a funnel-shaped depression is allowed.

Pharmacotherapeutic group:

Antibiotic - lincosamide.

ATX code: G01AA10.

pharmachologic effect

A bacteriostatic antibiotic from the lincosamide group, has a broad spectrum of action, binds to the 50S subunit of the ribosomal membrane and inhibits protein synthesis in the microbial cell. A bactericidal effect is possible against a number of gram-positive cocci.

Active against Staphylococcus spp. (including Staphylococcus epidermidis, producing and non-producing penicillinase), Streptococcus spp. (excluding Enterococcus faecalis), Streptococcus pneumoniae, Corynebacterium diphtheriae, Mycoplasma spp, anaerobic and microaerophilic gram-positive cocci (including Peptococcus spp. and Peptostreptococcus spp.), Clostridium perfringens, Clostridium tetani, Bacteroides spp. (including Bacteroides fragilis and Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., eubacterium and Actinomyces israelii.

Most strains of Clostridium perfringens are sensitive to clindamycin, but other Clostridium spp. (including Clostridium sporogenes, Clostridium tertium) are resistant to its action, and therefore for infections caused by Clostridium spp., it is recommended to determine an antibiogram.

Cross-resistance exists between clindamycin and lincomycin.

Pharmacokinetics
After a single intravaginal administration of 100 mg of clindamycin, 4% of the administered dose is subject to systemic absorption. The maximum concentration in plasma is 20 ng/ml.

Indications
Bacterial vaginosis caused by microorganisms sensitive to clindamycin.

Contraindications
Hypersensitivity, pregnancy 1st trimester. Use during pregnancy and lactation Clindamycin penetrates the placenta into the circulatory system of the fetus. Excreted in breast milk. Intravaginal use of clindamycin during pregnancy is possible only when the expected benefit to the mother outweighs the potential risk to the fetus.
It is recommended to be careful when prescribing to nursing women (stop breastfeeding during treatment).

Directions for use and doses
Intravaginally. Before use, one suppository is released from the contour packaging, having previously cut the film along the contour of the suppository, and inserted, if possible, deep into the vagina, in a lying position.
1 suppository 1 time per day, immediately before bedtime for 3-7 days in a row.

Side effects
From the genitourinary system: cervicitis, vaginitis, vulvovaginal irritation.
From the hematopoietic organs: rarely reversible leukopenia, neutropenia, eosinophilia, agranulocytosis, thrombocytopenia.
Allergic reactions: maculopapular rash, urticaria, itching.
With resorption, there is a possibility of developing systemic side effects, including, in rare cases, pseudomembranous enterocolitis.

Overdose
Due to the low absorption of the drug, an overdose is unlikely.

Interaction
Strengthens the effect of drugs rifampicin, aminoglycosides - streptomycin, gentamicin, deepens muscle relaxation caused by n-cholinergic blockers.
Incompatible with erythromycin, ampicillin, diphenylhydantoin, barbiturates, aminophylline, calcium gluconate and magnesium sulfate.

special instructions
Vaginal suppositories are not recommended for use simultaneously with other intravaginal medications.
The drug does not affect the reaction speed of vehicle drivers and persons servicing installations that require special attention.

Release form
Vaginal suppositories 100 mg.
3 suppositories in a blister pack. 1 blister pack together with instructions for use are placed in a cardboard pack.

Storage conditions
In a dry place, protected from light, at a temperature of 15 to 25 ° C.
Keep out of the reach of children.

Best before date
3 years. Do not use after the expiration date.

Conditions for dispensing from pharmacies
Over the counter.

Manufacturer
Pharmaprim LLC, Republic of Moldova, Chisinau, st. G. Tudor, 3.

Packer
Open Joint Stock Company "Chemical and Pharmaceutical Plant "AKRIKHIN", Russia, 142450, Moscow region, Noginsky district, Staraya Kupavna, Kirova St., 29.

Clindamycin suppositories are a medication intended for vaginal use. The drug belongs to the lincosamide group of antibiotics. The medicine is used in gynecology to treat infectious diseases caused by microorganisms that are sensitive to the active substance of suppositories.

Clindamycin.

ATX

Compound

Each suppository contains 100 mg of active substance -. An auxiliary component is suppotsir (the basis for the production of candles).

pharmachologic effect

The suppositories have a bacteriostatic effect: the active substance suppresses the growth and reproduction of pathogenic microflora, blocking the production of microbial cell proteins. The drug is effective against staphylococci, streptococci, ureaplasma, clostridia, mycoplasma and a number of other microorganisms.

Pharmacokinetics

Systemic absorption is no more than 5%. The half-life is 1.5-3.5 hours, but in patients suffering from kidney pathologies, this time increases. Excretion is slow - about one week.

What are Clindamycin suppositories prescribed for?

Suppositories are used for bacterial vaginosis. Before prescribing the drug, the causative agent of the disease is determined. To do this, bacterial culture of vaginal discharge is performed. The result of the analysis allows the doctor to understand whether the infectious agent is sensitive to the antibiotic.

Clindamycin is not active against Candida fungi, but for complicated forms of mixed thrush, the drug is prescribed as part of a complex treatment.

Contraindications

The drug has few contraindications. Suppositories should not be used if you are intolerant to the active or auxiliary components of the drug.

Suppositories are not prescribed to patients who have oncological pathologies of the vaginal walls.

How to take Clindamycin suppositories

The suppository is introduced after performing hygiene procedures.

• You must wash your hands thoroughly;
• remove the suppository from the package;
• lie down and insert the suppository into the vagina as deeply as possible, but so as not to experience discomfort;
• After this, you need to lie down for at least half an hour to allow the components of the drug to be absorbed and begin to act.

It is best to carry out treatment procedures before bedtime.

If no therapeutic effect is observed, then you should consult a doctor. The specialist may recommend a higher dosage or suggest taking a repeat course. It is possible that the causative agent of the disease was identified incorrectly. In this case, the doctor will prescribe another drug.

Clindamycin

Antibiotics: Clindamycin

For diabetes

The instructions do not contain any special instructions regarding the treatment of patients with diabetes mellitus with Clindamycin. When visiting a gynecologist, it is recommended to inform him about your diagnosis so that the doctor can select the most suitable drug.

Side effects of Clindamycin suppositories

The drug is well tolerated by patients. In rare cases, disruption of the menstrual cycle, irritation of the mucous membrane of the external and internal genital organs, and discharge of mucus from the vagina are possible. Side effects from other organs and systems are possible.

From the musculoskeletal and connective tissue side

With vaginal use of Clindamycin, no side effects from the musculoskeletal and connective tissue are observed.

Gastrointestinal tract

Abdominal pain and cramps, nausea and vomiting, diarrhea.

Blood-forming organs

Decreased leukocyte levels in the blood, neutropenia, eosinophilia, thrombocytopenia, agranulocytosis.

central nervous system

Dizziness, headache.

Allergies

Itching, rashes, redness of the skin.

Impact on the ability to operate machinery

The use of suppositories does not affect the ability to drive a car or engage in activities that involve complex mechanisms.

special instructions

During the treatment period, vaginal discharge increases, so women are advised to use panty liners. You should not use suppositories during menstruation: you must wait until the end of menstruation and then begin treatment.

Doctors advise avoiding sexual intercourse while using candles. But if this cannot be avoided, then you should remember that clindamycin reduces the strength of latex products - condoms and vaginal diaphragms, so the use of these means of protection during therapy is not recommended.

Use in old age

For children

Candles are not prescribed for children.

Use during pregnancy and lactation

During pregnancy and breastfeeding, suppositories can be prescribed by a doctor only if the expected benefit to the woman outweighs the possible risk to the development of the fetus or the health of the newborn.

Overdose

When using the drug, systemic absorption into the bloodstream is minimal, so overdose is unlikely. But a woman should not exceed the dose prescribed by the doctor to avoid side effects.

Interaction with other drugs

During therapy with Clindamycin in the form of suppositories, it is necessary to avoid douching, irrigation of the vaginal mucosa, and the use of antiseptics. These procedures reduce the therapeutic effect of the drug.

You cannot use suppositories and medications with erythromycin, calcium, or magnesium sulfate at the same time, as the risk of side effects increases. The same applies to barbiturates.

Alcohol compatibility

It is better to avoid alcoholic beverages while using suppositories.

Analogs

Clindamycin is available in several dosage forms. All drugs have the active ingredient clindamycin. This:

• capsules for oral use - 150 mg of active substance;
• cream for topical use - 2%, sometimes it is incorrectly called ointment (more details in the article);
• injection solution - 300 mg of clindamycin in one 2 ml ampoule.

Analogs of suppositories are:

• Zerkalin - solution for external use;
• Clindamycin B Prolong - cream for vaginal use with two active ingredients - clindamycin, butoconazole;
• Milagin - suppositories for vaginal use.

A cheaper analogue is Klimitsin suppositories.

Conditions for dispensing from a pharmacy

Clindamycin suppositories are available with a doctor's prescription.

Can I buy it without a prescription?

Unscrupulous pharmacy employees may sell medicine without a prescription.

Price

The cost of packaging (3 candles) is 550-600 rubles.

Storage conditions of the drug

Dry place, protected from light. Storage temperature - from +15 to +25°C.

With a wide range of bacteriostatic effects (stops reproduction) on microorganisms. It can also have a bactericidal effect against gram-positive cocci (destroy all forms). The treatment is effective for infection with corynebacteria, staphylococci, mycoplasmas, fusobacteria, and so on. Some types of clostridia are resistant to this medicine. Also, those bacteria that are resistant to another antibiotic from the same group (lincosamides) - lincomycin will not be sensitive to the use of Clindacin suppositories.

Applicable for:

• Vaginosis caused by bacteria sensitive to;

We have already noted that the most successful form of drug release is vaginal suppositories. They are used one per day for three days or a week. The instructions for the drug Clindacin indicate that the suppository should be inserted in a lying position, as deep as possible. As a rule, such procedures are carried out before bedtime.

Contraindicated for:

• Treatment of pregnant women (in the first trimester) and nursing mothers (excreted with breastfeeding);

Side effects

Since Clindacin is used in the form of suppositories, extremely small amounts of the antibiotic enter the systemic bloodstream. This ensures high safety of the drug. Local inflammation and irritation of the mucous membrane are possible. Also, if you are intolerant to the components of the drug, allergic reactions may develop. In some patients, the health of the hematopoietic system is reversibly affected (the number of certain blood cells decreases).

Analogs are cheaper than Clindacin candles

The antibiotic clindamycin is a component of many drugs. However, only one more product is produced in the form of suppositories based on it - Dalatsin. The cost of a similar package of this medicine is either equal to or higher than that of Klindayine. Accordingly, treatment with these very candles that we describe will be cheaper than using other means.

Reviews of Clindacin candles

On forums where women discuss their health, there is often talk about the treatment of various infections. Including, there are reviews of Clindacin suppositories as a fairly effective drug:

“I didn’t even feel particularly uncomfortable.” But during a routine examination, a smear was taken from a gynecologist and vaginosis was found. When the doctor said that I needed treatment, I immediately felt that something was wrong with me. But just three days of Klindacin candles brought back confidence. A secondary smear showed the absence of harmful bacteria.

- I was treated with Clindacin suppositories. Surprisingly, in three days he was able to overcome vaginosis. By the way, there are no side effects.

- I read about all sorts of undesirable effects of antibiotics. But my fears were in vain - for several days the Clindacin suppositories did not cause any unpleasant sensations.

These and many other reviews show that this drug is very successfully used for bacterial vaginosis and is quite safe.

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